Mitomycin betaines: Synthesis, structure, and solvolytic reactivity

Journal of Organic Chemistry

Volumn 61, Issue 26, 1996, Pages 9202-9206

  Wang, Shuang ^a   Kohn, Harold ^a  

^a University of Houston   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MITOMYCIN C DERIVATIVE;

ARTICLE; DRUG STRUCTURE; DRUG SYNTHESIS; NUCLEAR MAGNETIC RESONANCE; REACTION ANALYSIS; SPECTROPHOTOMETRY;

EID: 0030448145     PISSN: 00223263     EISSN: None     Source Type: Journal    
DOI: 10.1021/jo961378b     Document Type: Article

References (11)

1. Carter, S. K.; Crooke, S. T. Mitomycin C. Current Status and New Developments; Academic Press: New York, 1979.
2. (a) Remers, W. A.; Dorr, R. T. Alkaloids; Chemical and Biological Perspective; Pelletter, S. W., Ed.; Wiley and Sons: New York, 1988; Vol. 6, pp 1-74.
3. (b) Remers, W. A. The Chemistry of Antitumor Antibiotics; Wiley: New York, 1979; Vol. 1, pp 221-276.
4. Bradner, W. T.; Remers, W. A.; Vyas, D. M. Anticancer Res. 1989, 9, 1095-1100.
5. (a) Iyengar, B. S.; Sami, S. M.; Remers, W. A.; Bradner, W. T.; Schurig, J. E. J. Med. Chem. 1983, 26, 16-20.
6. (b) Iyengar, B. S.; Sami, S. M.; Tarnow, S. E.; Remers, W. A.; Bradner, W. T.; Schurig, J. E. J. Med. Chem. 1983, 26, 1453-1457.
7. (c) Sami, S. M.; Iyengar, B. S.; Tarnow, S. E.; Remers, W. A.; Bradner, W. T.; Schurig, J. E. J. Med. Chem. 1984, 27, 701-708.
8. Saito, Y.; Kasai, M.; Shirahata, K.; Kono, M.; Morimoto, M.; Ashizawa, T. (Kyowa Hakko Kogyo Co., Ltd.) U.S. Patent 4,853,385, Aug. 1, 1989; Eur. Pat. Appl. EP 287,855, Oct. 26, 1988; JP Appl. 63246379, March 31, 1987; Chem. Abstr. 1989, 111, 7145v.
9. 5
10. Kohn, H.; Wang, S. Tetrahedron Lett. 1996, 37, 2337-2340.
11. The calculations were done using the program PC MODEL version 5.1 from Secena Software, Bloomington, IN.