Treatment of human lung carcinoma xenografts with a combination of 131l-labelled monoclonal antibody Po66 and doxorubicin

Cancer Immunology, Immunotherapy

Volumn 43, Issue 5, 1997, Pages 269-274

  Desrues, B ^a   Brichory, F ^b   Lena H ^a   Bourguet, P ^b   Delaval, P ^a   Toujas, L ^b   Dazord, L ^b  

^a PONTCHAILLOU UNIVERSITY HOSPITAL   (France)

^b Ctr Reg de Lutte Contre le Cancer   (France)

Author keywords

Animal model; Lung cancer; Monoclonal antibodies; Radioimmunotherapy

Indexed keywords

DOXORUBICIN; IODINE 131; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY I 131; MONOCLONAL ANTIBODY PO66; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER CHEMOTHERAPY; CANCER IMMUNOTHERAPY; CELL LINE; CONTROLLED STUDY; LUNG CANCER; MOUSE; NONHUMAN; PRIORITY JOURNAL; SQUAMOUS CELL CARCINOMA; TUMOR GROWTH;

ANIMALS; ANTIBODIES, MONOCLONAL; COMBINED MODALITY THERAPY; DOXORUBICIN; HUMANS; IMMUNOTOXINS; IODINE RADIOISOTOPES; LUNG NEOPLASMS; MICE; MICE, NUDE; NEOPLASM TRANSPLANTATION;

EID: 0030460747     PISSN: 03407004     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002620050333     Document Type: Article

References (16)

1. Boven E, Winograd B, Berger DP, Dumont MP, Braakhuis BJM, Fodstad O, Langdon S, Fiebig HH (1992) Phase II preclinical drug screening in human tumor xenografts: a first European multicenter collaborative study. Cancer Res 52:5940
2. 131I-labeled TNT-1 monoclonal antibody. Cancer Res 49:4578
3. Cooper EH, Bedford AJ, Kenny TE (1975) Cell death in normal and malignant tissues. Adv Cancer Res 21:59
4. Dazord L, Bourel D, Martin A, Lecorre R, Bourguet P, Bohy J, Saccavini JC, Delaval Ph, Louvet M, Toujas L (1987) A monoclonal antibody (Po66) directed against human lung squamous cell carcinoma. Immunolocalization of tumor xenografts. Cancer Immunol Immunother 24:263
5. Desrues B, Léna H, Brichory F, Ramée MP, Toujas L, Delaval P, Dazord L (1995) Monoclonal antibody Po66 uptake by human lung tumours implanted in nude mice: effect of co-administration with doxorubicin. Br J Cancer 72:1076
6. Epstein AL, Chen F-M, Taylor CR (1988) A novel method for the detection of necrotic lesions in human cancers. Cancer Res 48:5842
7. Feld R, Rubinstein LV, Weisenberger TH and the lung cancer study group (1984) Sites of recurrence in resected stage I non-small-cell lung cancer: a guide for future studies. J Clin Oncol 2:1352
8. Goldenberg DM, Larson SM, Reisfeld RA, Schlom J (1995) Targeting cancer with radiolabeled antibodies. Immunol Today 16:261
9. Hoefnagel CA (1993) Radionuclide therapy of tumors: general aspects and considerations. Int J Biol Markers 8:172
10. Kalofonos HP, Ruschowski M, Siebecker DA, Sivolapenko GB, Snook D, Lavender JP, Epenetos AA, Hnatowich DJ (1990) Imaging of tumour in patients with indium-111-labeled biotin and streptavidin-conjugated antibodies: preliminary communication. J Nucl Med 31:1791
11. Le Doussal JM, Chetanneau A, Gruaz-Guyon A, Martin M, Gautherot E, Lehur P-A, Chatal J-F, Delaage M, Barbet J (1993) Bispecific monoclonal antibody-mediated targeting of an indium-111-labeled DTPA dimer to primary colorectal tumors: pharmacokinetics, biodistribution, scintigraphy and immune response. J Nucl Med 34:1662
12. Martin A, Pellen P, Guitton C, Youinou P, Collet B, Desrues B, Bourel D, Dazord L, Toujas L (1989) Characterization of the antigen identified by Po66. Cancer Immunol Immunother 29:118
13. Mountain CF, McMurtroy MS, Fragier OH (1980) Present status of postoperative adjuvant therapy for lung cancer. Cancer Bull 32:108
14. Myers MJ (1988) Dosimetry for radiolabelled antibodies - macro or micro? Int J Cancer 2s:71
15. Schlom J, Molinolo A, Simpson JF, Siler K, Roselli M, Hinkle G, Houchens DP, Colcher D (1990) Advantage of dose fractionation in monoclonal antibody-targeted radioimmunotherapy. J Natl Cancer Inst 82:763
16. Vaage J, Barbera-Guillem E, Abra R, Huang A, Working P (1994) Tissue distribution and therapeutic effect of intravenous free or encapsulated liposomal doxorubicin on human prostate carcinoma xenografls. Cancer 73:1478