The human β-globin locus control region confers an early embryonic erythroid-specific expression pattern to a basic promoter driving the bacterial lacZ gene

Development

Volumn 122, Issue 12, 1996, Pages 3991-3999

  Tewari, Rita ^a   Gillemans, Nynke ^a   Harper, Alex ^b   Wijgerde, Mark ^a   Zafarana, Gaetano ^a   Drabek, Dubravka ^a   Grosveld, Frank ^a   Philipsen, Sjaak ^a  

^a ERASMUS UNIVERSITY ROTTERDAM   (Netherlands)

^b ST THOMAS HOSPITAL   (United Kingdom)

Author keywords

globin; Basic promoter; DNaseI hypersensitive sites; Embryonic expression pattern; Erythropoiesis; LacZ gene; Locus control region; Mouse; Transgenic mice

Indexed keywords

BETA GALACTOSIDASE; BETA GLOBIN; DEOXYRIBONUCLEASE I; DNA FRAGMENT; GAMMA GLOBIN; TRANSCRIPTION FACTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BACTERIAL GENE; CHROMATIN STRUCTURE; CONTROLLED STUDY; EMBRYO; EMBRYO DEVELOPMENT; ERYTHROID CELL; FEMALE; GENE ACTIVATION; GENE CLUSTER; GENE CONTROL; GENE EXPRESSION; GENE LOCUS; GENETIC TRANSCRIPTION; GLOBIN GENE; IN SITU HYBRIDIZATION; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; TRANSGENE;

ANIMALS; BETA-GALACTOSIDASE; BINDING SITES; ERYTHROPOIESIS; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GLOBINS; HSP70 HEAT-SHOCK PROTEINS; HUMANS; IN SITU HYBRIDIZATION; LAC OPERON; LIVER; MICE; MICE, TRANSGENIC; PROMOTER REGIONS (GENETICS); RECOMBINANT PROTEINS; REGULATORY SEQUENCES, NUCLEIC ACID; TRANSCRIPTION, GENETIC;

EID: 0030453172     PISSN: 09501991     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (53)

1. Adams, C. C. and Workman, J. L. (1993). Nucleosome displacement in transcription. Cell 72, 305-8.
2. Antoniou, M., deBoer, E., Habets, G. and Grosveld, F. (1988). The human beta-globin gene contains multiple regulatory regions: identification of one promoter and two downstream enhancers. EMBO J. 7, 377-84.
3. Antoniou, M. and Grosveld, F. (1990). beta-globin dominant control region interacts differently with distal and proximal promoter elements. Genes Dev. 4, 1007-13.
4. Bonnerot, C. and Nicolas, J.-F. (1993). Application of lacZ gene fusions to postimplantation development. Meth, Enzymal. 225, 451-469.
5. Caterina, J. J., Ciavatta, D. J., Donze, D. Behringer, R. R. and Townes, T. M. (1994). Multiple elements in human beta-globin locus control region 5′ HS 2 are involved in enhancer activity and position-independent, transgene expression. Nucleic Acids Res. 22, 1006-11.
6. Caterina, J. J., Ryan, T. M., Pawlik, K. M., Palmiter, R. D., Brinster, R. L., Behringer, R. R. and Townes, T. M. (1991). Human beta-globin locus control region: analysis of the 5′ DNase I hypersensitive site HS 2 in transgenic mice. Proc. Natl Acad. Sci. USA 88, 1626-30.
7. Driscoll, M. C., Dobkin, C. S. and Alter, B. P. (1989). Gamma delta beta-thalassemia due to a de novo mutation deleting the 5′ beta-globin gene activation-region hypersensitive sites. Proc. Natl Acad. Sci. USA 86, 7470-4.
8. Dzierzak, E. and Medvinsky, A. (1995). Mouse embryonic hematopoiesis. Trends Genet. 11, 359-66.
9. Elgin, S. C. (1990). Chromatin structure and gene activity. Curr. Opin. Cell Biol. 2, 437-45.
10. Ellis, J., Talbot, D., Dillon, N. and Grosveld, F. (1993). Synthetic human beta-globin 5′HS2 constructs function as locus control regions only in multicopy transgene concatamers. EMBO J. 12, 127-34.
11. Ellis, J., Tan-Un, K. C, Harper, A., Michalovich, D., Yannoutsos, N., Philipsen, S. and Grosveld, F. (1996). A dominant chromatin-opening activity in 5′ hypersensitive site 3 of the human beta-globin locus control region. EMBO J. 15, 562-568.
12. Fiering, S., Epner, E., Robinson, K., Zhuang, Y., Telling, A., Hu, M., Martin, D. I, Enver, T., Ley, T. J. and Groudine, M. (1995). Targeted deletion of 5′HS2 of the murine beta-globin LCR reveals that it is not essential for proper regulation of the beta-globin locus. Genes Dev. 9, 220313.
13. Forrester, W. C., Epner, E., Driscoll, M. C., Enver, T., Brice, M., Papayannopoulou, T. and Groudine, M. (1990). A deletion of the human beta-globin locus activation region causes a major alteration in chromatin structure and replication across the entire beta-globin locus. Genes Dev. 4, 1637-49.
14. Fraser, P., Hurst, J., Collis, P. and Grosveld, F. (1990). DNasel hypersensitive sites 1, 2 and 3 of the human beta-globin dominant control region direct position-independent expression. Nucleic Acids Res. 18, 3503-8.
15. Fraser, P., Pruzina, S., Antoniou, M. and Grosveld, F. (1993). Each hypersensitive site of the human beta-globin locus control region confers a different developmental pattern of expression on the globin genes. Genes Dev. 7, 106-13.
16. Grosveld, F., van Assendelft, G. B., Greaves, D. R. and Kollias, G. (1987) Position-independent, high-level expression of the human beta-globin gene in transgenic mice. Cell 51, 975-85.
17. Guy, L.-G., Kothary, R., DeRepentigny, Y., Delvoye, N., Ellis, J. and Wall, L. (1996). The beta-globin locus control region enhances transcription but does not confer position-independent expression onto the lacZ gene in transgenic mice. EMBO J. 15, 3713-3721.
18. Hardison, R., Xu, J., Jackson, J., Mansberger, J., Selifonova, O., Grotch, B., Biesecker, J., Petrykowska, H. and Miller, W. (1993). Comparative analysis of the locus control region of the rabbit beta-like gene cluster: HS3 increases transient expression of an embryonic epsilon-globin gene. Nucleic Acids Res. 21, 1265-72.
19. Hebbes, T. R., Thorne, A. W., Clayton, A. L. and Crane-Robinson, C. (1992). Histone acetylation and globin gene switching. Nucleic Adas Res. 20, 1017-22.
20. Hug, B. A., Wesselschmidt, R. L., Fiering, S., Bender, M. A., Epner, E., Groudine, M. and Ley, T. J. (1996). Analysis of mice containing a targeted deletion of beta- globin locus control region 5′ hypersensitive site 3. Mol. Cell. Biol. 16, 2906-2912.
21. Jimenez, G., Gale, K. B. and Enver, T. (1992a). The mouse beta-globin locus control region: hypersensitive sites 3 and 4. Nucleic Acids Res. 20, 5797-803.
22. Jimenez, G., Griffiths, S. D., Ford, A. M., Greaves, M. F. and Enver, T. (1992b). Activation of the beta-globin locus control region precedes commitment to the erythroid lineage. Proc. Natl Acad. Sci. USA 89, 10618-22.
23. Kim, C. G., Epner, E. M., Forrester, W. C. and Groudine, M. (1992). Inactivation of the human beta-globin gene by targeted insertion into the beta-globin locus control region. Genes Dev. 6, 928-38.
24. Kioussis, D., Vanin, E., deLange, T., Flavell, R. A. and Grosveld, F. G. (1983). Beta-globin gene inactivation by DNA translocation in gamma beta-thalassaemia. Nature 306, 662-6.
25. Kollias, G., Wrighton, N., Hurst, J. and Grosveld, F. (1986). Regulated expression of human A gamma-, beta- and hybrid gamma beta-globin genes in transgenic mice: manipulation of the developmental expression patterns. Cell 46, 89-94.
26. Kothary, R., Clapoff, S., Brown, A., Campbell, R., Peterson, A. and Rossant, J. (1988). A transgene containing lacZ inserted into the dystonia locus is expressed in neural tube. Nature 335, 435-7.
27. Kothary, R., Clapoff, S., Darling, S., Perry, M. D., Moran, L. A. and Rossant, J. (1989). Inducible expression of an hsp68-lacZ hybrid gene in transgenic mice. Development 105, 707-14.
28. Kothary, R., Perry, M. D., Moran, L. A. and Rossant, J. (1987). Celllineage-specific expression of the mouse hsp68 gene during embryogenesis. Dev. Biol. 121, 342-8.
29. Lowrey, C. H., Bodine, D. M. and Nienhuis, A. W. (1992). Mechanism of DNase I hypersensitive site formation within the human globin locus control region. Proc. Natl Acad. Sci. USA 89, 1143-7.
30. Milot, E., Strouboulis, J., Trimborn, T., Wijgerde, M., De Boer, E., Langeveld, A., Tan-Un, K., Vergeer, W., Yannoutsos, N., Grosveld, F. and Fraser, P. (1996). Heterochromatin effect on the frequency and duration of LCR mediated gene transcription. Cell, in press.
31. Moon, A. M. and Ley, T. J. (1991). Functional properties of the beta-globin locus control region in K562 erythroleukemia cells. Blood 77, 2272-84.
32. Nandi, A. K., Roginski, R. S., Gregg, R. G., Smithies, O. and Skoultchi. A. I. (1988). Regulated expression of genes inserted at the human chromosomal beta-globin locus by homologous recombination. Proc. Natl Acad. Sci. USA 85, 3845-9.
33. Patterton, D. and Wolffe, A. P. (1996). Developmental roles for chromatin and chromosomal structure. Dev. Biol. 173, 2-13.
34. Pawlik, K. M and Townes, T. M. (1995). Autonomous, erythroid-specific DNase I hypersensitive site formed by human beta-globin locus control region (LCR) 5′ HS 2 in transgenic mice. Dev. Biol. 169, 728-32.
35. Philipsen, S., Pruzina, S. and Grosveld, F. (1993). The minimal requirements for activity in transgenic mice of hypersensitive site 3 of the beta globin locus control region. EMBO J. 12, 1077-85.
36. Philipsen, S., Talbot, D., Fraser, P. and Grosveld, F. (1990). The beta-globin dominant control region: hypersensitive site 2. EMBO J. 9, 2159-67.
37. Pruzina, S., Antoniou, M., Hurst, J., Grosveld, F. and Philipsen, S. (1994). Transcriptional activation by hypersensitive site three of the human beta-globin locus control region in murine erythroleukemia cells. Biochim. Biophys. Acta 9, 351-60.
38. Pruzina, S., Hanscombe, O., Whyatt, D., Grosveld, F. and Philipsen. S. (1991). Hypersensitive site 4 of the human beta globin locus control region. Nucleic Acids Res. 19, 1413-9.
39. Raap, A. K., van de Corput, M. P., Vervenne, R. A., van Gijlswijk, R. P., Tanke, H. J. and Wiegant, J. (1995). Ultra-sensitive FISH using peroxidase-mediated deposition of biotin- or fluorochrome tyramides. Hum. Mol. Genet. 4, 529-34.
40. Reitman, M., Lee, E., Westphal, H. and Felsenfeld, G. (1993). An enhancer/locus control region is not sufficient to open chromatin. Mol. Cell Biol. 13, 3990-8
41. Robertson, G., Garrick, D., Wu, W., Kearns, M., Martin, D. and Whitelaw, E. (1995). Position-dependent variegation of globin transgene expression in mice. Proc. Nutl Acad. Sci. USA 92, 5371-5.
42. Russell, E. S. and Bernstein, S. E. (1966). Blood and blood formation. In Biology of the Laborator Mouse, Second Edition (ed. E.L. Green), pp. 351-372. New York, McGraw-Hill.
43. Ryan, T. M., Behringer, R. R., Martin, N. C., Townes, T, M., Palmiter, R. D. and Brinster, R. L. (1989). A single erythroid-speciric DNase I super-hypersensitive site activates high levels of human beta-globin gene expression in transgenic mice. Genes Dev. 3, 314-23.
44. Shehee, W. R., Loeb, D. D., Adey, N. B., Burton, F. H., Casavant, N. C., Cole, P., Davies, C. J., McGraw, R. A., Schichman, S. A., Severynse, D. M., Voliva, C. F., Weyter, F. W., Wisely, G. B., Edgell, M. H. and Hutchison, C. A. III (1989). Nucleotide sequence of the BALB/c mouse beta-globin complex. J. Mol. Biol. 205, 41-62.
45. Shehee, W. R., Oliver, P. and Smithies, O. (1993). Lethal thalassemia after insertional disruption of the mouse major adult beta-globin gene. Proc. Nutl Acad. Sci. USA 90, 3177-81.
46. Shivdasani, R. A. and Orkin, S. H. (1996). The transcriptional control of hematopoiesis. Blood 87, 4025-4039.
47. Stamatoyannopoulos, J. A., Goodwin, A., Joyce, T. and Lowrey, C. H. (1995). NF-E2 and GATA binding motifs are required for the formation of DNase I hypersensitive site 4 of the human beta-globin locus control region. EMBO J. 14, 106-16.
48. Talbot, D., Collis, P., Antoniou, M., Vidal, M., Grosveld, F. and Greaves, D. R. (1989). A dominant control region from the human beta-globin locus conferring integration site-independent gene expression. Nature 338, 352-5.
49. Talbot, D., Philipsen, S., Fraser, P. and Grosveld, F. (1990). Detailed analysis of the site 3 region of the human beta-globin dominant control region. EMBO J. 9, 2169-77.
50. Taramelli, R., Kioussis, D., Vanin, E., Bartram, K., Groffen, J., Hurst, J. and Grosveld, F. G. (1986). Gamma delta beta-thalassaemias I and 2 are the result of a l00 kbp deletion in the human beta-globin cluster. Nucleic Acids Res. 14, 7017-29.
51. Tuan, D., Solomon, W., Li, Q. and London, I. M. (1985). The 'beta-like-globin' gene domain in human erythroid cells. Proc. Natl Acad. Sci. USA 82, 6384-8.
52. Tuan, D. Y., Solomon, W. B., London, I. M. and Lee, D. P. (1989). An erythroid-specific, developmenlal-stage-independent enhancer far upstream of the human 'beta-like globin' genes. Proc. Natl Acad. Sci. USA 86, 2554-8.
53. Wijgerde, M., Grosveld, F. and Fraser, P. (1995). Transcription complex stability and chromatin dynamics in vivo. Nature 377, 209-13.