Reaction properties of immobilized catalytic antibodies that deprotect acylated carbohydrates

Journal of Fermentation and Bioengineering

Volumn 82, Issue 5, 1996, Pages 452-457

  Kondo, Akihiko ^a   Fukuda, Hideki ^a   Iwabuchi, Yoshiharu ^b   Fujii, Ikuo ^b  

^a KOBE UNIVERSITY   (Japan)

^b BIOMOL ENG RESEARCH INSTITUTE   (Japan)

Author keywords

acylated carbohydrates; catalytic antibody; immobilization; regio and stereoselective deprotection

Indexed keywords

ACYLATION; ANTIGEN BINDING; ARTICLE; CARBOHYDRATE ANALYSIS; CARBOHYDRATE METABOLISM; CATALYSIS; CATALYST; CELL PROTECTION; STEREOCHEMISTRY;

EID: 0030443965     PISSN: 0922338X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0922-338X(97)86982-6     Document Type: Article

References (13)

1. Pollack, S. J., Jacobs, J. W., and Schnltz, P. G.: Selective chemical catalysis by an antibody. Science, 234, 1570-1572 (1986).
2. Tramontano, A., Janda, K. D., and Lerner, R. A.: Catalytic antibodies. Science, 234, 1566-1570 (1986).
3. Napper, A. D., Benkovic, S. J., Tramontano, A., and Lerner, R. A.: A stereospecific cyclization catalyzed by an antibody. Science, 237, 1041-1043 (1987).
4. Janda, K. D., Benkovic, S. J., and Lerner, R. A.: Catalytic antibodies with lipase activity and R or S substrate selectivity. Science, 244, 437-440 (1989).
5. Janda, K. D., Ashley, J. A., Jones, T. M., McLeod, D. A., Schloeder, D. M., and Weinhouse, M. I.: Immobilized catalytic antibodies in aqueous and organic solvents. J. Am. Chem. Soc., 112, 8886-8888 (1990).
6. Gouverneur, V. E., Houk, K. N., Pascual-Teresa, B., Beno, B., Janda, K. D., and Lerner, R. A.: Control of the exo and endo pathways of the Diels-Alder reaction by antibody catalysis. Science, 262, 204-208 (1993).
7. Hsieh, L. C., Yonkovich, S., Kochersperger, L., and Schults, P. G.: Controlling chemical reactivity with antibodies. Science, 260, 337-339 (1993).
8. Janda, K. D., Shevlin, C. G., and Lerner, R. A.: Antibody catalysis of a disfavored chemical transformation. Science, 259, 490-493 (1993).
9. Miyashita, H., Karaki, Y., Kikuchi, M., and Fujii, I.: Prodrug activation via catalytic antibodies. Proc. Natl. Acad. Sci. USA, 90, 5337-5340 (1993).
10. Iwabuchi, Y., Miyashita, H., Tanimura, R., Kinoshita, K., Kikuchi, M., and Fujii, I.: Regio- and stereoselective deprotection of acylated carbohydrates via catalytic antibodies. J. Am. Chem. Soc., 116, 771-772 (1994).
11. Sada, E., Katoh, S., Kondo, A., and Kiyokawa, A.: Effects of coupling method and ligand concentration on adsorption equilibrium in immune-affinity chromatography. J. Chem. Eng. Japan, 19, 502-506 (1986).
12. Sada, E., Katoh, S., Sukai, K., Tohma, M., and Kondo, A.: Adsorption equilibrium in immuno-affinity chromatography with polyclonal and monoclonal antibodies. Biotechnol. Bioeng., 28, 1497-1502 (1986).
13. Sada, E., Katoh, S., Yamanaka, K., and Sohma, Y.: Effects of antigen molecular weight on immunoadsorption equilibrium in immunoaffinity chromatography. J. Ferment. Bioeng., 68, 37-39 (1989).