Localization of p53 and proliferating cell nuclear antigen in fine-needle aspirates of benign and primary malignant tumors of the human breast: An immunocytochemical study using supersensitive monoclonal antibodies and the biotin-streptavidin-amplified method

Diagnostic Cytopathology

Volumn 15, Issue 4, 1996, Pages 277-281

  Alexiev, Borislav A ^a  

^a MEDICAL UNIVERSITY OF SOFIA   (Bulgaria)

Author keywords

Breast tumors; Fine needle aspiration biopsy; p53; PCNA

Indexed keywords

BIOTIN; CYCLINE; MONOCLONAL ANTIBODY; PROTEIN P53; STREPTAVIDIN;

ADULT; AGED; ANTIGEN EXPRESSION; ARTICLE; ASPIRATION BIOPSY; ASPIRATION CYTOLOGY; BREAST BIOPSY; BREAST CARCINOMA; BREAST TUMOR; CANCER CYTODIAGNOSIS; FEMALE; HISTOLOGY; HUMAN; HUMAN TISSUE; IMMUNOCYTOCHEMISTRY; MAJOR CLINICAL STUDY; NEEDLE BIOPSY; PRIORITY JOURNAL; PROGNOSIS;

ADULT; AGED; ANTIBODIES, MONOCLONAL; BACTERIAL PROTEINS; BIOPSY, NEEDLE; BIOTIN; BREAST NEOPLASMS; CARCINOMA; FIBROADENOMA; HUMANS; MIDDLE AGED; PROLIFERATING CELL NUCLEAR ANTIGEN; REAGENT KITS, DIAGNOSTIC; STAINING AND LABELING; STREPTAVIDIN; TUMOR MARKERS, BIOLOGICAL; TUMOR SUPPRESSOR PROTEIN P53;

EID: 0030442823     PISSN: 87551039     EISSN: None     Source Type: Journal    
DOI: 10.1002/(sici)1097-0339(199611)15:4<277::aid-dc5>3.3.co;2-9     Document Type: Article

References (20)

1. Alexiev BA, Valkov IN, Popov AA, Marinov VS. Immunocytochemical detection of carcinoembryonic antigen in fine-needle aspirates from patients with diverse breast diseases. Diagn Cytopathol 1993;4:377-382.
2. Bartek J, Iggo R, Gannon J, Lane DP. Genetic and immunochemical analysis of mutant p53 in human breast cancer cell lines. Oncogene 1990;5:893-899.
3. Bartkova J, Bartek J, Vojtesek B, et al. Immunochemical analysis of p53 oncoprotein in matched primary and metastatic human tumours. Eur J Cancer 1993;29:881-886.
4. Bernard NJ, Hall PA, Lemoine NR, Kadar N. Proliferative index in breast carcinoma determined in situ by Ki67 immunostaining and its relationship to clinical and pathological variables. J Pathol 1987;152; 287-295.
5. Coddington R, Cuthbert A, Campbell ID, et al. Determination of Ki67 growth fraction and oestrogen receptors in screendetected breast cancer using cytological preparations. Cytopathology 1993;4:217-266.
6. Dabbs DJ. Role of nuclear grading of breast carcinomas in fine needle aspiration specimens. Acta Cytol 1993;37:361-366.
7. Delmolino L, Band H, Band V. Expression and stability of p53 protein in normal human mammary epithelial cells. Carcinogenesis 1993;14: 827-832
8. Domagala W, Harezga B, Szadowska A, Markiewski M, Weber K, Osborn M. Nuclear p53 protein accumulates preferentially in medullary and high-grade ductal but rarely in lobular breast carcinomas. Am J Pathol 1993;142:669-674.
9. Drobnjak M, Cote RJ, Saad AD, Drudis T, Fuks Z, Cordoncardo C. P53 and rb alterations in primary breast carcinoma - Correlation with hormone receptor expression and lymph node metastases. Int J Oncol 1993; 2:173-178.
10. Frierson HF. Immunohistochemical analysis of proliferating cell nuclear antigen (PCNA) in infiltrating ductal carcinomas - Comparison with clinical and pathologic variables. Mod Pathol 1993;6:290-294.
11. Illustrated guide to the TNM/pTNM classification of malignant tumours. 3rd ed. 2nd revision. Springer-Verlag, 1992:185-195.
12. Lee AKC, Wiley B, Loda M, et al. DNA ploidy, proliferation, and neuoncogene protein overexpression in breast carcinoma. Mod Pathol 1992; 5:61-67.
13. Masood S. Use of monoclonal antibody for assessment of estrogen receptor content in fine-needle aspiration biopsy specimen for patients with breast cancer. Arch Pathol Lab Med 1989;113:26-30.
14. Noguchi M, Thomas M, Kitagawa H, Kinoshita K, Miyazaki I, Mizukami Y. PCNA expression and ag-NOR score in breast cancer - Correlation with clinicopathologic variables and patient survival. Int J Oncol 1993;2:265-269.
15. Noguchi M, Kitagawa H, Kinoshita K, Miyazaki I, Saito Y, Mizukami Y. Prognostic significance of p53 and c-erbB-2 expression in operable breast cancer. Int J Oncol 1993;2:587-591.
16. Siitonen SM, Kallioniemi OP, Isola JJ. Proliferating cell nuclear antigen immunohistochemistry using monoclonal antibody 19A2 and a new antigen retrieval technique has prognostic impact in archival paraffin-embedded node negative breast cancer. Am J Pathol 1993;142: 1081-1089.
17. Thorlacius S, Borresen AL, Eyfjord JE. Somatic p53 mutations in human breast carcinomas in an Icelandic population - A prognostic factor. Cancer Res 1993;53.1637-1641.
18. Tsuda H, Iwaya K, Fukutomi T, Hirohashi S. p53 mutations and c-erbB-2 amplification in intraductal and invasive breast carcinomas of high histologic grade. Jpn J Cancer Res 1993;84:394-401.
19. Walker RA. Biological markers in human breast carcinoma. J Pathol 1982;137:109-117.
20. WHO. International histological classification of tumours. Histological typing of breast tumours. Geneva: WHO, 1981: