Localization of apolipoprotein A-I epitopes involved in the activation of lecithin: Cholesterol acyltransferase

Journal of Lipid Research

Volumn 37, Issue 12, 1996, Pages 2557-2568

  Uboldi, Patrizia ^a   Spoladore, Monica ^a   Fantappiè, Simona ^a   Marcovina, Santica ^b   Catapano, Alberico L ^a  

^a UNIVERSITY OF MILAN   (Italy)

^b UNIVERSITY OF WASHINGTON   (United States)

Author keywords

epitopes; Fab fragments; HDL; monoclonal antibodies

Indexed keywords

APOLIPOPROTEIN A1; HIGH DENSITY LIPOPROTEIN; IMMUNOGLOBULIN F(AB) FRAGMENT; MONOCLONAL ANTIBODY; PHOSPHATIDYLCHOLINE STEROL ACYLTRANSFERASE;

ANTIBODY SPECIFICITY; ARTICLE; ATHEROSCLEROSIS; BINDING SITE; CORONARY RISK; DNA CLEAVAGE; ENZYME ACTIVATION; ENZYME SUBSTRATE; EPITOPE MAPPING; HUMAN; HUMAN CELL; LIPOPROTEIN METABOLISM; PEPTIDE SYNTHESIS; PRIORITY JOURNAL; PROTEIN LOCALIZATION; RNA TRANSLATION;

ANIMALS; APOLIPOPROTEIN A-I; BINDING SITES; ENZYME ACTIVATION; EPITOPE MAPPING; EPITOPES; HUMANS; MALE; MICE; MICE, INBRED BALB C; PHOSPHATIDYLCHOLINE-STEROL O-ACYLTRANSFERASE;

EID: 0030451848     PISSN: 00222275     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (52)

1. Eisenberg, S. 1984. High density lipoprotein metabolism. J. Lipid Res. 25: 1017-1058.
2. Schaefer, E. J. 1984. Clinical, biochemical, and genetic features in familial disorders of high density lipoprotein deficiency. Arteriosclerosis. 4: 303-322.
3. Cheung, M. C., and J. J. Albers. 1977. The measurement of apolipoprotein A-I and A-II levels in men and women by immunoassay. J. Clin. Invest. 60: 43-50.
4. Brewer, H. B., Jr., T. Fairwell, A. Larue, R. Ronan, A. Houser, and T. J. Bronzert. 1978. The amino acid sequence of human apoA-I, an apolipoprotein isolated from high density lipoproteins. Biochem. Biophys. Res. Commun. 80: 623-630.
5. Law, S. W., G. Gray, and H. B. Brewer, Jr. 1993. DNA cloning of human apoA-I: amino acid sequences of prepro apoA-I. Biochem. Biophys. Res. Commun. 112: 257-264.
6. Bojanovski, D., R. E. Gregg, G. Ghiselli, E. J. Schaefer, J. A. Light, and H. B. Brewer, Jr. 1985. Human apolipoprotein A-I isoprotein metabolism: proapoA-I conversion to mature apoA-I. J. Lipid Res. 26: 185-193.
7. Fielding, C. J., V. G. Shore, and P. E. Fielding. 1972. A protein cofactor of lecithin:cholesterol acyltransferase. Biochem. Biophys. Res. Commun. 46: 1493-1498.
8. Glomset, J. A., and K. R. Norum. 1973. The metabolic role of lecithin:cholesterol acyltransferase: perspective from pathology. Adv. Lipid Res. 11: 1-65.
9. Schmitz, G., H. Robenek, U. Lohmann, and G. Assmann. 1985. Interaction of high density lipoproteins with cholesteryl ester-laden macrophages: biochemical and morphological characterization of cell surface receptor binding, endocytosis and resecretion of high density lipoproteins by macrophages. EMBO J. 4: 613-622.
10. Allan, C. M., N. H. Fidge, J. R. Morrison, and J. Kanellos. 1993. Monoclonal antibodies to human apolipoprotein AI: probing the putative receptor binding domain of apolipoprotein AI. Biochem. J. 290: 449-455.
11. Catapano, A. L. 1987. Binding sites for HDL and HDL catabolism. Atheroscler. Rev. 16: 109-123.
12. 3 cholesterol, apoA-I and apoA-II, and increased risk of myocardial infarction. Circulation. 85: 22-29.
13. Curtiss, L. K., and T. S. Edgington. 1985. Immunochemical heterogeneity of human plasma high density lipoproteins. Identification with apolipoprotein A-I and A-II specific monoclonal antibodies. J. Biol. Chem. 260: 2982-2993.
14. Weech, P. K., R. W. Milne, P. Milthorp, and Y. L. Marcel. 1985. Apolipoprotein A-I from normal human plasma: definition of three distinct antigenic determinants. Biochim. Biophys. Acta. 835: 390-401.
15. 136 → Lys). J. Lipid Res. 27: 1259-1264.
16. Marcel, Y. L., P. R. Provost, H. Koa, E. Raffai, N. Vu Dac, J.C. Fruchart, and E. Rassart. 1991. The epitopes of apolipoprotein A-I define distinct structural domains including a mobile middle region. J. Biol. Chem. 266: 3644-3653.
17. Milthorp, P., P. K. Weeck, R. W. Milne, and Y. L. Marcel. 1986. Immunochemical characterization of apolipoprotein A-I from normal human plasma. Arteriosclerosis. 6: 285-296.
18. Pio, F., H. De Loof, N. Vu Dac, V. Clavey, and J. C. Fruchart. 1988. Immunochemical characterization of two antigenic sites on human apolipoprotein A-I; localization and lipid modulation of these epitopes. Biochim. Biophys. Acta. 959: 160-168.
19. Silberman, S. R., F. Bernini, J. T. Sparrow, A. M. Gotto, Jr., and L. C. Smith. 1987. Monoclonal antibodies as probes of high density lipoprotein structure: identification and localization of a lipid-dependent epitope. Biochemistry. 26: 5833-5843.
20. Allan, C. M., T. Tetaz, and N. H. Fidge. 1991. Epitope mapping of apolipoprotein A-I using endoproteinase cleavage and monoclonal antibodies in an enzyme-linked immunosorbent assay. J. Lipid Res. 32: 595-601.
21. Banka, C. L., A. S. Black, and L. K. Curtiss. 1994. Localization of an apolipoproiein A-I epitope critical for lipoprotein-mediated cholesterol efflux from monocytic cells. J. Biol. Chem. 269: 10288-10297.
22. Dalton, H. B., and S. B. Swaney. 1993. Structural and functional domains of apolipoprotein A-I within high density lipoproteins. J. Biol. Chem. 268: 19274-19283.
23. Leblond, L., and Y. L. Marcel. 1991. The amphipathic α-helical repeats of apolipoprotein A-I are responsible for binding of high lipoproteins to HepG2 cells. J. Biol. Chem. 266: 6058-6067.
24. Banka, C. L., D. J. Bonnet, A. S. Black, R. S. Smith, and L. K. Curtiss. 1991. Localization of an apolipoprotein A-I epitope critical for activation of lecithin-cholesterol acyltransferase. J Biol. Chem. 266: 23886-23892.
25. Meng, Q.-H. L. Calabresi, J. C. Fruchart, and Y. L. Marcel. 1993. Apolipoprotein A-I domains involved in the activation of lecithin:cholesterol acyltransferase. J. Biol. Chem. 268: 16966-16973.
26. Marcovina, S., S. Fantappiè, A. Zoppo, G. Franceschini, and A. L. Catapano. 1990. Immunochemical characterization of six monoclonal antibodies to human apolipoprotein A-I: epitope mapping and expression. J. Lipid Res. 31: 375-384.
27. Havel, R. J., H. A. Eder, and J. H. Bragdon. 1955. The distribution and chemical composition of ultracentrifugally separated lipoproteins in human serum. J. Clin. Invest. 34: 1340-1352.
28. Kane, J. T., T. Sata, R. L. Hamilton, and R. J. Havel. 1975. Apoprotein composition of very low density lipoproteins of human serum. J. Clin. Invest. 56: 1622-1630.
29. Catapano, A. L., R. L. Jackson, E. B. Gilliam, A. M. Gotto, Jr., and L. G. Smith. 1978. Quantification of apoC-II and apoC-III of human very low density lipoproteins by analytical isoelectric focusing. J. Lipid Res. 19:1047-1052.
30. Marcovina, S., P. J. Price, J. S. McDougal, and L. Cremonesi. 1984. Monoclonal antibodies directed against human low density lipoprotein and their characterization by the immunodot technique. In Protides of the Biological Fluids. Vol. 31. H. Peeters, editor. Pergamon Press Ltd., Oxford, England. 985-989.
31. Bilheimer, D. W., S. Eisenberg, and R. I. Levy. 1972. Metabolism of very low density lipoproteins. Part 1 (Preliminary in vitro and in vivo observations). Biochim. Biophys. Acta. 260:212-221.
32. Fraker, D. J., and J. G. Speck. 1978. Protein and cell membrane iodination with a sparingly soluble chloramide 1,3,4,6-tetra-chloro-3,6-diphenyl-glycoluril. Biochim. Biophys. Res. Commun. 80: 849-851.
33. Marcovina, S., D. France, R. A. Phillips, and S. J. T. Mao. 1985. Monoclonal antibodies can precipitate low-density lipoprotein. I. Characterization and use in determining apolipoprotein B. Clin. Chem. 31: 1654-1658.
34. Marcovina, S., B. A. Kottke, and S. J. T. Mao. 1985. Monoclonal antibodies can precipitate low-density lipoprotein. II. Radioimmunoassays with single and combined monoclonal antibodies for determining apolipoprotein B in serum of patients with coronary artery disease. Clin. Chem. 31: 1659-1663.
35. Scatchard, G. 1949. The attractions of proteins for small molecules and ions. Ann. N.Y. Acad. Sci. 51: 660-672.
36. Towbin, H., T. Staehelin, and J. Gordon. 1979. Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications. Proc. Natl. Acad. Sci. USA. 76: 4350-4354.
37. Weber, K., and M. Osborn. 1969. The reliability of molecular weight determination by dodecyl sulphate polyacrylamide gel electrophoresis. J. Biol. Chem. 244: 4406-4412.
38. Scann, A. M., and C. Edelstein. 1971. Solubility in aqueous solution of ethanol of the small molecular weight peptides of serum very low density lipoproteins. Anal. Biochem. 44: 576-588.
39. Hames, B. D., and D. Rikwood. 1981 Gel Electrophoresis of Proteins. IRL Press, Oxford.
40. Geysen, H. M. 1990. Review Molecular Technology: peptide epitope mapping and the pin technology. Southeast Asian J. Trop. Med. Public Health. 21: 523-533.
41. Chen, C. H., and J. J. Albers, 1985. A rapid large-scale procedure for purification of lecithin-cholesterol acyltransferase from human and animal plasma. Biochim. Biophys. Acta. 834: 188-195.
42. Pownall, H. J., Q. Pao, D. Hickson, J. T. Sparrow, S. K. Koserow, and J. B. Massey. 1981. Kinetics and mechanism of association of human plasma apolipoproteins with dimyristoyl phosphatidylcholine. Effect of protein structure and lipid clusters on reaction rates. Biochemistry. 20: 6630-6635.
43. Ghen, C. H., and J. J. Albers. 1982. Characterization of proteoliposomes containing apoprotein A-I: a new substrate for the measurement of lecithin:cholesterol acyltransferase activity. J. Lipid Res. 23: 680-691.
44. Glomset, J. A. 1968. The plasma lecithin:cholesterol acyltransferase reaction. J. Lipid Res. 9: 155-167.
45. Rail, S. C., K. H. Weisgraber, R. W. Mahley, Y. Ogawa, G. J. Fielding, G. Utermann, J. Haas, A. Steinmetz, M. J. Menzel, and G. Assmann. 1984. Abnormal lecithin:cholesterol acyltransferase activation by a human apolipoprotein A-I variant in which a single lysine residue is deleted. J. Biol. Chem. 259: 10063-10070.
46. 143 → Arg). Eur. J. Biochem. 144: 325-331.
47. Jonas, A., A. von Eckardstein, K. E. Kezdy, A. Steinmetz, and G. Assmann. 1991. Structural and functional properties of reconstituted high density lipoprotein discs prepared with six apolipoprotein A-I variants. J. Lipid Res. 32: 97-106.
48. Rall, S. C., K. H. Weisgraber, R. W. Mahley, C. Ehnholm, O. Schamaun, B. Olaisen, J. P. Blomhoff, and P. Teisberg. 1986. Identification of homozygosity for a human apolipoprotein A-I variant. J. Lipid Res. 27: 436-441.
49. Funke, H., A. von Eckardstein, P. H. Pritchard, M. Karas, J. J. Albers, and G. Assmann. 1991. A frameshift mutation in the human apolipoprotein A-I gene causes high density lipoprotein deficiency, partial lecithin:cholesterol-acyltransferase deficiency, and corneal opacities. J. Clin. Invest. 87: 371-376.
50. Cheung, M. C., A. V. Nichols, P. J. Blanche, E. L. Gong, G. Franceschini, and C. R. Sirtori. 1988. Characterization of apoA-I-containing lipoproteins in subjects with A-I Milano variant. Biochim. Biophys Acta. 960: 73-82.
51. Minnich, A., X. Collet, A. Roghani, C. Cladaras, R. M. Hamilton, G. J. Fielding, and V. I. Zannis. 1992. Site-directed mutagenesis and structure-function analysis of the human apolipoprotein A-I. J. Biol. Chem. 267: 16553-16560.
52. Sorci-Thomas, M., M. W. Kearns, and J. P. Lee. 1993. Apolipoprotein A-I domains involved in lecithin-cholesterol acyltransferase activation. Structure:function relationships. J. Biol. Chem. 268: 21403-21409.