Sevoflurane inhibits human platelet aggregation and thromboxane A 2 formation, possibly by suppression of cyclooxygenase activity

Anesthesiology

Volumn 85, Issue 6, 1996, Pages 1447-1453

  Hirakata, Hideo ^a   Ushikubi, Fumitaka ^b   Toda, Hiroshi ^c   Nakamura, Kumi ^c   Sai, Satoko ^a   Urabe, Nobukata ^a   Hatano, Yoshio ^d   Narumiya, Shuh ^c   Mori, Kenjiro ^b  

^a Kitano Hospital   (Japan)

^b KYOTO UNIVERSITY FACULTY OF MEDICINE   (Japan)

^c KYOTO UNIVERSITY HOSPITAL   (Japan)

^d WAKAYAMA MEDICAL UNIVERSITY   (Japan)

Author keywords

Anesthetic, volatile: sevoflurane; halothane; isoflurane; Blood: platelets, aggregation; Eicosanoids: thromboxane A 2; prostaglandin G 2; arachidonic acid

Indexed keywords

7 (3 BENZENESULFONAMIDOBICYCLO[2.2.1]HEPT 2 YL) 5 HEPTENOIC ACID; 9,11 EPITHIO 11,12 METHANOTHROMBOXANE A2; ADENOSINE DIPHOSPHATE; ADRENALIN; ARACHIDONIC ACID; HALOTHANE; INDOMETACIN; INHALATION ANESTHETIC AGENT; ISOFLURANE; PROSTAGLANDIN G2; PROSTAGLANDIN SYNTHASE; SEVOFLURANE; THROMBOXANE A2; THROMBOXANE RECEPTOR BLOCKING AGENT;

ANESTHESIA MECHANISM; ARACHIDONIC ACID METABOLISM; ARTICLE; BLEEDING TIME; CONTROLLED STUDY; DOSE RESPONSE; ENZYME ACTIVITY; HUMAN; HUMAN CELL; INHALATION ANESTHESIA; MINIMUM LUNG ALVEOLUS CONCENTRATION; PRIORITY JOURNAL; THROMBOCYTE AGGREGATION;

ADENOSINE DIPHOSPHATE; ANESTHETICS, INHALATION; ARACHIDONIC ACID; BINDING SITES; DRUG INTERACTIONS; EPINEPHRINE; ETHERS; HALOTHANE; HUMANS; ISOFLURANE; METHYL ETHERS; PLATELET AGGREGATION; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; RADIOIMMUNOASSAY; THROMBOXANE A2; THROMBOXANE B2;

EID: 0030443842     PISSN: 00033022     EISSN: None     Source Type: Journal    
DOI: 10.1097/00000542-199612000-00027     Document Type: Article

References (17)

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