Aberrant crypt foci in the colonic mucosa of rats treated with a genotoxic and nongenotoxic colon carcinogen

Toxicologic Pathology

Volumn 24, Issue 6, 1996, Pages 681-689

  Whiteley, Laurence O ^a   Hudson Jr , Leon ^b   Pretlow, Theresa P ^b  

^a PROCTER AND GAMBLE COMPANY   (United States)

^b CASE WESTERN RESERVE UNIVERSITY   (United States)

Author keywords

azoxymethane; Colon; dextran sulfate; morphology; pathology

Indexed keywords

AZOXYMETHANE;

ANIMAL TISSUE; ARTICLE; CHEMICAL CARCINOGENESIS; COLON CANCER; COLON CARCINOGENESIS; COLON MUCOSA; CRYPT CELL; GENOTOXICITY; MALE; NONHUMAN; PRIORITY JOURNAL; RAT;

EID: 0030451166     PISSN: 01926233     EISSN: None     Source Type: Journal    
DOI: 10.1177/019262339602400602     Document Type: Article

References (22)

1. Bird RP (1987). Observation and quantification of aberrant crypts in the murine colon treated with a colon carcinogen: Preliminary findings. Cancer Lett. 37: 147-151.
2. Bird RP (1995). Role of aberrant crypt foci in understanding the pathogenesis of colon cancer. Cancer Lett. 93: 55-71.
3. Deschner EE (1974). Experimentally induced cancer of the colon. Cancer 34: 824-828.
4. Magnuson BA and Bird RP (1993). Reduction of aberrant crypt foci induced in rat colon with azoxymethane or methylnitrosourea by feeding chohc acid. Cancer Lett. 68: 15-23.
5. Magnuson BA, Carr I, and Bird RP (1993). Ability of aberrant crypt foci characteristics to predict colonic tumor incidence in rats fed cholic acid. Cancer Res. 53: 4499-4504.
6. McLellan EA, Medline A, and Bird RP (1991). Sequential analyses of the growth and morphological characteristics of aberrant crypt foci: Putative preneoplastic lesions. Cancer Res. 51: 5270-5274.
7. Nauss KM, Locniskar ML, Pavlina T, and Newberne PM (1984). Morphology and distribution of 1,2-dimethylhydrazine dihydrochloride-induced colon tumors and their rcaltionship to gut-associated lymphoid tissue in rats. J. Natl. Cancer Inst. 73: 915-924.
8. Okayasu I, Hatakeyama S, Yamada M, Ohkusa T, Inagaki Y, and Nakaya R (1990). A novel method in the induction of reliable experimental acute and chronic ulcerative colitis in mice. Gastroenterology 98: 694-702.
9. Pozharisski KM (1975). Morphology and morphogenesis of experimental epithelial tumors of the intestine. J. Natl. Cancer Inst. 54: 1115-1135.
10. Pretlow TP (1994). Alteations associated with early neoplasia in the colon. In: Biochemical & Molecular Aspects of Selected Cancers, TG Pretlow and TP Pretlow (eds). Academic Press, San Diego, pp. 93-141.
11. Pretlow TP, O'Riordan MA, Kolman MF, and Jurcisek JA (1990). Colonic aberrant crypts in azoxymethane-treated F344 rats have decreased hexosaminidase activity. Am. J. Pathol. 136: 13-16.
12. Pretlow TP, O'Riordan MA, Pretlow TG, and Stellato TA (1992). Aberrant crypts in human colonic mucosa: Putative preneoplastic lesions. J. Cell Biochem. Suppl. 16G: 55-62.
13. Pretlow TP, O'Roirdan A, Somich GA, Amini SB, and Pretlow TG (1992) Aberrant crypts correlate with tumor incidence in F344 rats treated with azoxymethane and phytate. Carcinogenesis 13. 1509-1512.
14. Pretlow TP, O'Riordan MA, Spancake KM, and Pretlow TG (1993). Two types of putative preneoplastic lesions identified by hexosaminidase activity in whole-mounts of colons from F344 rats treated with carcinogen. Am. J. Pathol. 142: 1695-1700.
15. Riddell RH, Goldman H, Ransohoff DF, Appelman HD, Fenoglio CM, Haggitt RC, Ahren C, Correa P, and Hamilton SR (1983). Dysplasia in inflammatory bowel disease: Standardized classification with provisional clinical applications. Human Pathol 14: 931-966.
16. Shamsuddin AKM and Trump BF (1981). Colon epithelium. II. In vivo studies of colon carcinogenesis. Light microscopic, histochemical, and ultrastructural studies of histogenesis of azoxymethane-induced colon carcinomas in Fisher 344 rats. J. Natl. Cancer Inst. 66: 389-401.
17. Snedecor GW and WG Cochran (1989). Statistical Methods. University Press, Ames, Iowa.
18. Sutherland LA and Bird RP (1994). The effect of chenodeoxycholic acid on the development of aberrant crypt foci in the rat colon. Cancer Lett. 76: 101-107.
19. US Department of Health and Human Services (1985). Guide for the Care and Use of Laboratory Animals. Animal Resorces Program. Division of Research Resources, National Institutes of Health, Bethesda, Maryland.
20. Ward JM (1974). Morphogenesis of chemically induced neoplasms of the colon and small intestine. Lab. Invest. 30: 505-513.
21. Whiteley LO, Anver MR, Botts S, and Jokinen MP (1996). Proliferative lesions of the intestine, salivary glands, oral cavity and esophagus in rats. In: Guides for Toxicologic Pathology. STP/ARP/ AFIP, Washington. D.C
22. Yamashita N, Minamoto T, Onda M, and Esumi H (1994). Increased cell proliferation of azoxymethane-induced aberrant crypt foci of rat colon. Jpn. J. Cancer Res. 85: 692-698.