Upregulation of endothelial and neuronal constitutive nitric oxide synthase in pregnant rats

American Journal of Physiology - Regulatory Integrative and Comparative Physiology

Volumn 271, Issue 6 40-6, 1996, Pages

  Xu, Ding Li ^a   Martin, Pierre Yves ^a   St John, Judy ^a   Tsai, Phoebe ^a   Summer, Sandra N ^a   Ohara, Mamiko ^a   Kim, Jin K ^a   Schrier, Robert W ^a  

^a UNIVERSITY OF COLORADO   (United States)

Author keywords

blood pressure; hyposmolality; neurohypophysis; peripheral arterial vasodilation; regulation of vasopressin synthesis and release; reset osmostat

Indexed keywords

ARGIPRESSIN; MESSENGER RNA; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; SODIUM;

ANIMAL TISSUE; AORTA; ARTICLE; BLOOD LEVEL; CONTROLLED STUDY; ENDOTHELIUM; FEMALE; HYPOTHALAMUS; IMMUNOBLOTTING; MESENTERIC ARTERY; NONHUMAN; NORTHERN BLOTTING; OSMOLALITY; PREGNANCY; PRIORITY JOURNAL; RADIOIMMUNOASSAY; RAT; RECEPTOR UPREGULATION; VASODILATATION;

EID: 0030459513     PISSN: 03636119     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpregu.1996.271.6.r1739     Document Type: Article

References (39)

1. Allen, R., L. Castro, A. Chander, D. Krakow, S. Huang, and L. Platt. Endothelium-derived relaxing factor inhibition and the pressor response to norepinephrine in the pregnant rat. Obstet. Gynecol. 83: 92-96, 1994.
2. Bredt, D. S., P. M. Hwang, and S. H. Snyder. Localization of nitric oxide synthase indicating a neural role for nitric oxide. Nature Lond. 347: 768-770, 1990.
3. Brown, M. A., E. Tibben, V. C. Zammit, G. M. Cario, and M. A. Carlton. Nitric oxide excretion in normal and hypertensive pregnancies. Hypertens. Pregnancy 14: 319-326, 1995.
4. Cabrera, C., and D. Bohr. The role of nitric oxide in the central control of blood pressure. Biochem. Biophys. Res. Commun. 206: 77-81, 1995.
5. Ceccatelli, S., J. Lundberg, J. Fahrenkrug, D. S. Bredt, S. H. Snyder, and T. Hokfelt. Evidence for involvement of nitric oxide in the regulation of hypothalamic portal blood flow. Neuroscience 51: 769-772, 1993.
6. Conrad, K. P., G. M. Joffe, H. Kruszyna, R. Kruszyna, L. G. Rochelle, R. P. Smith, J. E. Chavez, and M. D. Mosher. Identification of increased nitric oxide biosynthesis during pregnancy in rats. FASEB. J. 7: 566-571, 1993.
7. Danielson, L. A., and K. P. Conrad. Acute blockade of nitric oxide synthase inhibits renal vasodilation and hyperfiltration during pregnancy in chronically instrumented conscious rats. J. Clin. Invest. 96: 482-490, 1995.
8. Davidge, S. T., and M. K. McLaughin. Endogenous modulation of the blunted adrenergic response in resistance-sized mesenteric arteries from the pregnant rat. Am. J. Obstet. Gynecol. 167: 1691-1698, 1992.
9. Davison, J. M., E. A. Shiells, P. R. Philips, and M. D. Lindheimer. Serial evaluation of vasopressin release and thirst in human pregnancy: role of human chorionic gonadotrophin in the osmoregulatory changes of gestation. J. Clin. Invest. 81: 798-806, 1988.
10. Delacretaz, E., N. De Quay, B. Waeber, Y. Vial, P. E. Schulz, M. Burnier, H. R. Brunner, H. Bossart, and N. C. Schaad. Differential nitric oxide synthase activity in human platelets during normal pregnancy and pre-eclampsia. Clin. Sci. Lond. 88: 607-610, 1995.
11. Durr, J.A., B. Stamoutsos, and M. D. Lindheimer. Osmoregulation during pregnancy in the rat: evidence for setting of the threshold for vasopressin secretion during gestation. J. Clin. Invest. 68: 337-346, 1981.
12. Gerstberger, R., R. Keil, M. Jurzak, H. Hjelmqvist, and S. Eriksson. Hormonal and haemodynamic effects of inhibition of nitric oxide synthase in the conscious sheep and rabbit. In: The Biology of Nitric Oxide. Physiological and Clinical Aspects, edited by S. Moncada, M. Feelisch, R. Busse, and E. A. Higgs. London: Portland Press, 1994, vol. 3, p. 344-347.
13. Goetz, R. M., I. Morano, T. Calovini, R. Studer, and J. Holtz. Increased expression of endothelial constitutive nitric oxide synthase in rat aorta during pregnancy. Biochem. Biophys. Res. Commun. 205: 905-910, 1994.
14. Goyer, M., H. Bui, L. Chou, J. Evans, L. C. Keil, and I. A. Reid. Effect of inhibition of nitric oxide syntheses on vasopressin secretion in conscious rabbits. Am. J. Physiol. 266 (Heart Circ. Physiol. 35): H822-H828, 1994.
15. Hines, T., M. D. Lindheimer, and W. M. Barron. Total autonomic blockade eliminates the attenuated pressor response to angiotensin II in pregnant rats. Am. J. Physiol. 265 (Regulatory Integrative Comp. Physiol. 34): R1270-R1275, 1993.
16. Hishikawa, K., T. Nakaki, T. Marumo, H. Susuki, R. Kato, and T. Saruta. Up-regulation of nitric oxide synthase by estradiol in human aortic endothelial cells. FEBS Lett. 360: 291-293, 1995.
17. Huang, P. L., Z. Huang, H. Mashimo, K. D. Bloch, M. A. Moskowitz, J. A. Bevan, and M. C. Fishman. Hypertension in mice lacking the gene for endothelial nitric oxide synthase. Nature Lond. 377: 239-242, 1995.
18. Kadowaki, K., J. Kishimoto, G. Leng, and P. C. Emson. Up-regulation of nitric oxide synthase (NOS) gene expression together with NOS activity in the rat hypothalamo-hypophysial system after chronic salt loading: evidence of a neuromodulatory role of nitric oxide in arginine vasopressin and oxytocin secretion. Endocinology 134: 1011-1017, 1994.
19. Longo, L. Maternal blood volume and cardiac output during pregnancy: a hypothesis of endocrinologic control. Am. J. Physiol. 245 (Regulatory Integrative Comp. Physiol. 14): R720-R729, 1983.
20. Martin, P. Y., D. L. Xu, M. Niederberger, A. Weigert, P. Tsai, J. St. John, P. Gines and R. W. Schrier. Upregulation of the endothelial constitutive NOS: a major role in the increased NO production in cirrhotic rats. Am. J. Physiol. 270 (Renal Fluid Electrolyte Physiol. 39): F494-F499, 1996.
21. Molnar, M., and F. Hertelendy. N-nitro-L-arginine, an inhibitor of nitric oxide synthase, increases blood pressure in rats and reverses the pregnancy-induced refractoriness to vasopressor agents. Am. J. Obstet. Gynecol. 166: 1560-1567, 1992.
22. Molnar, M., T. Suto, T. Toth, and F. Hertelendy. Prolonged blockade of nitric oxide synthase in gravid rats produces sustained hypertension, proteinuria, thrombocytopenia, and intrauterine growth retardation. Am. J. Obstet. Gynecol. 170: 1458-1466, 1994.
23. Nathan, L., J. Cuevas, and G. Chaudhuri. The role of nitric oxide in the altered vascular reactivity of pregnancy in the rat. Br. J. Pharmacol. 114: 955-960, 1995.
24. Ogura, T., T. Yokoyama, H. Fujisawa, Y. Kurashima, and H. Esumi. Structural diversity of neuronal nitric oxide synthase mRNA in the nervous system. Biochem. Biophys. Res. Commun. 193: 1014-1022, 1993.
25. Ota, M., J. T. Grofton, G. T. Festavan, and L. Share. Evidence that nitric oxide can act centrally to stimulate vasopressin release. Neuroendocrinology 57: 955-959, 1993.
26. Phippard, A. F., J. S. Horvath, and E. M. Glynn. Circulatory adaptation to pregnancy - serial studies of hemodynamics, blood volume renin and aldosterone in the baboon (Papio hamadryas). J. Hypertens. 4: 773-779, 1986.
27. Pyo, H. J., S. N. Summer, M. Niederberger, J. K. Kim, and R. W. Schrier. Arginine vasopressin gene expression in rats with puromycin-induced nephrotic syndrome. Am. J. Kidney Dis. 25: 58-62, 1995.
28. Rosselli, M., B. Imthurn, E. Macas, P. J. Keller, and R. K. Dubey. Circulating nitrite/nitrate levels increase with follicular development: indirect evidence for estradiol mediated NO release. Biochem. Biophys. Res. Commun. 202: 1543-1552, 1994.
29. Sessa, W. C., J. K. Harrison, D. R. Luthin, J. S. Pollock, and K. R. Lynch. Genomic analysis and expression patterns reveal distinct genes for endothelial and brain nitric oxide synthase. Hypertension Dallas 21: 934-938, 1993.
30. Sessa, W. C., K. Pritchard, N. Seyedi, J. Wang, and T. H. Hintze. Chronic exercise in dogs increases coronary vascular nitric oxide production and endothelial cell nitric oxide synthase gene expression. Circ. Res. 74: 349-353, 1994.
31. Schrier, R. W. Pathogenesis of renal sodium and water retension in high-output and low-output cardiac failure, nephrotic syndrome, cirrhosis, and pregnancy. N. Engl. J. Med. 319: 1065-1072 & 1127-1134, 1988.
32. Schrier, R. W., and V. A. Briner. Peripheral arterial vasodilation hypothesis of sodium, and water retension in pregnancy: implications for pathogenesis of preeclampsia-eclampsia. Obstet. Gynecol. 77: 632-639, 1991
33. Tojo, A., S. S. Gross, L. Zhang, C. C. Tisher, H. H. H. W. Schmidt, C. S. Wilcox, and K. M. Madsen. Immunocytochemical localization of distinct isoforms of nitric oxide synthase in the juxtaglomerular apparatus of normal rat kidney. J. Am. Soc. Nephrol. 4: 1438-1447, 1994.
34. Villar, M. J., S. Ceccatelli, M. Ronnqvist, and T. Hokfelt. Nitric oxide synthase increases in hypothalamic magnocellular neurons after salt loading in the rat: an immunohistochemical and in situ hybridization study. Brain Res. 644: 273-281, 1994.
35. Wang, Y., And P. A. Marsden. Nitric oxide synthase: biochemical and molecular regulator. Curr. Opin. Nephrol. Hypertens. 4: 12-22, 1995.
36. Weiner, C. P., I. Lizasoain, S. A. Baylis, R. G. Knowles, I. G. Charles, and S. Moncada. Induction of calcium-dependent nitric oxide synthases by sex hormones. Proc. Natl. Acad. Sci. USA 91: 5212-5216, 1994.
37. Weiner, C., K. Z. Liu, L. Thompson, J. Herrig, and D. Chestnut. Effect of pregnancy on endothelium and smooth muscle: their role in reduced adrenergic sensitivity. Am. J. Physiol. 261 (Heart Circ. Physiol. 30): H1275-H1283, 1991.
38. Weiner, C., E. Martinez, L. K. Zhu, A. Ghodsi, and D. Chestnut. In vitro release of endothelium-derived relaxing factor by acetylcholine is increased during the guinea pig pregnancy. Am. J. Obstet. Gynecol. 161: 1599-1605, 1989.
39. Yallampalli, C., and R. E. Garfield. Inhibition of nitric oxide synthase in rats during pregnancy produces signs similar to those of preeclampsia. Am. J. Obstet. Gynecol. 169: 1316-1320, 1993.