Efficacy of antitat gene therapy in the presence of high multiplicity infection and inflammatory cytokines

Human Gene Therapy

Volumn 7, Issue 18, 1996, Pages 2209-2216

  Lisziewicz, Julianna ^a,b   Sun, Daisy ^c   Gallo, Robert C ^d   Ensoli, Barbara ^c   Lori, Franco ^a,b  

^a Res Inst Genetic and Hum Ther   (United States)

^b FONDAZIONE IRCCS POLICLINICO SAN MATTEO   (Italy)

^c NATIONAL CANCER INSTITUTE   (United States)

^d INSTITUTE OF HUMAN VIROLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ARTICLE; CELL GROWTH; CONTROLLED STUDY; GENE THERAPY; GENETIC TRANSDUCTION; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; KAPOSI SARCOMA; NONHUMAN; TURNOVER TIME; VIRUS INHIBITION; VIRUS REPLICATION;

HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1; UNIDENTIFIED RETROVIRUS;

EID: 0030460622     PISSN: 10430342     EISSN: None     Source Type: Journal    
DOI: 10.1089/hum.1996.7.18-2209     Document Type: Article

References (39)

1. BARILLARI, G., BUONAGURO, L., FIORELLI, V., HOFFMAN, J., MICHAELS, F., GALLO, R.C., and ENSOLI, B. (1992). Effects of cytokines from activated immune cells on vascular cell growth and HIV-1 gene expression. J. Immunol. 149, 3727-3734.
2. BISWAS, D.K., SALAS, T.R., WANG, F., AHLERS, C.M., DEZUBE, B.J., and PARDEE, A.B. (1995). A Tat-induced auto-up-regulatory loop for superactivation of HIV-1 promoted. J. Virol. 69, 7437-7444.
3. BROTHER, M.B., MURTY, L.C., LISZIEWICZ, J., GALLO, R.C., and ENSOLI, B. (1996). Block of tat-mediated transactivation of tumor necrosis factor b gene expression by polymeric-TAR decoys. Virology 222, 252-256.
4. BUONAGURO, L., BARILLARI, G., CHANG, H.K., BOHAN, C.A., KAO, V., MORGAN, R., GALLO, R.C., and ENSOLI, B. (1992). Effects of the human immunodeficiency virus type 1 Tat protein on the expression of inflammatory cytokines. J. Virol. 66, 7159-7167.
5. BUONAGURO, L., BUONAGURO, F.M., GIRALDO, G., and ENSOLI, B. (1994). The human immunodeficiency virus type 1 Tat protein transactivates tumor necrosis factor beta gene expression through a TAR-like structure. J. Virol. 68, 2677-2682.
6. CHOWDHURY, M., TAYLOR, J.P., CHANG, C.F., RAPPAPORT, J., and KHALILI, K. (1992). Evidence that a sequence similar to TAR is important for induction of the JC virus late promoter by human immunodeficiency virus type 1 Tat. J. Virol. 66, 7355-7361.
7. + T cells. Science 270, 1811-1815.
8. CULLEN, B.R. (1986). Trans-activation of human immunodeficiency virus occurs via a bimodal mechanism. Cell 46, 973-982.
9. EMBERTSON, J., ZUPACIC, M., RIBAS, J.L., BURKE, P., RACZ, P., TENNER-RACZ, K., and HAASE, A.T. (1993). Massive cover infection of helper T lymphocytes and macrophages by HIV during the incubation period of AIDS. Nature 362, 359-362.
10. EMILIE, D., PEUCHMAU, M., MAILLOT, M.C., CREVON, M.C., BROUSSE, N., DELFRAISSY, J.F., and CORMONT, J. (1990). Production of interleukins in human immunodeficiency virus-1-replicating lymph nodes. J. Clin. Invest. 86, 148-159.
11. ENSOLI, B., BARILLARI, G., SALAHUDDIN, S.Z., GALLO, R.C., and WONG-STAAL, F. (1990). Tat protein of HIV-1 stimulates growth of AIDS Kaposi's sarcoma derived cells. Nature 345, 84-86.
12. ENSOLI, B., GENDELMAN, R., MARKHAM, P., FIORELLI, V., COLUMBINI, S., RAFFELD, M., CAFARO, A., CHANG, H.K., BRADY, J.N., and GALLO, R.C. (1994). Synergy between basic fibroblast growth factor and HIV-1 Tat protein in induction of Kaposi's sarcoma. Nature 371, 674-680.
13. FIORELLI, V., GENDELMAN, R., SAMANIEGO, F., MARKHAM, P.D., and ENSOLI, B. (1995). Cytokines from activated T-cells induce normal endothelial cells to acquire the phenotypic and functional features of AIDS-Kaposi's sarcoma spindle cells. J. Clin. Invest. 95, 1723-1734.
14. HERBEIN, G., KESHAV, S., COLLIN, M., MONTANER, L.J., and GORDON, S. (1994). HIV-1 induces tumor necrosis factor and IL-1 gene expression in primary human macrophages independent of productive infection. Clin. Exp. Immunol. 95, 442-449.
15. HO, D.D., NEUMANN, A.U., PERELSON, S., CHEN, W., LEONARD, J.M., and MARKOWITZ, M. (1995). Rapid turnover of plasma virions and CD4 lymphocytes in HIV-1 infection. Nature 373, 123-127.
16. HOBER, D., HAQUE, A., WATTRE, P., BEAUCAIRE, G., MOUTON, Y., and CAPRON, A. (1989). Production of tumor necrosis factor alpha and interleukin-1 in patients with AIDS. Enhanced level of TNF-α related to higher cytotoxic activity. Clin. Exp. Immunol. 78, 329-333.
17. HOFMAN, F.M., DOHADWALA, M.M., WRIGHT, A.D., HINTON, D.R., and WALKER, S.M. (1994). Exogenous tat protein activates central nervous system-derived endothelial cells. J. Neuroimmunol. 54, 19-28.
18. KINTER, A.L., POLI, G., FOX, L., HARDY, E., and FAUCI, A.S. (1995). HIV replication in IL-2-stimulated peripheral blood mononuclear cells is driven in an autocrine/paracrine manner by endogenous cytokines. J. Immunol. 154, 2448-2459.
19. KRASNOW, S.W., ZHANG, L.Q., LEUNG, K.Y., OSBORN, L., KUNKEL, S., and NABEL, G.J. (1991). Tumor necrosis factor-a1-pha, interleukin-1 and phorbol myristate acetate are independent activators of NF-κB which differentially activates T-cells. Cytokine 3, 372.
20. LADHEVIRTAM, J., MAURY, C.P., TEPPO, A.M., and REPO, H. (1988). Elevated levels of circulating cachectrin/tumor necrosis factor in patients with AIDS. Am. J. Med. 85, 289-291.
21. LATHEY, J.L., KANANGAT, S., and ROUSE, B.T. (1994). Differential expression of tumor necrosis factor alpha and interleukin 1 beta compared with interleukin 6 in monocytes from human immunodeficiency virus-positive individuals measured by polymerase chain reaction. J. Acquir. Immune Defic. Syndr. 7, 109-115.
22. LEE, S.W., GALLARDO, H.F., GILBOA, E., and SMITH, C. (1994). Inhibition of HIV-1 in human T-cells by a potent rev response element decoy consisting of the 13-nucleotide minimal rev-binding domain. J. Virol. 68, 8254-8264.
23. LEPE ZANUGA, J.L., MANSELL, P.W.A., and HERSH, E.M. (1987). Idiopathic production of IL-1 in AIDS. J. Clin. Microbiol. 25, 1695-1700.
24. LISZIEWICZ, J., SUN, D., LISZIEWICZ, A., and GALLO, R.C. (1995). Antitat gene therapy: a candidate for late-stage AIDS patients. Gene Ther. 2, 218-222.
25. LISZIEWICZ, J., SUN, D., TRAPPNEL, B., THOMSON, M., CHANG, H.K., ENSOLI, B., and PENG, B. (1995). An autoregulated dual-function antitat gene for human immunodeficiency virus type 1 gene therapy. J. Virol. 69, 206-212.
26. PANTALEO, G., GRAZIOSI, C., DEMAREST, J.F., BUTINI, L., MONTRONI, M., FOX, C.H., RENSTEIN, J.M., KOTLER, D.P., and FAUCI, A.S. (1993). HIV infection is active and progressive in lymphoid tissue during the clinically latent stage of disease. Nature 362, 355-358.
27. PAUWELS, R., BALZARANI, J., BABA, M., SNOECK, R., SCHOLS, D., HERDEWIJN, P., ESMYTER, J., and DECLERQ, E. (1988). Rapid and automated tetrazolium-based colorimetric assay for the detection of anti-HIV-1 compounds. J. Virol. Methods 20, 309-321.
28. POLI, G., and FAUCI, A.S. (1992). The role of monocyte/macrophages and cytokines in the pathogenesis of HIV infection. Pathobiology 60, 246-251.
29. POLI, G., KINTER, A.L., and FAUCI, A.S. (1994). Interleukin 1 induces expression of the human immuondeficiency virus alone and in synergy with interleukin 6 in chronically infected U1 cells: inhibition of inductive effects by the interleukin 1 receptor antagonist. Proc. Natl. Acad. Sci. USA 91, 108-112.
30. POPIK, W., and PITHA, P.M. (1993). Role of tumor necrosis factor alpha in activation and replication of the tat-defective human immunodeficiency virus type 1. J. Virol. 67, 1094-1099.
31. POPIK, W., and PITHA, P.M. (1994). The presence of tat protein or tumor necrosis factor alpha is critical for herpes simplex virus type 1-induced expression of human immunodeficiency virus type 1. J. Virol. 68, 1324-1333.
32. + T lymphocytes by retroviral vectors expressing anti-HIV genes. J. Virol. 69, 4045-4052.
33. + lymphocytes can control HIV infection in vitro by suppressing virus replication. Science 234, 1563-1566.
34. WEI, X., GHOSH, S., TAYLOR, M.E., JOHNSON, V.A., EMINI, E.A., DEUTSCH, P., LIFSON, J.D., BONHOEFFER, S., NOWAK, M.A., HAHN, B.H., SAAG, M.S., and SHAW, G.M. (1995). Viral dynamics in HIV-1 infection. Nature 373, 117-122.
35. WEISS, R.A. (1993). How does HIV cause AIDS? Science 260, 1273-1279.
36. WESTENDORP, M.O., FRANK, R., OCHSENBAUER, C., STRICKER, K., DHEIN, J., WALCZAK, H., DEBATIN, K.-M., and KRAMMER, P.H. (1995). Sensitization of T-cells to CD95-mediated apoptosis by HIV-1 Tat and gp120. Nature 375, 497-500.
37. WOFFENDIN, C., YANG, Z.Y., UDAYKUMAR, XU, L., YANG, N.-S., SHEEHY, M.F., and NABEL, G.F. (1994). Nonviral and viral delivery of a human immunodeficiency virus protective gene into primary human T cells. Proc. Natl. Acad. Sci. USA 91, 11581-11585.
38. YU, M., POESCHLAA, E., YAMADA, O., DEGRANDIS, P., LEAVITT, M.C., HEUSCH, M., YEES, J.-K., WONG-STAAL, F., and HAMPEL, A. (1995). In vitro and in vivo characterization of a second functional hairpin ribozyme against HIV-1. Virology 206, 381-386.
39. ZHOU, C., BAHNER, I.C., LARSON, G.P., ZAIE, J.A., ROSSI, J.J., and KOHN, D. (1994). Inhibition of HIV-1 in human T-lymphocytes by retrovirally transduced anti-tat and rev hammerhead ribozymes. Gene 149, 33-39.