Could dual G-Protein coupling explain [D-Met2]FMRFamide's mixed action in vivo?

Peptides

Volumn 17, Issue 8, 1996, Pages 1261-1265

  Raffa, Robert B ^a,c   Stone Jr , Dennis J ^b  

^a R W JOHNSON PHARMACEUTICAL RES I   (United States)

^b DREXEL UNIVERSITY   (United States)

^c TEMPLE UNIVERSITY SCHOOL OF PHARMACY   (United States)

Author keywords

D Met2 FMFFamide; Analgesia; FaRPs; FMRFamide; Mice; Phe D Met Arg Phe NH2

Indexed keywords

CHOLERA TOXIN; GUANINE NUCLEOTIDE BINDING PROTEIN; NALOXONE; OPIATE RECEPTOR; PERTUSSIS TOXIN; PHENYLALANYLMETHIONYLARGINYLPHENYLALANINAMIDE;

ANIMAL EXPERIMENT; ANTINOCICEPTION; ARTICLE; IN VIVO STUDY; INTRACEREBROVENTRICULAR DRUG ADMINISTRATION; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; RECEPTOR BINDING; SIGNAL TRANSDUCTION;

AMINO ACID SEQUENCE; ANIMALS; CHOLERA TOXIN; FMRFAMIDE; GTP-BINDING PROTEINS; MALE; MICE; MORPHINE; NALOXONE; NEUROPEPTIDES; NOCICEPTORS; PERTUSSIS TOXIN; VIRULENCE FACTORS, BORDETELLA;

EID: 0030446608     PISSN: 01969781     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0196-9781(96)00196-9     Document Type: Article

References (25)

1. 1. Bimbaumer, L.; Abramowitz, J.; Brown, A. M. Receptor-effector coupling by G proteins. Biochem. Biophys. Acta 1031:163-224; 1990.
2. 2. Dockray, G. J.; Vaillant, C.; Williams, R. G. New vertebrate braingut peptide related to a molluscan neuropeptide and an opioid peptide. Nature 293:656-657; 1981.
3. 3. Greenberg, M. J.; Painter, S. D.; Doble, K. E.; Nagle, G. T.; Price, D. A.; Lehman, H. K. The molluscan neurosecretory peptide FMRFamide: Comparative pharmacology and relationship to the enkephalins. Fed. Proc. 42:82-86; 1983.
4. 4. Haley, T. J.; McCormick, W. G. Pharmacological effects produced by intracerebral injection of drugs in the conscious mouse. Br. J. Pharmacol. 1:12-15; 1957.
5. 2 (FMRFamide) on morphine-induced inhibition of colonic propulsive motility in mice. Neurosci. Lett. 83:128-132; 1987.
6. 6. Janssen, P. A. J.; Niemegeers, C. J. E.; Dony, J. G. H. The inhibitory effect of fentanyl and other morphine-like analgesics on the warm water induced tail withdrawal reflex in rats. Arzneimittelforschung 13:502-507; 1963.
7. 7. Kubben, F. J. G. M.; van Assche, C. L. M. V. J.; Bosman, F. T. FMRFamide: Immunoreactiviry in the mammalian gastroenteropancreatic neuroendocrine system. Histochemistry 84:439-444; 1986.
8. 8. O'Donohue, T. L.; Bishop, J. F.; Chronwell, B. M.; Groome, J.; Watson, W. H. Characterization and distribution of FMRFamide immunoreactivity in the rat central nervous system. Peptides 5:563-568; 1984.
9. 9. Parker, E. M.; Kameyama, K.; Higashijima, T.; Ross, E. M. Reconstitutively active G protein-coupled receptors purified from baclovirus-infected insect cells. J. Biol. Chem. 266:519-527; 1991.
10. 10. Price, D. A.; Greenberg, M. J. Structure of a molluscan cardioexcitatory neuropeptide. Science 197:670-671; 1977.
11. 11. Price, D. A.; Davies, N. W.; Doble, K. E.; Greenberg, M. J. The variety and distribution of the FMRFamide-related peptides in molluscs. Zool. Sci. 4:395-410; 1987.
12. 2) and related peptides on mammals. Peptides 9:915-922; 1988.
13. 2), inhibit colonic bead expulsion time in mice. Peptides 10:873-875; 1989.
14. 2-related peptides on mouse colonic propulsive motility: A structure-activity relationship study. J. Pharmacol. Exp. Ther. 254:809-814; 1990.
15. 2]FMRF-amide in mice. Neuropeptides 22:195-203; 1992.
16. 2b receptors. Peptides 15:401-404; 1994.
17. 17. Rothman, R. B. A review of the role of anti-opioid peptides in morphine tolerance and dependence. Synapse 12:129-138; 1992.
18. 18. Strader, C. D.; Fong, T. M.; Tota, M. R. Structure and function of G protein-coupled receptors. Annu. Rev. Biochem. 63:101-132; 1994.
19. 2-like immunoreactivity. Proc. Natl. Acad. Sci. USA 81:5002-5005; 1984.
20. 20. Wang, Z.; Lange, A. B.; Orchard, I. Coupling of a single receptor to two different G proteins in the signal transduction of FMRFamide-related peptides. Biochem. Biophys. Res. Commun. 212:531-538; 1995.
21. 21. Wang, Z.; Orchard, I.; Lange, A. B.; Chen, X.; Starratt, A. N. A single receptor transduces both inhibitory and stimulatory signals of FMRFamide-related peptides. Peptides 16:1181-1186; 1995.
22. 22. Weber, E.; Evans, C. J.; Samuelson, S. J.; Barchas, J. D. Novel peptide neuronal system in rat brain and pituitary. Science 214:1248-1251; 1981.
23. z-mediated hormonal inhibition of cyclic AMP accumulation. Science 255:339-342; 1992.
24. 24. Zadina, J. E.; Kastin, A. J. Interactions of Tyr-MIF-1 at opiate receptor sites. Pharmacol. Biochem. Behav. 25:1303-1305; 1986.
25. 25. Zhu, X. Z.; Raffa, R. B. Low affinity inhibition of opioid receptor binding by FMRFamide. Neuropeptides 8:55-61; 1986.