Cytotoxic quinolines (part 3)1. Synthesis of 1-azolylalkyl-4(1H)-quinolones as cytotoxic agents

Drug Design and Discovery

Volumn 14, Issue 2, 1996, Pages 115-127

  Abel, Mark D ^a   Micetich, Ronald G ^a   Nukatsuka, Mamoru ^b   Oreski, A Bernadette ^a   Tempest, Mark L ^a   Daneshtalab, Mohsen ^a  

^a NAEJA Pharmaceutical Inc   (Canada)

^b TAIHO PHARMACEUTICAL CO LTD   (Japan)

Author keywords

Anticancer; Azolylalkylquinolones; Cytotoxic; Topoisomerase

Indexed keywords

1 AZOLYLALKYL 4(1H) QUINOLONE; ANTINEOPLASTIC AGENT; DNA TOPOISOMERASE; DOXORUBICIN; QUINOLINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTINEOPLASTIC ACTIVITY; ARTICLE; CARCINOMA CELL; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG MECHANISM; ENZYME INHIBITION; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; STRUCTURE ACTIVITY RELATION;

ANIMALS; ANTINEOPLASTIC AGENTS; AZOLES; DNA TOPOISOMERASES, TYPE I; DOXORUBICIN; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; QUINOLONES; TUMOR CELLS, CULTURED;

EID: 0030445976     PISSN: 10559612     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (3)

1. Abel M.D., Ha, C.M., Luu, H.T., Micetich, R.G., Nguyen, D.Q., Nukatsuka, M., Oreski, A.B., Tempest, M.L., Daneshtalab, M. (1995) Cytotoxic Quinolines (Part 1). Azolylalkyloxyquinolines and 1-Azolylalkyl-4(1H)-quinolones and Cytotoxic Quinolines (Part 2). Azolylalkylamino and -Thioquinolines. Drug Design and Discovery. Manuscripts in press.
2. 1 for the Quinolone Antibacterials. J. Med. Chem., 31, 991-1001.
3. Elsea, S.H., McGuirk, P.R., Gootz, T.D., Osheroff, N. (1993) Quinolones as Potent Topoisomerase II-Targeted Drugs with Cytotoxic Potential Toward Mammalian Systems. Proceedings of The Eighty-forth Annual Meeting of the American Association for Cancer Research, Orlando, FL, 34, Abstract #2513.