Moisaicism in the human preimplantation embryo

Reproduction Nutrition Development

Volumn 36, Issue 6, 1996, Pages 643-649

  Handyside, A H ^a  

^a ST THOMAS HOSPITAL   (United Kingdom)

Author keywords

Chromosomal mosaicism; Human embryo

Indexed keywords

CHROMOSOME ANALYSIS; CHROMOSOME MOSAICISM; CONFERENCE PAPER; CYTOGENETICS; EMBRYO; EMBRYO DEVELOPMENT; FERTILIZATION; FLUORESCENCE IN SITU HYBRIDIZATION; HUMAN; PREIMPLANTATION EMBRYO;

CELL NUCLEUS; CHROMOSOME ABERRATIONS; EMBRYO; EMBRYONIC AND FETAL DEVELOPMENT; EMBRYONIC DEVELOPMENT; FEMALE; FERTILIZATION; HUMANS; MOSAICISM; PREGNANCY;

EID: 0030461314     PISSN: 09265287     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (29)

1. Angell RR (1989) Chromosome abnormalities in human preimplantation embryos. In: Development of Preimplantation Embryos and their Environment (K Yoshinaga, T Mori, eds). Prog Clin Biol Res 294, 181-187
2. Angell RR, Templeton AA, Aitken RJ (1986) Chromosome studies in human in vitro fertilization. Hum Genet 72, 333-339
3. Burgoyne PS, Holland K, Stephens R (1991) Incidence of numerical chromosome anomalies in human pregnancy estimation from induced and spontaneous abortion data. Hum Reprod 6, 555-565
4. Coonen E, Harper JC, Ramaekers FCS, Delhanty JDA, Hopman AHN, Geraedts JPM, Handyside AH (1994) Presence of chromosomal mosaicism in abnormal human preimplantation embryos detected by fluorescent in situ hybridization (FISH). Hum Genst 54, 609-615
5. Delhanty JDA, Harper, JC, Ao A, Handyside AH, Winston RML (1996) Multicolour FISH detects frequent chromosomal mosaicism in normal preimplantation embryos from fertile patients. Hum Mol Genet (in press)
6. Hardy K, Handyside AH, Winston RM (1989) The human blastocyst. cell number, death and allocation during late preimplantation development in vitro. Development 107, 597-604
7. Hardy K, Martin, KL, Leese HJ, Winston RM, Handyside AH (1990) Human preimplantation development in vitro is not adversely affected by biopsy at the 8-cell stage. Hum Reprod 5, 708-714
8. Hardy K, Winston RM, Handyside AH (1993) Binucleate blastomeres in preimplantation human embryos in vitro: failure of cytokinesis during early cleavage. J Reprod Fertil 98, 549-558
9. Harper JC, Coonen E, Handyside AH, Winston RM, Hopman AH, Delhanty JD (1995) Mosaicism of autosomes and sex chromosomes in morphologically normal monospermic preimplantation human embryos. Prenatal Diagn 15, 41-49
10. Hassold TJ (1986) Chromosome abnormalities in human reproductive wastage. Trends Genet 2, 105-110
11. James RM, West JD (1994) A chimaeric animal model for confined placental mosaicism. Hum Genet 93, 603-604
12. James RM, Klerkx AH, Keighren M, Flockhart JH, West JD (1995) Restricted distribution of tetraploid cells in mouse tetraploid<==>diploid chimaeras. Dev Biol 167, 213-226
13. Jamieson ME, Courts JRT, Connor JM (1994) The chromosome consitution of human preimplantation embryos fertilised in vitro. Hum Reprod 9, 709-715
14. Juriscova A, Varmuza S, Casper RF (1996) Programmed cell death and human embryo fragmentation. Mol Hum Reprod 2, 93-98
15. Munné S, Grifo J, Cohen J, Weier HU (1994a) Chromosome abnormalities in human arrested preimplantation embryos: a multiple-probe FISH study. Am J Hum Genet 55, 150-159
16. Munné S, Weier HU, Grifo J, Cohen J (1994b) Chromosome mosaicism in human embryos. Biol Reprod 51, 373-379
17. Munné S, Sultan, KM, Weier HU, Gnfo JA, Cohen J, Rosenwaks Z (1995) Assessment of numeric abnormalities of X, Y, 18, and 16 chromosomes in preimplantation human embryos before transfer. Am J Obstet Gynecol 172, 1191-1199
18. Palermo G, Munné S, Cohen J (1994) The human zygote inherits its mitotic potential from the male gamete. Hum Reprod 9, 1220-1225
19. Pellestor F (1991) Frequency and distribution of aneuploidy in human female gametes. Hum Genet 86, 283-288
20. Piachot M, Mandelbaum, J, Junca AM, de Grouchy J, Cohen J, Salat Baroux J, Da Lage C (1986) Morphologic cytologic and cytogenetic studies of human embryos obtained by IVF. In: In vitro Fertilization. Proceedings of the 12th World Congress on Fertility and Sterility (SS Ratnam, ES Teon, eds) Parthenon Publishing group, Lans, UK, 61-65
21. Plachot M, Mandelbaum, J, Junka AM, de Grouchy J, Salat-Baroux J, Cohen J (1989) Cytogenetic analysis and developmental capacity of normal and abnormal embryos after IVF. Hum Reprod 4 (suppl), 99-103
22. Sathananthan AH, Kola I, Osborne J, Trounson A, Ng SC, Bongso A, Ratnam SS (1991) Centnoles in the beginning of human development. Proc Natl Acad Sci USA 88, 4806-4810
23. Strain L, Warner JP, Johnston T, Bonthron DT (1995) A human parthenogenetic chimaera. Nature Genet 11, 164-169
24. Sultan KM, Munné S, Palermo GD, Alikani M, Cohen J (1995) Chromosomal status of uni-pronuclear human zygotes following in-vitro fertilization and intracytoplasmic sperm injection. Hum Reprod 10, 132-136
25. Taylor AS, Braude PR (1994) The early development and DNA content of activated human oocytes and parthenogenetic human embryos. Hum Reprod 9, 2389-2397
26. Van Blertkom J, Bell H, Henry G (1987) The occurrence, recognition and developmental fate of pseudo-multipronuclear eggs after in-vitro fertilization of human oocytes. Hum Reprod 2, 217-225
27. Winston, NJ, Braude PR, Pickering SJ, George MA, Cant A, Currie J, Johnson MH (1991) The incidence of abnormal morphology and nucleocytoplasmic ratios in 2-, 3- and 5-day human pre-embryos. Hum Reprod 6, 17-24
28. Zenzes MT, Casper RF (1992) Cytogenetics of human oocytes, zygotes, and embryos after in vitro fertilization. Hum Genet 88, 367-375
29. Zenzes MT, Wang P, Casper RF (1992) Chromosome status of untransferred (spare) embryos and probability of pregnancy after in vitro fertilisation. Lancet 340, 391-394