Electrophysiological effects of a novel, short-acting and potent ester derivative of amiodarone, ATI-2001, in guinea pig isolated heart

Journal of Pharmacology and Experimental Therapeutics

Volumn 277, Issue 3, 1996, Pages 1454-1463

  Raatikainen, M J Pekka ^a   Napolitano, Charles A ^a   Druzgala, Pascal ^c   Dennis, Donn M ^a,b  

^a UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF FLORIDA   (United States)

^c Advanced Therapies Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMIODARONE; ATI 2001; DRUG DERIVATIVE; SOTALOL; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; ATRIOVENTRICULAR CONDUCTION; CONTROLLED STUDY; DRUG EFFECT; FEMALE; GUINEA PIG; HEART ELECTROPHYSIOLOGY; HEART RATE; HEART REPOLARIZATION; HEART VENTRICLE CONDUCTION; ISOLATED HEART; NONHUMAN; PRIORITY JOURNAL;

AMIODARONE; ANIMALS; ELECTROCARDIOGRAPHY; FEMALE; GUINEA PIGS; HEART; HEART RATE; MALE; TIME FACTORS;

EID: 0030435124     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (49)

1. ANDERSON, K. P., WALKER, R., DUSTMAN, T., Lux, R. L., ERSHLER, P. R., KATES, R. E. AND URIE, P. M.: Rate-related electrophysiologic effects of long-term administration of amiodarone on canine ventricular myocardium in vivop. Circulation 79: 948-958, 1989.
2. ANDREASEN, F., AGERBAEK, H., BJERREGAARD, P. AND GOTZSCHE, H.: Pharmacokinetics of amiodarone after intravenous and oral administration. Eur. J. Clin. Pharmacol. 19: 293-299, 1981.
3. BAZETT, H. C.: An analys: of the time relationship of electrocardiograms. Heart 7: 353-370, 1920.
4. CAMPBELL, T. J.: Kinetics onset of rate-dependent effects of class I antiarrhythmic drugs are imp cant in determining their effects on refractoriness in guinea-pig ventricle, and provide a theoretical basis for their subclassification. Cardiovasc. Res. 17: 344-352, 1983.
5. CASCADE Investigators: Randomized antiarrhythmic drug therapy in survivors of cardiac arrest (the CASCADE Study). Am. J. Cardiol. 72: 280-287, 1993.
6. DOVAL, H. C., NUL, D. R., GRANCELLI, H. O., PERRONE, S. V., BORTMAN, G. R. AND CURIEL, R.: Randomised trial of low-dose amiodarone in severe congestive heart failure: Grupo de Estudio de la Sobrevida en la Insuficiencia Cardiaca en Argentina (GESICA). Lancet 344: 493-498, 1994.
7. Du, X. J., ESLER, M. D. AND DART, A. M.: Sympatholytic action of intravenous amiodarone in the rat heart. Circulation 91: 462-470, 1995.
8. EL SHERIF, N., ZEILEH, R. H., CRAELIUS, W., GOUGH, W. B. AND HENKIN, R: QTU prolongation and polymorphic ventricular tachyarrhythmias due to bradycardia-dependent early afterdepolarizations: Afterdepolarizations and ventricular arrhythmias. Circ. Res. 63: 286-305, 1988.
9. FRANZ, M. R.: Method and theory of monophasic action potential recording. Prog. Cardiovasc. Dis. 33: 347-368, 1991.
10. FRANZ, M. R., CHIN, M. C., SHARKEY, H. R., GRIFFIN, J. C. AND SCHEINMAN, M. M.: A new single catheter technique for simultaneous measurement of action potential duration and refractory period in vivo. J. Am. Coll. Cardiol. 16: 878-886, 1990.
11. GANZ, L. I. AND FRIEDMAN, P. L.: Supraventricular tachycardia. N. Engl. J. Med. 332: 162-173, 1995.
12. GROH, W. J., GIBSON, K. J., MCANULTY, J. H. AND MAYLIE, J. G.: Beta-adrenergic blocking property of dl-sotalol maintains class III efficacy in guinea pig ventricular muscle after isoproterenol. Circulation 91: 262-264, 1995.
13. HERRE, J. M., SAUVE, M. J., MALONE, P., GRIFFIN, J. C., HELMY, I., LANGBERG, J. J., GOLDBERG, H. AND SCHEINMAN, M. M.: Long-term results of amiodarone therapy in patients with recurrent sustained ventricular tachycardia or ventricular fibrillation. J. Am. Coll. Cardiol. 13: 442-449, 1989.
14. HOHNLOSER, S. H., KLINGENHEBEN, T. AND SINGH, B. N.: Amiodarone-associated proarrhythmic effects: A review with special reference to torsade de pointes tachycardia. Ann. Intern. Med. 121: 529-535, 1994.
15. HOHNLOSER, S. H., MEINERTZ, T., DAMMBACHER, T., STEIERT, K., JAHNCHEN, E., ZEHENDER, M., FRAEDRICH, G. AND JUST, H.: Electrocardiographic and antiarrhythmic effects of intravenous amiodarone: Results of a prospective, placebo-controlled study. Am. Heart J. 121: 89-95, 1991.
16. HOHNLOSER, S. H. AND WOOSLEY, R. L.: Sotalol. N. Engl. J. Med. 331: 31-38, 1994.
17. HONDEGHEM, L. M. AND SNYDERS, D. J.: Class III antiarrhythmic agents have a lot of potential but a long way to go: Reduced effectiveness and dangers of reverse use dependence. Circulation 81: 686-690, 1990.
18. HUIKURI, H. V. AND YLI-MÄYRY, S.: Frequency-dependent effects of d-sotalol and amiodarone on the action potential duration of the human right ventricle. PACE 15: 2103-2107, 1992.
19. JANSE, M. J.: What a clinician needs to know about the mechanisms of action of antiarrhythmic drugs. Clin. Cardiol. 14: 65-67, 1991.
20. JENKINS, J. R. AND BELARDINELLI, L.: Atrioventricular nodal accommodation in isolated guinea pig hearts: Physiological significance and role of adenosine. Circ. Res. 63: 97-116, 1988.
21. KADISH, A. H., CHEN, R. F., SCHMALTZ, S. AND MORADY, F.: Magnitude and time course of beto-adrenergic antagonism during oral amiodarone therapy. J. Am. Coll. Cardiol. 16: 1240-1245, 1990.
22. KADISH, A. AND MORADY, F.: The use of intravenous amiodarone in the acute therapy of life-threatening tachyarrhythmias. Prog. Cardiovasc. Dis. 31: 281-294, 1989.
23. KATRITSIS, D. AND CAMM, A. J.: New class III antiarrhythmic drugs. Eur. Heart J. 14: suppl. H, 93-99, 1993.
24. KUS, T., DUBUC, M., LAMBERT, C. AND SHENASA, M.: Efficacy of propafenone in preventing ventricular tachycardia: Inverse correlation with rate-related prolongation of conduction time. J. Am. Coll. Cardiol. 16: 1229-1237, 1990.
25. MASON, J. W.: Amiodarone. N. Engl. J. Med. 316: 455-466, 1987.
26. MORADY, F., DICARLO, L. A. J., KROL, R. B., BAERMAN, J. M. AND DE BUITLEIR, M.: Acute and chronic effects of amiodarone on ventricular refractoriness, intraventricular conduction and ventricular tachycardia induction. J. Am. Coll. Cardiol. 7: 148-157, 1986.
27. NADEMANEE, K., STEVENSON, W. G., WEISS, J. N., FRAME, V. B., ANTIMISIABIS, M. G., SUITHICHAIYAKUL, T. AND PRUITT, C. M.: Frequency-dependent effects of quinidine on the ventricular action potential and QRS duration in humans. Circulation 81: 790-796, 1990.
28. NANAS, J. N. AND MASON, J. W.: Pharmacokinetice and regional electrophysiological effects of intracoronary amiodarone administration. Circulation 91: 451-461, 1995.
29. NATTEL, S. AND JING, W.: Rate-dependent changes in intraventricular conduction produced by procainamide in anesthetized dogs: A quantitative analysis based on the relation between phase O inward current and conduction velocity. Circ. Res. 65: 1485-1498, 1989.
30. NATTEL, S. AND ZENG, F. D.: Frequency-dependent effects of antiarrhythmic drugs on action potential duration and refractoriness of canine cardiac Purkinje fibers. J. Pharmacol. Exp. Ther. 229: 283-291, 1984.
31. PATTERSON, E., SZABO, B., SCHERLAG, B. J. AND LAZZARA, R.: Early and delayed afterdepolarizations associated with cesium chloride-induced arrhythmias in the dog. J. Cardiovasc. Pharmacol. 15: 323-331, 1990.
32. PODRID, P. J.: Amiodarone: Reevaluation of an old drug. Ann. Intern. Med. 122: 689-700, 1995.
33. POLSTER, P. AND BROEKHUYSEN, J.: The adrenergic antagonism of amiodarone. Biochem. Pharmacol. 25: 131-134, 1976.
34. RANGER, S., TALAJIC, M., LEMERY, R., ROY, D., VILLEMAIRE, C. AND NATTEL, S.: Kinetics of use-dependent ventricular conduction slowing by antiarrhythmic drugs in humans. Circulation 83: 1987-1994, 1991.
35. RODEN, D. M.: Pharmacokinetics of amiodarone: Implications for drug therapy. Am. J. Cardiol. 72: 45F-50F, 1993.
36. SAGER, P. T., FOLLMER, C., UPPAL, P., PRUITT, C. AND GODFREY, R.: The effects of β-adrenergic stimulation on the frequency-dependent electrophysiologic actions of amiodarone and sematilide in humans. Circulation 90: 1811-1819, 1994.
37. SAGER, P. T., NADEMANEE, K., ANTIMISIARIS, M., PACIFICO, A., PRUITT, C., GODFREY, R. AND SINGH, B. N.: Antiarrhythmic effects of selective prolongation of refractoriness: Electrophysiologic actions of sematilide HCl in humans. Circulation 88: 1072-1082, 1993a.
38. SAGER, P. T., UPPAL, P., FOLLMER, C., ANTIMISIAHIS, M., PRUITT, C. AND SINGH, B. N.: Frequency-dependent electrophysiologic effects of amiodarone in humans. Circulation 88: 1063-1071, 1993b.
39. SANGUINETTI, M. C., JURKIEWICZ, N. K., SCOTT, A. AND SIEGL, P. K.: Isoproterenol antagonizes prolongation of refractory period by the class III antiarrhythmic agent E-4031 in guinea pig myocytes: Mechanism of action. Circ. Res. 68: 77-84, 1991.
40. SCHMITT, C., BRACHMANN, J., KARCH, M., WALDECKER, B., NAVARRETE, L., MONTERO, M., BEYER, T. AND KUBLER, W.: Reverse use-dependent effects of sotalol demonstrated by recording monophasic action potentials of the right ventricle. Am. J. Cardiol. 68: 1183-1187, 1991.
41. SINGH, B. N., KEHOE, R., WOOSLEY, R. L., SCHEINMAN, M. AND QUART, B.: Multicenter trial of sotalol compared with procainamide in the suppression of inducible ventricular tachycardia: A double-blind, randomized parallel evaluation: Sotalol Multicenter Study Group. Am. Heart J. 129: 87-97, 1995.
42. SINGH, B. N. AND VAUGHAN WILLIAMS, E. M.: The effect of amiodarone, a new anti-anginal drug, on cardiac muscle. Br. J. Pharmacol. 39: 657-667, 1970.
43. SINGH, B. N., VENKATESH, N., NADEMANEE, K., JOSEPHSON, M. A. AND KANNAN, R.: The historical development, cellular electrophysiology and pharmacology of amiodarone. Prog. Cardiovasc. Dis. 31: 249-280, 1989.
44. STARK, G., SCHULZE BAUER, C., STARK, U., KASPER, K., DECRINIS, M. AND TRITTHART, H. A.: Comparison of the frequency-dependent effects on the atrioventricular node of verapamil, amiodarone, digoxin, and diltiazem in isolated guinea pig hearts. J. Cardiovasc. Pharmacol. 25: 330-335, 1995.
45. Vos, M. A., VERDUYN, S. C., GORGELS, A. P., LIPCSEI, G. C. AND WELLENS, H. J.: Reproducible induction of early afterdepolarizations and torsade de pointes arrhythmias by d-sotalol and pacing in dogs with chronic atrioventricular block. Circulation 91: 864-872, 1995.
46. VROBEL, T. R., MILLER, P. E., MOSTOW, N. D. AND RAKITA, L.: A general overview of amiodarone toxicity: Its prevention, detection, and management. Prog. Cardiovasc. Dis. 31: 393-426, 1989.
47. WELLENS, H. J., BRUGADA, P., ABDOLLAH, H. AND DASSEN, W. R.: A comparison of the electrophysiologic effects of intravenous and oral amiodarone in the same patient. Circulation 69: 120-124, 1984.
48. WILKINSON, P. R., REES, J. R., STOREY, G. C. AND HOLT, D. W.: Amiodarone: Prolonged elimination following cessation of chronic therapy. Am. Heart J. 107: 787-788, 1984.
49. YUSUF, S., PETO, R., LEWIS, J., COLLINS, R. AND SLEIGHT, P.: Beta blockade during and after myocardial infarction: An overview of the randomized trials. Prog. Cardiovasc. Dis. 27: 335-371, 1985.