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Volumn 118, Issue 49, 1996, Pages 12261-12266

Inductive effects on the energetics of prolyl peptide bond isomerization: Implications for collagen folding and stability

Author keywords

[No Author keywords available]

Indexed keywords

COLLAGEN; PROLINE DERIVATIVE;

EID: 0030457120     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja9623119     Document Type: Article
Times cited : (210)

References (59)
  • 1
    • 0004169147 scopus 로고
    • Ramachandran, G. N., Reddi, A. H., Eds.; Plenum Press: New York
    • Biochemistry of Collagen; Ramachandran, G. N., Reddi, A. H., Eds.; Plenum Press: New York, 1976.
    • (1976) Biochemistry of Collagen
  • 2
    • 0004289209 scopus 로고
    • CRC Press: Boca Raton, F1
    • Nimni, M. E. Collagen; CRC Press: Boca Raton, F1, 1988.
    • (1988) Collagen
    • Nimni, M.E.1
  • 31
    • 33847448489 scopus 로고    scopus 로고
    • The error in these values is ± 0.10, which is the error in measuring pH
    • The error in these values is ± 0.10, which is the error in measuring pH.
  • 36
    • 33847452526 scopus 로고    scopus 로고
    • note
    • A second vibrational mode was present in the amide I region of a 0.10 M solution of 2 in dioxane. This low frequency mode was absent in a 1.0 mM solution of 2. This second vibrational mode was likely the result of a hydrogen bond from the hydroxyl group of one molecule of 2 to the amide carbonyl group of another molecule of 2, as was observed in crystalline 2 (ref. 29). To minimize this apparent aggregation, FTIR experiments in dioxane were performed on 1.0 mM solutions of 1-3.
  • 47
    • 33847456135 scopus 로고    scopus 로고
    • note
    • A kinetic analysis of 2 in dioxane was precluded by aggregation. Decreasing the concentration of 2 from 0.10 M to 1.0 mM resulted in a 10-20% increase in isomerization rates and an increase in error from < 10% to >60%, depending on the temperature. The aggregation of 2 in dioxane during NMR spectroscopy experiments was also observed by FTIR spectroscopy (ref 36).
  • 48
    • 33847471727 scopus 로고    scopus 로고
    • note
    • 19F resonances at most temperatures.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.