Treatment of vancomycin-resistant Enterococcus faecium infections with an investigational streptogramin antibiotic (quinupristin/dalfopristin): A report of fifteen cases

Microbial Drug Resistance

Volumn 2, Issue 4, 1996, Pages 407-413

  Dever, Lisa L ^a,b   Smith, Sharon M ^a,b   Dejesus, Dino ^b   Masurekar, Malthi ^b   Patel, Deepa ^a   Kaminski, Zigmund C ^b   Johanson Jr , W G ^b  

^a VETERANS AFFAIRS MEDICAL CENTER   (United States)

^b RUTGERS NEW JERSEY MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DALFOPRISTIN; DALFOPRISTIN PLUS QUINUPRISTIN; QUINUPRISTIN; STREPTOGRAMIN; VANCOMYCIN;

ADULT; AGED; ANTIBIOTIC RESISTANCE; ANTIBIOTIC THERAPY; ARTICLE; BACTERICIDAL ACTIVITY; CLINICAL ARTICLE; CLINICAL TRIAL; ENTEROCOCCUS FAECALIS; FEMALE; HUMAN; INTRAVENOUS DRUG ADMINISTRATION; MALE; MINIMUM INHIBITORY CONCENTRATION; MULTICENTER STUDY; PHLEBITIS; PRIORITY JOURNAL; RELAPSE; SERUM BACTERICIDAL ACTIVITY; STREPTOCOCCUS INFECTION;

EID: 0030450104     PISSN: 10766294     EISSN: None     Source Type: Journal    
DOI: 10.1089/mdr.1996.2.407     Document Type: Article

References (14)

1. Boyle, J.F., S.A. Soumakis, A. Rendo, J.A. Herrington, D.G. Gianarkis, B.E. Thurberg, and B.G. Painter. 1993. Epidemiologic analysis and genotypic characterization of a nosocomial outbreak of vancomycin-resistant enterococci. J. Clin. Microbiol. 31:1280-1285.
2. Caron, F., J.F. Lemeland, G. Humbert, I. Klare, and L. Gutmann. 1993. Triple combination penicillin-vancomycin-gentamicin for experimental endocarditis caused by a highly penicillin-and glycopeptide-resistant isolate of Enterococcus faecium. J. Infect. Dis. 168:681-686.
3. Caron, F., M. Pestel, M.D. Kitzis, J.F. Lemeland, G. Humbert, and L. Hutman. 1995. Comparison of different β-lactam-glycopeptide-gentamicin combinations for an experimental endocarditis caused by a highly β-lactam-resistant and highly glycopeptide-resistant isolate of Enterococcus faecium. J. Infect. Dis. 171:106-112.
4. Chant, C., and M.J. Rybak. 1995. Quinupristin/dalfopristin (RP 59500): A new streptogramin antibiotic. Ann. Pharmacother. 29:1022-1027.
5. Collins, L.A., G.J. Malanoski, G.M. Eliopoulos, C.B. Wennersten, M.J. Ferraro, and R.C. Moellering. 1993. In vitro activity of RP59500, an injectable streptogramin antibiotic, against vancomycin-resistant gram-positive organisms. Antimicrob. Agents Chemother. 37:598-601.
6. Donabedian, S., J.W. Chow, D.M. Shlaes, M. Green, and M.J. Zervos. 1995. DNA hybridization and contour-clamped homogeneous electric field electrophoresis for identification of enterococci to the species level. J. Clin. Microbiol. 33:141-145.
7. Edmond, M.B., J.F. Ober, D.L. Weinbaum, M.A. Pfaller, T. Hwang, M.D. Sanford, and R.P. Wenzel. 1995. Vancomycin-resistant Enterococcus faecium bacteremia: Risk factors for infection. Clin. Infect. Dis. 20:1126-1133.
8. Facklam, R.R., and M.D. Collins. 1989. Identification of Enterococcus species isolated from human infections by a conventional test scheme. J. Clin. Microbiol. 27:731-734.
9. Fass, R.J. 1991. In vitro activity of RP 59500, a semisynthetic injectable pristinamycin, against staphylococci, streptococci, and enterococci. Antimicrob. Agents Chemother. 35:553-559.
10. Furlong, W.B., and F. Bompart. 1994. Therapy for enterococci with Van A/Van B resistance patterns using RP 599500 (quinupristin/dalfopristin), abstr. M66. In Program and abstracts of the 34th Interscience Conference on Antimicrobial Agents and Chemotherapy. October 3-8, Orlando, FL.
11. Gaillard, C., J. Cantfort, G. Montay, D. Piffard, A. LeLiboux, S. Etienne, A. Scheen, and A. Frydman. 1992. Disposition of the radiolabelled streptogramin RP 59500 in healthy male volunteers, abstr. 1317. In Program and abstracts of the 32nd Interscience Conference on Antimicrobial Agents and Chemotherapy. October 11-14, Anaheim, CA.
12. Handwerger, S., B. Raucher, D. Altarac, J. Monka, S. Marchione, K.V. Singh, B.E. Murray, J. Wolff, and B. Walters. 1993. Nosocomial outbreak due to Enterococcus faecium highly resistant to vancomycin, penicillin, and gentamicin. Clin. Infect. Dis. 16:750-755.
13. Hayden, M.K., G.M. Trenholme, J.E. Schultz, and D.F. Sahm. 1993. In vivo development of teicoplanin resistance in a VanB Enterococcus faecium isolate. J. Infect. Dis. 167:1224-1227.
14. Johnson, C.C., L. Slavoski, M. Schwartz, P. May, P.G. Pitsakis, A.L. Shur, and M.E. Levison. 1995. In vitro activity of RP 59500 (quinupristin/dalfopristin) against antibiotic-resistant strains of Streptococcus pneumoniae and enterococci. Diagn. Microbiol. Infect. Dis. 21:169-173.