Effects of chronic blockade of angiotensin II receptor on the maintenance of hypertension and vascular changes in spontaneously hypertensive rats

Canadian Journal of Physiology and Pharmacology

Volumn 74, Issue 9, 1996, Pages 1061-1069

  Gillies, L K ^a   Lee, R M K W ^a  

^a MCMASTER UNIVERSITY   (Canada)

Author keywords

Angiotensin II; Angiotensin II receptor; Cardiovascular; Hypertension

Indexed keywords

2 ETHYL 5,7 DIMETHYL 3 [4 [2 (2H TETRAZOL 5 YL)PHENYL]BENZYL]IMIDAZO[4,5 B]PYRIDINE; ANGIOTENSIN; ANGIOTENSIN 1 RECEPTOR ANTAGONIST; ANGIOTENSIN RECEPTOR; CATECHOLAMINE DERIVATIVE; DIPEPTIDYL CARBOXYPEPTIDASE; NORADRENALIN;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD VESSEL DIAMETER; BODY WEIGHT; CONTROLLED STUDY; DIASTOLIC BLOOD PRESSURE; HEART RATE; HYPERTENSION; MALE; MEAN ARTERIAL PRESSURE; MESENTERIC ARTERY; MORPHOMETRICS; NERVE STIMULATION; NONHUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; PULSE PRESSURE; RAT; SYSTOLIC BLOOD PRESSURE;

EID: 0030456730     PISSN: 00084212     EISSN: None     Source Type: Journal    
DOI: 10.1139/y96-107     Document Type: Article

References (35)

1. Adams, M.A., Bobik, A., and Korner, P.I. 1990. Enalapril can prevent vascular amplifier development in spontaneously hypertensive rats. Hypertension (Dallas), 16: 252-260.
2. Bunkenburg, B., Schnell, C., Baum, H.-P., Cumin, F., and Wood, J.M. 1991. Prolonged angiotensin II antagonism in spontaneously hypertensive rats. Hemodynamic and biochemical consequences. Hypertension (Dallas), 18: 278-288.
3. Bunkenburg, B., Van Amelsvoort, T., Rogg, H., and Wood, J.M. 1992. Receptor-mediated effects of angiotensin II on growth of vascular smooth muscle cells from spontaneously hypertensive rats. Hypertension (Dallas), 20: 746-754.
4. Chiu, A.T., McCall, D.E., Price, W.A., Wong, P.C., Carini, D.J., Duncia, J.V., Wexler, R.R., Yoo, S.E., Johnson, A.L., and Timmermans, P.B.M.W.M. 1990. Nonpeptide angiotensin II receptor antagonists. VII. Cellular and biochemical pharmacology of DuP 753, an orally active antihypertensive agent. J. Pharmacol. Exp. Ther. 252:711-718.
5. Cline, W.H. 1985. Enhanced in vivo responsiveness of presynaptic angiotensin II receptor-mediated facilitation of vascular adrenergic neurotransmission in spontaneously hypertensive rats. J. Pharmacol. Exp. Ther. 232(3): 661-669.
6. Dzau, V.J., Mukoyama, M., and Pratt, R.E. 1994. Molecular biology of angiotensin receptors: target for drug research. J. Hypertens. 12(Suppl. 2):S1-S5.
7. Faria, F.A.C., and Salgado, M.C. 1992. Facilitation of noradrenergic transmission by angiotensin in hypertensive rats. Hypertension (Dallas), 19(Suppl. II): II-30-II-35.
8. Folkow, B., Hallback, M., Lundgren, Y., Sivertsson, R., and Weiss, L. 1973. Importance of adaptive changes in vascular design for establisment of primary hypertension, studied in man and in spontaneously hypertensive rats. Circ. Res. XXXII: 1-2-1-13.
9. Friberg, P., Sundelin, B., Bohman, S.-O., Bobik, A., Nilsson, H., Wickman, A., Gustafsson, H., Petersen, J., and Adams, M.A. 1994. Renin-angiotensin system in neonatal rats: induction of a renal abnormality in response to ACE inhibition or angiotensin II antagonism. Kidney Int. 45: 485-492.
10. Gorbea-Oppliger, V.J., and Fink, G.D. 1994. Clonidine reverses the slowly developing hypertension produced by low doses of angiotensin II. Hypertension (Dallas), 23: 844-847.
11. Gorbea-Oppliger, V.J., Melaragno, MG., Potter, G.S., Petit, R.L., and Fink, G.D. 1994. Time course of losartan blockade of angiotensin II hypertension versus blockade of angiotensin II fast pressor effects.. J. Pharmacol. Exp. Ther. 271: 804-810.
12. Goto, M., Mukoyama, M., Tanaka, I., Suga, S., Matsumoto, T., Nakagawa, M., Ishibashi, R., Michibata, H., Kasahara, M., Sugawara, A., and Nakao, K. 1996. Type 2 angiotensin II receptor in the developing kidney of normotensive and spontaneously hypertensive rats. J. Hypertens. 14(Suppl. 1): S2.
13. Griendling, K.K., Lassegue, B., and Alexander, R.W. 1996. Angiotensin receptors and their therapeutic implications. Annu. Rev. Pharmacol. Toxicol. 36: 281-306.
14. Hefti, F., Fischli, W., and Gerold, M. 1986. Cilazapril prevents hypertension in spontaneously hypertensive rats. J. Cardiovasc. Pharmacol. 8:641-648.
15. Hilgers, K.F., Veelken, R., Rupprecht, G., Reeh, P.W., Luft, F.C., and Mann, J.F.E. 1993. Angiotensin II facilitates sympathetic transmission in rat hind limb circulation. Hypertension (Dallas), 21: 322-328.
16. Ibrahim, J., Schachter, M., Hughes, A.D., and Sever, P.S. 1995. Role of polyamines in hypertension induced by angiotensin II. Cardiovasc. Res. 29: 50-56.
17. Kivlighn, S.D., Gabel, R.A., and Siegl, P.K.S. 1991. L-158,809: antihypertensive efficacy and effects on renal function in the conscious spontaneously hypertensive rat (SHR). FASEB J. 5: A1576. (Abstr.)
18. Kline, R.L., and Liu, F. 1994. Modification of pressure natriuresis by long-term losartan in spontaneously hypertensive rats. Hypertension (Dallas), 24: 467-473.
19. Lee, R.M.K.W., Garfield, R.E., Forrest, J.B., and Daniel, E.E. 1983. Morphometric study of structural changes in the mesenteric blood vessels of spontaneously hypertensive rats. Blood Vessels, 20: 57-71.
20. Lee, R.M.K.W., Berecek, K.H., Tsoporis, J., McKenzie, R., and Triggle, C.R. 1991. Prevention of hypertension and vascular changes by captopril treatment. Hypertension (Dallas), 17:141-150.
21. Lee, R.M.K.W., Tsoporis, J., and Wang, R.R.J. 1992. Influence of chronic nadolol treatment on blood pressure and vascular changes in spontaneously hypertensive rats. Can. J. Physiol. Pharmacol. 70: 1261-1270.
22. Lee, R.M.K.W., Wang, H., and Smeda, J.S. 1994. The effects of perindopril on hypertension and stroke prevention in experimental animals. Can. J. Cardiol. 10(Suppl. D): 33D-36D.
23. Lee, R.M.K.W., Delaney, K.H., and Lu, M. 1995. Perindopril treatment prolonged the lifespan of spontaneously hypertensive rats. J. Hypertens. 13:471-476.
24. Linz, W., Wiemer, G., Gohlke, P., Unger, T., and Scholkens, B.A. 1995. Contribution of kinins to the cardiovascular actions of angiotensin-onverting enzyme inhibitors.. Pharmacol. Rev. 47: 25-49.
25. Morton, J.J., Beattie, E.C., and MacPherson, F. 1992. Angiotensin II receptor antagonist losartan has persistent effects on blood pressure in the young spontaneously hypertensive rat: Lack of relation to vascular structure. J. Vasc. Res. 29: 264-269.
26. Oddie, C.J., Dilley, R.J., and Bobik, A. 1992. Long-term angiotensin II antagonism in spontaneously hypertensive rats: effects on blood pressure and cardiovascular amplifiers. Clin. Exp. Pharmacol. Physiol. 19: 392-395.
27. Oddie, C.J., Dilley, R.J., Kanellakis, P., and Bobik, A. 1993. Chronic angiotensin II type 1 receptor antagonism in genetic hypertension: effects on vascular structure and reactivity. J. Hypertens. 11:717-724.
28. Qui, H.Y., Henrion, D., and Levy, B.I. 1994. Endogenous angiotensin II enhances phenylephrine-induced tone in hypertensive rats. Hypertension (Dallas), 24: 317-321.
29. Schelling, P., Fischer, H., and Ganten, D. 1991. Angiotensin and cell growth: a link to cardiovascular hypertrophy. J. Hypertens. 9: 3-15.
30. Smeda, J.S. 1992. Cerebral vascular changes associated with hemorrhagic stroke in hypertension. Can. J. Physiol. Pharmacol. 70: 552-564.
31. Smeda, J.S., Lee, R.M.K.W., and Forrest, J.B. 1988. Prenatal and postnatal hydralazine treatment does not prevent renal vessel wall thickening in SHR despite the absence of hypertension. Circ. Res. 63: 534-542.
32. Timmermans, P.B.M.W.M., Wong, P.C., Chiu, A.T., Herblin, W.F., Benfield, P., Carini, D.J., Lee, R.J., Wexler, R.R., Saye, J.A.M., and Smith, R.D. 1993. Angiotensin II receptors and angiotensin II receptor antagonists. Pharmacol. Rev. 45: 205-251.
33. Viswanathan, M., Tsutsumi, K., Correa, F.M.A., and Saavedra, J.M. 1991. Changes in expression of angiotensin receptor subtypes in the rat aorta during development. Biochem. Biophys. Res. Commun. 179: 1361-1367.
34. Wong, P.C., Price, W.A.J., Chiu, A.T., Duncia, J.V., Carini, D.J., Wexler, R.R., Johnson, A.L., and Timmermans, P.B.M.W.M. 1990. Hypotensive action of DuP753, an angiotensin II antagonist, in spontaneously hypertensive rats. Hypertension (Dallas), 15: 459-468.
35. Wong, P.C., Price, W.A., Chiu, A.T., Duncia, J.V., Carini, D.J., Wexler, R.R., Johnson, A.L., and Timmermans, P.B.M.W.M. 1991. In vivo pharmacology of DuP 753. Am. J. Hypertens. 4: 288S-298S.