MIC2 gene expression in cutaneous neuroendocrine carcinoma (Merkel cell carcinoma)

Applied Immunohistochemistry and Molecular Morphology

Volumn 4, Issue 4, 1996, Pages 235-240

  Soslow, Robert A ^a   Wallace, Michael ^b   Goris, Jose ^c   Pedemonte Coira, Bader Maria ^d   Smoller, Bruce R ^b  

^a WEILL CORNELL MEDICAL CENTER   (United States)

^b STANFORD UNIVERSITY MEDICAL CENTER   (United States)

^c College of Physicians and Surgeons ^*  (United States)

^d Gencare Laboratories   (United States)

Author keywords

12E7; CD99; Merkel cell carcinoma; MIC2; Neuroendocrine carcinoma

Indexed keywords

CD99 ANTIGEN; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; GENE EXPRESSION; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MERKEL CELL TUMOR; NEUROENDOCRINE TUMOR; ONCOGENE MIC; PRIORITY JOURNAL;

EID: 0030443445     PISSN: 10623345     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (29)

1. Fellinger EJ, Garin-Chesa P, Su SL, DeAngelis P, Lane JM, Rettig WJ. Biochemical and genetic characterization of the HBA71 Ewing's sarcoma cell surface antigen. Cancer Res 1991;51:336-40.
2. Smith MJ, Goodfellow PJ, Goodfellow PN. The genomic organisation of the human pseudoautosomal gene MIC2 and the detection of a related locus. Hum Mol Genet 1993;2:417-22.
3. Ambros IM, Ambros PJ, Strehl S, Kovar H, Gadner H, Salzer-Kuntschik M. MIC2 is a specific marker for Ewing's sarcoma and peripheral primitive neuroectodermal tumors. Cancer 1991;67: 1886-93.
4. Fellinger EJ, Garin-Chesa P, Triche TJ, Huvos AG, Rettig WJ. Immunohistochemical analysis of Ewing's sarcoma cell surface antigen p30/32 MIC2. Am J Pathol 1991;139:317-25.
5. Ladanyi M, Lewis R, Garin-Chesa P, et al. EWS rearrangement in Ewing's sarcoma and peripheral neuroectodermal tumor: molecular detection and correlation with cytogenetic analysis and MIC2 expression. Diagn Mol Pathol 1993;2:141-6.
6. Perlman EJ, Dickman PS, Askin FB, Grier HE, Miser JS, Link MP. Ewing's sarcoma: routine diagnostic utilization of MIC2 analysis. Hum Pathol 1994;25:304-7.
7. Ramani P, Rampling D, Link M. Immunocytochemical study of 12E7 in small round-cell tumors of childhood: an assessment of its sensitivity and specificity. Histopathology 1993;23:557-61.
8. Weidner N, Tjoe J. Immunohistochemical profile of monoclonal antibody O13: antibody that recognizes glycoprotein p30/32 MIC2 and is useful in diagnosing Ewing's sarcoma and peripheral neuroepithelioma. Am J Surg Pathol 1994;18:486-94.
9. Levy R, Dilley J, Fox RI, Warnke R. A human thymus-leukemia antigen defined by hybridoma monoclonal antibodies. Proc Natl Acad Sci USA 1979;76:6552-6.
10. Riopel M, Dickman PS, Link MP, Perlman EJ. MIC2 analysis in pediatric lymphomas and leukemias. Hum Pathol 1994;25:396-9.
11. Soslow RA, Bhargava V, Warnke RA. 12E7 reactivity distinguishes lymphoblastic lymphoma from small non-cleaved cell lymphoma. Mod Pathol 1995;1:121A.
12. Stevenson AJ, Chatten J, Bertoni F, Miettenen M. CD99 (p30/32 MIC2) neuroectodermal/Ewing's sarcoma antigen as an immunohistochemical marker: review of more than 600 tumors and the literature experience. Appl Immunohistochem 1994;2:231-40.
13. Lumadue JA, Askin FB, Perlman E. MIC2 analysis of small cell carcinoma. Am J Clin Pathol 1994;102:692-4.
14. Renshaw AA. O13 (CD99) in spindle cell tumors: reactivity with hemangiopericytoma, solitary fibrous tumor, synovial sarcoma, and meningioma, but rarely with sarcomatoid mesothelioma. Appl Immunohistochem 1995;3:250-6.
15. Hamilton G, Fellinger EJ, Schratter I, Fritsch A. Characterization of a human endocrine tissue and tumor-associated Ewing's sarcoma antigen. Cancer Res 1988;48:6127-34.
16. Bodger MP, Francis GE, Delia D, Granger SM. A monoclonal antibody specific for immature human hematopoietic cells and T lineage cells. J Immunol 1981;127:2269-74.
17. Burgoyne PS. Genetic homology and crossing over in the X and Y chromosomes of mammals. Hum Genet 1982;61:85-90.
18. Goodfellow PJ, Darling SM, Thomas NS, Goodfellow PN. A pseudoautosomal gene in man. Science 1986;234:740-3.
19. Gelin C, Aubrit F, Phalipon A, et al. The E2 antigen, a 32 kd glycoprotein involved in T-cell adhesion processes, is the MIC2 gene product. EMBO J 1989;8:3253-9.
20. Haneke E, Schulze H-J, Mahrle G. Immunohistochemical and immunoelectron microscopic demonstration of chromogranin A in formalin-fixed tissue of Merkel cell carcinoma. J Am Acad Dermatol 1993;28:222-6.
21. Sibley RK, Rosai J, Foucar E, et al. Neuroendocrine (Merkel cell) carcinoma of the skin: a histologic and ultrastructural study of two cases. Am J Surg Pathol 1980;4:211-21.
22. Wick MR, Goellner JR, Scheithauer BW, Thomas JR III, Sanchez NP, Schroeter AL. Primary neuroendocrine carcinomas of the skin (Merkel cell tumors). Am J Clin Pathol 1983;79:6-13.
23. Visscher D, Cooper PH, Zarbo RJ, Crissman JD. Cutaneous neuroendocrine (Merkel cell) carcinoma: an immunophenotypic, clinicopathologic, and flow cytometric study. Mod Pathol 1989;2: 331-8.
24. Shah IA, Netto D, Schlageter M-O, Muth C, Fox I, Manne RK, Rao K. Neurofilament immunoreactivity in Merkel-cell tumors: a differentiating feature from small-cell carcinoma. Mod Pathol 1993;6:3-9.
25. Cooper K, Haffajee Z. Immunohistochemical assessment of MIC2 gene product in granulocytic sarcoma using six epitope retrieval systems. Appl Immunohistochem 1995;3:198-210.
26. Moll I, Kuhn C, Moll R, Cytokeratin 20 is a general marker of cutaneous Merkel cells while certain neuronal proteins are absent. J Invest Dermatol 1995;104:910-5.
27. Moll R, Lowe A, Laufer J, Franke WW. Cytokeratin 20 in human carcinomas. A new histodiagnostic marker detected by monocloncal antibodies Am J Pathol 1992;140:427-17.
28. Wang NP, Zee S, Zarbo RJ, Bacchi CE, Gown AM. Coordinate expression of cytokeratins 7 and 20 defines unique subsets of carcinomas. Appl Immunohistochem 1995;3:99-107.
29. Perlman EJ, Lumadue JA, Hawkins AL, Cohen K, Colombani P, Griffin CA. Primary cutaneous neuroendocrine tumors: diagnostic use of cytogenetic and MIC2 analysis. Cancer Genet Cytogenet 1995;82:30-4.