Is nitric oxide and heparin treatment justified in inflammatory bowel disease? An experimental study

Scandinavian Journal of Clinical and Laboratory Investigation

Volumn 56, Issue 7, 1996, Pages 657-663

  Dobosz, M ^a   Mionskowska, L ^a   Dobrowolski, S ^a   Dymecki, D ^a   Makarewicz, W ^a   Hrabowska, M ^a   Wajda, Z ^a  

^a MEDICAL UNIVERSITY OF GDANSK   (Poland)

Author keywords

colitis; heparin; laser Doppler flowmetry; microcirculation; nitric oxide

Indexed keywords

ARGININE; HEPARIN; INTERLEUKIN 6; N(G) NITROARGININE;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD FLOW; CONTROLLED STUDY; ENTERITIS; HISTOLOGY; INTRAPERITONEAL DRUG ADMINISTRATION; LASER DOPPLER FLOWMETRY; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; RECTUM;

ANIMALIA;

EID: 0030444660     PISSN: 00365513     EISSN: None     Source Type: Journal    
DOI: 10.1080/00365519609090602     Document Type: Article

References (29)

1. Hanauer S. Medical therapy of ulcerative colitis. Lancet 1993; 342: 412-7.
2. Guslandi M, Polli D, Sorghi M, Tittobello A. Rectal blood flow in ulcerative colitis. Am J Gastroenterol 1995; 90: 579-80.
3. Sankey EA, Dhillon AP, Anthony A, Wakefield AJ, Sim R, More L, et al. Early mucosal changes in Crohn's disease. Gut 1993; 34: 375-81.
4. Hamilton MI, Dick R, Crawford L, Thompson NP, Pounder RE, Wakefield AJ. Is proximal demarcation of ulcerative colitis determined by the territory of the inferior mesenteric artery? Lancet 1995; 345: 688-90.
5. Liu X.-H, Kimura T, Ishikawa H, Yamaguchi H, Furukawa M, Nakano I, et al. Effect of endothelin-1 on the development of hemorrhagic pancreatitis in rats. Scand J Gastroenterol 1995; 30: 276-82.
6. Radomski MW, Palmer RMJ, Moncada S. The role of nitric oxide and cGMP in platelet adhesion to vascular endothelium. Biochem Biophys Res Commun 1987; 148: 1482-9.
7. May GR, Moove PK, Page CP. The role of nitric oxide as an endogenous regulator of platelet and neutrophil activation within the pulmonary circulation of the rabbit. Br J Pharmacol 1991; 102: 759-63.
8. Beckman JS, Beckman TW, Chen J, Marshall PA, Freeman BA. Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from NO and superoxide. Proc Natl Acad Sci USA 1990; 87: 1620-4.
9. Yamada T, Marshall S, Specian RD, Grisham MB. A comparative analysis of two models of colitis in rats. Gastroenterology 1991; 102: 1524-34.
10. Saverymuttu SH, Camerilli M, Rees H, Lavender JP, Hodgson HJF, Chadwick VS. Indium- 111 granulocyte scanning in the assessment of disease extent and disease activity in inflammatory bowel disease. Gastroenterology 1986; 90: 1121-8.
11. Tsujii M, Kawano S, Tsuji S, Kobayashi I, Takei Y, Nagano K, et al. Colonic mucosal hemodynamics and tissue oxygenation in patients with ulcerative colitis: investigation by organ reflectance spectrophotometry. J Gastroenterol 1995; 30: 183-8.
12. Leung FW, Koo A. Mucosal vascular stasis precedes loss of viability of endothelial cells in rat acetic acid colitis. Dig Dis Sci 1991; 36: 727-32.
13. Hyams JS, Fitzgerald JE, Treem WR, Wyzga N, Kreutzer DL. Relationship of functional and antigenic interleukin-6 to disease activity in inflammatory bowel disease. Gastroenterology 1993; 104: 1285-92.
14. Mitsuyama K, Sasaki E, Toyonaga A, Ikeda H, Tsuruta O, Irie A, et al. Colonic mucosal interleukin-6 in inflammatory bowel disease. Digestion 1991; 50: 104-11.
15. Lam A, Borda IT, Inwood MJ, Thomson S. Coagulation studies in ulcerative colitis and Crohn's disease. Gastroenterology 1975; 68: 245-51.
16. Dhillon AP, Anthony A, Sim R, Wakefield AJ, Sankey EA, Hudson M, et al. Mucosal capillary thrombi in rectal biopsies. Histopathology 1992; 21: 127-33.
17. Weiler JM, Edens RE, Linhardt RJ, Kapelanski DP. Heparin and modified heparin inhibit complement activation in vivo. J Immunol 1992; 148: 3210-15.
18. Lucio J, D'Brot J, Guo C-B. Immunologic mast cell-mediated responses and histamine release are attenuated by heparin. J Appl Physiol 1992; 73: 1093-101.
19. Sternberg WC III, Makhoul RG, Adelman B. Heparin prevents postischemic endothelial cell dysfunction by a mechanism independent of its anticoagulant activity. J Vasc Surg 1993; 17: 318-27.
20. Imai T, Hirata Y, Emori T, Marumo F. Heparin has an inhibitory effect on endothelin-1 synthesis and release by endothelial cells. Hypertension 1993; 21: 353-8.
21. Gaffney PR, Doyle CT, Gaffney A, Hogan J, Hayes DP, Annis P. Paradoxical response to heparin in 10 patients with ulcerative colitis. Am J Gastroenterol 1995; 90: 220-23.
22. Middleton SJ, Shorthouse M, Hunter JO. Increased nitric oxide synthesis in ulcerative colitis. Lancet 1993; 341: 465-6.
23. Boughton-Smith NK, Evans SM, Hawkey CJ, Cole AT, Balsitis M, Whittle BJR, et al. Nitric oxide synthase activity in ulcerative colitis and Crohn's disease. Lancet 1993; 342: 338-40.
24. Oudkerk Pool M, Bouma G, Visser JJ, Kolkman JJ, Train DD, Meuwissen SGM, et al. Serum nitrate levels in ulcerative colitis and Crohn's disease. Scand J Gastroenterol 1995; 30: 784-8.
25. Rachmilewitz D, Stamler JS, Bachwich D, Karmeli F, Ackerman Z, Podolsky DK. Enhanced colonic nitric oxide generation and nitric oxide synthase activity in ulcerative colitis and Crohn's disease. Gut 1995; 36: 718-23.
26. Rachmilewitz D, Stamler JS, Karmeli F, Mullins ME, Singel D, Loscalzo J. Peroxynitrite- induced rat colitis - a new model of colonic inflammation. Gastroenterology 1993; 105: 1681-8.
27. Boeckxtaens G, Mebis J, Janssens J, Geboes K, De Man J, Herman A, et al. Clinical relevance of nitric oxide in the gut. Lancet 1994; 344: 129.
28. Grisham MB, Ware K, Gilleland HE, Gilleland LB, Abell CL, Yamada T. Neutrophil-mediated nitrosamine formation: role of nitric oxide in rats. Gastroenterology 1992; 103: 1260-6.
29. Rachmilewitz D, Karmeli F, Okon E, Bursztyn M. Experimental colitis is ameliorated by inhibition of nitric oxide synthase activity. Gut 1995; 37: 247-55.