Synthesis of cyclopropyl taxane analogs via sequential Diels-Alder reactions

Journal of Organic Chemistry

Volumn 61, Issue 26, 1996, Pages 9074-9075

  Winkler, Jeffrey D ^a   Holland, Joanne M ^a   Peters, David A ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

TAXANE DERIVATIVE;

ARTICLE; DRUG SYNTHESIS; REACTION ANALYSIS; STEREOCHEMISTRY;

EID: 0030446694     PISSN: 00223263     EISSN: None     Source Type: Journal    
DOI: 10.1021/jo961617v     Document Type: Article

References (14)

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3. The sequence outlined in Scheme 2 formally involves sequential and not tandem cycloadditions, as the cyclopropanation and unleashing of the second dienophile intercede between the two cycloadditions.
4. Johnson, R. A.; Nidy, E. G.; Dobrowolski, P. J.; Gebhard, I.; Quails, S. J.; Wicnienski, N. A.; Kelly, R. C. Tetrahedron Lett. 1994, 35, 7893.
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14. Note Added in Proof: Wender and co-workers have recently reported the synthesis of cyclopropyl taxanes, albeit without establishment of the trans-B/C ring fusion. We congratulate Professor Wender on his elegant study (Wender, P. A.; Glass, T. E.; Krauss, N. E.; Muhlebach, M.; Peschke, B.; Rawlins, D. J. Org. Chem. 1996, 61, 7662-7663.