Immunohistochemical demonstration of the gap junctional protein connexin 32 and proliferating cell nuclear antigen in glutathione S-transferase placental form-negative lesions of rat liver induced by diethylnitrosamine and clofibrate

Toxicologic Pathology

Volumn 24, Issue 6, 1996, Pages 690-695

  Ito, Seiichi ^a,b   Tateno, Chise ^a,c   Tuda, Mina ^a   Yoshitake, Akira ^a  

^a SUMITOMO CHEMICAL CO LTD   (Japan)

^b Nippon Exp Med Res Inst Co L   (Japan)

^c JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

Author keywords

Cell proliferation; Gap junction; Hepatocarcinogenesis; Peroxisome proliferator

Indexed keywords

CELL NUCLEUS ANTIGEN; CLOFIBRATE; DIETHYLNITROSAMINE; GAP JUNCTION PROTEIN; GLUTATHIONE TRANSFERASE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL PROLIFERATION; CHEMICAL CARCINOGENESIS; LIVER CANCER; LIVER CARCINOGENESIS; MALE; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALS; CARCINOGENS; CLOFIBRATE; CONNEXINS; DIETHYLNITROSAMINE; DRUG SYNERGISM; GLUTATHIONE TRANSFERASE; IMMUNOHISTOCHEMISTRY; LIVER; LIVER NEOPLASMS; MALE; PROLIFERATING CELL NUCLEAR ANTIGEN; RATS; RATS, INBRED F344;

EID: 0030451490     PISSN: 01926233     EISSN: None     Source Type: Journal    
DOI: 10.1177/019262339602400603     Document Type: Article

References (20)

1. Ashby J, Brady A, Elcombe CR, Elliott BM, Ishael J, Tugwood JD, Kettle S, and Purchase IFH (1994). V. The role of cell proliferation in peroxisome proliferates mediated-hepatocarcinogenesis. In. Mechanistically-Based Human Hazard Assessment of Peroxisome Proliferator-Induced Hepatocarcinogenesis. Human Exp. Toxicol. 13(suppl. 2): S36-S40.
2. Cattley RC, Marsman D, Conolly RB, and Popp JA (1992). Cell proliferation and promotion in peroxisome proliferator-induced rodent hepatocarcinogenesis. CIIT Activities 12: 1-5.
3. Cattley RC, Marsman D, and Popp JA (1991). Age-related susceptibility to the carcinogenic effect of the peroxisome proliferator WY-14,643. Carcinogenesis 12: 469-473.
4. Hosokawa S, Tatematsu M, Aoki T, Nakanowatari J, Igarashi T, and Ito N (1989). Modulation of diethylnitrosamine-initiated placental gultathione S-transferase positive preneoplastic and neoplastic lesions by clofibrate, a hepatic peroxisome proliferator. Carcinogenesis 10: 2237-2241.
5. Ito N, Tatematsu M, Hasegawa R, and Tsuda H (1989). Medium-term bioassay system for detection of carcinogens and modifiers of hepatocarcinogenesis utilizing the GST-P positive liver cell focus as an endpoint marker. Toxicol. Pathol. 17: 630-641.
6. Ito S, Watanabe T, Yoshioka K, Tateno C, Okuno Y, Yanaihara N, and Yositake A (1993). Immunohistochemical demonstration of c-myc oncogene product and GST-P in rat hepatic preneoplastic lesions induced by diethylnitrosamine and clofibrate. Biomed Res. 14: 345-351.
7. Krutovskikh VA, Oyamada M, and Yamasaki H (1991). Sequential changes of gap-junctional intercellular communications during multistage rat liver carcinogenesis: Direct measurement of communication in vivo. Carcinogenesis 12: 1701-1706.
8. Mensnil M, Fitzgerald DJ, and Yamasaki H (1988). Phenobarbital specifically reduces gap junction protein mRNA level in rat liver. Mol. Carcinog. 1: 79-81
9. Milks LC, Kumar NM, Haughten R, Unwin N, and Gilula NB (1988). Topology of the 32 kd gap junction protein determined by site-directed antibody localizations. EMBO J. 7: 2967-2975.
10. Neveu MJ, Hully JR, Paul DL, and Pitot HC (1990). Reversible alteration in the expression of the gap junctional protein connexin 32 during tumor promotion in rat liver and its role during cell proliferation. Cancer Commun. 2: 21-31.
11. Ogiso T, Tatematsu M, Tamano S, Hasegawa R, and Ito N (1990). Correlation between medium-term liver bioassay system data and results of long-term testing in rats. Carcinogenesis 11: 561-566.
12. Rao MS, Tatematsu M, Subbarao V, Ito N, and Reddy K (1986). Analysis of peroxisome proliferator-induced preneoplastic and neoplastic lesions of rat liver for placental form of glutathione S-transferase and γ-glutamyltranspeptidase. Cancer Res. 46: 5287-5290.
13. Reddy JK and Lalwai ND (1983). Carcinogenesis by hepatic peroxisome proliferators: Evaluation of the risk of hypolipidemic drugs and industrial plasticizers to humans. CRC Crit. Rev. Toxicol. 12: 1-58.
14. Reddy JK and Qureshi SA (1973). Tumorigenicity of the hypolipidaemic peroxisome proliferator ethyl-α-p-chloro-phenoxyisobutyrate (clofibrate) in rats. Br. J. Cancer 40: 476-482.
15. Satoh K, Kitahara A, Soma Y, Hatayama I, and Sato K. (1985). Purification, induction and distribution of placental glutathione transferase: A new marker enzyme for preneoplastic cells in the rat chemical hepatocarcinogenesis. Proc. Natl. Acad. Sci. USA 82: 3964-3968.
16. Stott WT (1988). Chemically induced proliferation of peroxisomes: Implications for risk assessment. Reg. Toxicol. Pharmacol. 8: 125-159.
17. Sugie S, Mori H, and Takahashi M (1987). Effect of in vivo exposure to the liver tumor promoters phenobarbital or DDT on gap junctions of rat hepatocytes: A quantitative freeze-fracture analysis. Carcinogenesis 8: 45-51.
18. Tanaka K, Smith PF, Stromberg PC, Eydelloth RS, Herold EG, Grassman SJ, Frank JD, Hertzog PR, Soper KA, and Keenan KP (1992). Studies of early hepatocellular proliferation and peroxisomal proliferation in Sprague-Dawley rats treated with rumorigenic doses of clofibrate. Toxicol. Appl. Pharmacol. 116: 71-77.
19. Yamasaki H (1990). Gap junctional intercellular communication and carcinogenesis. Carcinogenesis 11: 1051-1058.
20. Zeilmarker MJ and Yamasaki H (1986). Inhibition of junctional intercellular communication as a possible short-term test to detect tumor-promoting agents: Results with nine chemicals tested by dye transfer assay in Chinese hamster V79 cells. Cancer Res. 46: 6180-6186.