Platelets from bleeding simmental cattle have a long delay in both ADP-activated expression of GpIIB-IIIA receptors and fibrinogen-dependent platelet aggregation

Thrombosis and Haemostasis

Volumn 76, Issue 6, 1996, Pages 1047-1052

  Frojmovic, Mony M ^a,c   Wong, Truman ^a   Searcy, Gene P ^b  

^a MCGILL UNIVERSITY   (Canada)

^b UNIVERSITY OF SASKATCHEWAN   (Canada)

^c McIntyre Medical Building ^*  (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE DIPHOSPHATE; ANTIBODY; CALCIMYCIN; COLLAGEN; FIBRINOGEN; FIBRINOGEN RECEPTOR; FLUORESCEIN ISOTHIOCYANATE; MYOSIN LIGHT CHAIN;

ANIMAL CELL; ARTICLE; BLEEDING; CALCIUM MOBILIZATION; CATTLE; CONTROLLED STUDY; CYTOSKELETON; FLOW CYTOMETRY; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN PHOSPHORYLATION; RECEPTOR BINDING; THROMBOCYTE AGGREGATION;

EID: 0030442595     PISSN: 03406245     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-0038-1650705     Document Type: Article

References (20)

1. Searcy GP, Frojmovic MM, McNicol A, Robertson C, Wong T, Gerrard John M. Platelets from bleeding Simmental cattle mobilize calcium, phosphorylate myosin light chain and bind normal numbers of fibrinogen molecules but have abnormal cytoslcelelal assembly and aggregation in response to ADP. Thromb Haemost 1994; 71: 240-6.
2. Searcy GP, Petrie L. Clinical and laboratory findings of a bleeding disorder in Simmental cattle. Can Vet J 1990; 31: 101-3.
3. Searcy GP, Sheridan D, Dobson KA. Preliminary studies of a platelet function disorder in Simmental cattle. Can J Vet Res 1990; 54: 394-6.
4. Frojmovic MM, Milton J, Gear A. Platelet aggregation measured in vitro by microscopic and electronic particle counting methods. Methods Enzymol 1989; 169: 134-9.
5. Frojmovic MM, Mooney RM, Wong T. Dynamics of platelet glycoprotein IIb-IIIa receptor expression and fibrinogen binding II. Quantal activation parallels platelet capture in stirdependent microaggregation. Biophys J 1994; 67: 2069-75.
6. Phillips DR, Charo IF, Parise LV, Fitzgerald LA. The platelet membrane glycoprotein IIb-IIIa complex. Blood 1988; 71: 831-43.
7. Frojmovic MM, Wong T, van de Ven T. Dynamic measurements of the platelet membrane glycoprotein IIb-IIIa receptor for fibrinogen by flow cytometry: I. Methodology, theory, and results for two distinct activators. Biophys J 1991; 59: 815-27.
8. Shattil SJ, Cunningham M, Hoxie JA. Detection of activated platelets in whole blood using activation-dependent monoclonal antibodies and flow cytometry. Blood 1987; 70: 307-15.
9. Xia Z, Frojmovic MM. Aggregation efficiency of activated normal or fixed platelets in a simple shear field: Effect of shear and fibrinogen occupancy. Biophys J 1994; 66: 2190-201.
10. Xia Z, Wong T, Liu Q, Kasirer-Friede A, Brown E, Frojmovic MM. Optimally-functional fluorescein isothiocyanate (FITC)-labelled fibrinogen for quantitative studies of binding to activated platelets and platelet aggregation. Br J Haematol 1996; 93: 204-14.
11. Frelinger AL III, Cohen I, Plow EF, Smith MA, Roberts J, Lam SC-T, Ginsberg MH. Selective inhibition of integrin function by antibodies specific for ligand-occupied receptor conformers. J Biol Chem 1990; 265: 6346-52.
12. Frojmovic MM, Mooney RM, Wong T. Dynamics of platelet glycoprotein IIb-IIIa receptor expression and fibrinogen binding I. Quantal activation of platelet subpopulations varies with adenosine diphosphate concentration. Biophys J 1994; 67: 2060-8.
13. Ugarova TP, Budzynski AZ, Shattil SJ, Ruggeri ZM, Ginsberg MH, Plow EF. Conformational changes in fibrinogen elicited by its interaction with platelet membrane glycoprotein IIb-IIIa. J Biol Chem 1993; 268: 21080-7.
14. Ginsberg MH, Frelinger AL, Lam SCT, Forsyth J, McMillan R, Plow EF, Shattil SJ. Analysis of platelet aggregation disorders based on flow cytometric analysis of membrane glycoprolein IIb-IIIa with conformation-specific monoclonal antibodies. Blood 1990; 76: 2017-23.
15. Ginsberg MH, Lightsey A, Kunicki TJ, Kaufman A, Marguerie GA, Plow EF. Divalent cation regulation of the surface orientation of platelet membrane glycoprotein IIb: Correlation with fibrinogen binding function and definition of a novel variant of Glanzmann's thrombasthenia. J Clin Invest 1986; 78: 1103-11.
16. 3 (glycoprotein IIb-IIIa) in a variant of Glanzmann thrombasthenia. Proc Natl Acad Sci USA 1992; 89: 10169-73.
17. Sullivan PS, Grubbs ST, Olchowy TWJ, Andrews FM, White JG, Catalfamo JL, Dodd PA, McDonald TP. Bleeding diathesis associated with variant von Willebrand factor in a Simmental calf. J Am Vet Med Assoc 1994; 205: 1763-6.
18. Ruggeri ZM. Mechanisms of shear-induced platelet adhesion and aggregation. Thromb Haemost 1993; 70: 119-23.
19. Plow EF, Pierschbacher MD, Ruoslahti E, Marguerie G, Ginsberg MH. The effect of ARG-GLY-ASP-containingpeptides on fibrinogen and von Willebrand factor binding to platelets. Proc Natl Acad Sci USA 1985; 82: 8057-61.
20. Piétu G, Cherel G, Marguerie G, Meyer D. Inhibition of von Wiltebrand factor-platelet interaction by fibrinogen. Nature 1984; 308: 648-9.