A microemulsion of cyclosporine without intravenous cyclosporine in liver transplantation

Transplantation

Volumn 62, Issue 12, 1996, Pages 1798-1802

  Hemming, Alan W ^a   Greig, Paul D ^a   Cattral, Mark S ^a   Chung, Stephen W ^a   Lilly, Leslie B ^a   Aljumah, Abdul A ^a,b   Levy, Gary A ^a  

^a UNIVERSITY HEALTH NETWORK   (Canada)

^b Riyadh Armed Forces Hospital ^*  (Saudi Arabia)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOSPORIN; CYCLOSPORIN A;

CLINICAL ARTICLE; CLINICAL TRIAL; CONFERENCE PAPER; DRUG EFFICACY; DRUG SAFETY; GRAFT REJECTION; GRAFT SURVIVAL; HUMAN; HUMAN TISSUE; IMMUNOSUPPRESSIVE TREATMENT; INTRAVENOUS DRUG ADMINISTRATION; LIVER TRANSPLANTATION; NEUROTOXICITY; PRIORITY JOURNAL;

ADULT; CYCLOSPORINE; DOSE-RESPONSE RELATIONSHIP, DRUG; EMULSIONS; GRAFT SURVIVAL; HUMANS; INJECTIONS, INTRAVENOUS; INTESTINAL ABSORPTION; LIVER TRANSPLANTATION; NERVOUS SYSTEM DISEASES; SURVIVAL RATE; TIME FACTORS;

EID: 0030444116     PISSN: 00411337     EISSN: None     Source Type: Journal    
DOI: 10.1097/00007890-199612270-00020     Document Type: Conference Paper

References (23)

1. European Multicentre Trial Group. Cyclosporin in cadaveric renal transplantation: one year follow-up of a multicentre trial. Lancet 1983; 2: 986.
2. Opelz G. Superior long term kidney graft survival in patients on maintenance immunosuppression with cyclosporine and azathioprine. Transplant Proc 1993; 25: 1289.
3. White DJ, Friend P. J. Immunosuppression. In: Calne RY, ed. Liver transplantation. London: Grune & Stratton. 1987: 301.
4. Pichlmayr R, Brolsch C, Neuhaus P, et al. Report on 68 human orthotopic liver transplants with special reference to rejection phenomena. Transplant Proc 1983; 15: 1279.
5. Wallwork J, Corey-Pearce R, English TA. Cyclosporine for cardiac transplantation. Transplant Proc 1983; 15: 2559.
6. Ptachcinski RJ, Venkataramanan R, Burckart GJ. Clinical pharmacokinetics of cyclosporin. Clin Pharmacokinet 1986; 11: 107.
7. Lindholm A, Henricsson S, Lind M, Dahlqvist R. Intraindividual variability in the relative systemic availability of cyclosporin after oral dosing. Eur J Pharmacol 1988; 34: 461.
8. Gaspari F, Ruggenenti P, Torre L, Bertocchi C, Remuzzi G, Perico N. Failure to predict area under the curve using a limited sampling strategy. Kidney Int 1993; 44: 436.
9. Lemaire M, Fahr A, Maurer G. Pharmacokinetics of cyclosporine: inter and intraindividual variations and metabolic pathways. Transplant Proc 1990; 22: 1110.
10. Naoumov NV, Tredger JM, Steward CM, et al. Cyclosporin A pharmacokinetics in liver transplant recipients in relation to biliary T-tube clamping and liver dysfunction. Gut 1989; 30: 391.
11. Mehta MU, Venkataramanan R, Burckart GJ. Effect of bile on cyclosporine absorption in liver transplant patients. Br J Clin Pharmacol 1988; 25: 579.
12. Starzl TE, Hakala TR, Rosenthal AT, et al. The Colorado-Pittsburgh cadaveric renal transplantation study with cyclosporine. Transplant Proc 1983; 15: 2459.
13. Levy G, Grant D. Potential for CsA-Neoral in organ transplantation. Transplant Proc 1994; 26: 2932.
14. Adams DH, Gunson B, Honigsberger L, et al. Neurological complications following liver transplantation. Lancet 1987; i: 949.
15. DeGroen PC, Aksamit AJ, Rakela J, et al. Central nervous system toxicity after liver transplantation: the role of cyclosporine and cholesterol. N Engl J Med 1987; 317: 861.
16. Kahan BD. Individualization of cyclosporine therapy using pharmacokinetic and pharmacodynamic parameters. Transplantation 1985; 40: 457.
17. Vonderscher J, Meinzer A. Rationale for the development of Sandimmune Neoral. Transplant Proc 1994; 26: 2925.
18. Farges O, Haddad N, Girault D, Cabiac MD, Samuel D, Bismuth H. Conversion from cyclosporine Sandimmun to cyclosporine Neoral in liver transplant patients with cholestasis or external biliary drainage. Transplant Proc 1995; 27: 2506.
19. Trull AK, Tan KKC, Tan L, Alexander GJM, Jamieson NV. Enhanced absorption of new oral cyclosporin microemulsion formulation, Neoral in liver transplant recipients with external biliary diversion. Transplant Proc 1994; 26: 2977.
20. Mueller EA, Kallay Z, Kovarik JM, et al. Bile-independent absorption of cyclosporine from a microemulsion formulation in liver transplant patients. Transplantation 1995; 60: 515.
21. Drewe J, Mejer R, Vonderscher J, et al. Enhancement of the oral absorption of cyclosporin in man. Br J Clin Pharmacol 1993; 34: 60.
22. Holt DW, Mueller EA, Kovarik JM, van Bree JB, Kutz K. The pharmacokinetics of Sandimmun Neoral: a new oral formulation. Transplant Proc 1994; 26: 2935.
23. Levy G, Rochon D, Freeman D, et al. Cyclosporine Neoral in liver transplant recipients. Transplant Proc 1994; 26: 2949.