Ectopic pregnancy after in-vitro fertilization is characterized by delayed implantation but a normal increase of serum human chorionic gonadotrophin and its subunits

Human Reproduction

Volumn 11, Issue 12, 1996, Pages 2750-2757

  Korhonen, J ^a   Tiitinen, A ^a   Alfthan, H ^a   Ylostalo P ^a   Stenman, U H ^a  

^a UNIVERSITY OF HELSINKI   (Finland)

Author keywords

Ectopic pregnancy; HCG ; HCG ; IVF and embryo transfer; Spontaneous abortion

Indexed keywords

CHORIONIC GONADOTROPIN; CHORIONIC GONADOTROPIN ALPHA SUBUNIT; CHORIONIC GONADOTROPIN BETA SUBUNIT;

ADULT; ARTICLE; BLOOD LEVEL; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DELAYED IMPLANTATION; ECTOPIC PREGNANCY; EMBRYO; EMBRYO TRANSFER; FEMALE; FERTILIZATION IN VITRO; HUMAN; PREGNANCY;

EID: 0030455997     PISSN: 02681161     EISSN: None     Source Type: Journal    
DOI: 10.1093/oxfordjournals.humrep.a019203     Document Type: Article

References (28)

1. Alfthan, H., Schröder, J., Fraser, R. et al. (1988) Choriogonadotropin and its β subunit separated by hydrophobic-interaction chromatography and quantified in serum during pregnancy by time-resolved immunofluorometric assays. Clin. Chem., 34, 1758-1762.
2. Alfthan, H., Haglund, C., Dabek, J. et al. (1992) Concentrations of human choriogonadotropin, its β-subunit, and the core fragment of the β-subunit in serum and urine of men and nonpregnant women. Clin. Chem., 38, 1981-1987.
3. Barnea, E.R., Oelsner, G., Benveniste, R. et al. (1986) Progesterone, estradiol, and α-human chorionic gonadotropin secretion in patients with ectopic pregnancy. J. Clin. Endocrinol. Metab., 62, 529-531.
4. Benveniste, R. and Scommegha, A. (1981) Human chorionic gonadotropin α-subunit in pregnancy. Am. J. Obstet. Gynecol., 141, 952-961.
5. Buck, R.H., Moodley, J. and Norman, R.J. (1995) Is the human chorionic gonadotropin secreted by ectopic trophoblast different from that in normal intrauterine pregnancies? Fertil. Steril., 64, 724-729.
6. Cacciatore, B., Stenman, U.-H. and Ylöstalo, P. (1994) Early screening for ectopic pregnancy in high-risk symptom-free women. Lancet, 343, 517-518.
7. Check, J.H., Weiss, R.M. and Lurie, D. (1992) Analysis of serum human chorionic gonadotrophin levels in normal singleton, multiple and abnormal pregnancies. Hum. Reprod., 7, 1176-1180.
8. Cole, L.A., Restrepo, C.H., Lavy, G. et al. (1987) hCG free β-subunit: an early marker of outcome of in vitro fertilization clinical pregnancies. J. Clin. Endocrinol. Metab., 64, 1328-1330.
9. Dor. J., Rudak, E., Rotmench, S. et al. (1988) The role of early post-implantation β-HCG levels in the outcome of pregnancies following invitro fertilization. Hum. Reprod., 3, 663-667.
10. FIVNAT (1995) Pregnancies and births resulting from in vitro fertilization: French national registry, analysis of data 1986-1990. Fertil. Steril., 64, 746-756.
11. Hahlin, M., Thorburn, J. and Bryman, I. (1995) The expectant management of early pregnancies of uncertain site. Hum. Reprod., 10, 1223-1227.
12. Hay, D.L. (1985) Discordant and variable production of human chorionic gonadotropin and its free α- and β-subunits in early pregnancy. J. Clin. Endocrinol. Metab., 61, 1195-1200.
13. Henderson, D.J., Bennett, P.R. and Moore, G.E. (1992) Expression of human chorionic gonadotrophin α and β subunits is depressed in trophoblast from pregnancies with early embryonic failure. Hum. Reprod. 7, 1474-1478.
14. Klein, M., Graf, A.-H., Hütter, W. et al. (1995) Proliferative activity in ectopic trophoblastic tissue. Hum. Reprod., 10, 2441-2444.
15. Levy, T., Dicker, D., Ashkenazi, J. et al. (1991) The prognostic value and significance of preclinical abortions in in vitro fertilization-embryo transfer programs. Fertil. Steril., 56, 71-74.
16. Marcus, S.F. and Brinsden, P.R. (1995) Analysis of the incidence and risk factors associated with ectopic pregnancy following in-vitro fertilization and embryo transfer. Hum. Reprod., 10, 199-203.
17. Marcus, S.F., Macnamee, M. and Brinsden, P.R. (1995) The prediction of ectopic pregnancy after in-vitro fertilization and embryo transfer. Hum. Reprod., 10, 2165-2168.
18. Morgan, F.J., Birken, S. and Canfield, R.E. (1975) The amino acid sequence of human chorionic gonadotropin. The α subunit and β subunit. J. Biol. Chem., 250, 5247-5258.
19. Okamoto, S.H., Healy, D.L., Morrow, L.M. et al. (1987) Predictive value of plasma human chorionic gonadotrophin β subunit in diagnosing ectopic pregnancy after in vitro fertilisation and embryo transfer. Br. Med. J. Clin. Res. Educ., 294, 667-670.
20. Reuter, A.M., Gaspard, U.J., Deville, J.L. et al. (1980) Serum concentrations of human chorionic gonadotrophin and its α and β subunits. 1. During normal singleton and twin pregnancies. Clin. Endocrinol., 13, 305-318.
21. SART (1995) Assisted reproductive technology in the United States and Canada: 1993 results generated from the American Society for Reproductive Medicine/Society for Assisted Reproducive Technology Registry. Fertil. Steril., 64, 13-19.
22. Schmidt, L.L., Asch, R.H., Frederick, J.L. et al. (1994) The predictive value of a single β human chorionic gonadotropin in pregnancies achieved by assisted reproductive technology. Fertil. Steril., 62, 333-338.
23. Stenman, U.-H., Bidart, J.M., Birken, S. et al. (1993) Standardization of protein immunoprocedures. Choriogonadotropin (CG). Scand. J. Clin. Lab. Invest. Suppl., 216, 42-78.
24. Tan, S.L., Royston, P., Campbell, S. et al. (1992) Cumulative conception and livebirth rates after in-vitro fertilisation [see comments]. Lancet, 339, 1390-1394.
25. Wehmann, R.E., Amr, S., Rosa, C. et al. (1984) Metabolism, distribution and excretion of purified human chorionic gonadotropin and its subunits in man. Ann. Endocrinol. Paris, 45, 291-295.
26. Wilcox, L.S., Peterson, H.B., Haseltine, F.P. et al. (1993) Defining and interpreting pregnancy success rates for in vitro fertilization. Fertil Steril., 60, 18-25.
27. Yamashita, T., Okamoto, S., Thomas, A. et al. (1989) Predicting pregnancy outcome after in vitro fertilization and embryo transfer using estradiol, progesterone, and human chorionic gonadotropin β-subunit. Fertil. Steril., 51, 304-309.
28. Zegers-Hochschild, F., Altieri, E., Fabres, C. et al. (1994) Predictive value of human chorionic gonadotrophin in the outcome of early pregnancy after invitro fertilization and spontaneous conception. Hum. Reprod., 9, 1550-1555.