Characterization of in vitro relaxant mechanisms in erectile tissue from rabbits of different ages

Urological Research

Volumn 24, Issue 6, 1996, Pages 317-322

  Ragazzi, E ^a   Chinellato, A ^a   Italiano, G ^b   Pagano, F ^a   Calabro A ^a  

^a UNIVERSITY OF PADOVA   (Italy)

^b Fidia Advanced Biopolymers   (Italy)

Author keywords

acetylcholine; ageing; erectile tissue; nifedipine; purines; sodium nitrate

Indexed keywords

ACETYLCHOLINE; ADENOSINE; ADENOSINE TRIPHOSPHATE; N(G) NITROARGININE METHYL ESTER; NIFEDIPINE; NORADRENALIN; SODIUM NITRITE; SURAMIN;

AGING; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; IN VITRO STUDY; MALE; NONHUMAN; PENIS ERECTION; PRIORITY JOURNAL; RABBIT; SMOOTH MUSCLE CONTRACTION; SMOOTH MUSCLE RELAXATION;

ACETYLCHOLINE; AGING; ANIMALS; CALCIUM CHANNEL BLOCKERS; MALE; MUSCLE CONTRACTION; NIFEDIPINE; NOREPINEPHRINE; PENILE ERECTION; PENIS; PURINES; RABBITS; SODIUM NITRITE;

EID: 0030450250     PISSN: 03005623     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF00389786     Document Type: Article

References (44)

1. Aboseif SR, Lue TF (1988) Hemodynamics of penile erection. Urol Clin North Am 15:1
2. Adaikan PG, Kottegoda SR, Ratnam SS (1986) Is vasoactive intestinal polypeptide the principal transmitter involved in human penile erection? J Urol 135:638
3. Anderson KE, Holmquist F (1990) Mechanisms for contraction and relaxation of human penile smooth muscle. Int J Impotence Res 2:209
4. Anderson KE, Wagner G (1995) Physiology of penile erection. Physiol Rev 75:191
5. Banya Y, Aoki H, Takagane H, Fujioka T, Kubo T, Ohhori T, Monma N, Satodate R (1988) Age-related changes of smooth muscle and collagen fibers in human corpus cavernosum penis: a histo-quantitative study by an image analyzer Proc Third Biennial World Meeting on Impotence, Boston, p 10
6. Bondil P, Costa P, Daures JP, Louis JF, Navratil H (1992) Clinical study of the longitudinal deformation of the flaccid penis and of its variations with aging Eur Urol 21:284
7. Burnstock G (1987) Local control of blood pressure by purines Blood Vessels 24:156
8. Burnstock G, Kennedy C (1985) Is there a basis for distinguishing two types of P2-purinoceptor? Gen Pharmacol 16:433
9. Bush PA, Aronson WJ, Rajfer J, Buga GM, Ignarro LJ (1992) Comparison of nonadrenergic, noncholinergic- and nitric-oxide mediated relaxation of corpus cavornosum. Int J Impotence Res 4:85
10. Calabr̀ A, Italiano G, Pescatori ES, Marin A, Oliva G, Abatangelo G, Pagano F (1996) Physiological aging and penile erectile funtion: a study in the rat. Eur Urol 29:240
11. Chiang PH, Wu SN, Tsai EM, Wu CC, Shen MR, Huang CH, Chiang CP (1994) Adenosine modulation of neurotransmission in penile erection. Br J Clin Pharmacol 38:357
12. Chinellato A, Ragazzi E (1995) Receptor-mediated pathways of endothelium activity in experimental atherosclerosis. Pharmacol Res 31:163
13. Chinellato A, Pandolfo L, Ragazzi E, Zambonin MR, Froldi G, De Biasi M, Caparrotta L, Fassina G (1991) Effect of age on rabbit aortic responses to relaxant endothelium-dependent agents. Blood Vessels 28:358
14. Chinellato A, Banchieri N, Pandolfo L, Ragazzi E, Froldi G, Norido F, Caparrotta L, Fassina G (1991) Aortic response to relaxing agents in Watanabe heritable hyperlipidemic (WHHL) rabbits of different age Atherosclerosis 89:223.
15. Chinellato A, Ragazzi E, Pandolfo L, Froldi G, Caparrotta L, Fassina G (1994) Purine- and nucleotide-mediated relaxation of rabbit thoracic aorta: common and different sites of action. J Pharm Pharmacol 46:337
16. 2 receptor and an intracellular site. Eur J Pharmacol 96:61
17. Conti G, Virag R (1989) Human penile erection and organic impotence: normal histology and histopathology. Urol Int 44:303
18. De Mey JG, Vanhoutte PM (1981) Role of the intima in cholinergic and purinergic relaxation of isolated canine femoral arteries. J Physiol (London) 316:347
19. Fuchs AM, Mehringer CM, Rajfer J (1989) Anatomy of penile venous drainage in potent and impotent men during cavernosography. J Urol 141:1353
20. Gerlach E, Nees S, Becker BF (1985) The vascular endothelium: a survey of some newly evolving biochemical and physiological features. Basic Res Cardiol 80:459
21. Hedlund H, Andersson KE (1985) Contraction and relaxation induced by some prostanoids in isolated human penile erectile tissue and cavernous artery. J Urol 134:1245
22. Hynes MR, Duckies SP (1987) Effect of increasing age on the endothehum-mediated relaxation of rat blood vessels in vitro. J Pharmacol Exp Ther 241:387
23. Ignarro L (1992) Nitric oxide as the physiological mediator of penile erection. J N I H Res 4:59
24. Ishii N, Watanabe H, Irisawa M (1989) Intracavernous injection of prostaglandin E1 for the treatment of erectile impotence. J Urol 141:323
25. Kelm M, Schrader J (1990) Control of coronary vascular tone by nitric oxide. Circulation Res 66:1561
26. Kim YC, Kim JH, Davies MG, Hagen PO, Carson CC (1995) Modulation of vasoactive intestinal polypeptide (VIP)-mediated relaxation by nitric oxide and prostanoids in the rabbit corpus cavernosum. J Urol 153:807
27. Knispel HH, Goessl C, Beckmann R (1992) Nitric oxide mediates relaxation in rabbit and human corpus cavernosum smooth muscle Urol Res 20:253
28. Lue TF, Tanagho EA (1987) Physiology of erection and pharmacological management of impotence. J Urol 137:829
29. Miller MAW, Morgan RJ, Thompson CS, Mikhailidis DP, Jeremy JY (1994) Adenylate and guanylate cyclase activity in the penis and aorta of the diabetic rat: an in vitro study. Br J Urol 74 106
30. Ragazzi E, Chinellato A, Pandolfo L, Froldi G, Caparrotta L, Fassina G (1994) Effect of calcium antagonists on isolated aorta from hypercholesterolemic Yoshida rats of different ages. Gen Pharmacol 25:1321
31. Rajfer J, Aronson WJ, Bush PA, Dorey FJ, Ignarro LJ (1992) Nitric oxide as a mediator of relaxation of the corpus cavernosum in reponse to nonadrcnergic, noncholinergic neurotransmission. N Engl J Med 326:90
32. 2-purinoceptor subtype in the isolated perfused mesenteric bed of the rat Br J Pharmacol 95:637
33. 2 purinoceptors are involved in endothelium-dependent relaxation of the rat thoracic aorta. Br J Pharmacol 100:576
34. Saenz de Tejada I, Goldstein I, Blanco R, Cohen RA, Krane RJ (1985) Smooth muscle of the corpora cavernosae: role in penile erection. Surg Forum 36:623
35. Saenz de Tejada I, Goldstein I, Krane R (1988) Local control of penile erection. Urol Clin N Am 15:9
36. Saenz de Tejada I, Goldstein I, Azadzoi K, Krane RJ, Cohen RA (1989) Impaired neurogenic and endothelium-dependent relaxation of human penile smooth muscle from diabetic men with impotence. N Engl J Med 320:1025
37. Saenz de Tejada I, Moroukian P, Tessier J, Kim JJ, Goldstein I, Frohrib D (1991) Trabecular smooth muscle modulates the capacitor function of the penis. Studies on a rabbit model. Am J Physiol 260:H1590
38. 1 - Four years experience on intracavernous injection. Int J Impotence Res 2(Suppl): 255
39. Stief C, Benard F, Bosch R, Aboseif S, Nunes L, Lue RF, Tanagho E A (1989) Acetylcholine as a possible neuro transmitter in penile erection. J Urol 141:1444
40. Taub HC, Lerner SE, Melman A, Christ GJ (1993) Relationship between contraction and relaxation in human and rabbit corpus cavernosum. Urology 42:698
41. Tong Y-C, Broderick G, Hypolite J, Levin RM (1992) Relaxant effect of adenosine 5′-triphosphate on rabbit corpus cavernosal tissue. Int J Impotence Res 4(Suppl 1):111
42. Vom Saal FS, Finch CE (1988) Reproductive senescence: phenomena and mechanisms in mammals and selected vertebrates. In: Knobil E, Neill JD (eds) The physiology of reproduction. Raven Press. New York, pp 2351-2413
43. Wespes E, Moretra De Goes P, Schulman C (1992) Age-reduction of smooth muscle fibers in potent men. Int J Impotence Res 4(Suppl 2): P32
44. White TD, Angus JA (1987) Relaxant effects of ATP and adenosine on canine large and small coronary arteries in vitro. Eur J Pharmacol 143:119