RNAs encoded by a 3.5-kb bovine vasopressin gene construct are targeted to the neurohypophysis of transgenic mice

Molecular Brain Research

Volumn 42, Issue 2, 1996, Pages 287-292

  Burke, Z D ^a   Morgan, H ^a   Murphy, D ^b   Carter, D A ^a  

^a CARDIFF UNIVERSITY   (United Kingdom)

^b NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

Hypothalamus; Osmotic stimulation; Pituitary; Polymerase chain reaction; Transgene

Indexed keywords

ARGIPRESSIN; RNA; VASOPRESSIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; GENE CONTROL; MOUSE; NEUROHYPOPHYSIS; NONHUMAN; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TRANSGENE; TRANSGENIC MOUSE;

ANIMALS; CATTLE; MICE; MICE, TRANSGENIC; PITUITARY GLAND; POLYMERASE CHAIN REACTION; RNA, MESSENGER; VASOPRESSINS;

ANIMALIA; BOVINAE; MURINAE; MUS MUSCULUS;

EID: 0030445503     PISSN: 0169328X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0169-328X(96)00132-5     Document Type: Article

References (25)

1. [1] Ang, H.-L., Carter, D.A. and Murphy, D., Neuron-specific expression and physiological regulation of bovine vasopressin transgenes in mice, EMBO J., 12 (1993) 2397-2409.
2. [2] Carter, D.A., Leukemia inhibitory factor expression in cultured rat anterior pituitary is regulated by glucocorticoids, J. Neuroendocrinol., 7 (1995) 623-628.
3. [3] Giuditta, A., Menichini, E., Capano, C.P., Langells, M., Martin, R., Castigli, E. and Kaplan, B.B., Active polysemes in the axoplasm of the squid giant axon, J. Neurosci. Res., 28 (1991) 18-28.
4. [4] Hara, Y., Battey, J.F. and Gainer, H., Structure of mouse vasopressin and oxytocin genes, Mol. Brain Res., 8 (1990) 319-324.
5. [5] Jirikowski, G.F., Sanna, P.P. and Bloom, F.E., mRNA coding oxytocin is present in axons of the hypothalamo-neurohypophyseal tract, Proc. Natl. Acad. Sci. USA, 87 (1990) 7400-7404.
6. [6] Kislauskis, E.H., Li, Z., Singer, R.H. and Taneja, K.L., Isoformspecific 3′-untranslated sequences sort α-cardiac and β-cytoplasmic actin messenger RNAs to different cytoplasmic compartments, J. Cell. Biol., 123 (1993) 165-172.
7. [7] Lehmann, E., Untersuchungen zur Expression des Vasopressingens in der Ratte, Ph.D. Thesis, University of Heidelberg (1988).
8. [8] Levy, A., Lightman, S.L., Carter, D.A. and Murphy, D., The origin and regulation of posterior pituitary RNA in osmotically stimulated rats, J. Neuroendocrinol., 2 (1990) 329-334.
9. [9] Mohr, E., Fehr, S. and Richter, D., Axonal transport of neuropeptide encoding mRNAs within the hypothalamo-hypophyseal tract of rats, EMBO J., 10 (1991) 2419-2424.
10. [10] Mohr, E., Morris, J.F. and Richter, D., Differential sucellular mRNA targeting: deletion of a single nucleotide prevents the transport to axons but not to dendrites of rat hypothalamic magnocellular neurons, Proc. Natl. Acad. Sci. USA, 92 (1995) 4377-4381.
11. [11] Mohr, E. and Richter, D., Diversity of mRNAs in the axonal compartment of peptidergic neurons in the rat, Eur. J. Neurosci., 4 (1990) 870-876.
12. [12] Mohr, E., Zhou, A., Thorn, N.A. and Richter, D., Rats with physically disconnected hypothalamo-pituitary tracts no longer contain vasopressin-oxytocin gene transcripts in the posterior lobe, FEBS Lett., 263 (1990) 332-336.
13. [13] Mowry, K.L. and Melton, D.A., Vegetal messenger RNA localization directed by a 340nt sequence element in Xenopus oocytes, Science, 255 (1992) 991-994.
14. [14] Murphy, D., Ang, H.-L., Zeng, Q., Ho, M.-Y., Funkhouser, J. and Carter, D., Neuropeptide gene expression in transgenic animals. In: J. Joosse, R.M. Buijs and F.J.H. Tilders (Eds.), Prog. Brain Res., 92 (1992) 77-96.
15. [15] Murphy, D. and Carter, D.A., Vasopressin gene expression in the rodent hypothalamus: transcriptional and post-transcriptional responses to physiological stimulation, Mol. Endocrinol., 4 (1990) 1051-1059.
16. [16] Murphy, D., Funkhouser, J., Ang, H.-L., Foo, N.-C. and Carter, D.A., Extrahypothalamic expression of the vasopressin and oxytocin genes, Ann. NY Acad. Sci., 689 (1993) 91-106.
17. [17] Murphy, D., Levy, A., Lightman, S. and Carter, D., Vasopressin RNA in the neural lobe of the pituitary: dramatic accumulation in the neural lobe of the pituitary, Proc. Natl. Acad. Sci. USA, 86 (1989) 9002-9005.
18. [18] Pu, L.-P., van Leeuwen, F.W., Tracer, H.L., Sonnemans, M.A.F. and Loh, Y.P., Localization of vasopressin mRNA and inmmunore-activity in pituicytes of pituitary stalk-transected rats after osmotic stimulation, Proc. Natl. Acad. Sci. USA, 92 (1995) 10653-10657.
19. [19] Rehbein, M., Hilliers, M., Mohr, E., Ivell, R., Morley, S., Schmale, H. and Richter, D., The neurohypophyseal hormones vasopressin and oxtytocin: precursor structure, synthesis and regulation, Biol. Chem. Hoppe-Seyler, 367 (1986) 675-704.
20. [20] Ruppert, S., Scherer, G. and Schutz, G., Recent gene conversion involving bovine vasopressin and oxytocin precursor genes suggested by nucleotide sequence, Nature, 308 (1984) 554-557.
21. [21] Schmale, H. and Richter, D., Single base deletion in the vasopressin gene is the cause of diabetes insipidus in Brattleboro rats, Nature, 308 (1984) 705-709.
22. [22] Skutella, T., Probst, J.C., Blanco, E. and Jirikowski, G.F., Localization of tyrosine hydroxylase mRNA in the axons of the hypothalamo-neurohypophyseal system, Mol. Brain Res., 23 (1994) 179-184.
23. [23] Stewart, O., Targeting of mRNAs to sub-synaptic microdomains in dendrites, Curr. Opin. Neurobiol, 5 (1995) 55-61.
24. [24] Trembleau, A., Melia, K.R. and Bloom, F.E., BC1 RNA and vasopressin mRNA in rat neurohypophysis: axonal compartmentalization and differential regulation during dehydration and rehydration, Eur. J. Neurosci., 7 (1995) 2249-2260.
25. [25] Trembleau, A., Morales, M. and Bloom, F.E., Aggregation of vasopressin mRNA in a subset of axonal swellings of the median eminence and posterior pituitary: light and electron microscopic evidence, J. Neurosci., 14 (1994) 39-53.