Etoposide at different concentrations may open different apoptotic pathways in thymocytes

European Journal of Histochemistry

Volumn 40, Issue 4, 1996, Pages 289-298

  Pellicciari, C ^a   Bottone, M G ^a   Schaack, V ^a   Manfredi, A A ^b   Barni, S ^a  

^a CNR   (Italy)

^b SAN RAFFAELE HOSPITAL   (Italy)

Author keywords

apoptosis; cell cycle; electron microscopy; etoposide; thymocytes

Indexed keywords

ANTINEOPLASTIC AGENT; DNA; ETOPOSIDE;

ANIMAL; APOPTOSIS; ARTICLE; CELL CYCLE; DOSE RESPONSE; DRUG EFFECT; ELECTRON MICROSCOPY; IN VITRO STUDY; METABOLISM; RAT; T LYMPHOCYTE; ULTRASTRUCTURE;

ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; CELL CYCLE; DNA; DOSE-RESPONSE RELATIONSHIP, DRUG; ETOPOSIDE; MICROSCOPY, ELECTRON; RATS; T-LYMPHOCYTES;

ANIMALIA;

EID: 0030453858     PISSN: 1121760X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (29)

1. Arends M.J., Morris R.G., and Wyllie H.: Apoptosis: the role of endonuclease. Am. J. Pathol. 136, 593-608, 1990.
2. Barni S., Porcelli F., Scherini E., and Spadari S.: Induction of karyological damage by bleomycin in poliploidizating rabbit hapatocytes. Anticancer Res. 12, 521-528, 1992.
3. Boehme S.A., and Lenardo M.J.: Propriocidal apoptosis of mature T lymphocytes occurs at S phase of the cell cycle. Eur. J. Immunol. 23, 1552-1559, 1993.
4. Bruno S., Lassotta P., Giaretti W., and Darzynkiewizc Z.: Apoptosis of rat thymocytes by prednisolone, camptothecin or teniposide ia selective to G0 cells and is prevented by inhibitors of preteases. Oncology Res. 4, 29-35, 1992.
5. Catchpoole D.R., and Stewart B.W.: Formation of apoptotic bodies is associated with internucleosomal DNA fragmentation during drug-induced apoptosis. Expt. Cell Res. 216, 169-177, 1995.
6. Cohen J.J., Duke R.C., Fadok V.A., and Sellins K.S.: Apoptosis and programmed cell death in immunity. Annu. Rev. Immunol. 10, 267-293, 1992a.
7. Cohen J.J., Sun X.-.M., Snowden R.T., Dinsdale D., and Skilleter D.N.: Key morphological features of apoptosis may occur in the absence of internucleosomal DNA fragmentation. Biochem. J. 256, 331-334, 1992b.
8. Cohen J.J.: Apoptosis. Immunology Today 14, 126-130, 1993.
9. Cossanzza A., Kalashnikova G., Grassilli E., Chiappelli F., Salvioli S., Capri M., Barbieri D., Troiano L., Monti D., and Franceschi C.: Mitochondrial modifications during rat thymocyte apoptosis: a study at the single cell level. Exp. Cell Res. 214, 323-330, 1994.
10. Darzynkiewicz Z., Bruno S., Del Bino G., Gorczyca W., Hotz M.A., Lassotta P., and Traganos F.: Features of apoptotic cells measured by flow cytometry. Cytometry 13, 795-808, 1992.
11. Del Bino G., Skierski J.S., and Darzynkiewicz Z.: The concentration-dependent diversity of effects of DNA topoisomerase I and II inhibitors on the cell cycle of HL-60 cells. Exp. Cell Res. 195, 485-491, 1991.
12. Dini L., Coppola S., Ruzittu M.T., and Ghibelli L.: Multiple pathways for apoptotic nuclear fragmentation. Exp. Cell Res. 223, 340-347, 1996.
13. Fearnhead H.O., Chwalinski M., Snowden R.T., Ormerod M.G., Cohen G.M.: Dexamethasone and etoposide induce apoptosis in rat thymocytes from different phases of the cell cycle. Biochem. Pharmacol. 48, 1073-1079, 1994.
14. Ferrarini M., Heltai S., Toninelli E., Sabbadini M.G., Pelliccian C., and Manfredi A.A.: Daudi lymphoma killing triggers the programmed death of cytotoxic Vgamma9/ Vdelta2 T lymphocytes. J. Immunol. 154, 3704-3712, 1995.
15. Giocanti N., Hennequin C., Balosso J., Mahler M., and Favaudon V.: Topoisomerase II poison etoposide. Cancer Res. 53, 2105-2111, 1993.
16. Gorczyca W., Ardelt B., and Darzynkiewicz Z.: Different rate of degradation of the proliferation-associated nuclear and nucleolar antigens during apoptosis of HL-60 cells induced by DNA topoisomerase inhibitors. Int. J. Oncol. 3, 627-634, 1993.
17. Kaufmann S.H.: Induction of endonucleolytic DNA cleavage in human acute myoelogenous, leukemia cells by etoposide, camptothecin, and other cytotoxic anticancer drugs. A cautionary note. Cancer Res. 49, 5870-5878, 1989.
18. Kerr J.F.R., and Harmon B.V.: Definition and incidence of apoptosis: an historical perspective. In Apoptosis: The Molecular Basis of Cell Death. Curr. Comm. Cell and Mol. Biol., vol. 3. (Eds. Tomei, L.D., and Cope, F.O.) Cold Spring Harbor Laboratory Press, New York, 1991, pp. 5-29.
19. Kerr J.F.R., Wyllie A.H., and Currie A.R.: Apoptosis: a basic biological phenomenon with wide-range implications in tissue kinetics. Br. J. Cancer 26, 239-257, 1972.
20. Kerr J.F.R., Winterford C.M., and Harmon B.V.: Morphological criteria for identifying apoptosis. In Cell Biology, a Laboratory Handbook, Vol. 1. (Ed. Celis, J.E.), Academic Press Inc., London, pp. 319-337, 1994.
21. Mc Conkey D.J., and Orrenius S.: Cellular signaling in thymocyte apoptosis. In Apoptosis: The Molecular Basis of Cell Death. Curr. Comm. Cell and Mol. Biol., vol. 3. (Eds. Tomei, L.D., and Cope, F.O.) Cold Spring Harbor Laboratory Press, New York, 1991, pp. 227-246.
22. Miller M.M., Teng C.J., Mitmaker B., and Wang E.: Characterization of the tissue regression process in the uterus of older mice as apoptotic by the presence of Tp30, an isoform of terminin. Eur. J. Histochem. 39, 91-100, 1995.
23. Onishi Y., Azuma Y., Sato Y., Mizuno Y., Tadakuma T., and Kizaki H.: Topoisomerase inhibitors induce apoptosis in thymocytes. Biochem. Biophys. Acta 1175, 147-154, 1993.
24. Pellicciari C., Manfredi A.A., Bottone M.G., Schaack V., and Barni S.: A single-step staining procedure for the detection and sorting of unfixed apoptotic thymocytes. Eur. J. Histochem. 37, 381-390, 1993.
25. Pellicciari C., Bottone M.G., Schaack V., Barni S., and Manfredi A.A.: Spontaneous apoptosis of thymocytes is uncoupled with progression through the cell cycle. Exp. Cell Res., 229, 1996 (in press).
26. Rothenberg E.V., and Lugo J.P.: Differentiation and cell division in mammalian thymus. Dev. Biol. 112, 1-17, 1985.
27. Walker P.R., Smith C., Yondale T., Leblanc J., Whitfield J.F., and Sikorska M.: Topoisomerase II-reactive chemotherapeutic drugs induce apoptosis in thymocytes. Cancer Res. 52, 1078-1085, 1991.
28. Wyllie A.H., Kerr J.F.R., and Currie A.R.: Cell death: the sisnificance of apoptosis. Int. Rev. Cytol. 68, 251-306, 1980.
29. Zakeri Z., Bursch W., Tenniswood M., and Lockshin R.A.: Cell death: programmed, apoptosis, necrosis or other? Cell Death Differentiation 2, 87-96, 1995.