Endothelin-1: A scientist's curiosity, or a real player in ischemic heart disease?

American Heart Journal

Volumn 132, Issue 6, 1996, Pages 1236-1243

  Cesari, Maurizio ^a   Pavan, Edoardo ^a   Sacchetto, Alfredo ^a   Rossi, Gian Paolo ^a,b  

^a UNIVERSITY OF PADUA MEDICAL SCHOOL   (Italy)

^b UNIVERSITY HOSPITAL OF PADOVA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ALDOSTERONE; ARGIPRESSIN; ENDOTHELIN 1; ENDOTHELIN A RECEPTOR; ENDOTHELIN B RECEPTOR; ENDOTHELIUM DERIVED RELAXING FACTOR; NITRIC OXIDE; PROSTACYCLIN; RECEPTOR SUBTYPE;

ANGINA PECTORIS; ANIMAL TISSUE; CHROMOSOME 1P; CORONARY ARTERY; CORONARY ARTERY ATHEROSCLEROSIS; CORONARY ARTERY THROMBOSIS; DOG; HEART INFARCTION; HEART MUSCLE NECROSIS; HEART VENTRICLE FIBRILLATION; HEMODYNAMICS; HUMAN; HUMAN TISSUE; ISCHEMIC HEART DISEASE; NONHUMAN; PRIORITY JOURNAL; RESTENOSIS; REVIEW; THROMBOCYTE AGGREGATION; TRANSLUMINAL CORONARY ANGIOPLASTY; VASCULAR ENDOTHELIUM; VASOCONSTRICTION; VASOSPASM;

EID: 0030448622     PISSN: 00028703     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0002-8703(96)90468-8     Document Type: Article

References (76)

1. Yanagisawa M, Kurihara H, Kimura S, Tomobe Y, Kobayashi M, Mitsui Y, et al. A novel potent vasoconstrictor peptide produced by vascular endothelial cells. Nature 1988;332:411-5.
2. Xu D, Emoto N, Giaid A, Slaughter C, Kaw S, deWit D, et al. ECE-1: a membrane-bound metalloprotease that catalyzes the proteolytic activation of big endothelin-1. Cell 1994;78:473-85.
3. Rossi GP, Albertin G, Franchin E, Sacchetto A, Cesari M, Palù G, et al. Expression of the endothelin-converting enzyme gene in human tissues. Biochem Biophys Res Comm 1995;211:249-53.
4. Valdenaire O, Rohrbacher E, Mattel MG. Organization of the gene encoding the human endothelin converting enzyme (ECE-1). J Biol Chem 1995;270:29794-8.
5. Albertin G, Rossi GP, Majone F, Tiso N, Mattara A, Danieli GA, et al. Fine mapping of the human ECE gene by fluorescent in situ hybridization and radiation hybrids. Biochem Biophys Res Commun 1996;221:682-7.
6. Rossi GP, Albertin G, Belloni A, Zanin L, Biasolo MA, Prayer Galetti T, et al. Gene expression, localization, and characterization of endothelin A and B receptors in the human adrenal cortex. J Clin Invest 1994;94:1226-34.
7. Belloni AS, Rossi GP, Zanin L, Pessina AC, Nussdorfer GG. In vitro autoradiographic demonstration of endothelin-1 binding sites in the human adrenal cortex. Biomed Res 1994;15:95-9.
8. Levin ER. Endothelins. N Engl J Med 1995;333:356-63.
9. Hosoda K, Nakao K, Hiroshi Arai, Suga S, Ogawa Y, Mukoyama M, et al. Cloning and expression of human endothelin-1 receptor cDNA. FEBS Lett 1991;287:23-6.
10. Arai H, Hori S, Aramori I, Ohkubo H, Nakanishi S. Cloning and expression of a cDNA encoding an endothelin receptor. Nature 1990;348:730-2.
11. Ogawa M, Nakao K, Arai H, Nagakawa O, Hosoda K, Suga S, et al. Molecular cloning of a non-isopeptide selective human endothelin receptor. Biochem Biophys Res Commun 1991;178:248-55.
12. Lin HY, Kaji EH, Winkel GK, Ives HE, Lodish HF, Cloning and functional expression of a vascular smooth muscle endothelin 1 receptor. Proc Natl Acad Sci USA 1991;88:3185-9.
13. Clozel JP, Clozel M. Effects of endothelin on the coronary vascular bed in open-chest dogs. Circ Res 1989;65:1193-200.
14. Baydoun AR, Peers SH, Cirino G, Woodward B. Effects of endothelin-1 on the rat isolated heart. J Cardiovasc Pharmacol 1989;13(Suppl 5):S193-6.
15. Mehta JL, Lawson DL, Yang BC, Mehta P, Nichols WW. Modulation of vascular tone by endothelin-1: role of preload, endothelial integrity and concentration of endothelin-1. Br J Pharmacol 1992;106:127-32.
16. Clozel M, Gray GA, Breu V, Loffler BM, Osterwalder R. The endothelin ETB receptor mediates both vasodilation and vasoconstriction in vivo. Biochem Biophys Res Commun 1992;186:867-73.
17. Ezra D, Goldstein RE, Czaja JF, Feuerstein GZ. Lethal ischemia due to intracoronary endothelin in pigs. Am J Physiol 1989;257:H339-43.
18. Chester AH, Dashwood MR, Clarke JG, Larkin SW, Davies GJ, Tadjkarimi S, et al. Influence of endothelin on human coronary arteries and localization of its binding sites. Am J Cardiol 1989;63:1395-8.
19. Cocks TM, Broughton A, Dib M, Sudhir K, Angus JA. Endothelin is blood vessel selective: studies on a variety of human and dog vessels in vitro and on regional blood flow in the conscious rabbit. Clin Exp Pharmacol Physiol 1989;16:243-6.
20. Grover GJ, Sleph PG, Fox M, Trippodo NC. Role of endothelin-1 and big endothelin-1 in modulating coronary vascular tone, contractile function and severity of ischemia in rat hearts. J Pharmacol Exp Ther 1992;263:1074-82.
21. Hirata K, Matsuda Y, Akita H, Yokoyama M, Fukuzaki H. Myocardial ischaemia induced by endothelin in the intact rabbit: angiographic analysis. Cardiovasc Res 1990;24:879-83.
22. Donckier J, Hanet C, Stoleru L, Van Mechelen H, Galanti L, Hayashida W, et al. Effects of endothelin-1 at pathophysiologic concentrations on coronary perfusion and mechanical function of normal and postischemic myocardium. J Cardiovasc Pharmacol 1994;23:212-9.
23. Neild GH. Endothelin plasma levels in hypertensive patients with vascular disease. J Hypertens Suppl 1994;12:S17-20.
24. Eglen RM, Michel AD, Sharif NA, Swank SR, Whiting RL. The pharmacological properties of the peptide, endothelin. Er J Pharmacol 1989;97:1297-307.
25. Kurihara H, Yamaoki K, Nagai R, Yoshizumi M, Takaku F, Satoh H, et al. Endothelin: a potent vasoconstrictor associated with coronary vasospasm. Life Sci 1989;44:1937-43.
26. Smith TPJ, Zhang L, Gugino SF, Russel JA, Canty JMJ. Differential effect of endothelin on coronary conduit and resistance arteries [abstract]. Circulation 1995;92(suppl 8):I-320.
27. Godfraind T. Evidence for heterogeneity of endothelin receptor distribution in human coronary artery. Br J Pharmacol 1993;110:1201-5.
28. Balwierczak JL. Two subtypes of the endothelin receptor (ETA and ETB) mediate vasoconstriction in the perfused rat heart. J Cardiovasc Pharmacol 1993;22(Suppl 8):S248-51.
29. Teerlink JR, Breu V, Sprecher U, Clozel M, Clozel JP. Potent vasoconstriction mediated by endothelin ETB receptors in canine coronary arteries. Circ Res 1994;74:105-14.
30. Cannan CR, Burnett JCJ, Brandt RR, Lerman A. Endothelin at pathophysiological concentrations mediates coronary vasoconstriction via the endothelin-A receptor. Circulation 1995;92:3312-7.
31. B receptors mediate contraction to endothelin-1 in human blood vessels. Circulation 1994;89:1203-8.
32. Williams DL, Jones KL, Pettibone DJ, Lis EV, Clineschmidt BV. Sarafatoxin S6C: an agonist which distinguishes between endothelin receptor subtypes. Biochem Biophys Res Comm 1991;175:556-61.
33. Bax WA, Bruinvels AT, van Suylen RJ, Saxena PR, Hoyer D. Endothelin receptors in the human coronary artery, ventricle and atrium. A quantitative radiographic analysis. Naunyn Schmiedebergs Arch Pharmacol 1993;348:403-10.
34. Rigel DF, Lappe RW. Differential responsiveness of conduit and resistance coronary arteries to endothelin A and B receptor stimulation in anesthetized dogs. J Cardiovasc Pharmacol 1993;22(suppl. 8):S243-7.
35. 3H] Bosentan binding to human coronary artery: functional correlates. J Cardiovasc Pharmacol 1995;26(Suppl 3):S376-9.
36. Linz W, Albus U, Scholkens BA. Effects of endothelin on isolated ischaemic rat hearts during ramiprilat, bradykinin and indomethacin perfusion. J Hypertens Suppl 1989;7:S310-1.
37. Takeda M, Komeyama T, Katayama Y, Tsutsui T, Mizusawa T, Takahashi H, et al. Dissociation of selective renal venous plasma endothelin-1 activity and corresponding plasma renin activity in a patient with hypertension, severe stenosis of unilateral renal artery and ipsilaterally decreased renal function. Nephron 1994;68:372-4.
38. Salvati P, Chierchia S, Dho L, Ferrario RG, Parenti P, Vicedomini G, Patrono C. Proarrhythmic activity of intracoronary endothelin in dogs: relation to the site of administration and to changes in regional flow. J Cardiovasc Pharmacol 1991;17:1007-14.
39. Wagner OF, Christ G, Wojta J, Vierhapper H, Parzer S, Nowotny PJ, et al. Polar secretion of endothelin-1 by cultured endothelial cells. J Biol Chem 1992;267:16066-8.
40. Salminen K, Tikkanen I, Saijonmaa O, Nieminen M, Fyhrquist F, Frick MH. Modulation of coronary tone in acute myocardial infarction by endothelin [letter]. Lancet 1989;2:747.
41. Miyauchi T, Yanagisawa M, Tomizawa T, Sugishita Y, Suzuki N, Fujino M, et al. Increased plasma concentrations of endothelin-1 and big endothelin-1 in acute myocardial infarction [letter]. Lancet 1989;2:53-4.
42. Arendt RM, Wilbert Lampen U, Heucke L, Schmoeckel M, Suhler K, Richter W. Increased endothelin plasma concentrations in patients with coronary artery disease or hyperlipoproteinemia without coronary events. Res Exp Med (Berl) 1993;193(4):225-30.
43. Wieczorek I, Haynes WG, Webb DJ, Ludlam CA, Fox KA. Raised plasma endothelin in unstable angina and non-Q wave myocardial infarction: relation to cardiovascular outcome. Br Heart J 1994;72:436-41.
44. Dashwood MR, Timm M, Muddle JR, Shah D, Tipping JR, Kaski JC. Endothelin-like immunoreactivity in atherosclerotic human coronary arteries. J Cardiovasc Pharmacol 1993;26(Suppl 3):S376-9.
45. Zeiher AM, Ihling C, Pistorius K, Schächinger V, Schaefer HE. Increased tissue endothelin immunoreactivity in atherosclerotic lesions associated with acute coronary syndromes. Lancet 1994;344:1405-6.
46. Zeiher AM, Goebel H, Schächinger V, Ihling C. Tissue endothelin-1 immunoreactivity in the active coronary atherosclerotic plaque. A clue to the mechanism of increased vasoreactivity of the culprit lesion in unstable angina. Circulation 1995;91:941-7.
47. Toyooka T, Aizawa T, Suzuki N, Hirata Y, Miyauchi T, Shin WS, et al. Increased plasma level of endothelin-1 and coronary spasm induction in patients with vasospastic angina pectoris. Circulation 1991;83:476-83.
48. Yang ZH, Richard V, von Segesser L, Bauer E, Stulz P, Turina M, et al. Threshold concentrations of endothelin-1 potentiate contractions to norepinephrine and serotonin in human arteries. A new mechanism of vasospasm? Circulation 1990;82:188-95.
49. Matsuyama K, Yasue H, Okumura K, Saito Y, Nakao K, Shirakami G, et al. Increased plasma level of endothelin-1-like immunoreactivity during coronary spasm in patients with coronary spastic angina. Am J Cardiol 1991;68:991-5.
50. Velasco C, Giaid A, Williamson J, Yanagisawa M. Myocardial ischemia and local endothelin-1 production. Eur Heart J 1994;15(suppl):118.
51. Watanabe T, Suzuki N, Shimamoto N, Fujino M, Imada A. Endothelin in myocardial infarction [letter]. Nature 1990;344:114.
52. Tonnessen T, Naess PA, Kirkeboen KA, Offstad J, Ilebekk A, Christensen G. Release of endothelin from the porcine heart after short term coronary artery occlusion. Cardiovasc Res 1993;27:1482-5.
53. Liu JJ, Casley DJ, Nayler WG. Ischaemia causes externalization of endothelin-1 binding sites in rat cardiac membranes. Biochem Biophys Res Commun 1989;164:1220-5.
54. Watts JA, Chapat S, Johnson DE, Janis RA. Effects of nisoldipine upon vasoconstrictor responses and binding of endothelin-1 in ischemic and reperfused rat hearts. J Cardiovasc Pharmacol 1992;19:929-36.
55. Neubauer S, Zimmermann S, Hirsch A, Pulzer F, Tian R, Bauer W, et al. Effects of endothelin-1 in the isolated heart in ischemia/reperfusion and hypoxia/reoxygenation injury. J Mol Cell Cardiol 1991;23:1397-1409.
56. Velasco CE, Jackson EK, Morrow JA, Vitola JV, Inagami T, Forman MB. Intravenous adenosine suppresses cardiac release of endothelin after myocardial ischaemia and reperfusion. Cardiovasc Res 1993;27:121-8.
57. Watanabe T, Suzuki N, Shimamoto N, Fujino M, Imada A. Contribution of endogenous endothelin to the extension of myocardial infarct size in rats. Circ Res 1991;69:370-7.
58. Grover GJ, Dzwonczyk S, Parham CS. The endothelin-1 receptor antagonist BQ-123 reduces infarct size in a canine model of coronary occlusion and reperfusion. Cardiovasc Res 1993;27:1613-8.
59. Hagar JM, Geda M. Endogenous endothelin increases myocardial infarct size [abstract]. Circulation 1995;92(suppl 8):I-455.
60. Velasco C, Yanagisawa M, Williamson J, Fernando Triana J. Cardioprotective action of endothelin-1 during ischemia. Circulation 1993;88(2):I-544.
61. Velasco C, Yanagisawa M. Endothelins protect the ischemic myocardium. J Am Coll Cardiol 1994;(suppl):30A.
62. Richard V, Kaeffer N, Hogie M, Tron C, Blanc T, Thuillez C. Role of endogenous endothelin in myocardial and coronary endothelial injury af-ter ischaemia and reperfusion in rats: studies with bosentan, a mixed ETA-ETB antagonist. Br J Pharmacol 1994;113:869-76.
63. Mertz TE, McClanahan TB, Flynn MA, Reynolds EE, Bradford L, Hallak H, et al. Endothelin A receptor antagonism by PD 156707 does not reduce infarct size following coronary artery occlusion/reperfusion in pigs [abstract]. Circulation 1995;92(suppl 8):I-455.
64. McMurdo L, Corder R, Thiemermann C, Vane J. The effects of the endothelin ETA receptor antagonist, FR 139317, on infarct size in a rabbit model of acute myocardial ischemia and reperfusion. Br J Pharmacol 1994;112:75-80.
65. 2+ transient and contractility in ferret myocardium. Circ Res 1992;71(3):631-9.
66. 111indium-labelled platelets. Br J Pharmacol 1990;99:303-8.
67. Ohlstein EH, Storer B, Nambi P, Given M, Lippton H. Endothelin and platelet function. Thromb Res 1990;57:967-74.
68. Edlund A, Wennmalm A. Endothelin does not affect aggregation of human platelets. Clin Physiol 1990;10:585-90.
69. Thiemermann C, Lidbury P, Thomas R, Vane J. Endothelin inhibits ex vivo platelet aggregationin the rabbit. Eur J Pharmacol 1988;158:181-2.
70. Leadley RJJ, Lee P, Erickson LA, Shebuski RJ. The snake venom pep-tide sarafotoxin S6b inhibits repetitive platelet thrombus formation in the stenosed canine coronary artery [abstract]. J Cardiovasc Pharmacol 1993;22(Suppl 8):S199-203.
71. Ameli S, Kaul S, Castro L, Arora C, Mirea A, Shah PK. Effect of percutaneous transluminal coronary angioplasty on circulating endothelin levels. Am J Cardiol 1993;72:1352-6.
72. Montalescot G, Viossat I, Chabrier PE, Sotirov I, Detienne JP, Drobinski G, et al. Endothelin-1 in patients with coronary heart disease undergoing cardiac catheterization. J Am Coll Cardiol 1994;24:1236-41.
73. Malatino LS, Grassi R, Stancanelli B, Polizzi G, Leonardi C, Tamburino C, et al. Release of immunoreactive endothelin from the heart during percutaneous transluminal coronary angioplasty. Am Heart J 1993;126:700-2.
74. Tahara A, Kohno M, Yanagi S, Itagane H, Toda I, Akioka K, et al. Circulating immunoreactive endothelin in patients undergoing percutaneous transluminal coronary angioplasty [abstract]. Metabolism 1991;40:1235-7.
75. Azuma H, Hamasaki H, Niimi Y, Terada T, Matsubara O. Role of endothelin-1 in neointima formation after endothelial removal in rabbit carotid arteries. Am J Physiol 1994;267:H2259-67.
76. Tamirisa P, Frishman WH, Kumar C. Endothelin and endothelin antagonism: roles in cardiovascular health and disease. Am Heart J 1995;130:601-10.