A Risk-Benefit Assessment of the Levonorgestrel-Releasing Intrauterine System

Drug Safety

Volumn 15, Issue 6, 1996, Pages 430-440

  Sturridge, Frances ^a   Guillebaud, John ^a  

^a Margaret Pyke Family Planning Centre   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CONTRACEPTIVE AGENT; ESTRADIOL; LEVONORGESTREL;

ACNE; AMENORRHEA; CELL PROLIFERATION; DRUG EFFICACY; DRUG TOLERABILITY; DYSMENORRHEA; ECTOPIC PREGNANCY; ENDOMETRIUM; ENDOMETRIUM HYPERPLASIA; FEMALE; HEADACHE; HIRSUTISM; HUMAN; INTRAUTERINE CONTRACEPTIVE DEVICE; INTRAUTERINE DRUG ADMINISTRATION; MASTALGIA; MENORRHAGIA; MENSTRUATION; MOOD; NAUSEA; OVARY CYST; OVARY FUNCTION; PELVIC INFLAMMATORY DISEASE; PRIORITY JOURNAL; REVIEW; SIDE EFFECT; UTERINE CERVIX MUCUS; UTERUS MYOMA;

BIOLOGY; CONTRACEPTION; CONTRACEPTIVE AGENTS, FEMALE--BENEFICIAL EFFECTS; CONTRACEPTIVE AGENTS, FEMALE--PHARMACODYNAMICS; CONTRACEPTIVE AGENTS, FEMALE--SIDE EFFECTS; CONTRACEPTIVE AGENTS, PROGESTIN--BENEFICIAL EFFECTS; CONTRACEPTIVE AGENTS, PROGESTIN--PHARMACODYNAMICS; CONTRACEPTIVE AGENTS, PROGESTIN--SIDE EFFECTS; CONTRACEPTIVE AGENTS--BENEFICIAL EFFECTS; CONTRACEPTIVE AGENTS--PHARMACODYNAMICS; CONTRACEPTIVE AGENTS--SIDE EFFECTS; CONTRACEPTIVE METHODS--BENEFICIAL EFFECTS; CONTRACEPTIVE METHODS--SIDE EFFECTS; ENDOMETRIAL EFFECTS; ENDOMETRIUM; FAMILY PLANNING; GENITALIA; GENITALIA, FEMALE; IUD, HORMONE RELEASING--BENEFICIAL EFFECTS; IUD, HORMONE RELEASING--SIDE EFFECTS; IUD--BENEFICIAL EFFECTS; IUD--SIDE EFFECTS; LEVONORGESTREL--BENEFICIAL EFFECTS; LEVONORGESTREL--PHARMACODYNAMICS; LEVONORGESTREL--SIDE EFFECTS; LITERATURE REVIEW; PHYSIOLOGY; UROGENITAL SYSTEM; UTERUS;

DELAYED-ACTION PREPARATIONS; FEMALE; HUMANS; INTRAUTERINE DEVICES, MEDICATED; LEVONORGESTREL; RISK ASSESSMENT;

EID: 0030458735     PISSN: 01145916     EISSN: None     Source Type: Journal    
DOI: 10.2165/00002018-199615060-00006     Document Type: Article

References (66)

1. ® product monograph. 2nd ed. Turku, Finland: Leiras Oy, 1995
2. Luukkainen T, Lahteenmaki P, Toivonen J. Levonorgestrel-releasing intrauterine device. Ann Med 1990; 22: 85-90
3. Barbosa I, Bakos O, Olsson S, et al. Ovarian function during use of a levonorgestrel-releasing IUD. Contraception 1990; 42: 51-66
4. Silverberg S, Haukkamaa M, Arko H, et al. Endometrial morphology during long-term use of levonorgestrel-releasing devices. Int J Gynecol Pathol 1986; 5: 235-41
5. Nilsson C, Pertti L, Lahteenmaki A, et al. Ovarian function in amenorrheic and menstruating users of a levonorgestrel-releasing device. Fertil Steril 1984; 41: 52-5
6. Videla-Rivero L, Etchepareborda J, Kesseru E. Early chorionic activity in women bearing inert IUD, copper IUD and levonorgestrel-releasing IUD. Contraception 1987; 36: 217-26
7. Zhu P, Hongzhi L, Ruhua X, et al. The effect of intrauterine devices, the stainless steel ring, the copper T220, and releasing levonorgestrel, on the bleeding profile and the morphological structure of the human endometrium - a comparative study of three IUDs. Contraception 1989; 40: 425-38
8. Perino A, Quartararo P, Catinella E, et al. Acta Eur Fertil 1987; 18: 137-40
9. Nilsson C, Lahteenmaki P. Recovery of ovarian function after the use of a d-norgestrel-releasing IUD. Contraception 1977; 15; 389-400
10. Jonsson B, Landgren B, Eneroth P. Effects of various IUDs on the composition of cervical mucus. Contraception 1991; 43: 447-58
11. Ortiz M, Croxatto H. The mode of action of IUDs. Contraception 1987; 36: 37-53
12. Nilsson CG, Lahteenmaki P, Luukkainen T. Levonorgestrel plasma concentrations and hormone profiles after insertion and after one year of treatment with a levonorgestrel-IUD. Contraception 1980; 21: 225-33
13. Xiao B, Zhou L, Zhang X, et al. Pharmacokinetic and pharmacodynamic studies of levonorgestrel-releasing intrauterine device. Contraception 1990; 41: 353-61
14. Xaio B, Zeng T, Shangchun W, et al. Effect of levonorgestrel releasing intrauterine device on hormonal profile and menstrual pattern after long-term use. Contraception 1995; 51: 359-65
15. Scholten P, van Eykeren M, Christiaens G, et al. Menstrual blood loss with levonorgestrel Nova-T and multiload Cu 250 intrauterine devices [thesis]. Utrecht: University Hospital 1989: 35-45
16. ® rods, or levonorgestrel-releasing or copper TCu 380Ag intrauterine contraceptive devices. Am J Obstet Gynecol 1992; 166: 1208-13
17. Belhadj H, Sivin I, Diaz S. Recovery of fertility after use of the levonorgestrel 20mcg/d or copper T 380Ag intrauterine device. Contraception 1986; 34: 261-7
18. Andersson K, Batar I, Rybo G. Return to fertility after removal of a levonorgestrel-releasing intrauterine device and Nova-T. Contraception 1992; 46: 575-84
19. Luukkainen T. Levonorgestrel-releasing intrauterine device. Ann NY Acad Sci 1991; 626: 43-9
20. ® implants. Contraception 1987; 35: 551-67
21. Kuhnz W, Al-Yacoub G, Fuhrmeister A. Pharmacokinetics of levonorgestrel and ethinylestradiol in 9 women who received a low-dose oral contraceptive over a treatment period of 3 months and, after a washout phase, a single oral administration of the same contraceptive formulation. Contraception 1992; 46: 455-69
22. Nilsson C, Lahteenmaki P, Luukkainen T, et al. Sustained intrauterine release of levonorgestrel over five years. Fertil Steril 1986; 45: 805-7
23. Weiner E, Victor A, Johansson E. Plasma levels of d-norgestrel after oral administration. Contraception 1976; 14: 563-70
24. Luukkainen T, Toivonen J. Levonorgestrel-releasing IUD as a method of contraception with therapeutic properties. Contraception 1995; 52: 269-76
25. Jia M, Zhou L, Ren S, et al. Serum SHBG levels during normal menstrual cycle and after insertion of levonorgestrel-releasing IUD. Adv Contracept 1992; 8: 33-40
26. Luukkainen T, Lahteenmaki P, Toivonen J. Levonorgestrel-releasing intrauterine device. Ann Med 1990; 22: 85-90
27. Nilsson C, Haukkamaa M, Vierola H, et al. Tissue concentrations of levonorgestrel in women using a levonorgestrel-releasing IUD. Clin Endocrinol 1982; 17: 529-36
28. Toivonen J, Luukkainen T, Allonen H. Protective effect of intrauterine release of levonorgestrel on pelvic infection: three years' comparative experience of levonorgestrel-and copper-releasing devices. Obstet Gynecol 1990; 77: 261-4
29. Bounds W, Robinson G, Kubba A, et al. Clinical experience with a levonorgestrel-releasing intrauterine contraceptive device (LNG-IUD) as a contraceptive and in the treatment of menorrhagia. Br J Fam Plan 1993; 19: 193-4
30. Scholten P, Christianens G, Haspels A. Treatment of menorrhagia by intrauterine administration of levonorgestrel. The levonorgestrel IUD: clinical performance and impact on menstruation [thesis]. Utrecht: University Hospital 1989: 71-84
31. Faundes A, Alvarez F, Brache V, et al. The role of the levonorgestrel intrauterine device in the prevention and treatment of iron deficiency anaemia during fertility regulation. Int J Gynaecol Obstet 1988; 26: 429-33
32. Thiery M, Van der Pas H, Delborge W, et al. Da levonorgestrel-intrauterin pessar. Geburtshilfe Fraunenheilkd 1089; 49: 186-8
33. Sivin I, Alvarez F, Diaz J, et al Intrauterine contraception with copper and with levonorgestrel: a randomized study of the T Cu 380 Ag and levonorgestrel 20μg/day. Contraception 1984; 30: 443-56
34. Sivin I, Stern J, Diaz J, et al. Two years of intrauterine contraception with levonorgestrel and with copper: a randomised comparison of the TCu 380 Ag and levonorgestrel 20μg/day devices. Contraception 1987; 35: 245-55
35. Sivin I, El-Mahgoub S, McCarthy T, et al. Long-term contraception with the levonorgestrel 20mcg/day (LNG-20) and the copper T 380Ag intrauterine devices: a five-year randomised study. Contraception 1990; 42: 361-78
36. Sivin I, Stern J, Coutinho E, et al. Prolonged intrauterine contraception: a seven year randomized study of the levonorgestrel 20mcg/day (LNg 20) and the copper T 380 Ag IUDs. Contraception 1991; 44: 473-80
37. Indian Council of Medical Research. Task Force on IUD. Randomised clinical trial with intrauterine devices (levonorgestrel intrauterine device (LNG), Cu T380 Ag, Cu T 220C and Cu T 200B): a 36-month study. Contraception 1989; 39: 37-52
38. Nilsson CG, Luukkainen T; Diaz J, et al. Intrauterine contraception with levonorgestrel: a comparative randomised clinical performance study. Lancet 1981; 1: 577-80
39. Nilsson CG, Allonen H, Diaz J, et al. Two years' experience with two levonorgestrel-releasing intrauterine devices and one copper-releasing intrauterine device: randomised comparative performance study. Fertil Steril 1983; 39: 187-92
40. Luukkainen T, Allonen H, Haukkamaa M, et al. Five years' experience with levonorgestrel IUDs. Contraception 1986; 33: 139-48
41. Luukkainen T, Allonen H, Haukkamaa M, et al. Effective contraception with the levonorgestrel-releasing intrauterine device: a 12-month report of a European multicentre study. Contraception 1987; 36: 169-79
42. Andersson K, Odlind V, Ryho G. Levonorgestrel-releasing and copper-releasing (Nova T) IUDs during five years of use: a randomised comparative trial. Contraception 1994; 49: 56-72
43. ®-II implants in China. Contraception 1990; 41: 485-94
44. Wang SL, WU SC, Xin XM, et al. Three years' experience with levonorgestrel-releasing intrauterine device and Norplant-2 implants: a randomised comparative study. Adv Contracept 1992; 8: 105-14
45. Vessey M, Lawless M, Yeates D. Efficacy of different contraceptive methods. Lancet 1982; 1: 841-2
46. Andersson JK, Rybo G. Levonorgestrel-releasing intrauterine device in the treatment of menorrhagia. Br J Obstet Gynecol 1990; 97: 690-4
47. Hallherg L, Hogdahl A-M, Nilsson L, et al. Menstrual blood loss - a population study. Acta Obstet Gynecol Scand 1996; 45: 320-51
48. Sivin I, Stern J. Health during prolonged use of levonorgestrel 20mcg/d and the Copper TCu 380 Ag intrauterine contraceptive devices: a multicenter study. Fertil Steril 1994; 61: 70-7
49. Lahteenmaki P. Health Benefits of a levonorgestrel releasing IUD [abstract]. 7th European Congress of Gynaecology and Obstetrics: 1992 28 June - 1 July; Helsinki, Finland
50. Magos A. Management of menorrhagia. BMJ 1990; 300: 1537-8
51. Department of Health, Welsh Office, Scottish Home Office and Health Department, Department of Health and Social Security, Northern Ireland London: HMSO Report on Confidential Enquiries into Maternal Deaths in the United Kingdom 1988-1990; 6: 61-7
52. Franks A, Beral V, Cates W, et al. Contraception and ectopic pregnancy risk. Am J Obstet Gynecol 1990; 163: 1120-3
53. Singer A, Ikomi A. Successful treatment of fibroids using an intrauterine progesterone device [abstract]. Int J Gynecol Obstet 1994; 46: 55
54. Pekonen F, Nyman T, Lahteenmaki P, et al. Intrauterine progestin induces continuous insulin-like growth factor-binding protein-1 production in the human endometrium. J Clin Endo Metab 1992; 75: 660-4
55. Gasparri F, Scarselli G, Colafranceschi M, et al. Management of precancerous lesions of the endometrium. Proceedings of the eleventh World Congress of Obstetrics and Gynecology. In: H Ludwig, K Thomsen, editors. Gynaecology and Obstetrics. Berlin: Springer-Verlag, 1986
56. Scarselli G, Tantini C, Colafranceschi M. Levonorgestrel-Nova-T and precancerous lesions of the endometrium. Eur J Gynecol Oncol 1988; 9 (4): 284-6
57. Andersson K, Mattsson L, Rybo G, et al. Intrauterine release of levonorgestrel - a new way of adding progestogen in hormone replacement therapy. Obstet Gynecol 1992; 79: 963-7
58. Raudaskoski T, Lahti E, Kauppila A, et al. Transdermal estrogen with a levonorgestrel-releasing intrauterine device for climacteric complaints: clinical and endometrial responses. Am J Obstet Gynecol 1994; 179: 114-9
59. Suhonen S, Allonen H, Lahteenmaki P. Sustained release subdermal estradiol implants: A new alternative in estrogen replacement therapy. Am J Obstet Gynecol 1993; 169: 1248-54
60. Suhonen S, Alonen H, Lahteenmaki P. Sustained-release estradiol implants and a levonorgestrel-releasing intrauterine device in hormone replacement therapy. Am J Obstet Gynecol 1995; 172: 562-7
61. Tayoub Y, Adams J, Jacobs H, et al. Ultrasound demonstration of increased frequency of functional ovarian cysts in women using progestogen-only oral contraception. Br J Obstet Gynaecol 1985; 92: 1003-9
62. Robinson G, Bounds W, Kubba A, et al. Functional ovarian cysts associated with the levonorgestrel - releasing intrauterine device. Br J Fam Plan 1989; 14: 131-2
63. Luukkainen T. The levonorgestrel releasing IUD. Br J Fam Plan 1993; 19: 221-4
64. Chi I, Farr G. The non-contraceptive effects of the levonorgestrel-releasing intrauterine device. Adv Contracept 1994; 10: 271-85
65. Heikkila M, Luukkainen T. Duration of breast-feeding and development of children after insertion of a levonorgestrel-releasing intrauterine contraceptive device. Contraception 1982; 25: 279-92
66. Mann R. Unlicensed medicines and the use of drugs in unlicensed indications. In: Goldberg A, Dodd-Smith I, editors. Pharmaceutical medicine and the law. London: Royal College of Physicians, 1991: 103-10