Pharmacological targeting of signaling pathways in protein kinase C-stimulated superoxide generation in neutrophil-like HL-60 cells: Effect of phorbol ester, arachidonic acid and inhibitors of kinase(s), phosphatase(s) and phospholipase A2

Journal of Pharmacology and Experimental Therapeutics

Volumn 279, Issue 2, 1996, Pages 633-644

  Mayer, Alejandro M S ^a   Brenic, Susan ^b   Glaser, K B ^c  

^a MIDWESTERN UNIVERSITY   (United States)

^b MIDWESTERN UNIVERSITY   (United States)

^c ABBOTT LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 2 [1 (3 AMIDINOTHIOPROPYL) 1H INDOL 3 YL] 3 (1 METHYL 1H INDOL 3 YL)MALEIMIDE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; ALPHA METHYL 6 (2 QUINOLYLMETHOXY) 2 NAPHTHYLACETIC ACID; ARACHIDONIC ACID; ARSENOSOBENZENE; CALYCULIN A; CYCLOSPORIN A; DIAMIDE; ENZYME INHIBITOR; GENISTEIN; HERBIMYCIN A; MANOALIDE; N [4 METHYL 3 [4 (3 PYRIDINYL) 2 PYRIMIDINYLAMINO]PHENYL]BENZAMIDE; OKADAIC ACID; ORTHOVANADIC ACID; PHORBOL 13 ACETATE 12 MYRISTATE; PHOSPHOLIPASE A2 INHIBITOR; PHOSPHOPROTEIN PHOSPHATASE INHIBITOR; PROTEIN KINASE C; PROTEIN KINASE INHIBITOR; SCALARADIAL; SPHINGOSINE; STAUROSPORINE; SUPEROXIDE; TACROLIMUS; UNCLASSIFIED DRUG;

ARTICLE; CELL STRAIN HL 60; CONTROLLED STUDY; HUMAN; HUMAN CELL; NEUTROPHIL; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

ARACHIDONIC ACID; CA(2+)-CALMODULIN DEPENDENT PROTEIN KINASE; ENZYME INHIBITORS; HL-60 CELLS; HUMANS; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; NEUTROPHILS; PHOSPHOLIPASES A; PROTEIN KINASE C; PROTEIN KINASES; PROTEIN-TYROSINE KINASES; PROTEIN-TYROSINE-PHOSPHATASE; SUPEROXIDES; TETRADECANOYLPHORBOL ACETATE; TRETINOIN;

EID: 0030439223     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (130)

1. ABRAMSON, S. B., LESZCCZYNSKA-PIZIAK, J. AND WEISSMANN, G.: Arachidonic acid as a second messenger. J. Immunol. 147: 231-236, 1991.
2. AKIYAMA, T. AND OGAWARA, H.: Use and specificity of genistein as inhibitor of protein-tyrosine kinases. Methods Enzymol. 201: 362-370, 1991.
3. ALONSO, F., HENSON, P. M. AND LESLIE, C. C.: A cytosolic phospholipase in human neutrophils that hydrolyzes arachidonoyl-containing phosphatidylcholine. Biochim. Biophys. Acta 878: 273-280, 1986.
4. 2 oxidoreductase in human neutrophils after stimulation with phorbol myristate acetate. J. Biol. Chem. 265: 924-930, 1990.
5. AZUMA, E. K., KITAGAWA, S., YUO, A., MIZOGUCHI, H., UMEZAWA, K., TAKAKU, F. AND SAITO, M.: Activation of the respiratory burst and tyrosine phosphorylation in human neutrophils: No direct relationship and involvement of protein kinase C-dependent and -independent signaling pathways. Biochim. Biophys. Acta 1179: 213-223, 1993.
6. BABIOR, B.: The respiratory burst oxidase. Adv. Enzymol. 65: 49-95, 1992.
7. BADWEY, J. A., CURNUTTE, J. T. AND KARNOVSKT, M. L.: cis-Polyunsaturated fatty acids induce high levels of superoxide production by human neutrophils. J. Biol. Chem. 256: 12640-12643, 1981.
8. BADWEY, J. A., HORN, W., HEYWORTH, P. G., ROBINSON, J. M. AND KARNOVSKY, M. L.: Paradoxical effects of retinal in neutrophil stimulation. J. Biol. Chem. 264: 14947-14953, 1989.
9. BAGGIOLINI, M., BOULAY, F., BADWET, J. A. AND CURNUTTE, J. T.: Activation of neutrophil leukocytes: Chemoattractant receptors and respiratory burst. Fed. Am. Soc. Exp. Biol. J. 7: 1004-1010, 1993.
10. BARRET, J. M., ERNOULD, A. P., FERRY, G., GENTON, A. AND BOUTIN, J. A.: Integrated system for the screening of the specificity of protein kinase inhibitors. Biochem. Pharmacol. 46: 439-448, 1993.
11. 2 activation in human neutrophils. J. Biol. Chem. 263: 16787-16795, 1988.
12. BEERE, H. M. AND HICKMAN, J. A.: Differentiation: A suitable strategy for cancer chemotherapy? Anticancer Drug Design 299-322, 1993.
13. BERGSTRAND, H., ERIKSSON, T., HALLBERG, A., JOHANSSON, B., KARABELAS, K., MICHELSEN, P. AND NYBOM, A.: Modulation of neutrophil superoxide generation by inhibitors of protein kinase C, calmodulin, diacylglycerol and myosin light chain kinases and peptidyl prolyl cis-trans isomerase. J. Pharmacol. Exp. Ther. 263: 1334-1346, 1992.
14. 2+ in a protein kinase C-independent mechanism. Biochem. Biophys. Res. Commun. 144: 683-691, 1987.
15. BONSER, R. W., SIEGEL, M. I., CHUNG, S. M., MCCONNEL, R. T. AND CUATRECASAS, P.: Esterification of an endogenously synthesized lipoxygenase product into granulocyte cellular lipids. Biochemistry 20: 5301-5297, 1981a.
16. BONSER, R. W., SIEGEL, M. I., MCCONNEL, R. R. AND CUATRECASAS, P.: The appearance of phospholipase and cyclooxygenase activities in the human promyelocytic leukemia cell line HL-60 during dimethyl sulfoxide-induced differentiation. Biochem. Biophys. Res. Commun. 98: 614-620, 1981b.
17. BREITMAN, T. R., SELONICK, S. E. AND COLLINS, S. J.: Induction of differentiation of the human promyelocytic leukemia cell line (HL-60) by retinoic acid. Proc. Natl. Acad. Sci. U.S.A. 77: 2936-2940, 1980.
18. BROMBERG, Y. AND PICK, E.: Unsaturated fatty acids as second messengers of superoxide generation by macrophages. Cell. Immunol. 79: 240-252, 1983.
19. BUCHDUNGER, E., ZIMMERMANN, J., METT, H., MEYER, T., MULLER, M., REGENASS, U. AND LYDON, N. B.: Selective inhibition of the platelet-derived growth factor signal transduction pathway by a protein-tyrosine kinase inhibitor of the 2-phenylaminopyrimidine class. Proc. Natl. Acad. Sci. U.S.A. 92: 2558-2562, 1995.
20. BUDWORTH, J. AND GESCHER, A: Differential inhibition of cytosolic and membrane-derived protein kinase C activity by staurosporine and other kinase inhibitors. FEBS Lett. 362: 139-142, 1995.
21. 2. Cell. Signaling 7: 351-364, 1995.
22. BULANOVA, E. G. AND BUDAGYAN, V. M.: Protein phosphatases: Structure and function (A review). Mol. Biol. 28: 639-645, 1994.
23. 3 results in differentiation towards neutrophils or monocytes or a failure to differentiate and apoptosis. Leukemia 9: 410-418, 1995.
24. CASTAGNA, M., TAKAI, Y., KAIBUCHI, K., SANO, K., KIKKAWA, U. AND NISHIZUKA, Y.: Direct activation of calcium-activated, phospholipid-dependent protein kinase by tumor-promoting phorbol esters. J. Biol. Chem. 257: 7847-7851, 1982.
25. CHARLES, C. H., SUN, H., LAU, L. F. AND TONKS, N. K.: The growth factor-inducible immediate-early gene 3CH134 encodes a protein-tyrosine-phosphatase. Proc. Natl. Acad. Sci. U.S.A. 90: 5292-5296, 1993.
26. COBB, M. H., BOULTON, T. G. AND ROBBINS, D. J.: Extracellular signal-regulated kinases:ERKs in progress. Review. Cell. Regul. 2: 965-978, 1991.
27. COLLINS, S. J.: The HL-60 promyelocytic leukemia cell line: Proliferation, differentiation, and cellular oncogene expression. Blood 70: 1233-1244, 1987.
28. COLLINS, S. J., GALLO, R. C. AND GALLAGHER, R. E.: Continuous growth and differentiation of human myeloid leukemic cells in suspension culture. Nature (Lond.) 270: 347-349, 1977.
29. CROSS, A. R.: Inhibitors of the leukocyte superoxide generating oxidase. Free Rad. Biol. Med. 8: 71-93, 1990.
30. CURNUTTE, J. T., BADWEY, J. A., ROBINSON, J. M., KARNOVSKY, M. J. AND KARNOVSKY, M. L.: Studies on the mechanism of superoxide release from human neutrophils stimulated with arachidonate. J. Biol. Chem. 259: 11851-11857, 1984.
31. DANG, P. M.-C., RAIS, S., HAKIN, J. AND PERIANIN, A.: Redistribution of protein kinase C isoforms in human neutrophils stimulated by formyl peptides and phorbol myristate acetate. Biochem. Biophys. Res. Commun. 212: 664-672, 1995.
32. 2 by scalaradial. Biochem. Pharmacol. 42: 1621-1626, 1991.
33. DEGOS, L.: Retinoic acid in acute promyelocytic leukemia: A model for differentiation therapy. Curr. Opin. Oncol. 4: 45-52, 1992.
34. DENNIS, E. A., RHEE, S. G., BILLAH, M. M. AND HANNUN, Y. A.: Role of phospholipases in generating lipid second messengers in signal transduction. Fed. Am. Soc. Exp. Biol. J. 5: 2068-2077, 1991.
35. DEVALIA, V., THOMAS, N. S. B., ROBERTS, P. J., JONES, H. M. AND LINCH, D. C.: Down-regulation of human protein kinase C α is associated with terminal neutrophil differentiation. Blood 80: 68-76, 1992.
36. DIMITRIJEVIC, S. M., RYVES, W. J., PARKER, P. J. AND EVANS, F. J.: Characterization of phorbol ester binding to protein kinase C isotypes. Mol. Pharmacol. 48: 259-267, 1995.
37. DING, J. AND BADWEY, J. A.: Effects of antagonists of protein phosphatases on superoxide release by neutrophils. J. Biol. Chem. 267: 6442-6448, 1992.
38. phox movements in human neutrophils by tyrosine kinase inhibitors. J. Leuk. Biol. 58: 108-113, 1995.
39. DOUVILLE, E., DUNCAN, P., ABRAHAM, N. AND BELL, J. C.: Dual specificity kinases - A new family of signal transducer. Cancer Metastasis Rev. 13: 1-7, 1994.
40. DUDLEY, D. T., OLSON, A. L. AND BURNS, C. P.: Relationship of differentiation and prostaglandin production in human promyelocytic leukemia. In Prostaglandins and Cancer, ed. by T.J. Powles et al., pp. 487-491, Alan R. Liss, New York, 1982.
41. DUDLEY, D. T., PANG, L., DECKER, S. J., BRIDGES, A. J. AND SALTIEL, A. R.: A synthetic inhibitor of the mitogen-activated protein kinase cascade. Proc. Natl. Acad. Sci. U.S.A. 92: 7686-7689, 1995.
42. ERNOULD, A. P., FERRY, G., BARRET, J.-M., GENTON, A. AND BOUTIN, J. A.: Purification and characterization of the major tyrosine protein kinase from the human promyelocytic cell line, HL-60. Eur. J. Biochem. 214: 503-514, 1993.
43. FUKAZAWA, H., LI, P.-M., YAMAMOTO, C., MURAKAMI, Y., MIZUNO, S., UEHARA, Y.: Specific inhibition of cytoplasmatic protein tyrosine kinases by herbimycin A in vitro. Biochem. Pharmacol. 42: 1661-1671, 1991.
44. GALLAGHER, R., COLLINS, S., TRUJILLO, J., MCCREDIE, M., AHEARN, M., TSAI, S., METZGAR, R., AULAHK, G., TING, R., RUSCETTI, F. AND GALLO, R.: Characterization of the continuous, differentiating myeloid cell line (HL-60) from a patient with acute promyelocytic leukemia. Blood 54: 713-733, 1979.
45. GARCIA, R. C., WHITAKER, M., HEYWORTH, P. G. AND SEGAL, A. W.: Okadaic acid produces changes in phosphorylation and translocation of proteins and in intracellular calcium in human neutrophils. Biochem. J. 286: 687-692, 1992.
46. GAY, J. C., ENGLISH, D. AND LUKENS, J. N.: Stimulation of neutrophil oxidative metabolism by indomethacin. Agents Actions 16: 336-341, 1985.
47. GILBERT, C., GAUDRY, M. AND NACCACHE, P. H.: Rapid priming of calcium mobilization and superoxide anion production in human neutrophils by substimulatory concentrations of phorbol esters: A novel role for protein kinase C and tyrosine phosphorylation in the up-modulation of signal transduction. Cell. Signaling 4: 511-523, 1992.
48. 2 production in vivo. (Abstract). Fed. Proc. 3: 2866, 1989.
49. 2 enzymes: Regulation and inhibition. Trends Pharmacol. Sci. 14: 92-98, 1993.
50. 2 and macrophage lipid mediator production. Biorg. Med. Chem. Lett. 4: 1873-1878, 1994.
51. GORDON, J. A.: Use of vanadate as protein-phosphotyrosine phosphatase inhibitor. Methods Enzymol. 201: 477-482, 1991.
52. GRABER, R., SUMIDA, C., AND NUNEZ, E. A.: Review: Fatty acids and cell signal transduction. J. Lipid Mediators Cell. Signal 9: 91-116, 1994.
53. GREEN, S. P., HAMILTON, J. A. AND PHILLIPS, W. A.: Zymosan-triggered tyrosine phosphorylation in mouse bone-marrow-derived macrophages is enhanced by respiratory-burst priming agents. Biochem. J. 288: 427-432, 1992.
54. GREEN, S. P. AND PHILLIPS, W. A.: Activation of the macrophage respiratory burst by phorbol myristate acetate: Evidence for both tyrosine-kinase-dependent and -independent pathways. Biochim. Biophys. Acta 1222: 241-248, 1994.
55. GRIMES, D., STURM, R. J., MARINARI, L. R., CARLSON, R. P., BERKENKOPF, J. W., MUSSER, J. H., KREFT, A. F. AND WEICHMAN, B. M.: WY-50,295 tromethamine, a novel, orally active 5-lipoxygenase inhibitor: Biochemical characterization and antiallergic activity. Eur. J. Pharmacol. 236: 217-228, 1993.
56. GRINSTEIN, S., BUTLER, J. R., FURUYA, W., L'ALLEMAIN, G. AND DOWNEY, G. P.: Chemotactic peptides induce phosphorylation and activation of MEK-1 in human neutrophils. J. Biol. Chem. 269: 19313-19320, 1994.
57. GRINSTEIN, S. AND FURUYA, W.: Chemoattractant-induced tyrosine phosphorylation and activation of microtubule-associated protein kinase in human neutrophils. J. Biol. Chem. 267: 18122-18125, 1992.
58. HANNUN, Y. A., MERRILL, A. H., JR. AND BELL, R. M.: Use of sphingosine as inhibitor of protein kinase C. Methods Enzymol. 201: 316-328, 1991.
59. HARDIE, D. G., HAYSTEAD, T. A. AND SIM, A. T. R.: Use of okadaic acid to inhibit protein phosphatases in intact cells. Methods Enzymol. 201: 469-476, 1991.
60. HARRIS, P. AND RALPH, P: Human leukemic models of myelomonocytic development: A review of HL-60 and U937 cell lines. J. Leuk. Biol. 37: 407-422, 1985.
61. 2 inhibitors. Biochem. J. 264: 249-255, 1989.
62. HIRATA, F., NOTSU, F., MATSUDA, K., VASANTHAKUMAR, G., SCHIFFMANN, E., WONG, R. W. AND GOLDBERG, A. R.: Inhibition of leukocyte chemotaxis by Glu-Glu-Glu-Glu-Tyr-Pro-Met-Glu and Leu-Ile-Glu-Asp-Asn-Glu-Tyr-Thr-Ala-Arg-Gln-Gly. Biochem. Biophys. Res. Commun. 118: 682-690, 1984.
63. ISHIHARA, H., MARTIN, B. L., BRAUTIGAN, D. L., KARAKI, H., OZAKI, H., KATO, Y., FUSETANI, N., WATABE, S., HASHIMOTO, K., UEMURA, D. AND HARTSHORNE, D. J.: Calyculin A and okadaic acid: Inhibitors of protein phosphatase activity. Biochem. Biophys. Res. Commun. 159: 871-877, 1989.
64. 2 by the marine natural product, manoalide. Biochem. Pharmacol. 39: 1557-1564, 1990.
65. KHAN, W. A., BLOBE, G. C. AND HANNUN, Y. A.: Arachidonic acid and free fatty acids as second messengers and the role of protein kinase C. Cell. Signaling 7: 171-184, 1995.
66. KAPLAN, H. B., EDELSON, H. S., KORCHAK, H. M., GIVEN, W. P., ABRAMSON, S. AND WESISMANN, G.: Effects of non-steroidal anti-inflammatory agents on human neutrophil functions in vitro and in vivo. Biochem. Pharmacol. 33: 371-378, 1984.
67. KITAGAWA, S., OHTA, M., NOJIRI, H., KAKINUMA, K., SAITO, M., TAKAKU, F. AND MIURA, Y.: Functional maturation of membrane potential changes and superoxide-producing capacity during differentiation of human granulocytes. J. Clin. Invest. 73: 1062-1071, 1984.
68. KUSUNOKI, T., HIGASHI, H., HOSOI, S., HATA, D., SUGIE, K., MAYUMI, M. AND MIKAWA, H.: Tyrosine phosphorylation and its possible role in superoxide production by human neutrophils stimulated with FMLP and IgG. Biochem. Biophys. Res. Commun. 183: 789-796, 1992.
69. LE CABEC, V. AND MARIDONNEAU-PARINI, I.: Complete and reversible inhibition of NADPH oxidase in human neutrophils by phenylarsine oxide at a step distal to membrane translocation of the enzyme subunits. J. Biol. Chem. 270: 2067-2073, 1995.
70. LEE, J. C., LAYDON, J. T., MCDONNELL, P. C., GALLAGHER, T. F., KUMAR, S., GREEN, D., MCNULTY, D., BLUMENTHAL, M. J., HEYS, J. R., LANDVATTER, S. W., STRICKLER, J. E., MCLAUGHLIN, M. M., SIEMENS, I. R., FISHER, S. M., LIVI, G. P., WHITE, J. R., ADAMS, J. L. AND YOUNG, P. R.: A protein kinase involved in the regulation of inflammatory cytokine biosynthesis. Nature (Lond.) 372: 739-746, 1994.
71. LESTER, D. S., COLLIN, C., ETCHEBERRIGARAY, R. AND ALKON, D. L.: Arachidonic acid and diacylglycerol act synergistically to activate protein kinase C in vitro and in vivo. Biochem. Biophys. Res. Commun. 179: 1522-1528, 1991.
72. LEVY, R., DANA, R., LETO, T. L. AND MALECH, H. L.: The requirement of p47 phosphorylation for activation of NADPH oxidase by opsonized zymosan in human neutrophils. Biochim. Biophys. Acta 1220: 253-260, 1994.
73. LEVY, R., ROTROSEN, D., NAGAUKER, O., LETO, T. L. AND MALECH, H. L.: Induction of the respiratory burst in HL-60 cells. J. Immunol. 145: 2595-2601, 1990.
74. LIM, L. K., HUNT, N. H. AND WEIDEMAN, M. J.: Reactive oxygen production, arachidonate metabolism and cyclic AMP in macrophages. Biochem. Biophys. Res. Commun. 114: 549-555, 1983.
75. 2 is phosphorylated and activated by MAP Kinase. Cell 72: 269-278, 1993.
76. LU, D. J., TAKAI, A., LETO, T. L. AND GRINSTEIN, S.: Modulation of neutrophil activation by okadaic acid, a protein phosphatase inhibitor. Am. J. Physiol. 262: C39-C49, 1992.
77. MACKINSTOSH, C. AND MACKINTOSH, R. W.: Inhibitors of protein kinases and phosphatases. Trends Biochem. Sći. 19: 444-447, 1994.
78. MAKOWSKE, M., BALLESTER, R., CAYRE, Y. AND ROSEN, O. M.: Immunochemical evidence that three protein kinase C isozymes increase in abundance during HL-60 differentiation induced by dimethylsulfoxide and retinoic acid. J. Biol. Chem. 263: 3402-3410, 1988.
79. 2 in intact neutrophils but not in the cell free system. Biochem. Biophys. Res. Commun. 138: 1099-1105, 1986.
80. MAHIDONNEAU-PARINI, I., TRINGALE, S. M. AND TAUBER, A. I.: Identification of distinct activation pathways of the human neutrophil NADPH-oxidase. J. Immunol. 137: 2925-2929, 1986.
81. MARQUARDT, B., FRITH, D. AND STABEL, S.: Signaling from TPA to MAP kinase requires protein kinase C, raf and MEK: Reconstitution of the signaling pathway in vitro. Oncogene 9: 3213-3218, 1994.
82. 2, protein serine-threonine phosphatase(s), protein tyrosine kinase(s) and phosphatase(s). J. Pharmacol. Exp. Ther. 274: 427-436, 1995.
83. MAYER, A. M. S., GLASER, K. B. AND JACOBS, R. S.: Regulation of eicosanoid biosynthesis in vitro and in vivo by the marine natural product manoalide: A potent inactivator of venom phospholipases. J. Pharmacol. Exp. Ther. 244: 871-878, 1988.
84. MAYER, A. M. S. AND SPITZER, J. A.: Modulation of superoxide anion generation by manoalide, arachidonic acid and staurosporine in liver infiltrated neutrophils in a rat model of endotoxemia. J. Pharmacol. Exp. Ther. 267: 400-409, 1993.
85. MAYER, A. M. S. AND SPITZER, J. A.: Modulation of superoxide generation in in vivo lipopolysaccharide-primed Kupffer cells by staurosporine, okadaic acid, manoalide, arachidonic acid, genistein and sodium orthovanadate. J. Pharmacol. Exp. Ther. 268: 238-247, 1994.
86. 2+-dependent protein kinase. Science (Wash. DC) 234: 622-624, 1984.
87. MCPHAIL, L. C., QUALLIOTINE-MANN, D., AGWU, D. E. AND MCCALL, C. E.: Phospholipases and activation of the NADPH oxidase. Eur. J. Haematol. 51: 294-300, 1993.
88. MCPHAIL, L. C., STRUM, S. L., LEONE, P. A. AND SOZZANI, S.: The neutrophil respiratory burst mechanism. Immunol. Ser. 2: 47-75, 1992.
89. MEADE, C. J., TURNER, G. A. AND BATEMAN, P. E.: The role of polyphosphoinositides and their breakdown products in A23187 induced release of AA from rabbit polymorphonuclear leukocytes. Biochem. J. 238: 425-436, 1986.
90. 2 activity and tumor necrosis factor expression in HL-60 cells. J. Immunol. 144: 2678-2682, 1990.
91. MONTEIRO, H. P., IVASCHENKO, Y., FISCHER, R. AND STERN, A.: Inhibition of protein tyrosine phosphatase activity by diamide is reversed by epidermal growth factor in fibroblasts. FEBS Lett. 295: 146-18, 1991.
92. MOREL, F., DOUSSIERE, J. AND VIGNAIS, P. V.: The superoxide-generating oxidase of phagocytic cells. Eur. J. Biochem. 201: 523-546, 1991.
93. 2 activity on superoxide generation by human neutrophils. FEBS Lett. 234: 235-240, 1991.
94. MURAYAMA, A., SUZUKI, T. AND MATSUI, M.: Biological effect of 9-cis retinoic acid and 9,13-di-cis-retinoic acid on human acute promyelocytic leukemia cell line HL-60. Proc. Jpn. Acad. 69: 185-190, 1993.
95. NACCACHE, P. H., GILBERT, C., CAON, A. C., GAUDRY, M., HUANG, C. K., BONAK, V. A., UMEZAWA, K. AND MCCOLL, S. R.: Selective inhibition of human neutrophil functional responsiveness by erbstatin, an inhibitor of tyrosine protein kinase. Blood 78: 2098-2104, 1990.
96. NAKAMAKI, T., HINO, K.-I., YOKOYAMA, A., HISATAKE, J.-I., TOMOYASU, S., HONMA, Y., HOZUMI, M. AND TSURUOKA, N.: Effect of cytokines on the proliferation and differentiation of acute promyelocytic leukemia cells: Possible relationship to the development of "retinoic acid syndrome." Anticancer Res. 14: 817-824, 1994.
97. NATH, J., OHNO, Y., GALLIN, J. I. AND WRIGHT, D. G.: A novel post-translational incorporation of tyrosine into multiple proteins in activated human neutrophils. J. Immunol. 149: 3360-3371, 1992.
98. 2 by p42 microtubule-associated protein 2 kinase and protein kinase C. J. Biol. Chem. 268: 1960-1964, 1993.
99. NEWBURGER, P. E., CHOVANIEC, M. E., GREENBERGER, J. S. AND COHEN, H. J.: Functional changes in human leukemic cell line HL-60. J. Cell. Biol. 82: 315-322, 1979.
100. NEWBURGER, P. E., SPEIER, C., BORREGAARD, N., WALSH, C. E., WHITIN, J. C. AND SIMONS, E. R.: Development of the superoxide generating system during differentiation of the HL-60 human promyelocytic leukemia cell line. J. Biol. Chem. 259: 3771-3776, 1984.
101. NISHIZUKA, Y.: Protein kinase C and lipid signaling for sustained cellular responses. Fed. Am. Soc. Exp. Biol. J. 9: 484-496, 1995.
102. NIXON, J. S., BRADSHAW, D., DAVIS, P. D., HILL, C. H., ELLIOTT, L. H., KUMAR, H., LAWTON, G., LEWIS, E. J., MULQUEEN, M., WESTMACOTT, D., WADSWORTH, J. AND WILKINSON, S. E.: The design and biological properties of potent and selective inhibitors of protein kinase C. Biochem. Soc. Trans. 20: 419-425, 1992.
103. NOMURA, Y., KITAMURA, Y., TOHDA, M. AND TOKUMITSU, Y.: Drugs acting on the intracellular signaling system. Med. Res. Rev. 13: 1-60, 1993.
104. PHILLIPS, W. A., CROATTO, M., VEIS, N. AND HAMILTON, J. A.: Protein kinase C has both stimulatory and suppressive effects on macrophage superoxide production. J. Cell. Physiol. 152: 64-70, 1992.
105. POSADA, J. AND COOPER, J. A.: Molecular signal integration. Interplay between serine, threonine, and tyrosine phosphorylation. Mol. Biol. Cell. 3: 583-592, 1992.
106. POWIS, G.: Signaling pathways as targets for anticancer drug development. Pharmacol. Ther. 62: 57-95, 1994.
107. 2. J. Biol. Chem. 269: 19480-19487, 1994.
108. QUINTRELL, N., LEBO, R., VARMUS, H., BISHOP, J. M., PETTENATI, M. J., LE BEAU, M. M., DIAZ, M. O. AND ROWLEY, J. D.: Identification of a human gene (HCK) that encodes a protein-tyrosine kinase and is expressed in hemopoietic cells. Mol. Cell. Biol. 7: 2267-2275, 1987.
109. ROBINSON, J. M., HEYWORTH, P. G. AND BADWEY, J. A.: Utility of staurosporine in uncovering differences in the signal transduction pathways for superoxide production in neutrophils. Biochim. Biophys. Acta 1055: 55-62, 1990.
110. SEGER, R. AND KREBS, E. G.: The MAPK signaling cascade. Fed. Am. Soc. Exp. Biol. J. 9: 726-735, 1995.
111. SEYNAEVE, C. M., KAZANIETZ, M. G., BLUMBERG, P. M., SAUSVILLE, E. A. AND WORLAND, P. J.: Differential inhibition of protein kinase C isozymes by UCN-01, a staurosporine analog. J. Pharmacol. Exp. Ther. 45: 1207-1214, 1994.
112. SMITH, M. A., PARKINSON, D. R., CHESON, B. D. AND FRIEDMAN, M. A.: Retinoids in cancer therapy. J. Clin. Oncol. 10: 839 -864, 1992.
113. SMITH, R. L. AND WEIDEMANN, M. J.: Reactive oxygen production associated with arachidonic acid metabolism by peritoneal macrophages. Biochem. Biophys. Res. Commun. 97: 973-980, 1980.
114. STEINBECK, M. J., HEGG, G. G. AND KARNOVSKY, M. J.: Arachidonic activation of the neutrophil NADPH-oxidase. J. Biol. Chem. 266: 16336-16342, 1991.
115. TAMAOKI, T.: Use and specificity of staurosporine, UNC-01, and calphostin C as protein kinase inhibitors. Methods Enzymol. 201: 340-347, 1991.
116. 2+ dependent protein kinase. Biochem. Biophys. Res. Commun. 135: 397-402, 1986.
117. TAUBER, A. I. AND SIMONS, E. R.: Dissociation of human neutrophil membrane depolarization, respiratory burst stimulation and phospholipid metabolism by quinacrine. FEBS Lett. 156: 161-164, 1983.
118. THOMPSON, B. Y., SIVAM, G., BRITIGAN, B. E., ROSEN, G. M. AND COHEN, M. S.: Oxygen metabolism of the HL-60 cell line: Comparison of the effects of monocytoid and neutrophilic differentiation. J. Leuk. Biol. 43: 140-147, 1988.
119. TORRES, M., HALL, F. L. AND O'NEILL, K.: Stimulation of human neutrophils with formyl-methionyl-leucyl-phenylalanine-induces tyrosine phosphorylation and activation of two distinct mitogen-activated protein-kinases. J. Immunol. 150: 1563-1577, 1993.
120. UTSUMI, T., KLOSTERGAARD, J., AKIMARU, K., EDASHIGE, K., SATO, E. F. AND UTSUMI, K.: Modulation of TNF-α priming and stimulation-dependent superoxide generation in human neutrophils by protein kinase inhibitors. Arch. Biochem. Biophys. 294: 271-278, 1992.
121. VANE, J. R.: Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs. Nature New Biol. 231: 232-235, 1971.
122. WALSH, C. E., WAITE, B. M., THOMAS, M. J. AND DECHATELET, L. R.: Release and metabolism of arachidonic acid in human neutrophils. J. Biol. Chem. 256: 7228-7234, 1981.
123. WARRELL, R. P., JR., FRANKEL, S. R., MILLER, W. H., SCHEINBERG, D. A., ITRI, L. M., HITTELMAN, W. N., VYAS, R., ANDREEFF, M., TAFURI, A., JAKUBOWSKI, A., GABRILOVE, J., GORDON, M. S. AND DMITROVSKY, W.: Differentiation therapy of acute promyelocytic leukemia with tretinoin (all-trans-retinoic acid). New Engl. J. Med. 324: 1385-1393, 1991.
124. WENZEL-SEIFERT, K., SCHACHTELE, C. AND SEIFERT, R.: N-protein kinase C isoenzymes may be involved in the regulation of various neutrophil functions. Biochem. Biophys. Res. Commun. 200: 1536-1543, 1994.
125. WILSON, A. K., TAKAI, A. K., RUEGG, J. C. AND DE LANEROLLE, P.: Okadaic acid, a phosphatase inhibitor, decreases macrophage motility. Am. J. Physiol. 260: L105-L112, 1991.
126. 2 activity in undifferentiated and neutrophil-like HL-60 cells. J. Biol. Chem. 269: 3117-3124, 1994.
127. YAM, L. T., LI, C. Y. AND COSBY, W. W.: Cytochemical identification of monocytes and granulocytes. Am. J. Clin. Pathol. 55: 283-290, 1971.
128. YU, H., SUCHARD, S. J., NAIRN, R. AND JOVE, R.: Dissociation of mitogen-activated protein kinase activation from the oxidative burst in differentiated 5 day RA-treated HL-60 cells and human neutrophils. J. Biol. Chem. 270: 15719-15724, 1995.
129. ZHANG, Z.-Y.: Are protein-tyrosine phosphatases specific for phosphotyrosine? J. Biol. Chem. 270: 16052-16055, 1995.
130. ZHAO, Z., SHEN, S.-H. AND FISCHER, E. H.: Phorbol ester-induced expression, phosphorylation, and translocation of protein-tyrosine-phosphatase 1C in HL-60 cells. Proc. Natl. Acad. Sci. U.S.A. 91: 5007-5011, 1994.