The application of factorial design to evaluate granular formation in a fluidized-bed granulator

Chinese Pharmaceutical Journal

Volumn 48, Issue 5, 1996, Pages 355-365

  Kao, Ching Cheng ^a   Tsai, Chin San ^a   Chen, Shou Chiung ^a   Sheu, Ming Thau ^a  

^a TAIPEI MEDICAL UNIVERSITY   (Taiwan)

Author keywords

factorial design; fluidized bed granulator; geometric mean diameter; granule; process

Indexed keywords

LACTOSE;

ARTICLE; DRUG DESIGN; DRUG FORMULATION; MULTIPLE REGRESSION; PARTICLE SIZE; TABLET MANUFACTURE; TEMPERATURE;

EID: 0030440728     PISSN: 10161015     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (7)

1. Banker, G. S. Tablet and Tablet Product Design. in Sprowl's American Pharmacy, 7th ed.; L. Dittert, W. ed.; J. B. Lippincott Co. 1974; p 362.
2. Alkan, M. H.; Yuksel, A. Granulation in a Fluidized Bed II: Effect of Binder Amount on the Final Granule. Drug Dev. and Ind. Pharm. 1986, 12, 1529-1543.
3. Jones, D. M. Factors to Consider in Fluid Bed Processing. Pharm. Tech. 1985, 9, 50-62.
4. Gore, A. Y.; Mcfarland, D. W.; Batuyios, N. H. Fluid-bed Granulation: Factors Affecting the Process in the Laboratory Development and Production Scale-up. Pharm. Tech. 1985, 9, 114-122.
5. Jones, D. M. Introduction to Fluid-bed Granulating, 1988, by Glatt Air Technique Co., Germany.
6. Stetsko, G. Statistical Experimental Design and Its Application to Pharmaceutical Development Problems. Drug Dev. and Ind. Pharm. 1986, 12, 1109-1123.
7. "SAS System for Elementary Statistical Analysis", 1987, by SAS Institute Inc., Cary, NC, USA.