DNA-binding specificity of PAR and C/EBP leucine zipper proteins: A single amino acid substitution in the C/EBP DNA-binding domain confers PAR-like specificity to C/EBP

Biological Chemistry

Volumn 377, Issue 12, 1996, Pages 797-809

  Falvey, Eileen ^a   Marcacci, Lysiane ^a   Schibler, Ueli ^a  

^a UNIVERSITY OF GENEVA   (Switzerland)

Author keywords

C EBP; DBP; DNA binding specificity; HLF; PAR basic leucine zipper proteins; TEF

Indexed keywords

DNA BINDING PROTEIN; LEUCINE ZIPPER PROTEIN; MUTANT PROTEIN; TRANSCRIPTION FACTOR;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ARTICLE; BINDING AFFINITY; BINDING SITE; CONTROLLED STUDY; DNA SEQUENCE; MOLECULAR RECOGNITION; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN DNA BINDING; PROTEIN DOMAIN; STRUCTURE ACTIVITY RELATION;

ANIMALS; BASE SEQUENCE; CCAAT-ENHANCER-BINDING PROTEINS; DNA FOOTPRINTING; DNA-BINDING PROTEINS; ELECTROPHORESIS, POLYACRYLAMIDE GEL; LEUCINE ZIPPERS; MOLECULAR SEQUENCE DATA; NUCLEAR PROTEINS; POLYMERASE CHAIN REACTION; PROMOTER REGIONS (GENETICS); RATS; SEQUENCE ALIGNMENT; STRUCTURE-ACTIVITY RELATIONSHIP; TRANSCRIPTION FACTORS;

EID: 0030445282     PISSN: 14316730     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (47)

1. Agre, P., Johnson, P.F., and S.L. McKnight. (1989). Cognate DNA-binding specificity retained after leucine zipper exchange between GCN-4 and C/EBP. Science 246, 922-926.
2. Blackwell, T.K., and H. Weintraub. (1990). Differences and similarities in DNA-binding preferences of MyoD and E2A protein complexes revealed by binding site selection. Science 250, 1104-1110.
3. Cao, Z., R. M. Umek, and S. L. McKnight. (1991). Regulated expression of three C/EBP isoforms during adipose conversion of 3T3-L1 cells. Genes Dev. 5, 1538-1552.
4. Descombes, P., M. Chojkier, S. Lichtsteiner, E. Falvey, and U. Schibler. (1990). Lap, a novel member of the C/EBP gene family, encodes a liver-enriched transcriptional activator protein. Genes Dev. 4, 1541-1551.
5. Descombes, P. and U. Schibler. (1991). A liver-enriched transcriptional activator protein, LAP, and a transcriptional inhibitory protein, LIP are translated from the same mRNA. Cell 67, 569-579.
6. Drolet, D. W., K. M. Scully, D. M. Simmons, M. Wegner, K. Chu, L. W. Swanson and M. G. Rosenfeld. (1991). TEF, a transcription factor expressed specifically in the anterior pituitary during embryogenesis, defines a new class of leucine zipper proteins. Genes Dev. 5, 1739-1753.
7. Ellenberger, T. E., C. J. Brandl, K. Struhl, and S. C. Harrison. (1992). The GCN4 basic region leucine zipper binds DNA as a dimer of uninterrupted a helices: crystal structure of the protein-DNA complex. Cell 71, 1223-1237.
8. Falvey, E., F. Fleury-Olela, and U. Schibler. (1995). The rat hepatic leukemia factor (HLF) gene encodes two transcriptional activators with distinct circadian rhythms, tissue distribution and target preferences. EMBO J. 14, 4307-4317.
9. Fonjallaz, P., V. Ossipow, G. Wanner, and U. Schibler. (1996). The two PAR leucine zipper proteins TEF and DBP display similar circadian and tissue-specific expression, but have different target promoter preferences. EMBO J. 15, 351-362.
10. Glover, J. N. M., and S. C. Harrison. (1995). Crystal structure of the heterodimeric bZIP transcription factor c-Fos c-Jun bound to DNA. Nature 373, 257-261.
11. Haas, N. B., C. A. Cantwell, P. F. Johnson, and J. B. Burch. (1995). DNA-binding specificity of the PAR basic leucine zipper protein VBP partially overlaps those of the C/EBP and CREB/ATF families and is influenced by domains that flank the core basic region. Mol. Cell. Biol. 75, 1923-1932.
12. Hunger, S. P., K. Ohyashiki, K. Toyama, and M. L. Cleary. (1992). HLF, a novel hepatic bZip protein, shows altered DNA-binding properties following fusion to E2A in t(17;19) acute lymphoblastic leukemia. Genes Dev. 6, 1608-1620.
13. Hunger, S. P., R. Brown, and M. L Cleary. (1994). DNA-binding and transcriptional regulatory properties of hepatic leukemia factor (HLF) and the t(17;19) acute lymphoblastic leukemia. Mol. Cell. Biol. 14, 5986-5996.
14. Hurst, H. C. (1994). Transcription factors 1, bZIP proteins. Protein Profiles 1, 123-168.
15. Inaba, T., W. M. Roberts, L. H. Shapiro, K. W. Jolly, S. C. Raimondi, S. D. Smith, and A. T. Look. (1992). Fusion of the leucine zipper gene HLF to the E2A gene in human acute B-lineage leukemia. Science. 257, 531-534.
16. Inaba, T., L. H. Shapiro, T. Funabiki, A. E. Sinclair, B. G. Jones, R. A. Ashmun, and A.T. Look. (1994). DNA-binding specificity and trans-activating potential of the leukemia-associated E2A-hepatic leukemia factor fusion protein. Mol. Cell. Biol. 14, 3403-3413.
17. Inaba, T., Inukai, T., Yoshihara, T., Seyschab, H., Ashmun, R.A., Canman, E., Laken, S.E., Kastan, M.B., and Look, A.T. (1996). Reversal of apoptosis by the leukemia-associated E2A-HLF chimaeric transcription factor. Nature 382, 541-544.
18. Iyer, S. V., D. L. Davis, S. N. Seal, and J. B. Burch. (1991). Chicken vitellogenin gene-binding protein, a leucine zipper transcription factor that binds to an important control element in the chicken vitellogenin II promoter, is related to rat DBP. Mol. Cell. Biol. 11, 4863-4875.
19. Johnson, P.F. (1993). Identification of C/EBP basic region residues involved in DNA sequence recognition and half-site spacing preference. Mol. Cell. Biol. 13, 6919-6930.
20. Kerppola, T., and T. Curran. (1995). Transcription: Zen and the art of Fos and Jun. Nature 373, 199-200.
21. Kim, J., D. Tzamarias, T. Ellenberger, S. C. Harrison, and K. Struhl. (1993). Adaptability at the protein-DNA interface is an important aspect of sequence recognition by bZIP proteins. Proc. Natl. Acad. Sci. USA 90, 4513-4517.
22. König, P., and T. J. Richmond. (1993). The X-ray structure of the GCN4-bZip bound to ATF/CREB site DNA shows the complex depends on DNA flexibility. J. Mol. Biol. 233, 139-154.
23. Kouzarides, T., and E. B. Ziff. (1988). The role of the leucine zipper in the fos-jun interaction. Nature 336, 646-651.
24. Landschulz, W. H., P. F. Johnson, and S. L. McKnight. (1988). The leucine zipper: a hypothetical structure common to a new class of DNA-binding proteins. Science 240, 1759-1764.
25. Landschulz, W. H., P. F. Johnson, and S. L. McKnight. (1989). The DNA-binding domain of the rat liver nuclear protein C/EBP is bipartite. Science 243, 1681-1688.
26. Lavery, D. J., and U. Schibler. (1993). Circadian transcription of the cholesterol 7α hydroxylase gene may involve the liver-enriched bZIP protein DBP. Genes Dev. 7, 1871-1884.
27. Lavery, D. J., and U. Schibler. (1994). DBP and related transcription factors of the PAR family. In: Liver Gene Expression. F. Tronche and M. Yaniv, eds (Austin, TX, USA; R.G. Landes Co.), pp. 259-275.
28. Lichtsteiner, S., J. Wuarin, and U. Schibler. (1987). The interplay of DNA-binding proteins on the promoter of the mouse albumin gene. Cell 51, 963-973.
29. Lin, F. T., and M. D. Lane. (1994). CCAAT/enhancer binding protein alpha is sufficient to initiate the 3T3-L1 adipocyte differentiation program. Proc. Natl. Acas. Sci. USA 91, 8757-8761.
30. Lumb, K. J., and P.S. Kim. (1995). Measurement of interhelical electrostatic interactions in the GCN4 leucine zipper. Science 268, 436-439.
31. McKnight, S. L., M. D. Lane, and S. Glueckson-Waelsch. (1989). Is CCAAT/enhancer-binding protein a central regulator of energymetabolism? Genes. Dev. 3, 2021-2024.
32. Metzstein, M.M., Hengartner, M.O., Tsung, N., Ellis, R.E., and Horvitz, H.R. (1996). Transcriptional regulator of programmed cell death encoded by Caenorhabditis elegans gene ces-2. Nature 383, 545-547.
33. Mueller, C. R., P. Maire, and U. Schibler. (1990). DBP, a liver-enriched transcriptional activator is expressed late in ontogeny and its tissue specificity is determined posttranscriptionally. Cell 61, 279-291.
34. O'Shea, E.K., , R. Rutkowski, and P. S. Kim. (1992). Mechanism of specificity in the Fos-Jun oncoprotein heterodimer. Cell 68, 699.
35. Pu, W.T., and K. Struhl. (1991). Highly conserved residues in the bZip domain of yeast GCN4 are not essential for DNA-binding. Mol. Cell. Biol. 11, 4918-4926.
36. Sambrook, J., T. Maniatis, and E. F. Fritsch. (1989). Molecular Cloning: A Laboratory Manual. (Cold Spring Harbor, New York: Cold Spring Harbor Laboratory Press).
37. Scatchard, G. (1949). The attractions of proteins for small molecules and ions. Ann. N.Y. Acad. Sci. 51, 660-672.
38. Screpanti, I., L. Romani, P. Musiani, A. Modesti, E. Fattori, D. Lazzaro, C. Sellitto, S. Scarpa, D. Bellavia, G. Lattanzio, F. Bistoni, L. Frati, R. Cortese, A. Gulino, G. Ciliberto, F. Constantini, and V. Poli. (1995). Lymphoproliferative disorder and imbalanced T helper response in C/EBPβ-deficient mice. EMBO J. 14, 1932-1941.
39. Shuman, J.D., C.R. Vinson, and S.L. McKnight. (1990). Evidence of changes in protease sensitivity and subunit exchange on DNA-binding by C/EBP. Science 29, 771.
40. Studier, F. W., A. H. Rosenberg, J. J. Dunn, and J. W. Dubendorff. (1990). Use of T7 RNA polymerase to direct expression of cloned genes. Methods Enzymol. 185, 60-89.
41. Suckow, M., B. von Wilcken-Bergmann, and B. Muller-Hill. (1993a). Identification of three residues in the basic regions of bZip proteins GCN4, C/EBP, and TAF-1 that are involved in specific DNA-binding. EMBO J. 12, 1193-1200.
42. Suckow, M., B. von Wilcken-Bergmann, and B. Muller-Hill. (1993b). The DNA-binding specificity of the basic region of the yeast transcriptional activator GCN4 can be changed by substitution of a single amino acid. Nucleic Acids Res. 21, 2081-2086.
43. Vinson, C. R., T. Hai, and S. M. Boyd. (1993). Dimerization specificity of the leucine zipper-containing bZip motif on DNA-binding: prediction and rational design. Genes Dev. 7, 1047-1058.
44. Wang, N. D., M.J. Finegold, A. Bradley, C. N. Ou, S. V. Abdelsayed, M. D. Wilde, L. R. Taylor, D. R. Wilson, and G. Darlington. (1995). Impaired energy homeostasis in C/EBPα knockout mice. Science 269, 1108-1112.
45. Wuarin J., and U. Schibler. (1990). Expression of the liver-enriched transcriptional activator protein DBP follows a stringent circadian rhythm. Cell 63, 1257-1266
46. 450 CYP2C6 gene. Mol. Cell. Biol. 12, 2847-2854.
47. Yeh, W. C., Z. Cao, M. Classon, and S. L. McKnight. (1995). Cascade regulation of terminal adipocyte differentiation by three members of the C/EBP family of leucine zipper proteins. Genes Dev. 7, 168-181.