Loewi's discovery and the XXI century

Progress in Brain Research

Volumn 109, Issue , 1996, Pages 1-27

  Karczmar, A G ^a  

^a HINES VA HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCHOLINESTERASE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; BEHAVIOR; CHOLINERGIC SYSTEM; CONFERENCE PAPER; HISTORY OF MEDICINE; HUMAN; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

EID: 0030447318     PISSN: 00796123     EISSN: None     Source Type: Book Series    
DOI: None     Document Type: Conference Paper

References (208)

1. M.D. Abou-Donia D.G. Graham A.A. Komcil Delayed neurotoxicity of O -(2,4-dichlorophenyl)- O -ethyl phosphonothioate. Effect of a single dose on hens. Toxicol. Appl. Pharmacol. 49 1979 293 303
2. M.B. Abou-Donia D.M. Lapadula Mechanisms of organophosphorus ester-induced neurotoxicity: Type I and Type II. Annu. Rev. Pharmacol. Toxicol. 30 1990 405 440
3. K. Akert K. Peper C. Sandri Structural organization of motor end plate and central synapses. P.G. Waser Cholinergic Mechanisms 1975 Raven Press New York 43 57
4. E.X. Albuquerque C.N. Allen Y. Aracava A. Akaike K.P. Shaw D.L. Rickett Activation and inhibition of the nicotinic receptor: actions of physostigmine, pyridostigmine and meprodifen. I. Hanin Dynamics of Cholinergic Function 1986 Plenum Press New York 677 695
5. H. Antony M. Rotmann Zum Mechanismus der negativ inotropen Acetylcholin-Wirkung auf das isolierte Froschmyokard. Pflügers Arch. 1 1968 67 86
6. M. Appleyard Secreted acetylcholinesterase: Non-classical aspects of a classical enzyme. Trends Neurosci. 1 1992 485 490
7. S.-M Aquilonius P.-G Gillberg Cholinergic Neurotransmission: Functional and Clinical Aspects 1990 Elsevier Amsterdam 493
8. E.J. Ariens A.M. Simonis Cholinergic and anticholinergic drugs, do they act on common receptors? Ann. N. Y. Acad. Sci. 1 1967 842 867
9. P. Arnsberg Mitten im Satz vom Tod überrascht. Erinnerungen an Otto Loewi. Frankfurter Allg. Ztg. 1 1973 6 9
10. P. Arnsberg Die Geschichte der Frankfurter Juden seit der Französischen Revolution. H.-O. Schembs Biographisches Lexikon der Juden in den Bereichen: Wissenschaft, Kultur, Bildung, Öffentlichkeitsarbeit in Frankfurt am Main 1983 Eduard Roether Verlag Darmstadt 287 290
11. H. Askmark S.-M Aquilonius P.-G. Gillberg Neuropharmacology of amyotrophic lateral sclerosis. S.-M. Aquilonius P.-G. Gillberg Cholinergic Neurotransmission: Functional and Clinical Aspects 1990 Elsevier Amsterdam 371 380
12. D.A. Baylor T.D. Lamb K.W. Yau Responses of retinal rods to single photons. J. Physiol. 1 1979 589 611
13. R. Ben Aziz-Aloya M. Sternfeld H. Soreq Promoter elements and alternative splicing in the human ACHE gene. A.C. Cuello Cholinergic Function and Dysfunction. Progress in Brain Research Vol. 98 1993 Elsevier Amsterdam 147 159
14. J.D. Bernal Science and Industry in the Nineteenth Century 1956 Rutledge London 230
15. C. Bernard Action de curare et de la nicotine sur le systeme nerveux et sur le systeme musculaire. C. R. Soc. Biol 2 1858 195
16. C. Bernard Lecons sur la Physiologie et la Pathologie du Systeme Nerveux 1858 J.-B. Bailliere Paris 524
17. D. Bertrand J.-P. Changeux Nicotinic receptor: an allosteric protein specialized for intercellular communication. Semin. Neurosci. 1 1995 75 90
18. M.R. Brann J. Ellis H. Jorgensen D. Hill-Eubanks S.V.P. Jones Muscarinic acetylcholine receptor subtypes: localization and structure/function. A.C. Cuello Cholinergic Function and Dysfunction. Progress in Brain Research Vol. 98 1993 Elsevier Amsterdam 121 127
19. M.A.B. Brazier The historical development of neurophysiology. J. Field Handbook of Physiology. Section I: Neurophysiology 1959 American Physiological Society Washington, DC 1 58
20. + current in a vertebrate neuron. Nature 1 1980 673 676
21. J.H. Brown The Muscarinic Receptors 1989 Humana Press New Jersey 478
22. G.A. Buznikov The actions of neurotransmitters and related substances on early embryogenesis. Pharmacol. Ther. 1 1984 23 59
23. W.B. Cannon The Way of an Investigator 1945 Norton New York 229
24. M.P. Caulfield J. Robbins H. Higashida D.A. Brown Postsynaptic actions of acetylcholine: the coupling of muscarinic receptor subtypes to neuronal channels. A.C. Cuello Cholinergic Function and Dysfunction, Progress in Brain Research Vol. 98 1993 Elsevier Amsterdam 293 308
25. C. Chagas A.P. de Carvalho Bioelectrogenesis 1963 Elsevier Amsterdam 413
26. J.-P. Changeux Chemical signaling in the brain. Sci. Am. 1993 58 62 November
27. J.-P. Changeux A. Danchin Selective stabilization of developing synapses as mechanisms for specification of neuronal networks. Nature 1 1976 705 712
28. J.-P. Changeux A. Monnes Conversations on Mind, Matter and Mathematics 1995 Princeton University Press Princeton, NJ 260
29. N. Chomsky Language and Mind 1968 Harcourt Brace & World New York 88
30. P.M. Churchland The Engine of Reason, the Seat of the Soul 1995 MIT Press Cambridge, MA 329
31. P.S. Churchland T.J. Sejnowsky Perspectives on computational neuroscience. Science 1 1992 741 745
32. A.J. Clark The reaction between acetylcholine and muscle cells. J. Physiol. 1 1926 530 546
33. A.J. Clark General Pharmacology. Heffter's Handb. exp. Pharmakol. Vol. 4 1937 Springer-Verlag Berlin 228
34. J. Codina L. Birnbaumer Requirement for intramolecular domain interaction in activation of G protein alpha subunit by aluminum fluoride and GDP but not GTP gamma S. J. Biol. Chem. 1 1994 29339 29342
35. B. Collier A. Tandon M.A.M. Prado M. Bachoo Storage and release of acetylcholine in a sympathetic ganglion. A.C. Cuello Cholinergic Function and Dysfunction, Progress in Brain Research Vol. 98 1993 Elsevier Amsterdam 183 189
36. D. Colquhoun B. Sakmann Fast events in single-channel currents activated by acetylcholine and its analogues at the frog muscle end-plate. J. Physiol. 1 1985 501 557
37. D. Colquhoun A.B. Cachelin C.G. Marshall A. Mathie D.C. Ogden Function of nicotinic receptors. S.-M. Aquilonius P.-G. Gillberg Cholinergic Neurotransmission: Functional and Clinical Aspects 1990 Elsevier Amsterdam 43 50
38. S. Consolo E. Palazzi R. Bertorelli G. Fisone J. Crawley T. Hökfelt T. Bartfai Functional aspects of acetylcholine-galanine coexistence in the brain. S.-M. Aquilonius P.-G. Gillberg Cholinergic Neurotransmission: Functional and Clinical Aspects 1990 Elsevier Amsterdam 279 287
39. J.R. Cooper Unsolved problems in the cholinergic nervous system. J. Neurochem. 1 1994 395 399
40. A.C. Cuello Cholinergic Neurotransmission: Function and Dysfunction Proc. 8th Int. Cholinergic Symp. 1993 Elsevier Amsterdam 462
41. H.H. Dale The action of certain esters and ethers of choline, and their relation to muscarine. J. Pharmacol. Exp. Ther. 1 1914 147 190
42. H.H. Dale Nomenclature of fibres in the autonomic system and their effects. J. Physiol. 82 1933 10
43. H.H. Dale Progress in autopharmacology; survey of present knowledge of the chemical regulation of certain functions by natural constituents of the tissues. Introduction. John Hopkins Hosp. Bull. 1 1933 297 312
44. H.H. Dale Progress in autopharmacology; survey of present knowledge of chemical regulation of certain functions by natural constituents of tissues. Acetylcholine. John Hopkins Hosp. Bull. 1 1933 312 329
45. H.H. Dale Chemical transmission of nerve impulses. Br. Med. J. 1934 1 20
46. H.H. Dale Pharmacology and nerve endings. Proc. Soc. Med. 1 1935 319 322
47. H.H. Dale Acetylcholine as a chemical transmitter of the effects of nerve impulses. I. History of ideas and evidence. Peripheral autonomic actions. Functional nomenclature of nerve fibres. J. Mt. Sinai Hosp. 1 1938 401 429
48. H.H. Dale Otto Loewi 1873--1961. Biographical Memoirs Fellows R. Soc. 1 1962 67 89
49. T.M. Dawson J.I. Dawson S.H. Snyder A novel neuronal messenger molecule in brain: the free radical, nitric oxide. Ann. Neurol. 1 1992 297 311
50. R. Descartes Discours de la Methode Pour Bien Conduire sa Raison, et Chercher la Verite Dans les Sciences. 1637 A. Leyde Paris 413
51. W.G. De Groat Mechanisms underlying recurrent inhibition in the sacral parasympathetic outflow to the urinary bladder. J. Physiol. 1 1976 503 513
52. P. Deniker C. Radouco-Thomas A. Villeneuve Neuro-psychopharmacology Proc. 10th Cong. CINP Vols. 1--2 1978 Pergamon Press Oxford UK
53. D.C. Dennet Darwin's Dangerous Idea. 1995 Simon and Schuster New York 586
54. H.A. Dieterich K. Löffelholz H. Pompetzki Acetylcholine overflow from isolated perfused hearts of various species in the absence of cholinesterase inhibition. Naunyn-Schmiedeberg's Arch. Pharmacol. 1 1977 149 152
55. H.A. Dieterich R. Lindmar K. Löffelholz The role of choline in the release of acetylcholine in isolated hearts. Naunyn-Schmiedeberg's Arch. Pharmacol. 1 1978 207 215
56. W.E. Dixon Vagus inhibition. Br. Med. J. II 1906 1807
57. W.E. Dixon On the mode of action of drugs. Med. Mag. London 1 1907 454 457
58. D.S. Drachman Central cholinergic system and memory. M.A. Lipton K.F. Killam Psychopharmacology; A Generation of Progress 1978 Raven Press New York 651 652
59. K. Dross H. Kewitz Concentration and origin of choline in the rat brain. Naunyn-Schmiedeberg's Arch. Pharmacol. 1 1972 91 106
60. F.H. Duffy J.L. Buchfiel Long term effects of the organophosphate sarin on EEG in monkeys and humans. Neurotoxicology 1 1980 667 689
61. S.B. Dunnett H.C. Fibiger Role of forebrain cholinergic systems in learning and memory: relevance to the cognitive deficits of aging and Alzheimer's dementia. A.C. Cuello Cholinergic Function and Dysfunction, Progress in Brain Research Vol. 98 1993 Elsevier Amsterdam 413 420
62. F.J. Dyson Infinite in All Directions. 1988 Harper and Row New York 321
63. T. Ebendal H. Persson L. Olson New directions in NGF experimental therapy of Alzheimer's disease. R. Becker E. Giacobini Cholinergic Basis for Alzheimer Therapy 1991 Birkhäuser Boston, MA 468 473
64. J.C. Eccles The Physiology of Synapses. 1963 Springer-Verlag Berlin 316
65. J.C. Eccles The Human Mystery. 1979 Springer-Verlag Berlin 255
66. J.C. Eccles How the Self Controls Its Brain. 1994 Springer-Verlag Berlin 197
67. J.C. Eccles B. Katz K. Koketsu Cholinergic and inhibitory synapses in a pathway from motor-axon collaterals to motoneurones. J. Physiol. 1 1954 524 562
68. R.M. Eccles B. Libet Origin and blockade of synaptic responses of curarized sympathetic ganglia. J. Physiol. 1 1961 484 503
69. T.R. Elliott On the action of adrenalin. J. Physiol. 1 1904 20 21
70. W. Feldberg Present views on the mode of action of acetylcholine in the central nervous system. Physiol. Rev. 1 1945 596 642
71. W. Feldberg O. Krayer Das Auftreten eines azetylcholinartigen Stoffes im Herzvenenblut von Warmblütern bei Reizung der Nervi vagi. Naunyn-Schmiedebergs Arch. exp. Path. Pharmak. 1 1933 170 193
72. W.M. Fletcher John Newport Langley. In memoriam. J. Physiol. 1 1926 1 27
73. A. Freedman Brainmakers. 1995 Simon and Schuster New York 214
74. A. Friedman Circumstances influencing Otto Loewi's discovery of chemical transmission in the nervous system. Pflügers Arch. 1 1972 85 86
75. R. Furchgott The pharmacology of vascular smooth muscle. Pharmacol. Rev. 1 1955 183 265
76. H. Gardner Art, Mind and Brain. 1982 Basic Books New York 380
77. G.H. Geison Otto Loewi. C.C. Gillispie Dictionary of Scientific Biography Vol. VIII 1973 Charles Scribner's Sons New York 451 457
78. D. Gelernter The Muse in the Machine. 1995 The Free Press New York 203
79. C.F. Gerfen K.A. Keefe Neurostriatal receptors. Trends Neurosci. 1 1994 2 3
80. E. Giacobini Pharmacotherapy of Alzheimer disease: new drugs and novel strategies. A.C. Cuello Cholinergic Function and Dysfunction, Progress in Brain Research Vol. 98 1993 Elsevier Amsterdam 447 454
81. P.-G. Gillberg H. Askmark S.-M. Aquilonius Spinal cholinergic mechanisms. S.-M. Aquilonius P.-G. Gillberg Cholinergic Neurotransmission: Functional and Clinical Aspects 1990 Elsevier Amsterdam 361 370
82. A. Gilman G proteins: transducers of receptor-generated signals. Annu. Rev. Biochem. 1 1987 505 649
83. K. Godel Über formal unentscheidbare Sätze per Principia Mathematica und verwandter Systeme. Monatshefte f. Mathem. u. Phys. 1 1931 173 198
84. P. Greengard Possible role for cyclic nucleotides and phosphorylated membrane proteins in postsynaptic actions of neurotransmitters. Nature 1 1976 101 108
85. P. Greengard Neuronal phosphoproteins. Neurobiology 1 1987 81 119
86. S. Hecht S. Shlaer M.H. Pirenne Energy, quanta and vision. J. Gen. Physiol. 1 1941 891 940
87. I.W. Held Professor Otto Loewi. S.R. Kagan Victor Robinson Memorial Volume 1948 Froben Press New York 123 128
88. F. Hirata J. Axelrod Enzymatic synthesis and rapid translocation of phosphatidylcholine by two methyltransferases in erythrocyte membrane. Proc. Natl. Acad. Sci. USA 1 1978 2348 2352
89. J.A. Hobson S. Datta J.M. Calvo J. Quatrochi Acetylcholine as a brain state modulator: triggering and long-term regulation of REM sleep. A.C. Cuello Cholinergic Function and Dysfunction, Progress in Brain Research Vol. 98 1993 Elsevier Amsterdam 389 404
90. F.B. Hofmann Über die Einheitlichkeit der Herzhemmungsfasern und über die Abhängigkeit ihrer Wirkung vom Zustande des Herzens. Zeitsch. f. Biol. 1 1917 427 452
91. D. Hofstadter Computer Models of the Fundamental Mechanisms of Thought. 1995 Basic Books New York 518
92. L.E. Hokin J.F. Dixon I. Historical background. II. Effects of lithium on the accumulation of second messenger inositol 1,4,5-trisphosphate in brain cortex slices. A.C. Cuello Cholinergic Function and Dysfunction. Progress in Brain Research Vol. 98 1993 Elsevier Amsterdam 309 315
93. B. Holmstedt Pharmacology of organophosphorus cholinesterase inhibitors. Pharmacol. Rev. 1 1959 567 688
94. B. Holmstedt Pharmacology of organophosphorus anticholinesterase agents. G.B. Koelle Cholinesterases and Anticholinesterase Agents, Handb. exp. Pharmakol. Vol. 15 1963 Springer-Verlag Berlin 428 485
95. B. Holmstedt The ordeal bean of old calabar: the pageant of Physostigma venenosum in medicine. T. Swain Plants in the Development of Modern Medicine 1972 Cambridge University Press Cambridge, MA 303 360
96. B. Holmstedt G. Liljenstrand Readings in Pharmacology. 1963 Pergamon Press Oxford 395
97. R. Hunt Further observations on the blood pressure lowering body in the suprarenal gland. Am. J. Physiol. 1 1901 6 7
98. R. Hunt R. Taveau M. de On the physiological action of certain choline derivatives and new methods for detecting choline. Br. Med. J. II 1906 1788 1791
99. Y. Ishihara K. Kato G. Goto Central cholinergic agents. I. Potent acetylcholinesterase inhibitors. Chem. Pharmacol. Bull. (Tokyo) 1 1991 3225 3235
100. D.J. Jenden Achievements in cholinergic research, 1969--1989: drug development. S.-M. Aquilonius P.-G. Gillberg Cholinergic Neurotransmission: Functional and Clinical Aspects 1990 Elsevier Amsterdam 479 486
101. E.R. John Neural correlates of learning and memory. A.G. Karczmar J.C. Eccles Brain and Human Behavior 1972 Springer-Verlag Berlin 291 301
102. A.G. Karczmar The role of amputation and nerve resection in the regressing limbs of urodele larvae. J. Exp. Zool. 1 1946 401 427
103. A.G. Karczmar Antagonism between a bis-quaternary oxamide, WIN8078, and depolarizing and competitive blocking agents. J. Pharmacol. Exp. Ther. 1 1957 39 47
104. A.G. Karczmar Ontogenetic effects. G.B. Koelle Cholinesterases and Anticholinesterase Agents, Handb. exp. Pharmakol. Vol. 15 1963 Springer-Verlag Berlin 799 832
105. A.G. Karczmar Pharmacologic, toxicologic and therapeutic properties of anticholinesterase agents. W.S. Root F.G. Hoffman Physiological Pharmacology Vol. 3 1967 Academic Press New York 163 322
106. A.G. Karczmar Discussion of the paper of S. Ehrenpreis. Ann. N. Y. Acad. Sci. 1 1967 734 735
107. A.G. Karczmar History of the research with anticholinesterase agents. A.G. Karczmar Anticholinesterase Agents, Section 13 Int. Encyclop. Pharmacol. Ther. Vol. 1 1970 Pergamon Press Oxford, UK 1 44
108. A.G. Karczmar Multitransmitter mechanisms underlying selected functions, particularly aggression, learning and sexual behavior. P. Deniker C. Radouco-Thomas A. Villeneuve Neuropsychopharmacology. Proc. Xth Cong. CINP Vol. 1 1978 Pergamon Press Oxford, UK 581 608
109. A.G. Karczmar Brain acetylcholine and animal electrophysiology. K.L. Davis P.A. Berger Brain Acetylcholine and Neuropsychiatric Disease 1979 Plenum Press New York 265 310
110. A.G. Karczmar Acute and long lasting central actions of organophosphorus agents. Fund. Appl. Toxicol. 4 1984 S1 S17
111. A.G. Karczmar Historical development of concepts of ganglionic transmission. A.G. Karczmar K. Koketsu S. Nishi Autonomic and Enteric Ganglia 1986 Plenum Press New York 3 26
112. A.G. Karczmar Physiological cholinergic functions in the CNS. S.-M. Aquilonius P.-G. Gillberg Cholinergic Neurotransmission: Functional and Clinical Aspects 1990 Elsevier Amsterdam 437 466
113. A.G. Karczmar Historical aspects of the cholinergic transmission. T.C. Napier P.W. Kalivas I. Hanin The Basal Forebrain 1991 Plenum Press New York 453 476
114. A.G. Karczmar SDAT models and their dynamics. R. Becker E. Giacobini Cholinergic Basis for Alzheimer Therapy 1991 Birkhäuser Boston, MA 141 152
115. A.G. Karczmar Comments to session on electrophysiological aspects of cholinergic mechanisms. A.C. Cuello Cholinergic Function and Dysfunction Progress in Brain Research Vol. 108 1993 Elsevier Amsterdam 279 284
116. A.G. Karczmar Brief presentation of the story and the present status of studies of the vertebrate cholinergic system. Neuropsychopharmacology 1 1993 181 199
117. A.G. Karczmar Cholinergic substrates of cognition and organism-environment interaction. Prog. Neuro-Psychopharmacol. Biol. Psychiatry 1 1995 187 211
118. A.G. Karczmar Loewi's discovery and the future of our notions of central cholinergic transmission and its behavioral correlates. Perspect. Biol. Med. 1996 in press
119. A.G. Karczmar N.J. Dun Effects of anticholinesterases pertinent for SDAT treatment but not necessarily underlying their clinical effectiveness. E. Giacobini R. Becker Current Research in Alzheimer Therapy 1988 Taylor and Francis New York 15 29
120. A.G. Karczmar S. Nishi L.C. Blaber Synaptic modulations. A.G. Karczmar J.C. Eccles Brain and Human Behavior 1972 Springer-Verlag Berlin 63 92
121. B. Katz R. Miledi Membrane noise produced by acetylcholine. Nature 1 1970 962 963
122. H. Kewitz O. Pleul K. Dross Schwartzkopff The supply of choline in rat brain. P.G. Waser Cholinergic Mechanisms 1975 Raven Press New York 131 135
123. G.B. Koelle Organophosphorus poisoning - an overview. Fund. Appl. Toxicol. 1 1981 129 137
124. G.B. Koelle Otto Loewi. Trends Pharmacol. Sci. 1 1986 290 291
125. G.B. Koelle Enhancement of acetylcholinesterase synthesis by glycyl-l-glutamine: an example of a small peptide that regulates differential transcription? Trends Pharmacol. Sci. 1 1988 318 321
126. A. Koestler The Act of Creation. 1964 Macmillan New York 751
127. A. Koestler The Ghost in the Machine. 1967 Macmillan New York 384
128. K. Koketsu Restorative action of fluoride on synaptic transmission blocked by organophosphorus anticholinesterases. Int. J. Neuropharmacol. 1 1966 254 257
129. K. Koketsu Cholinergic synaptic potentials and the underlying ionic mechanisms. Fed. Proc. Am. Soc. Exp. Biol. 1 1969 101 112
130. K. Koketsu A.G. Karczmar Action of NaF at various cholinergic synapses. Fed. Proc. 25 1966 627
131. A. Köppen J. Klein T. Holler K. Löffelholz Synergistic effect of nicotinamide and choline administration on extracellular choline levels in the brain. J. Pharm. Exp. Ther. 1 1993 720 725
132. K. Krnjevic Central cholinergic pathways. Fed. Proc. 1 1969 115 120
133. K. Krnjevic Central cholinergic mechanisms and function. A.C. Cuello Cholinergic Function and Dysfunction Progress in Brain Research Vol. 98 1993 Elsevier Amsterdam 285 292
134. F. Kutscher Beiträge zur Kenntnis der Eiweisskörper. Ztschft. physiol. Chem. 1 1903 111 134
135. R. Lahoz-Beltra S. Hameroff J.E. Dayhoff Cytoskeletal logic: a model for molecular computation via Boellean operations in microtubules and microtubule-associated proteins. Biosystems 1 1993 1 23
136. J.N. Langley On the reaction of cells and of nerve endings to certain poisons, chiefly as regards the reaction of striated muscle to nicotine and to curare. J. Physiol. 1 1905 374 413
137. J.N. Langley W.L. Dickinson On the local paralysis of peripheral ganglia, and on the connection of different classes of nerve fibres with them. Proc. R. Soc. 1 1889 423 431
138. F. Lembeck W. Giere Otto Loewi. Ein Lebensbild in Dokumenten. 1968 Springer-Verlag Berlin 241
139. B. Libet Generation of slow inhibitory and excitatory potentials. Fed. Proc. 1 1970 1945 1956
140. B. Libet Slow postsynaptic actions in ganglionic functions. C.M. Brooks K. Koizumi A. Sato Integrative Functions of the Autonomic Nervous System 1979 University of Tokyo Press Tokyo 199 222
141. B. Libet Unconscious cerebral initiative and the role of conscious will in voluntary action. Behav. Brain Sci. 1 1985 529 566
142. B. Libet The neural time factor in conscious and unconscious events. T. Nagel Experimental and Theoretical Studies of Consciousness CIBA Foundation Symposium No. 174 1993 CIBA New York 123 146
143. B. Libet A testable field theory of mind-brain interaction. J. Consciousness Studies 1 1994 119 126
144. R. Levi-Montalcini P.L. Angeletti Nerve growth factor. Physiol. Rev. 1 1968 534 569
145. O. Loewi Über Eiweiszsynthese in Thierkorper. Arch. exp. Path. Pharmakol. 1 1902 303 330
146. O. Loewi Über Beziehungen zwischen Herzmittel- und Kationenwirkung. II. Mitteilung. Über den Zusammenhang zwischen Digitalis- und Kalziumwirkung. Arch. exp. Path. Pharmakol. 1 1918 131 158
147. O. Loewi Über humorale Übertragbarkeit der Herznervenwirkung. I. Mitteilung. Pflügers Arch. ges. Physiol. 1 1921 239 242
148. O. Loewi Über humorale Übertragbarkeit der Herznervenwirkung. II. Mitteilung. Pflügers Arch. ges. Physiol. 1 1922 201 213
149. O. Loewi Über humorale Übertragbarkeit der Herznervenwirkung. III. Mitteilung. Pflügers Arch. ges. Physiol. 1 1924 408 412
150. O. Loewi Über den Mechanismus der Stoffwechselwirkung der Hypophysen-vorderlappens. Fiziol. Zh. SSSR 1 1938 241 244
151. O. Loewi On the action of fluoride on the heart of Rana pipiens; preliminary note. J. Mt. Sinai Hosp. 1 1952 1 3
152. O. Loewi An autobiographic sketch. Perspect. Biol. Med. 1 1960 1 25
153. O. Loewi G. Mansfeld Über den Wirkungsmodus des Physostigmins. Arch. exp. Pathol. Pharmakol. 1 1911 180 185
154. O. Loewi E. Navratil Über humorale Übertragbarkeit der Herznervenwirkung. VII. Mitteilung. Pflügers Arch. ges. Physiol. 1 1924 135 140
155. O. Loewi E. Navratil Über humorale Übertragbarkeit der Herznerven-wirkung. X. Mitteilung. Über das Schicksal des Vagusstoffes. Pflügers Arch. ges. Physiol. 1 1926 678 688
156. O. Loewi E. Navratil Über humorale Übertragbarkeit des Herznerven-wirkung. XI. Mitteilung. Über den Mechanismus der Vaguswirkung von Physostigmin und Ergotamin. Pflügers Arch. ges. Physiol. 1 1926 689 696
157. K. Löffelholz Receptor regulation of choline phospholipid hydrolysis. Biochem. Pharmacol. 1 1989 1543 1549
158. K. Löffelholz J. Klein A. Köppen Choline, a precursor of acetylcholine and phospholipids in the brain. A.C. Cuello Cholinergic Function and Dysfunction Progress in Brain Research Vol. 98 1993 Elsevier Amsterdam 197 200
159. J.P. Long Structure-activity relationships of the reversible anticholinesterase agents. G.B. Koelle Cholinesterases and Anticholinesterase Agents Handb. exp. Pharmakol. Vol. 15 1963 Springer-Verlag Berlin 374 427
160. T. Mann H.T. Lowe-Porter Joseph and His Brothers. 1948 A.A. Knopf New York 1207
161. J. Massoulié S. Bon N. Duval C. Legay E. Krejci F. Coussens Expression of Torpedo and rat acetylcholinesterase forms in transfected cells. A.C. Cuello Cholinergic Function and Dysfunction Progress in Brain Research Vol. 98 1993 Elsevier Amsterdam 153 157
162. D.A. McCormick Actions of acetylcholine in the cerebral cortex and thalamus and implications for function. A.C. Cuello Cholinergic Function and Dysfunction Progress in Brain Research Vol. 98 1993 Elsevier Amsterdam 303 308
163. J.L. McGaugh M.J. Herz Memory Consolidation. 1972 Albion Publishing Co. San Francisco, CA 204
164. R.H. Michell Inositol phospholipids and cell surface receptor function. Biochim. Biophys. Acta 1 1975 81 147
165. D. Nachmansohn A.L. Machado The formation of acetylcholine. A new enzyme “choline acetylase”. J. Neurophysiol. 1 1943 397 404
166. T.C. Napier P.W. Kalivas I. Hanin The Basal Forebrain. 1991 Plenum Press New York 489
167. S. Nishi H. Soeda K. Koketsu Release of acetylcholine from sympathetic preganglionic nerve terminals. J. Neurophysiol 1 1967 114 134
168. Y. Nishizuka Studies and perspectives of protein kinase C. Science 1 1986 305 311
169. R.A. North Electrophysiology of the enteric neurons. G. Bertaccini Mediators and Drugs in Gastrointestinal Motility Vol. 59 1982 Springer-Verlag Berlin 145 179
170. S.M. Parsons B.A. Bahr G.A. Rogers E.D. Clarkson K. Noremberg B.W. Hicks Acetylcholine transporter - vesamicol receptor pharmacology and structure. A.C. Cuello Cholinergic Function and Dysfunction Progress in Brain Research Vol. 98 1993 Elsevier Amsterdam 175 181
171. J. Patrick P. Sequela S. Vernino M. Amador C. Luetje J.A. Dani Functional diversity of neuronal nicotinic acetylcholine receptors. A.C. Cuello Cholinergic Function and Dysfunction Progress in Brain Research Vol. 98 1993 Elsevier Amsterdam 113 120
172. A. Peacock The relationship between the soul and the brain. F.C. Rose W.F. Bynum Historical Aspects of the Neurosciences 1982 Raven Press New York 83 98
173. R. Penrose The Emperor's New Mind. 1989 Oxford University Press Oxford, UK 466
174. R. Penrose Shadows of the Mind. 1994 Oxford University Press Oxford, UK 457
175. G. Pepeu Overview and future directions of CNS cholinergic mechanisms. A.C. Cuello Cholinergic Function and Dysfunction Progress in Brain Research Vol. 98 1993 Elsevier Amsterdam 455 458
176. G. Pepeu G. Spignoli Nootropic drugs and brain cholinergic mechanisms. Prog. Neuro-Psychopharmacol. Biol. Psychiatry 13 1989 S77 S88
177. G. Pepeu F. Casamenti M.G. Giovannini M.G. Vannucchi F. Pedata Principal aspects of the regulation of acetylcholine release in the brain. S.-M. Aquilonius P.-G. Gillberg Cholinergic Neurotransmission: Functional and Clinical Aspects 1990 Elsevier Amsterdam 273 278
178. R. Pinsky The Muse in the Machine: or, the Poetics of Zork. 1955 Book Review Section, The New York Times March 19
179. J.R. Pollard N. Rojas E. Arispe H.B. Pollard A geometric sequence that accurately describes allowed multiple conductance levels of ion channels: the “Three-Halves” rule. Biophysics J. 1 1994 647 655
180. K.R. Popper J.R. Eccles The Self and its Brain. 1977 Springer-Verlag Berlin
181. L.L. Protas G.R. Leontieva Ontogeny of cholinergic and adrenergic mechanisms in the frog (Rana temporaria) heart. Am. J. Physiol. 262 1992 R150 R161
182. G. Racagni N. Brunello S.Z. Langer Recent Advances in the Treatment of Neurodegenerative Disorders and Cognitive Dysfunction. 1994 Karger Basel 264
183. D.D. Rasmusson Cholinergic modulation of sensory information. A.C. Cuello Cholinergic Function and Dysfunction Progress in Brain Research Vol. 98 1993 Elsevier Amsterdam 357 364
184. G.A. Robeson R.W. Butcher E.W. Sutherland Cyclic AMP. 1971 Academic Press New York 531
185. S. Rose The Making of Memory. 1992 Anchor Books New York 355
186. E. Rothstein Where Melody Merges With Moonlight. 1955 New York Times, Arts Section June 4, 1995, p. 17
187. R.J. Rylett B.M. Schmidt Regulation of the synthesis of acetylcholine. A.C. Cuello Cholinergic Function and Dysfunction Progress in Brain Research Vol. 98 1993 Elsevier Amsterdam 161 166
188. P.B. Sargent The diversity of neuronal nicotinic acetylcholine receptors. Annu. Rev. Neurosci. 1 1993 403 443
189. S.M. Schuetze L.W. Role Developmental regulation of nicotinic acetylcholine receptors. Annu. Rev. Neurosci. 1 1987 403 457
190. M.I. Schimerlik Structure and function of muscarinic receptors. S.-M. Aquilonius P.-G. Gillberg Cholinergic Neurotransmission: Functional and Clinical Aspects 1990 Elsevier Amsterdam 11 19
191. J. Searle Minds, brains and programs. Behav. Brain Sci. 1 1980 417 453
192. P. Shinnick-Gallagher J.P. Gallagher P. Yoshimura The pharmacology of sympathetic preganglionic neurons. A.G. Karczmar K. Koketsu S. Nishi Autonomic and Enteric Ganglia 1986 Plenum Press New York 409 424
193. A.M. Sillito Cholinergic neuromodulatory system: an evaluation of its functional roles. A.C. Cuello Cholinergic Function and Dysfunction Progress in Brain Research Vol. 98 1993 Elsevier Amsterdam 371 378
194. B.F. Skinner Verbal Behavior. 1957 Appleton-Century-Crofts New York 478
195. A. Szutowicz H. Bielarczyk H. Skulimowska Effects of dichloroacetate on acetyl-CoA content and acetylcholine synthesis in rat brain synaptosomes. Neurochem. Res. 1 1994 1107 1112
196. S. Thesleff The mode of neuromuscular block caused by acetylcholine, nicotine, decamethonium and succinylcholine. Acta Physiol. Scand. 1 1955 218 231
197. S. Thesleff Functional aspects of quantal and non-quantal release of acetylcholine at the neuromuscular junction. S.-M. Aquilonius P.-G. Gillberg Cholinergic Neurotransmission: Functional and Clinical Aspects 1990 Elsevier Amsterdam 93 99
198. S. Tucek The synthesis of acetylcholine: twenty years of progress. S.-M. Aquilonius P.-G. Gillberg Cholinergic Neurotransmission: Functional and Clinical Aspects 1990 Elsevier Amsterdam 467 477
199. F.W. Turek Circadian rhythms. Rec. Prog. Horm. Res. 1 1994 43 90
200. A.M. Turing On computable numbers, with an application to the Entscheidungsproblem. Proc. London Math. Soc., Ser. 2 1 1937 544 546
201. E. Usdin Reactions of cholinesterases with substrates, inhibitors and reactivators. A.G. Karczmar Anticholinesterases Agents Int. Encyclop. Pharmacol. Therap. Vol. 1 1970 Pergamon Press Oxford 47 354
202. Van der Kloot, W. R. 1972 Letter to G.L. Geison June 2, 1972
203. M.T. Vilaro G. Mengod J.M. Palacios Advances and limitations of the molecular neuroanatomy of cholinergic receptors: the example of multiple muscarinic receptors. A.C. Cuello Cholinergic Function and Dysfunction Progress in Brain Research Vol. 98 1993 Elsevier Amsterdam 95 101
204. R.L. Volle Muscarinic and nicotinic stimulant actions at autonomic ganglia. A.G. Karczmar Ganglionic Blocking and Stimulating Agents Int. Encyclop. Pharmacol. Therap. Vol. 1 1966 Pergamon Press Oxford 1 106
205. V.P. Whittaker The Cholinergic Synapse. Handb. exp. Pharmacol. Vol. 86 1988 Springer-Verlag Berlin 762
206. V.P. Whittaker The Cholinergic Neuron and Its Target: The Electromotor Innervation of the Electric Ray “Torpedo” as a Model. 1992 Birkhäuser Boston MA 572
207. C.D. Woody Memory, Learning and Higher Function. A Cellular View. 1982 Springer-Verlag Berlin 483
208. R.F. Wurtman Choline metabolism as a basis for selective vulnerability of cholinergic neurons. Trends Neurosci. 1 1992 117 122