Comparative clinical pharmacology of short-acting mu opioids in drug abusers

Journal of Pharmacology and Experimental Therapeutics

Volumn 277, Issue 3, 1996, Pages 1228-1236

  Greenwald, Mark K ^a,c   June, Harry L ^b,c   Stitzer, Maxine L ^c   Marco, Alan P ^c  

^a WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b INDIANA UNIVERSITY   (United States)

^c JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALFENTANIL; FENTANYL; MU OPIATE RECEPTOR; MU OPIATE RECEPTOR AGONIST; NALOXONE; PLACEBO;

ADULT; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DOSE RESPONSE; DRUG ABUSE; DRUG EFFECT; DRUG WITHDRAWAL; HUMAN; INTRAMUSCULAR DRUG ADMINISTRATION; INTRAVENOUS DRUG ADMINISTRATION; MALE; OPIATE ADDICTION; PRIORITY JOURNAL; PUPIL; RANDOMIZED CONTROLLED TRIAL; RESPIRATION DEPRESSION; WITHDRAWAL SYNDROME;

ADOLESCENT; ADULT; ALFENTANIL; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; FENTANYL; HUMANS; MALE; MIDDLE AGED; PUPIL; RECEPTORS, OPIOID, MU; RESPIRATION; SUBSTANCE-RELATED DISORDERS;

EID: 0030438717     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (52)

1. ANDREWS, C. J. H., SINCLAIR, M., PRYS-ROBERTS, C. AND DYE, A.: Ventilatory effects during and after continuous infusion of fentanyl or alfentanil. Br. J. Anaesth. 55: 211S-216S, 1983.
2. AZORLOSA, J., STITZER, M. L. AND GREENWALD, M. K.: Opioid physical dependence development: Effects of single versus repeated morphine pretreatments and of subjects' opioid exposure history. Psychopharmacology 114: 71-80, 1994.
3. BAILEY, P. L., STREISAND, J. B., EAST, K. A., EAST, T. D., ISERN, S., HANSEN, T. W., POSTHUWA, E. F. M., ROZENDAAL, F. W., PACE, N. L. AND STANLEY, T. H.: Differences in magnitude and duration of opioid-induced respiratory depression and analgesia with fentanyl and sufentanil. Anesth. Analg. 70: 8-15, 1990.
4. BICKEL, W. K., STITZER, M. L., LIEBSON, I. A. AND BIGELOW, G. E.: Acute physical dependence in man: Effects of naloxone after brief morphine exposure. J. Pharmacol. Exp. Ther. 244: 126-132. 1988.
5. BOAS, R. A. AND VILLIGER, J. W.: Clinical actions of fentanyl and buprenorphine. Br. J. Anaesth. 57: 192-196, 1985.
6. BOVILL, J. G.: Which potent opioid? Important criteria for selection. Drugs 33: 520-530, 1987.
7. BOWER, S. AND HULL, C. J.: Comparative pharmackinetics of fentanyl and alfentanil. Br. J. Anaesth. 54: 871-877, 1982.
8. BROWN, J. H., PLEUVRY, B. J. AND KAY, B.: Respiratory effects of a new opiate analgesic, R30209, in the rabbit: Comparison with fentanyl. Br. J. Anaesth. 52: 1101-1106, 1980.
9. COOKSON, R. F., NIEMEGEERS, C. J. E. AND BUSSCHE, G. V.: The development of alfentanil. Br. J. Anaesth. 55: 147S-155S, 1983.
10. DESIO, J. M., BACON, D. R., PEER, G. AND LEMA, M. J.: Intravenous abuse of transdermal fentanyl therapy in a chronic pain patient. Anesthesiology 79: 1139-1141, 1993.
11. EBLING, W. F., LEE, E. N. AND STANSKI, D. R.: Understanding pharmacokinetics and pharmacodynamics through computer simulation: I. The comparative clinical profiles of fentanyl and alfentanil. Anesthesiology 72: 650-658, 1990.
12. FRASER, H. F., VAN HORN, G. D., WOLBACH, A. B. AND ISBELL, H.: Methods for evaluating addiction liability. (A) "Attitude" of opiate addicts toward opiate-like drugs, (B) A short term "direct" addiction test. J. Pharmacol. Exp. Ther. 133: 371-387, 1961.
13. GHONEIM, M. M., MEWALDT, S. P. AND THATCHER, J. W.: The effect of diazepam and fentanyl on mental, psychomotor and electroencephalographic functions and their rate of recovery. Psychopharmacologia 44: 61-66, 1975.
14. HAYS, L. R., STILLNER, V. AND LITTRELL, R.: Fentanyl dependence associated with oral ingestion. Anesthesiology 77: 819-820, 1992.
15. HEISHMAN, S. J., STITZER, M. L., BIGELOW, G. E. AND LIEBSON I. A.: Acute opioid physical dependence in postaddict humans: naloxone dose effects after brief morphine exposure. J. Pharmacol. Exp. Ther. 248: 127-134, 1989a.
16. HEISHMAN, S. J., STITZER, M. L., BIGELOW, G. E. AND LIEBSON, I. A.: Acute opioid physical dependence in humans: Effect of varying the morphine-naloxone interval I. J. Pharmacol. Exp. Ther. 250: 485-491, 1989b.
17. HEISHMAN, S. J., STITZER, M. L., BIGELOW, G. E. AND LIEBSON, I. A.: Acute opioid physical dependence in humans: effect of naloxone at 6 and 24 hours postmorphine. Pharmacol. Biochem. Behav. 36: 393-399, 1990.
18. HENDERSON, G. L.: Designer drugs: Past history and future prospects. J. Forensic Sci. 33: 569-575, 1988.
19. HIBBS, J., PERPER, J. AND WINEK, C. L.: An outbreak of designer drug-related deaths in Pennsylvania. J. Am. Med. Assoc. 265: 1011-1033, 1991.
20. HOEHE, M.: Influence of the menstrual cycle on neuroendocrine and behavioral responses to an opiate agonist in humans: Preliminary results. Psychoneuroendocrinology 13: 339-344, 1988.
21. HOEHE, M., DUKA, T. AND DOENICKE, A.: Human studies on the mu opiate receptor agonist fentanyl: Neuroendocrine and behavioral responses. Psychoneuroendocrinology 13: 397-408, 1988.
22. HUGHES, M. A., GLASS, P. S. A. AND JACOBS, J. R.: Context-sensitive half-time in multicompartment pharmacokinetic models for intravenous anesthetic drugs. Anesthesiology 76: 334-341, 1992.
23. JAFFE, J. H. AND MARTIN, W. R.: Opioid analgesics and antagonists. In: The Pharmacological Basis of Therapeutics, ed. by A. G. Gilman, T. W. Rail, A. S. Niles and P. Taylor, 8th ed., pp. 485-521, Pergamon Press, New York, 1990.
24. JASINSKI, D. R.: Assessment of the abuse potential of morphine-like drugs (methods used in man). In: Drug Addiction I, ed. by W. R. Martin, vol. 45/1, pp. 197-258, Springer-Verlag, Heidelberg, 1977.
25. JASINSKI, D. R., JOHNSON, R. E. AND HENNINGFIELD, J. E.: Abuse liability assessment in human subjects. Trends Pharmacol. Sci. 5: 196-200, 1984.
26. JOHNSON, S. M. AND FLEMING, W. W.: Mechanisms of cellular adaptive sensitivity changes: Applications to opioid tolerance and dependence. Pharmacol. Rev. 41: 435-488, 1989.
27. JUNE, H. L., STITZER, M. L. AND CONE, E.: Acute physical dependence: time course and relation to human plasma morphine concentrations. Clin. Pharmacol. Ther. 57: 270-280, 1995.
28. KAY, B.: Postoperative pain relief: Use of an on-demand analgesia computer (ODAC) and a comparison of the rate of use of fentanyl and alfentanil. Anaesthesia 36: 949-951, 1981.
29. KIRBY, K. C. AND STITZEH, M. L.: Opioid physical dependence development in humans: Effect of time between agonist pretreatments. Psychopharmacology 112: 511-517, 1993.
30. KIRBY, K. C., STITZER, M. L. AND HEISHMAN, S. J.: Acute opioid physical dependence in humans: effect of varying the morphine-naloxone interval II. J. Pharmacol. Exp. Ther. 255: 730-737, 1990.
31. LUTSKY, I., HOPWOOD, M., ABRAM, S. E., JACOBSON, G. R., HADDOX, J. D. AND KAMPINE, J. P.: Psychoactive substance use among American anesthesiologists: A 30-year retrospective study. Can. J. Anaesth. 40: 915-921, 1993.
32. MANNER, T., KANTO, J. AND SALONEN, M.: Simple devices in differentiating the effects of buprenorphine from fentanyl in healthy volunteers. Eur. J. Clin. Pharmacol. 31: 673-676, 1987.
33. MARQUARDT, K. A. AND THARRATT, R. S.: Inhalation abuse of fentanyl patch. J. Toxicol. Clin. Toxicol. 32: 75-78, 1994.
34. MENK, E. J., BAUMGARTEN, R. K., KINGSLEY, C. P., CULLING, R. D. AND MIDDAUGH, R.: Success of reentry into anesthesiology training programs by residents with a history of substance abuse. J. Am. Med. Assoc. 263: 3060-3062, 1990.
35. MATUSSEK, N. AND HOEHE, M.: Investigations with the specific mu-opiate receptor agonist fentanyl in depressive patients: Growth hormone, prolactin, cortisol, noradrenaline and euphoric responses. Neuropsychobiology 21: 1-8, 1989.
36. MCCLAIN, D. A. AND HUG, C. C.: Intravenous fentanyl kinetics. Clin. Pharmacol. Ther. 28: 106-114, 1980.
37. PRESTON, K. L. AND JASINSKI, D. R.: Abuse liability studies of opioid agonistantagonists in humans. Drug Alcohol Depend. 28: 49-82, 1991.
38. SCAMMAN, F., GHONEIM, M. M. AND KORTTILA, K.: Ventilatory and mental effects of alfentanil and fentanyl. Acta Anaesthesiol. Scand. 28: 63-67, 1984.
39. SCOTT, J. C., PONGANIS, K. V. AND STANSKI, D. R.: EEG quantitation of narcotic effect: The comparative pharmacodynamics of fentanyl and alfentanil. Anesthesiology 62: 234-241, 1985.
40. SHAFER, S. L. AND VARVEL, J. R.: Pharmacokinetics, pharmacodynamics, and rational opioid selection. Anesthesiology 74: 53-63, 1991.
41. SILSBY, H. D., KRUZICH, D. J. AND HAWKINS, M. R.: Fentanyl citrate abuse among health care professionals. Milit. Med. 149: 227-228, 1984.
42. SMIALEK, J. E., LEVINE, B., CHIN, L., WU, S. C. AND JENKINS, A. J.: A fentanyl epidemic in Maryland 1992. J. Forensic Sci. 39: 159-164, 1994.
43. SMITS, S. E.: Antagonism by naloxone of morphine-induced single dose dependence and antinociception in mice. Res. Commun. Chem. Pathol. Pharmacol. 15: 689-696, 1976.
44. SPIEGELMAN, W. G., SAUNDERS, L. AND MAZZE, R. I.: Addiction and anesthesiology. Anesthesiology 60: 335-341, 1984.
45. STANSKI, D. R. AND HUG, C. C.: Alfentanil: A kinetically predictable narcotic analgesic. Anesthesiology 57: 435-138, 1982.
46. STITZER, M. L., WRIGHT, C., BIGELOW, G. E., JUNE, H. L. AND FELCH, L. J.: Time course of naloxone-precipitated withdrawal after acute methadone exposure in humans. Drug Alcohol Depend. 29: 39-46, 1991.
47. WARD, C. F., WARD, G. C. AND SAIDMAN, L. J.: Drug abuse in anesthesia training programs: A survey: 1970 through 1980. J. Am. Med. Assoc. 250: 922-925, 1983.
48. WAY, E. L., LOH, H. H. AND SHEN, F. H.: Simultaneous quantitative assessment of morphine tolerance and physical dependence. J. Pharmacol. Exp. Ther. 167: 1-8, 1969.
49. WILEY, J. N. AND DOWNS, D. A.: Naloxone-precipitated jumping in mice pretreated with acute injections of opioids. Life Sci. 25: 797-802, 1979.
50. WRIGHT, C., BIGELOW, G. E., STITZER, M. L. AND LIEBSON, I. A.: Acute physical dependence in humans: repeated naloxone-precipitated withdrawal after a single dose of methadone. Drug Alcohol Depend. 27: 139-148, 1991.
51. YANO, I. AND TAKEMORI, A. E.: Inhibition by naloxone of tolerance and dependence in mice treated acutely and chronically with morphine. Res. Commun. Chem. Pathol. Pharmacol. 16: 721-734, 1977.
52. ZACNY, J. P., LICHTOR, J. L., ZARAGOSA, J. G. AND DE WIT, H.: Subjective and behavioral responses to intravenous fentanyl in healthy volunteers. Psychopharmacology 107: 319-326, 1992.