Systemically administered cycloheximide reduces inhibition in rat neocortical slice preparation

Brain Research

Volumn 743, Issue 1-2, 1996, Pages 329-332

  Buchkremer Ratzmann, Irmgard ^a   Witte, Otto W ^a  

^a HEINRICH HEINE UNIVERSITY   (Germany)

Author keywords

brain slice; cycloheximide; global cerebral ischemia; protein synthesis inhibition

Indexed keywords

CYCLOHEXIMIDE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN ISCHEMIA; BRAIN SLICE; CONTROLLED STUDY; ELECTROPHYSIOLOGY; MALE; NERVE CELL EXCITABILITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN SYNTHESIS; RAT;

ANIMALS; BRAIN ISCHEMIA; CEREBRAL CORTEX; CYCLOHEXIMIDE; DRUG EVALUATION, PRECLINICAL; ELECTRIC STIMULATION; EVOKED POTENTIALS; INJECTIONS, INTRAPERITONEAL; MALE; NEURAL INHIBITION; NEURONS; PROTEIN BIOSYNTHESIS; PROTEIN SYNTHESIS INHIBITORS; RATS; RATS, WISTAR;

EID: 0030447368     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(96)01109-2     Document Type: Article

References (26)

1. Agranoff, B.W., Learning and memory. In: G.J. Siegel, B. Agranoff, R.W. Albers and P. Molinoff (Eds.), Basic Neurochemistry, Raven Press, New York, 1989, pp. 915-927.
2. Bergstedt, K., Hu, B.R. and Wieloch, T., Postischemic changes in protein synthesis in the rat brain: effects of hypothermia, Exp. Brain Res., 95 (1993) 91-95.
3. Borden, L.A., Czajkowski, C., Chan, C.Y. and Farb, D.H., Benzodiazepine receptor synthesis and degradation by neurons in culture, Science, 226 (1984) 857-860.
4. Buchkremer-Ratzmann, I., August, M., Hagemann, G. and Witte, O.W., Electrophyiological transcortical diaschisis after cortical thrombosis in the rat brain, Stroke, 27 (1996) 1105-1111.
5. Burda, J., Martín, M.E., García, A., Alcázar, A., Fando, J.L. and Salinas, M., Phosphorylation of the alpha subunit of initiation factor 2 correlates with the inhibition of tranlation following transient cerebral ischemia in the rat, Biochem. J., 302 (1994) 335-338.
6. Carew, T.J., A comparison of the mechanistic relationships between development and learning in Aplysia. In: N. Elsner and R. Menzel (Eds.), Learning and Memory: Proceedings of the 23rd Göttingen Neurobiology Conference 1995, Thieme, Stuttgart, 1995, pp. 83-104.
7. Chee, P.Y. and Dahl, J.L., Measurement of protein turnover in rat brain, J. Neurochem., 30 (1978) 1485-1493.
8. Cohen, H.D., Ervin, F. and Barondes, S.H., Puromycin and cycloheximide: different effects on hippocampal electrical activity, Science, 154 (1966) 1557-1558.
9. 14C]leucine, Brain Res., 248 (1982) 109-119.
10. Dietrich, W.D., Busto, R., Valdes, I. and Loor, Y., Effects of normothermic versus mild hyperthermic forebrain ischemia in rats, Stroke, 21 (1990) 1318-1325.
11. Domann, R., Hagemann, G., Kraemer, M., Freund, H.-J. and Witte, O.W., Electrophysiological changes in the surrounding brain tissue of photochemically induced corical infarcts in the rat, Neurosci. Lett., 155 (1993) 69-72.
12. Hossmann, K.-A., Widmann, R., Wiessner, C., Dux, E., Djuricic, B. and Röhn, G., Protein synthesis after global ischemia and selective vulnerability. In: J. Krieglstein and H. Oberpichler-Schwenk (Eds.), Pharmacology of Cerebral Ischemia, Wissenschaftliche Verlagsgesellschaft, Stuttgart, 1992, pp. 289-299.
13. Jonec, V. and Wasterlain, C.G., Effects of inhibitors of protein synthesis on the development of kindled seizures in rats, Exp. Neurol., 66 (1979) 525-532.
14. Kiessling, M., Xie, Y. and Kleihues, P., Regional impairment of protein synthesis in the rat brain during bicuculline-induced seizures, Brain Res., 296 (1984) 1-13.
15. a receptor, J. Neurochem., 60 (1993) 1972-1974.
16. Luhmann, H.J., Ischemia and lesion induced imbalances in cortical function, Prog. Neurobiol., 48 (1996) 131-166.
17. Luhmann, H.J., Mudrick-Donnon, L.A., Mittmann, T. and Heinemann, U., Ischaemia-induced long-term hyperexcitability in rat neocortex, Eur. J. Neurosci., 7 (1995) 180-181.
18. Matsumoto, H. and Ajmone-Marsan, C., Cortical cellular phenomena in experimental epilepsy: interictal manifestations, Exp. Neurol., 9 (1964) 286-304.
19. Mies, G., Ishimaru, S., Xie, Y., Seo, K. and Hossmann, K.-A., Ischemic thresholds of cerebral protein synthesis and energy state following middle cerebral artery occlusion in rat, J. Cereb. Blood Flow Metab., 11 (1991) 753-761.
20. Neumann-Haefelin, T., Hagemann, G. and Witte, O.W., Cellular correlates of neuronal hyperexcitability in the vicinity of photochemically induced cortical infarcts in rats in vitro, Neurosci. Lett., 193 (1995) 101-104.
21. Paxinos, G. and Watson, C., The Rat Brain in Stereotaxic Coordinates, Academic Press, London, 1986.
22. Phillis, J.M., A "radical" view of cerebral ischemic injury, Prog. Neurobiol., 42 (1994) 441-448.
23. Schiene, K., Bruehl, C., Zilles, K., Qü, M., Domann, R., Kraemer, M. and Witte, O.W., Neuronal hyperexcitability and reduction of GABA receptor expression in the surround of cerebral thrombosis, J. Cereb. Blood Flow Metab., 16 (1996) 906-914.
24. Ungerer, A., Ropartz, P. and Karli, P., Perturbations de l'activité bioélectrique de l'hippocampe de la souris, induites par l'acétoxycycloheximide (Modifications of bioelectrical activity of the hippocampus of mice induced by acetoxycycloheximide (author's transi.)), Physiol. Behav., 13 (1974) 653-660.
25. Wilcox, Jr., G.L., Andry, D.K. and Luttges, M.W., Cycloheximide effects on electroencephalographic and evoked responses in mice, Behav. Biol., 12 (1974) 81-92.
26. Xue, D., Slivka, A. and Buchan, A.M., Tirilazad reduces cortical infarction after transient but not permanent focal cerebral ischemia in rats, Stroke, 23 (1992) 894-899.