Diclofenac combined with cyclosporine in treatment refractory rheumatoid arthritis: Longitudinal safety assessment and evidence of a pharmacokinetic / dynamic interaction

Journal of Rheumatology

Volumn 23, Issue 12, 1996, Pages 2033-2038

  Kovarik, John M ^a   Kurki, Pekka ^a   Mueller, Edgar ^a   Guerret, Madeleine ^b   Markert, Ellen ^c   Alten, Rieke ^d   Zeidler, Henning ^e   Genth Stolzenburg, Susanne ^e  

^a Sandoz Pharma Ltd   (Switzerland)

^b Laboratoires Sandoz   (France)

^c Sandoz Wander AG   (Germany)

^d Schlosspark Klinik   (Germany)

^e HANNOVER MEDICAL SCHOOL   (Germany)

Author keywords

Cyclosporine; Diclofenac; Drug interaction; Rheumatoid arthritis

Indexed keywords

CYCLOSPORIN; CYCLOSPORIN A; DICLOFENAC;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG SAFETY; FEMALE; HUMAN; MALE; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; RHEUMATOID ARTHRITIS;

ADULT; AGED; ARTHRITIS, RHEUMATOID; CYCLOSPORINE; DICLOFENAC; DRUG COMBINATIONS; DRUG INTERACTIONS; FEMALE; HUMANS; KIDNEY; LONGITUDINAL STUDIES; MALE; MIDDLE AGED;

EID: 0030444303     PISSN: 0315162X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (20)

1. Tugwell P: Cyclosporine in rheumatoid arthritis: Documented efficacy and safety. Semin Arthritis Rheum 1992;(suppl 3)21:30-8.
2. Dijkmans BA, van Rijthoven AW, Goei Thé HS, et al: Cyclosporine in rheumatoid arthritis. Semin Arthritis Rheum 1992;22:30-6.
3. Førre Ø: Cyclosporine in rheumatoid arthritis: An overview. Clin Rheumatol 1995;(suppl 2)14:33-6.
4. Yocum DE, Torley H: Cyclosporine in rheumatoid arthritis. Rheum Dis Clin North Am 1995;21:835-44.
5. Deray G, Le Hoang P, Aupetit B, et al: Enhancement of cyclosporin A nephrotoxicity by diclofenac (letter). Clin Nephrol 1987;27:213-4.
6. Harris KP, Jenkins D, Walls J: Nonsteroidal antiinflammatory drugs and cyclosporin: A potentially serious adverse interaction (letter). Transplantation 1988;46:598-9.
7. Branthwaite JP, Nicholls A: Cyclosporin and diclofenac interaction in rheumatoid arthritis (letter). Lancet 1991;337:252.
8. Berg KJ, Førre Ø, Djoseland M, et al: Renal side effects of high and low cyclosporin A doses in patients with rheumatoid arthritis. Clin Nephrol 1989;31:232-8.
9. Altman RD, Perez GO, Sfakianakis GN: Interaction of cyclosporin A and nonsteroidal anti-inflammatory drugs on renal function in patients with rheumatoid arthritis. Am J Med 1992;93:396-402.
10. Mueller EA, Kovarik JM, Koelle EU, et al: Pharmacokinetics of cyclosporine and multiple-dose diclofenac during coadministration. J Clin Pharmacol 1993;33:936-43.
11. Arnett FC, Edworthy SM, Bloch DA, et al: American rheumatism association 1987 revised criteria for the classification of RA. Arthritis Rheum 1988;31:315-24.
12. 3H radioimmunoassay with a monoclonal antibody for monitoring cyclosporine in blood. Clin Chem 1988;34:257-60.
13. Mustofa M, Suryawati S, Dwiprahasto I, Santoso B: The relative bioavailability of diclofenac with respect to time of administration. Br J Clin Pharmacol 1991;32:246-7.
14. Todd PA, Sorkin EM: Diclofenac sodium: A reappraisal of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy. Drugs 1988;35:244-85.
15. Kovarik JM, Mueller EA, Gaber M, et al: Pharmacokinetics of cyclosporine and steady-state aspirin during coadministration. J Clin Pharmacol 1993;13:513-21.
16. Leeman TD, Kondo M, Dayer P: NSAIDs from various chemical classes competitively inhibit P450TB (CYP2C) (abstr). Clin Pharmacol Ther 1992;51:179.
17. Yocum DE, Klippel JH, Wilder RL, et al: Cyclosporin A in severe, treatment-refractory rheumatoid arthritis. Ann Intern Med 1988;109:863-9.
18. Boers M, van Rijthoven AWAM, Goei The HS, et al: Serum creatinine levels two years later: Follow-up of a placebo-controlled trial of cyclosporine in rheumatoid arthritis patients. Transplant Proc 1988;(suppl 4)3:371-5.
19. Feutren G, Mihatsch MJ: Risk factors for cyclosporine-induced nephropathy in patients with autoimmune diseases. N Engl J Med 1992;326:1654-60.
20. Panayi GS, Tugwell P: The use of cyclosporin A in rheumatoid arthritis. Conclusions of an international review. Br J Rheumatol 1994;33:967-9.