Enantiomeric bioanalysis of simendan and levosimendan by chiral high-performance liquid chromatography

Chirality

Volumn 8, Issue 7, 1996, Pages 511-517

  Wikberg, Tom ^a   Korkolainen, Tapio ^a   Karlsson, Marianne ^a  

^a ORION CORPORATION   (Finland)

Author keywords

Enantiomers; Enantiospecific bioanalysis; Isomerization; Plasma; Protein binding; cyclodextrin

Indexed keywords

LEVOSIMENDAN;

ANIMAL EXPERIMENT; ARTICLE; CONGESTIVE HEART FAILURE; DOG; DRUG BLOOD LEVEL; DRUG CONFORMATION; DRUG DETERMINATION; DRUG PROTEIN BINDING; ENANTIOMER; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN EXPERIMENT; MALE; NONHUMAN; NORMAL HUMAN; PRIORITY JOURNAL; RAT;

ANIMALS; BLOOD CHEMICAL ANALYSIS; BLOOD PROTEINS; CARDIOTONIC AGENTS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DOGS; HUMANS; HYDRAZONES; MALE; MOLECULAR STRUCTURE; PROTEIN BINDING; PYRIDAZINES; RATS; RATS, WISTAR; REPRODUCIBILITY OF RESULTS; STEREOISOMERISM;

EID: 0030460758     PISSN: 08990042     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1520-636X(1996)8:7<511::AID-CHIR8>3.0.CO;2-D     Document Type: Article

References (21)

1. Haikala, H., Linden, I.-B., Pohto, P. Simendan, a novel calcium sensitizer, is as potent and efficient in the skinned fibre as in the electrically paced papillary muscle. J. Mol. Cell. Cardiol. 24 (Suppl. 1): S260, 1992.
2. Haikala, H, Undén, I.-B. Mechanisms of action of calcium-sensitizing drugs. J. Cardiovasc. Pharmacol. 26(Suppl. 1):S10-S19, 1995.
3. Ovaska, M., Haikala, H., Lundström, K., Korkolainen, T., Taskinen, J., Lindén, I.-B. Studies on calcium-dependent binding of simendan to troponin complex and troponin C.J. Mol. Cell Cardiol. 24 (Suppl. 1):S260, 1992.
4. 2+ affinity by drugs. Proteins 11:79-94, 1991.
5. 2+ sensitizer, levosimendan, to recombinant human cardiac troponin C. J. Biol Chem. 269:28584-28590, 1994.
6. Haikala, H., Lindén, I.-B., Pohto, P. Changes in contraction-relaxation cycle by levosimendan indicate calcium sensitization in paced papillary muscle without impairment of relaxation. Eur. Heart J. 13(suppl.):P765, 1992.
7. Haikala, H., Nissinen, E., Ettemadzadeh, E., Levijoki, J., Lindén, L-B., Troponin C-mediated calcium sensitization induced by levosimendan does not impair relaxation. J. Cardiovasc. Pharmacol. 25:794-801, 1995.
8. Lilleberg, J.M., Sundberg, S., Leikola-Pelho, T., Nieminen, M.S. Hemodynamic effects of the novel cardiotonic drug simendan: Echocardiographic assessment in healthy volunteers. Cardiovasc. Drugs Ther. 8:263-269, 1994.
9. Végh, Á., Papp, J.G., Udvary, É., Kaszala, K. Hemodynamic effects of calcium-sensitizing agents. J. Cardiovasc. Pharmacol. 26(Suppl. 1):S20-S31, 1995.
10. Lilleberg, J., Sundberg, S., Nieminen, M.S. Dose-range study of a new calcium sensitizer, levosimendan, in patients with left ventricular dysfunction. J. Cardiovasc. Pharmacol. 26(Suppl. 1):S63-S69, 1995.
11. Lilleberg, J., Antila, S., Karlsson, M., Nieminen, M.S., Pentikäinen, P.J. Pharmacokinetics and pharmacodynamics of simendan, a novel calcium sensitizer, in healthy volunteers. Clin. Pharmacol. Ther. 56:554-563, 1994.
12. Sandell, E.-P., Häyhä, M., Antila, S., Heikkinen, P., Ottoila, P., Lehtonen, L.A., Pentikäinen, P.J. Pharmacokinetics of levosimendan in healthy volunteers and patients with congestive heart failure. J. Cardorvasc. Pharmacol. 26(Suppl. 1):S57-S62, 1995.
13. Hutt, A.J. Drug chirality: Impact on pharmaceutical regulation. Chirality 3:161-164, 1991.
14. Rauws, A.G., Groen, K. Current regulatory (Draft) guidance on chiral medical products: Canada, EEC, Japan, United States. Chirality 6:72-75, 1994.
15. Karlsson, M., Korkolainen, T., Wikberg, T. Automated analysis of levosimendan in human plasma by on-line dialysis and liquid chromatography. Biomed. Chromatogr, 1996 in press.
16. Han, S.M., Han, Y.I., Armstrong, D.W. Structural factors affecting chiral recognition and separation on β-cyclodextrin bonded phases. J. Chromatogr. 441:376-381, 1988.
17. Chu, K.-M., Shieh, S.-M., Wu, S.-H., Hu, O. Y.-P. Enantiomeric separation of a cardiotonic agent pimobendan and its major active metabolite, UDCG 212 BS, by coupled achiral-chiral normal-phase high-performance liquid chromatography. J. Chromatogr. Sci. 30:171-176, 1992.
18. Karnes, H.T., Sarkar, M.A. Enantiomeric resolution of drug compounds by liquid chromatiography. Pharm. Res. 4:285-292, 1987.
19. Beeson, M.D., Vigh, G. Examination of the retention behaviour of underivatized profen enantiomers on cyclodextrin silica stationary phases. J. Chromatogr. 634:197-204, 1993.
20. Ward, T.J., Armstrong, D.W. Improved cyclodextrin chiral phases: A comparison and review. J. Liq. Chromatogr. 9:407-423, 1986.
21. Williams, K., Lee, E. Importance of drug enantiomers in clinical pharmacology. Drugs 30:333-354, 1985.