Antibody responses of rats and humans to flagella-less cells and OspA protein of Borrelia burgdorferi

Annals of the New York Academy of Sciences

Volumn 797, Issue , 1996, Pages 140-150

  Sadziene, Ariadna ^a   Thompson, Patricia A ^a   Barbour, Alan G ^a,b  

^a UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL PROTEIN; BACTERIAL VACCINE; RECOMBINANT PROTEIN;

ANIMAL EXPERIMENT; ANTIBODY RESPONSE; BACTERIAL INFECTION; BORRELIA BURGDORFERI; CELL MUTANT; CONFERENCE PAPER; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; FLAGELLUM; HUMAN; IMMUNIZATION; IMMUNOBLOTTING; IMMUNOGENICITY; LYME DISEASE; NONHUMAN; NORMAL HUMAN; POLYACRYLAMIDE GEL ELECTROPHORESIS; RAT;

ANIMALIA; BACTERIA (MICROORGANISMS); BORRELIA; BORRELIA BURGDORFERI;

EID: 0030451547     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.1996.tb52956.x     Document Type: Conference Paper

References (30)

1. BARBOUR, A. G. & D. FISH. 1993. The biological and social phenomenon of Lyme disease. Science 260: 1610-1616.
2. FIKRIG, E., S. W. BARTHOLD, F. S. KANTOR & R. A. FLAVELL 1990. Protection of mice against the Lyme disease agent by immunizing with recombinant OspA. Science 250: 553-556.
3. SCHAIBLE, U. E., M. D. KRAMER, K. EICHMANN, M. MODOLELL, C. MUSETEANU & M. M. SIMON. 1990. Monoclonal antibodies specific for the outer surface protein A (OspA) of Borrelia burgdorferi prevent Lyme borreliosis in severe combined immunodeficiency (scid) mice. Proc. Natl. Acad. Sci. USA 87: 3768-3772.
4. SIMON, M. M., U. E. SCHAIBLE, M. D. KRAMER, C. ECKERSKORN, C. MUSETEANU, H. MULLER-HERMELINK & R. WALLICH. 1991. Recombinant outer surface protein A from Borrelia burgdorferi induces antibodies protective against spirochetal infection in mice. J. Infect. Dis. 164: 123-132.
5. ERDILE, L. F., M.-A. BRANDT, D. J. WARAKOMSKI, G. J. WESTRACK, A. SADZIENE, A. G. BARBOUR & J. P. MAYS. 1993. The role of attached lipid in the immunogenicity of Borrelia burgdorferi OspA. Infect. Immun. 61: 81-90.
6. STOVER, C. K., G. P. BANSAL, M. S. HANSON, J. E. BURLEIN, S. R. PALASZYNSKI, J. F. YOUNG, S. KOENIG, D. B. YOUNG, A. SADZIENE & A. G. BARBOUR. 1993. Protective immunity elicited by recombinant bacille Calmette-Guerin (BCG) expressing outer surface protein A (OspA) lipoprotein: A candidate Lyme disease vaccine. J. Exp. Med. 178: 197-209.
7. KELLER, D., F. T. KOSTER, D. H. MARKS, P. HOSBASCH, L. F. ERDILE & J. P. MAYS. 1994. Safety and immunogenicity of a recombinant outer surface protein A Lyme vaccine. JAMA 271: 1764-1768.
8. JOHNSON, R. C., C. KODNER & M. RUSSEL. 1986. Active immunization of hamsters against experimental infection with Borrelia burgdorferi. Infect. Immun. 54: 897-898.
9. CHU, H. J., L. G. CHAVEZ, B. M. BLUMER, R. W. SEBRING, T. L. WASMOEN & W. M. ACREE. 1992. Immunogenicity and efficacy study of a commercial Borrelia burgdorferi bacterin. J. Am. Vet. Med. Assoc. 201: 403-411.
10. HUGHES, C. A., S. M. ENGSTROM, L. A. COLEMAN, C. B. KODNER & R. C. JOHNSON. 1993. Protective immunity is induced by a Borrelia burgdorferi mutant that lacks OspA and OspB. Infect. Immun. 61: 5115-5122.
11. BARBOUR, A. G., S. F. HAYES, R. A. HEILAND, M. E. SCHRUMPF & S. L. TESSIER. 1986. A Borrelia genus-specific monoclonal antibody binds to a flagellar epitope. Infect. Immun. 52: 549-554.
12. ABERER, E., C. BRUNNER, G. SUCHANEK, H. KLADE, A. BARBOUR, G. STANEK & H. LASSMANN. 1989. Molecular mimicry and Lyme borreliosis: A shared antigenic determinant between Borrelia burgdorferi and human tissue. Ann. Neurol. 26: 732-737.
13. FIKRIG, E., R. BERLAND, M. CHEN, S. WILLIAMS, L. H. SIGAL & R. A. FLAVELL. 1993. Serologic response to the Borrelia burgdorferi flagellin demonstrates an epitope common to a neurablastoma cell line. Proc. Natl. Acad. Sci. USA 90: 183-187.
14. SIGAL, L. H. 1990. Molecular mimicry and Lyme borreliosis. Ann. Neurol. 28: 195-196.
15. SADZIENE, A., D. D. THOMAS, V. G. BUNDOC, S. H. HOLT & A. G. BARBOUR. 1991. A flagella-less mutant of Borrelia burgdorferi. J. Clin. Invest. 88: 82-92.
16. FIKRIG, E., S. W. BARTHOLD, N. MARCANTONIO, K. DEPONTE, F. S. KANTOR & R. A. FLAVELL. 1992. Roles of OspA, OspB, and flagellin in protective immunity to Lyme borreliosis in laboratory mice. Infect. Immun. 60: 657-661.
17. BUNDOC, V. G. & A. G. BARBOUR. 1989. Clonal polymorphisms of outer membrane protein OspB of Borrelia burgdorferi. Infect. Immun. 57: 2733-2741.
18. SADZIENE, A., P. A. THOMPSON & A. G. BARBOUR. 1993. In vitro inhibition of Borrelia burgdorferi growth by antibodies. J. Infect. Dis. 167: 165-172.
19. BARBOUR, A. G., W. BURGDORFER, E. GRUNWALDT & A. C. STEERE. 1983. Antibodies of patients with Lyme disease to components of the Ixodes dammini spirochete. J. Clin. Invest. 72: 504-515.
20. BARBOUR, A. G., S. L. TESSIER & W. J. TODD. 1983. Lyme disease spirochetes and Ixodes tick spirochetes share a common surface antigen determinant defined by a monoclonal antibody. Infect. Immun. 41: 795-804.
21. SADZIENE, A., P. A. ROSA, P. A. THOMPSON, D. M. HOGAN & A. G. BARBOUR. 1992. Antibody-resistant mutants of Borrelia burgdorferi: In vitro selection and characterization. J. Exp. Med. 176: 799-809.
22. SIMPSON, W. J., M. E. SCHRUMPF & T. G. SCHWAN. 1990. Reactivity of human Lyme borreliosis sera with 39-kilodalton antigen specific to Borrelia burgdorferi. J. Clin. Microbiol. 28: 1329-1337.
23. KINDER, S. A. & S. C. HOLT. 1989. Characterization of coaggregation between Bacteroides gingivalis T22 and Fusobacterium nucleatum T18. Infect. Immun. 57: 3425-3433.
24. SADZIENE, A., M. JONSSON, S. BERGSTRÖM, R. K. BRIGHT, R. C. KENNEDY & A. G. BARBOUR. 1994. A bactericidal antibody is directed against a variable region of the OspB protein. Infect. Immun. 62: 2037-2045.
25. SADZIENE, A., A. G. BARBOUR, P. A. ROSA & D. D. THOMAS. 1993. An OspB mutant of Borrelia burgdorferi has reduced invasiveness in vitro and reduced infectivity in vivo. Infect. Immun. 61: 3590-3596.
26. SADZIENE, A., D. D. THOMAS & A. G. BARBOUR. 1995. Borrelia burgdorferi mutant lacking Osp: Biological and immunological characterization. Infect. Immun. 63: 1573-1580.
27. BARBOUR, A. G., L. W. MAVER & B. G. SPRATT. 1981. Mecillinam resistance in Escherichia coli: Dissociation of growth inhibition and morphologic change. J. Infect. Dis. 143: 114-121.
28. BARTHOLD, S. W. & L. K. BOCKENSTEDT. 1993. Passive immunizing activity of sera from mice infected with Borrelia burgdorferi. Infect. Immun. 61: 4696-4702.
29. FIKRIG, E., L. K. BOCKENSTEDT, S. W. BARTHOLD, M. CHEN, H. TAO, P. ALI-SALAAM, S. R. TELFORD & R. A. FLAVELL. 1994. Sera from patients with chronic Lyme disease protect mice from Lyme borreliosis. J. Infect. Dis. 169: 568-574.
30. BARBOUR, A. G. & S. F. HAYES. 1986. Biology of Borrelia species. Microbiol. Rev. 50: 381-400.