Inhibitory effects of phenolic compounds on development of naturally occurring preneoplastic hepatocytic foci in long-term feeding studies using male F344 rats

Teratogenesis Carcinogenesis and Mutagenesis

Volumn 16, Issue 6, 1996, Pages 317-325

  Hagiwara, A ^a   Kokubo, Y ^a   Takesada, Y ^a   Tanaka, H ^a   Tamano, S ^a   Hirose, M ^b   Shirai, T ^b   Ito, N ^c  

^a Daiyukai Research Institute for Medical Science   (Japan)

^b NAGOYA CITY UNIV MEDICAL SCHOOL   (Japan)

^c NAGOYA CITY UNIVERSITY   (Japan)

Author keywords

4 methoxyphenol; Caffeic acid; Catechol; F344 rats; GST P+ hepatocytic foci; Hydroquinone; Inhibitory effect; Naturally occurring foci; Sesamol; TGF + foci

Indexed keywords

CAFFEIC ACID; CANCER GROWTH FACTOR; GLUTATHIONE TRANSFERASE; HYDROQUINONE; MEQUINOL; PHENOL DERIVATIVE; SESAMOL; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; CONTROLLED STUDY; DOSE RESPONSE; IMMUNOHISTOCHEMISTRY; LIVER; LIVER CARCINOGENESIS; LIVER WEIGHT; MALE; NONHUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; RAT;

ANIMALS; ANTICARCINOGENIC AGENTS; BODY WEIGHT; DRUG ADMINISTRATION SCHEDULE; GLUTATHIONE TRANSFERASE; IMMUNOHISTOCHEMISTRY; LIVER; LIVER NEOPLASMS, EXPERIMENTAL; MALE; ORGAN SIZE; PHENOLS; PRECANCEROUS CONDITIONS; RATS; RATS, INBRED F344; TRANSFORMING GROWTH FACTOR ALPHA;

EID: 0030434738     PISSN: 02703211     EISSN: None     Source Type: Journal    
DOI: 10.1002/(sici)1520-6866(1996)16:6<317::aid-tcm4>3.0.co;2-l     Document Type: Article

References (27)

1. Asakawa E, Hirose M, Hagiwara A, Takahashi S, Ito N: Carcinogenicity of 4-methoxyphenol and 4-methylcatechol in F344 rats. Int J Cancer 56:146-152, 1994.
2. Hagiwara A, Hirose M, Takahashi S, Ogawa K, Shirai T, Ito N: Forestomach and kidney carcinogenicity of caffeic acid in F344 rats and C57BL/6N × C3H/HeN F1 mice. Cancer Res 51:5655-5660, 1991.
3. 1 mice. Carcinogenesis 14:525-529, 1993.
4. Shibata M-A, Hirose M, Tanaka H, Asakawa E, Shirai T, Ito N: Induction of renal cell tumors in rats and mice, and enhancement of hepatocellular tumor development in mice after long-term hydroquinone treatment. Jpn J Cancer Res 82:1211-1219, 1991.
5. Tamano S, Hirose M, Tanaka H, Asakawa E, Ogawa K, Ito N: Forestomach neoplasm induction in F344 rats and B6C3F1 mice exposed to sesamol. Jpn J Cancer Res 83:1279-1285, 1992.
6. Ito N, Tsuda H, Tatematsu M, Inoue T, Tagawa Y, Aoki T, Uwagawa S, Kagawa M, Ogiso T, Masui T, Imaida K, Fukushima S, Asamoto M: Enhancing effect of various hepatocarcinogens on induction of preneoplastic glutathione S-transferase placental form positive foci in rats - An approach for a new medium-term bioassay system. Carcinogenesis 9:387-394, 1988.
7. Goodman DG, Ward JM, Squire RA, Chu KC, Linhart MS: Neoplastic and nonneoplastic lesions in aging F344 rats. Toxicol Appl Pharmacol 48:237-248, 1979.
8. Fukushima S, Hagiwara A, Ogiso T, Shibata M-A, Kurata Y, Ito N: Spontaneous tumors in F344/DuCrj rats. Nagoya Med J 29:163-172, 1984.
9. Maita K, Hirano M, Harada T, Mitsumori K, Yoshida A, Takahashi K, Nakashima N, Kitazawa T, Enomoto A, Inui K, Shirasu Y: Spontaneous tumors in F344/DuCrj rats from 12 control groups of chronic and oncogenicity studies. J Toxicol Sci 12:111-126, 1987.
10. Solleveld HA, Haseman JK, McConell EE: Natural history of body weight gain, survival, and neoplasia in the F344 rat. J Natl Cancer Inst 72:929-940, 1984.
11. Ward JM, Henneman JR: Naturally-occurring age-dependent glutathione S-transferase pi immunoreactive hepatocytes in aging female F344 rat liver as potential promotable targets for non-genotoxic carcinogens. Cancer Lett 52:187-195, 1990.
12. Schulte-Herman R, Timmermann-Trosiener I, Schuppler J: Promotion of spontaneous preneoplastic cells in rat liver as a possible explanation of tumor production by nonmutagenic compounds. Cancer Res 43:839-844, 1983.
13. Popp JA, Scortichini BH, Garrey LK: Quantitative evaluation of hepatic foci of cellular alteration occurring spontaneously in Fischer-344 rats. Fundam Appl Toxicol 5:314-319, 1985.
14. Ogawa K, Onoe T, Takeuchi M: Spontaneous occurrence of γ-glutamyl transpeptidase-positive hepatocytic foci in 105-week-old Wistar and 72-week-old Fischer 344 male rats. J Natl Cancer Inst 67:407-412, 1981.
15. Wattenberg LW: Chemoprevention of cancer. Cancer Res 45:1-8, 1985.
16. Ito N, Imaida K: Strategy of research for cancer-chemoprevention. Teratogenesis Carcinog Mutagen 12:79-95, 1992.
17. Maronpot RR, Montgomery CA, Boorman GA, McConnell EE: National Toxicology Program nomenclature for hepatoproliferative lesions of rats. Toxicol Pathol 14:263-273, 1986.
18. Welch BL: The generalization of student's problem when several different population variances are involved. Biometrika 34:28-35, 1947.
19. Ulland B, Weisburger J, Yamamoto R, Weisburger E: Antioxidants and Carcinogenesis: Butylated hydroxytoluene, but not diphenyl-p-phenylenediamine, inhibits cancer inducnon by N-2-fluorenylacetamide and by N-hydroxy-N-2-fluorenylacetamide in rats. Food Cosmet Toxicol 11:199-207, 1973.
20. Frankfurt O, Lipchina L, Bunto T: The influence of 4-methyl-2,6-tert-butylphenol (Ionol) on the development of hepatic tumors in rats. Bull Exp Biol Med 8:86-88, 1967.
21. Hasegawa R, Ito N; Liver medium-term bioassay in rats for screening of carcinogens and modifying factors in hepatocarcinogenesis. Food Chem Toxicol 30:979-992, 1992.
22. NTP Technical Report on the Toxicology and Carcinogenesis Studies of Hydroquinone (CAS No. 123-31-9) in F344/N Rats and B6C3F1 Mice (Gavage Studies). NTP TR 366. Research Triangle Park, NC. U.S. Department of Health and Human Services, Public Health Service, National Institute of Health, 1989.
23. Hagiwara A, Diwan BA, Ward JM: Modifying effects of butylated hydroxyanisole, di(2-ethylhexyl)phthalate or indomethacin on mouse hepatocarcinogenesis initiated by N-nitrosodiethylamine. Jpn J Cancer Res 77:1215-1221, 1986.
24. Goldsworthy TL, Pitot HC: An approach to the development of a short-term whole-animal bioassay to distinguish initiating agents (incomplete carcinogens), promoting agents, complete carcinogens, and noncarcinogens in rat liver. J Toxicol Environ Health 16:389-402, 1985.
25. Tamano S, Merlino GT, Ward JM: Rapid development of hepatic tumors in transforming growth factor α transgenic mice associated with increased cell proliferation in precancerous hepatocellular lesions initiated by N-nitrosodiethylamine and promoted by phenobarbital. Carcinogenesis 15:1791-1798, 1994.
26. Kaufmann WK, Zhang Y, Kaufmann DG: Association between expression of transforming growth factor-alpha and progression of hepatocellular foci to neoplasms. Carcinogenesis 13:1481-1483, 1992.
27. Takagi H, Sharp R, Takayama H, Anver MR, Ward JM, Merlino G: Collaboration between growth factors and diverse chemical carcinogens in hepatocarcinogenesis of transforming growth factor α transgenic mice. Cancer Res 53:4329-4336, 1993.