Progestins can have a membrane-mediated action in rat midbain for facilitation of sexual receptivity

Hormones and Behavior

Volumn 30, Issue 4, 1996, Pages 682-691

  Frye, Cheryl A ^a   Gardiner, Sara G ^a  

^a The Holleran Center for Community Action and Public Policy   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3ALPHA HYDROXY 5ALPHA PREGNAN 20 ONE; DRUG METABOLITE; ESTRADIOL BENZOATE; GESTAGEN; PROGESTERONE; PROGESTERONE RECEPTOR;

ARTICLE; CONTROLLED STUDY; DRUG EFFECT; DRUG RESPONSE; FEMALE; IMPLANT; MESENCEPHALON; MODULATION; NONHUMAN; PRIORITY JOURNAL; RAT; SEXUAL BEHAVIOR; SUBCUTANEOUS DRUG ADMINISTRATION;

EID: 0030435336     PISSN: 0018506X     EISSN: None     Source Type: Journal    
DOI: 10.1006/hbeh.1996.0069     Document Type: Article

References (71)

1. Beyer, C., Gonzalez-Flores, O., and Gonzalez-Mariscal, G. (1995). Ring-A reduced progestins potently stimulate estrous behavior in rats: Paradoxical effect through the progesterone receptor. Physiol. Behav. 58, 985-993.
2. Beyer, C., Gonzalez-Mariscal, G., Equibar, J. R., and Gomora, P. (1988). Lordosis facilitation in estrogen primed rats by intrabrain injection of pregnanes. Pharmacol. Biochem. Behav. 31, 919-926.
3. Blaustein, J. D., and Feder, H. H. (1979). Cytoplasmic progestin receptor in guinea pig brain: Characteristics and relationship to the induction of sexual behavior. Brain Res. 169, 481-487.
4. Blaustein, J. D., and Olster, D. O. (1989). Gonadal steroid hormones, receptors and social behavior. In J. Balthazart (Ed.), Advances in Comparative and Environmental Physiology, Vol. 3, pp. 31-104. Springer-Verlag, Berlin.
5. Brown, T. J., Moore, M. J., and Blaustein, J. D. (1987). Maintenance of progesterone-facilitated sexual behavior in female rat requires continued hypothalamic protein synthesis and nuclear progestin occupation. Endocrinology 121, 298-304.
6. Davis, P. G., McEwen, B. S., and Pfaff, D. W. (1979). Localized behavioral effects of tritiated estradiol implants in the ventromedial hypothalmus of female rats. Endocrinology 104, 898-903.
7. DeBold, J. F., and Frye, C. A. (1994a). Genomic and non-genomic actions of progesterone in the control of female hamster sexual behavior. Horm. Behav. 24, 445-453.
8. DeBold, J. F., and Frye, C. A. (1994b). Progesterone and the neural mechanisms of hamster sexual behavior. Psychoneuroendocrinology 19, 563-579.
9. DeBold, J. F., and Malsbury, C. W. (1989). Facilitation of sexual receptivity by hypothalmic and midbrain implants of progesterone in female hamsters. Physiol. Behav. 46, 655-660.
10. De Goeij, A. F. P. M., van Zeeland, J. K., Beek, C. J. L., and Bosman, F. T. (1986). Steroid-BSA conjugates: Molecular characterization and their interaction with androgen and estrogen receptors. J. Steroid Biochem. 24, 1017-1031.
11. Donoso, A. O., and Zarate, M. B. (1981). Enhancement of lordotic behavior by injection of GABA into the ventromedial nucleus of the hypothalamus. IRCS: J. Med. Sci. 9, 1039.
12. Etgen, A. M., and Barfield, R. J. (1986). Antagonism of female sexual behavior with intracerebral implants of antiprogestin RU 38486: Correlation with binding to neural progestin receptors. Endocrinology 119, 1610-1617.
13. Feder, H. H. (1984). Hormone and sexual behavior. Annu. Rev. Psychol. 35, 165-200.
14. Fernandez-Guasti, A., Larsson, K., and Beyer, C. (1986). Lordosis behavior and GABAergic neurotransmission. Pharmacol. Biochem. Behav. 24, 673-676.
15. A receptor activation induces GABA and glutamate release from pre-optic area. Life Sci. 56, 1665-1678.
16. Frankfurt, M., and McEwen, B. S. (1991). 5,7-Dihydroxytryptamine and gonadal steroid manipulation alter spine density in ventrome-dial hypothalamic neurons. Neuroendocrinology 54, 653-657.
17. Frye, C. A., and DeBold, J. F. (1992a). Muscimol facilitates sexual receptivity in hamsters when infused into the ventral tegmentum. Pharmacol. Biochem. Behav. 42, 879-887.
18. Frye, C. A., and DeBold, J. F. (1992b). P-3-BSA, but not P-11-BSA, implants in the VTA rapidly facilitate receptivity in hamsters after progesterone priming to the VMH. Behav. Brain Res. 53, 167-175.
19. Frye, C. A., and DeBold, J. F. (1993). 3α-OH-DHP and 5α-THDOC implants to the VTA facilitate sexual receptivity in hamsters after progesterone priming to the VMH. Brain Res. 612, 130-137.
20. Frye, C. A., and Gardiner, S. (1996). Progestins can have membrane-mediated effects in rat midbrain for sexual receptivity. Soc. Neurosci. Abstr. 22ii, 1291.
21. Frye, C. A., and Leadbetter, E. M. (1994). 5α-Reduced progesterone metabolites are essential in hamster VTA for sexual receptivity. Life Sci. 54, 653-659.
22. Frye, C. A., Mermelstein, P. G., and DeBold, J. F. (1992). Evidence for a non-genomic action of progestins on sexual receptivity in hamster VTA but not hypothalamus. Brain Res. 578, 87-93.
23. Frye, C. A., Mermelstein, P. G., and DeBold, J. F. (1993). Bicuculline infused in the hamster ventral tegmentum inhibits, while sodium valproate facilitates, sexual receptivity. Pharmacol. Biochem. Behav. 46, 1-8.
24. Frye, C. A., Van Keuran, K. R., Rao, P. N., and Erskine, M. S. (1996). Progesterone and 3α-androstanediol conjugated to bovine serum albumin affects estrous behavior when applied to the MBH and POA. Behav. Neurosci. 96, 603-612.
25. Glaser, J. H., and Barfield, R. J. (1984). Blockade of progesterone-activated estrous behavior in rats by intercerebral anisomycin is site specific. Neuroendocrinology 38, 337-343.
26. Glaser, J. H., Etgen, A. M., and Barfield, R. J. (1985). Intrahypothalamic effects of progestin agonists on estrous behavior and progestin receptor binding. Physiol. Behav. 34, 871-878.
27. Gonzalez-Mariscal, G., Gonzalez-Flores, O., and Beyer, C. (1989). Intrahypothalamic injection of RU 486 antagonizes the lordosis induced by ring A-reduced progestins. Physiol. Behav. 46, 435-438.
28. Iswari, S., Colas, A. E., and Karavolas, H. J. (1986). Binding of 5α-dihydroprogesterone and other progestins to female rat anterior pituitary nuclear extracts. Steroids 47, 189-203.
29. Ke, F.-C., and Ramirez, V. D. (1987). Membrane mechanism mediates progesterone stimulatory effect on LHRH release from superfused rat hypothalami in vitro. Neuroendocrinology 45, 514-517.
30. Kontula, K., Janne, O., Vihko, R., de Jager, E., de Visser, J., and Zeelen, F. (1975). Progesterone-binding proteins: In vitro binding and biological activity of different steroidal ligands. Acta Endocrinol. 78, 574-592.
31. Krause, J. E., and Karavolas, H. J. (1980). Pituitary 5α-dihydroprogesterone 3α-hydroxysteroid-oxireductases. J. Biol. Chem. 255, 11807-11814.
32. Kubli-Garfias, C., and Whalen, R. E. (1977). Induction of lordosis behavior in female rats by intravenous administration of progestins. Horm. Behav. 9, 380-386.
33. Lisk, R. D. (1960). A comparison of the effectiveness of intravenous, as opposed to subcutaneous, injections of progesterone for the induction of estrous behavior in the rat. Can. J. Biochem. Psychol. 38, 1381-1383.
34. Luttge, W. R., and Hughes, J. R. (1976). Intracerebral implantation of progesterone: Re-examination of the brain sites responsible for facilitation of sexual receptivity in estrogen-primed ovariectomized rats. Physiol. Behav. 17, 771-775.
35. MacLusky, N. J., and McEwen, B. S. (1980). Progestin receptors in the rat brain: Distribution and properties of cytoplasmic progestin binding sites. Endocrinology 106, 192-202.
36. Majewska, M. D., Harrison, N. L., Schwartz, R. D., Barker, J. L., and Paul, S. M. (1986). Steroid hormone metabolites are barbiturate-like modulators of the GABA receptor. Science 232, 1004-1007.
37. Mani, S. K., Allen, J. M. C., Clark, J. H., Blaustein, J. D., and O'Malley, B. W. (1994). Convergent pathways for steroid hormone- and neurotransmitter-induced rat sexual behavior. Science 265, 1246-1249.
38. Masco, D., Weiger, R., and Carrer, H. F. (1986). Gamma aminobutyric acid mediates ventromedial hypothalamic mechanisms controlling the execution of lordotic responses in the female rat. Behav. Brain Res. 19, 153-162.
39. McCarthy, M. M., Coirini, H., Schumacher, M., Johnson, A. E., Pfaff, D. W., Schwartz-Giblin, S., and McEwen, B. S. (1992). Steroid regulation and sex differences in H-3 muscimol binding in hippocampus, hypothalamus and midbrain in rats. J. Neuroendocrinol. 4, 393-399.
40. McCarthy, M. M., Malik, K., and Feder, H. H. (1990). Increased GA-BAergic transmission in medial hypothalamus facilitates lordosis but has the opposite effect in the preoptic area. Brain Res. 507, 40-44.
41. McCarthy, M. M., Masters, D. B., Fiber, J. M., Lopez-Colome, A. M., Beyer, C., Komisaruk, B. R., and Feder, H. H. (1991). GABAergic control of receptivity in the female rat. Neuroendocrinology 53, 473-479.
42. A receptor activation enhances, and blockade reduces, sexual behavior in the female rat. Exp. Brain Res. 86, 108-116.
43. McGinnis, M. Y., Parsons, B., Rainbow, T. C., Krey, L. C., and McEwen, B. S. (1981). Temporal relationship between cell nuclear progestin receptor levels and sexual receptivity following intravenous progesterone administration. Brain Res. 218, 365-371.
44. Meisel, R. L., Fraile, I. G., and Pfaff, D. W. (1990). Hypothalamic sites of progestin action on aggression and sexual behavior in female Syrian hamsters. Physiol. Behav. 47, 219-223.
45. Meyerson, B. (1972). Latency between intravenous injection of progestins and the appearance of estrous behavior in estrogen-treated rats. Horm. Behav. 3, 1-9.
46. Moguilewsky, M., and Raynaud, J. (1979). The relevance of hypothalamic and hypophyseal progestin receptor regulation in the induction and inhibition of sexual behavior in the female rat. Endocrinology 105, 516-522.
47. 3H]R5020. Brain Res. 274, 1-10.
48. Paxinos, G., and Watson, C. (1986). The Rat Brain. Academic Press, New York.
49. Petitti, N., and Etgen, A. M. (1990). Alpha-1 adrenoceptor augmentation of beta-stimulated cAMP formation is enhanced by estrogen and reduced by progesterone in rat hypothalamic slices. J. Neurosci. 10, 2842-2849.
50. Pleim, E. T., Baumann, J., and Barfield, R. J. (1991). A contributory role for midbrain progesterone in the facilitation of female sexual behavior in rats. Horm. Behav. 25, 19-28.
51. Pleim, E. T., Lisciotto, C. A., and DeBold, J. F. (1990). Facilitation of sexual receptivity in hamsters by simultaneous progesterone implants in the VMH and the ventral mesencephalon. Horm. Behav. 24, 139-151.
52. Qureshi, G. A., Bednar, I., Forsberg, G., and Sodersten, P. (1988). GABA inhibits sexual functioning in female rats. Neuroscience 27, 169-174.
53. Ramirez, V. (1992). Characterization of membrane actions of steroids. Neuroprotocols: Companion Methods Neurosci. 1, 35-41.
54. Raynaud, J.-P., Ojasoo, T., Pottier, J., and Salmon, J. (1982). Chemical substitution of steroid hormones: Effect of receptor binding and pharmacokinetics. In G. Litwack (Ed.), Biochemical Actions of Hormones, Vol. IX, pp. 305-342. Academic Press, New York.
55. Rose, J. D. (1990). Tectoreticular neuronal activity associated with behavior and progesterone action during the induction of lordosis responding in hamsters. Soc. Neurosci. Abstr. 16, 924.
56. Rose, J. D., and Bieber, S. L. (1984). Joint and separate effects of estrogen and progesterone on responses of midbrain neurons to lordosis-controlling somatic stimuli in the female golden hamster. J. Neurophysiol. 51, 1040-1054.
57. Ross, J., Claybaugh, C., Clemens, L. G., and Gorski, R. A. (1971). Short latency induction of estrous behavior with intracerebral gonadal hormones in ovariectomized rats. Endocrinology 89, 32-38.
58. Rubin, B. S., and Barfield, R. J. (1983a). Induction of estrous behavior in ovariectomized rats by sequential replacement of estrogen and progesterone to the ventromedial hypothalamus. Neuroendocrinology 37, 218-224.
59. Rubin, B. S., and Barfield, R. J. (1983b). Progesterone in the ventromedial hypothalamus facilitates estrous behavior in ovariectomized, estrogen primed rats. Endocrinology 113, 797-804.
60. Rupprecht, R., Hauser, C. A. E., Trapp, T., and Holboer, F. (1996). Neurosteroids: Molecular mechanisms of action and psychopharmacological significance. J. Steroid Biochem. Mol. Biol. 56, 163-168.
61. Rupprecht, R., Reul, J. M. H. M., Trapp, T., van Steensel, B., Wetzel, C., Damm, K., Zieglgansberger, W., and Holsboer, F. (1993). Progesterone receptor-mediated effects neuroactive steroids. Neuron 11, 523-530.
62. Saffran, J., Loeser, B. K., Bohnett, S. A., Gray, M. A., and Faber, L. E. (1978). The binding of 5α-pregnane-3,20-dione by cytosol and nuclear preparations of guinea pig uterus. Endocrinology 102, 1088.
63. Schumacher, M., Coirini, H., Johnson, A. E., Flanagan, L. M., Frankfurt, M., Pfaff, D. W., and McEwen, B. S. (1993). The oxytocin receptor: A target for steroid hormones. Regul. Peptides 45, 115-119.
64. Smith, H. E., Smith, R. G., Toft, D. O., Neegard, J. R., Burrows, E. P., and O'Malley, B. W. (1974). Binding of steroids to progesterone receptor proteins in chick oviduct and human uterus. J. Biol. Chem. 249, 5924-5932.
65. Takahashi, L. K., and Lisk, R. D. (1985). Estrogen action in the anterior and ventromedial hypothalamus and the modulation of heterosexual behavior in female golden hamsters. Physiol. Behav. 34, 233-239.
66. Takahashi, L. K., Lisk, R. D., and Burnett, A. L. (1985). Dual estradiol action in diencephalon and the regulation of socio-sexual behavior in female golden hamsters. Brain Res. 359, 194-207.
67. Tennent, B. J., Smith, E. R., and Davidson, J. M. (1982). Effects of progesterone implants in the habenula and midbrain on proceptive and receptive behavior in the female rat. Horm. Behav. 16, 352-363.
68. Thornton, J. E., and Carson, S. (1995). The neuropeptide Y antagonist PYX2 decreases lordosis behavior. Endocrinology 3, 807-811.
69. Vincent, P. A., and Etgen, A. M. (1993). Steroid priming promotes oxytocin-induced norepinephrine release in the ventromedial hypothalamus of female rats. Brain Res. 620, 189-194.
70. 3H labelled synthetic progestin by rat brain and pituitary: A radioautography study. Neurosci. Lett. 9, 329-332.
71. Yanase, M., and Gorski, R. A. (1976). Sites of estrogen and progesterone facilitation of lordosis behavior in the spayed rat. Biol. Reprod. 15, 536-543.