Role of reactive oxygen and argininosuccinate in guanidinosuccinate synthesis in isolated rat hepatocytes

Enzyme and Protein

Volumn 49, Issue 4, 1996, Pages 205-211

  Aoyagi, Kazumasa ^a,b   Nagase, Sohji ^a   Gotoh, Michihiro ^a   Akiyama, Kayo ^b   Satoh, Makiko ^a   Hirayama, Aki ^a   Koyama, Akio ^a  

^a Department of Internal Medicine ^*  (Japan)

^b UNIVERSITY OF TSUKUBA   (Japan)

Author keywords

Argininosuccinate; Guanidinosuccinic acid; Isolated hepatocyte; Reactive oxygen; Uremic toxin

Indexed keywords

ARGININOSUCCINIC ACID; DIMETHYL SULFOXIDE; ENZYME INHIBITOR; FERROUS CHLORIDE; GUANIDINOSUCCINIC ACID; HYDROXYL RADICAL; REACTIVE OXYGEN METABOLITE; SCAVENGER; UREA; UREMIC TOXIN;

ANIMAL CELL; ARTICLE; BIOSYNTHESIS; KIDNEY FAILURE; LIVER CELL; MALE; NONHUMAN; RAT; UREA BLOOD LEVEL; UREA CYCLE; UREMIA;

EID: 0030455685     PISSN: 10196773     EISSN: None     Source Type: Journal    
DOI: 10.1159/000468630     Document Type: Article

References (14)

1. Cohen BD: Guanidinosuccinic acid in uremia. Arch Intern Med 1970;126:847-850.
2. Kopple JD, Gordon SI, Wang M, Swendseid ME: Factors affecting serum and urinary guanidinosuccinic acid levels in normal and uremic subjects. J Lab Clin Med 1968;90:303-311.
3. Mikami H, Orita Y, Ando A, Fujii M, Kikuchi T, Yoshihara K, Okada A, Abe H: Metabolic pathway of guanidino compounds in chronic renal failure. Adv Exp Med Biol 1982;153:449-458.
4. Aoyagi K, Ohba S, Narita M, Tojo S: Regulation of biosynthesis of guanidinosuccinic acid in isolated rat hepatocytes and in vivo. Kidney Int 1983;24(suppl 16):224-228.
5. Tofuku Y, Kuroda M, Muramoto H, Takeda R: A study of guanidine metabolism in uremia, with special reference to serum guanidinoacetic acid in anephric patients (in Japanese). Jpn J Nephrol 1984;26:171-181.
6. Menyhart J, Grof J: Urea is a selective inhibitor of argininosuccinate lyase. Eur J Biochem 1977;75:405-409.
7. Aoyagi K, Nagase S, Narita M, Tojo S: Role of active oxygen on methylguanidine synthesis in isolated rat hepatocytes. Kidney Int 1987:22(suppl):229-233.
8. Aoyagi K, Nagase S, Satoh M, Tomida T, Takemura K, Akiyama K, Koyama A: Synthesis of guanidinosucci nate from argininosuccinate and reactive oxygen in vitro. Enzyme Protein 1996;49:199-204.
9. Berry MN, Friend DS: High-yield preparation of isolated liver cells. J Cell Biol 1969;43:506-520
10. Zahlten RN, Fredrick WS, Lardy HA: Regulation of glucose synthesis in hormone-sensitive isolated hepatocytes. Proc Natl Acad Sci USA 1973;70:3213-3218.
11. Yamamoto Y, Manji T, Saito A, Maeda K, Ohta K: Ion-exchange Chromatographic separation and fluorometric determination of guanidino compounds in physiological fluids. J Chromatogr 1979;162:327-340.
12. Halliwell B, Gutteridge JMC: Oxygen toxicity, oxygen radicals, transition metals and disease. Biochem J 1984;219:1-14.
13. Cohen G: The Fenton reaction: in Greenwald RA (ed): Handbook of Methods for Oxygen Radical Research. Boca Raton, CRC Press, 1985. pp 55-64.
14. Sein IM, Cohen BD, Kornhauser PS: Guanidinosuccinic acid renal failure, experimental azotemia and inborn error of the urea cycle. N Engl J Med 1969;280:920-930.