The role of nebulized IFN-γ in the modulation of allergic responses

Advances in Experimental Medicine and Biology

Volumn 409, Issue , 1996, Pages 17-23

  Lack, Gideon ^a   Gelfand, Erwin W ^a  

^a NATIONAL JEWISH MEDICAL AND RESEARCH CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALLERGEN; CYTOKINE; GAMMA INTERFERON; IMMUNOGLOBULIN E; IMMUNOGLOBULIN G2A; INTERLEUKIN 4; OVALBUMIN;

AEROSOL; ALLERGIC REACTION; ALLERGIC RHINITIS; ANIMAL EXPERIMENT; ATOPIC DERMATITIS; CLINICAL TRIAL; CONFERENCE PAPER; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG BIOAVAILABILITY; HUMAN; IMMUNOGLOBULIN BLOOD LEVEL; IMMUNOGLOBULIN PRODUCTION; IMMUNOMODULATION; INHALATIONAL DRUG ADMINISTRATION; INTRAPERITONEAL DRUG ADMINISTRATION; MOUSE; NEBULIZATION; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; T LYMPHOCYTE SUBPOPULATION;

ANIMALIA;

EID: 0030436369     PISSN: 00652598     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-1-4615-5855-2_3     Document Type: Conference Paper

References (15)

1. Snapper, C. M., and W. E. Paul. 1987. Interferon-γ and B cell stimulatory factor-1 reciprocally regulate Ig isotype production. Science 236:944-947.
2. Coffman, R. L., and J. Carty. 1986. A T cell activity that enhances polyclonal IgE production and its inhibition by interferon-γ. J. Immunol. 136:949-954.
3. 2. Proc. Natl. Acad. Sci. USA 85:6880-6884.
4. Chrétien, I., J. Péne, F. Briére, R. De Waal-Malefijt, F. Rousset, and J. E. DeVries. 1990. Regulation of human IgE synthesis. I. Human IgE synthesis in vitro is determined by the reciprocal antagonistic effects of interleukin 4 and interferon-γ. Eur. J. Immunol. 20:243-251.
5. deVries, J. E. and Zurawski, G. 1995. Immunoregulatory properties of IL-13: Its potential role in atopic disease. Int. Arch. Allergy Immunol. 106:175-179.
6. Bradley, L. M., K. Yoshimoto, and S. L. Swain. 1995. The cytokines IL-4, IFN-g, and IL-12 regulate the development of subsets of memory effictor/helper T cells in vitro. J. Immunol. 155:1713-1724.
7. Jung, T., G. Lack, U. Schauer, W. Uberück, H. Renz, E. W. Gelfand, C. H. L. Rieger. 1995. Decreased frequency of interferon-γ and interleukin-2-producing cells in patients with atopic diseases measured at the single cell level. J All Clin Immunol, in press, 1995.
8. Jaffe, H. A., R. Buhl, A. Mastrangeli, K. J. Holroyd, C. Saltini, D. Czerski, H. S. Jaffe, S. Kramer, S. Sherwin, and R. G. Crystal. 1991. Organ specific cytokine therapy. Local activation of mononuclear phagocytes by delivery of an aerosol of recombinant interferon-γ to the human lung. J. Clin. Invest. 88:297-302.
9. Renz, H., H. R. Smith, J. E. Henson, B. S. Ray, C. G. Irvin, and E. W. Gelfand. 1992. Aerosolized antigen exposure without adjuvant causes increased IgE production and increased airway responsiveness in the mouse. J Allergy Clin. Immunol. 89:1127-1138.
10. Saloga, J., H. Renz, G. Lack, K. L. Bradley, J. L. Greenstein, G. Larsen, and E. W. Gelfand. 1993. Development and transfer of immediate cutaneous hypersensitivity in mice exposed to aerosolized antigen. J. Clin. Invest. 91:133-140.
11. Larsen, G. L., H. Renz, J. E. Loader, K. L. Bradley, and E. W. Gelfand. 1992. Airway response to electrical field stimulation in sensitized inbred mice. J. Clin. Invest. 89:747-752.
12. Larsen, G. L., T. M. Fame, H. Renz, J. E. Loader, J. Graves, M. Hill and E. W. Gelfand. 1994. Increased acetylcholine release in tracheas from allergen-exposed IgE-immune mice. Am. J. Physiol. 266:L263-L270.
13. Lack, G., Renz, H., Saloga, J., Bradley, K. L., Loader, J., Leung, D. Y. M., Larsen, G., and Gelfand, E. W. 1994. Nebulized but not parenteral IFN-γ decreases IgE production and normalizes airways function in a murine model of allergen sensitization. J. Immunol. 152:2546-2554.
14. Finkelman, F. D., I. M. Katona, J. F. Urban, Jr., J. Holmes, J. O'hara, A. S. Tung, J. G. Sample and W. E. Paul. 1988. IL-4 is required to generate and sustain in vivo IgE responses. J. Immunol. 252:2335-2341.
15. Renz, H., G. Lack, J. Saloga, R. Schwinzer, K. Bradley, J. Loader, A. Kupfer, G. L. Larsen and E. W. Gelfand. Inhibition of IgE production and normalization of airways responsiveness by sensitized CD8 T cells in a mouse model of allergen-induced sensitization. J Immunol. 152:351-360, 1993.