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Volumn 61, Issue 26, 1996, Pages 9080-9081

Tandem quinone methide generation for cross-linking DNA

Author keywords

[No Author keywords available]

Indexed keywords

PHENOL DERIVATIVE;

EID: 0030448144     PISSN: 00223263     EISSN: None     Source Type: Journal    
DOI: 10.1021/jo961864z     Document Type: Article
Times cited : (76)

References (28)
  • 1
  • 10
    • 0001425959 scopus 로고
    • see also references cited within
    • Diao, L.; Yang, C.; Wan, P. J. Am. Chem. Soc. 1995, 117, 5369 and see also references cited within.
    • (1995) J. Am. Chem. Soc. , vol.117 , pp. 5369
    • Diao, L.1    Yang, C.2    Wan, P.3
  • 18
    • 12644311803 scopus 로고    scopus 로고
    • note
    • A detailed description of the synthesis, characterization and application of 1-3 is included in the Supporting Information. Product yields were determined by excising the cross-linked product and starting material from the gel and measuring their radioactivity by scintillation counting. The yields reported were calculated relative to the total material recovered.
  • 27
    • 12644307409 scopus 로고    scopus 로고
    • note
    • The mixed water-acetonitrile medium appeared by ultraviolet spectroscopy to dissolve the methoxy derivative completely, thus suggesting that its inability to modify DNA was not due to a potential problem in solubility. The expected pH dependence for reaction of the hydroxyl derivative has been confirmed with a model system (manuscript in preparation).


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