Enhancing effects of (2S,3S,4R)-1-O-(α-D-galactopyranosyl)-2-(N- hexacosanoylamino)-1,3,4-octadecanetriol (KRN7000) on antigen-presenting function of antigen-presenting cells and antimetastatic activity of KRN7000- pretreated antigen-presenting cells

Oncology Research

Volumn 8, Issue 10-11, 1996, Pages 399-407

  Yamaguchi, Yasunori ^a   Motoki, Kazuhiro ^a   Ueno, Hitomi ^a   Maeda, Kazuko ^a   Kobayashi, Eiichi ^a   Inoue, Hideo ^a   Fukushima, Hideaki ^a   Koezuka, Yasuhiko ^a  

^a KIRIN BREWERY CO LTD   (Japan)

Author keywords

antigen presenting cells; antitumor agent; dendritic cells; immunostimulatory agent; KRN7000

Indexed keywords

1 O (ALPHA GALACTOPYRANOSYL) 2 HEXACOSANOYLAMINO 1,3,4 OCTADECANETRIOL; ANTIMETASTATIC AGENT; ANTINEOPLASTIC AGENT; IMMUNOMODULATING AGENT; UNCLASSIFIED DRUG;

ADOPTIVE TRANSFER; ANIMAL CELL; ANTIGEN PRESENTATION; ANTIGEN PRESENTING CELL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER IMMUNOTHERAPY; FEMALE; IMMUNOSTIMULATION; MALIGNANT NEOPLASTIC DISEASE; METASTASIS INHIBITION; MIXED LEUKOCYTE CULTURE; MOUSE; NONHUMAN; NUDE MOUSE; PRIORITY JOURNAL;

EID: 0030433656     PISSN: 09650407     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (37)

1. 1. Svennerholm, L.; Bruce, A.; Mansson, J. E.; Rynmark, B. M.; Vanier, M. T. Sphingolipids of human skeletal muscle. Biochem. Biophys. Acta 280:626-636; 1972.
2. 2. Karlsson, K.-A.; Samuelsson, B. E.; Steen, G. O. The sphingolipid composition of bovine kidney cortex. Biochem. Biophys. Acta 316:317-335; 1973.
3. 3. Endo, M.; Nakagawa, M.; Hamamoto, Y.; Ishida, M. Pharmacologically active substances from southern Pacific marine invertebrates. Pure & Appl. Chem. 1986:387-394; 1986.
4. 4.Hirsh, S.; Kashma, Y. New glycosphingolipids from marine organisms. Tetrahedron 45:3897-3906; 1989.
5. 5.Natori, T.; Morita, M.; Akimoto, K.; Koezuka, Y. Agelasphins, novel antitumor and immunostimulatory cerebrosides from the marine sponge Agelas mauritianus. Tetrahedron 50:2771-2784; 1994.
6. 6. Motoki, K.; Kobayashi, E.; Uchida, T.; Fukushima, H.; Koezuka, Y. Antitumor activities of α-, β-monogalactosylceramides and four diastereomers of an α-galactosylceramide. Bioorganic Med. Chem. Lett. 5:705-710; 1995.
7. 7. Morita, M.; Motoki, K.; Akimoto, K.; Natori, T.; Sakai, T.; Sawa, E.; Yamaji, K.; Kobayashi, E.; Fukushima, H.; Koezuka, Y. Structure-activity relationship of α-galactosylceramides against B 16-bearing mice. J. Med. Chem. 38:2176-2187; 1995.
8. 8. Fidler, I. J.; Kripke, M. L. Metastasis results from preexisting variant cells within a malignant tumor. Science 197:893-895; 1977.
9. 9. Nicolson, G. L. Tumor cell instability, diversification, and progression to the metastatic phenotype: from oncogene to oncofetal expression. Cancer Res. 47:1473-1487; 1987.
10. 10. Kobayashi, E.; Motoki, K.; Uchida, T.; Fukushima, H.; Koezuka, Y. KRN7000, a novel immunomodulator, and its antitumor activities. Oncol. Res. 7:529-534; 1995.
11. 11. Karupian, G.; Coupar, B. E. H.; Andrew, M. E.; Boyle, D. V.; Phillips, S. M.; Mullbacher, A.; Blander, R. V.; Ramshaw, I. A. Elevated natural killer cell responses in mice infected with recombinant vaccinia virus encoding murine IL-2. J. Immunol. 144:290-298; 1990.
12. 12. Talmadge, J. E.; Herberman, R. B.; Chirigos, M. A.; Maluish, A. E.; Schneider, M. A.; Adams, J. S.; Philips, H.; Thurman, G. B.; Varesiol, L.; Long, C.; Oldham, R. K.; Wiltrout, R. H. Hyporesponsiveness to augmentation of murine natural killer cell activity in different anatomical compartments by multiple injections of various immunomodulators including recombinant interferons and interleukin 2. J. Immunol. 135:2483-2491; 1985.
13. 13. Crowley, M.; Inaba, K.; Witmer-Pack, M. D.; Steinman, R. M. The cell surface of mouse dendritic cells: FACS analyses of dendritic cells from different tissues including thymus. Cell Immunol. 118:108-125; 1989.
14. 14. Ohteki, T.; Okuyama, R.; Seki, S.; Abo, T.; Sugiura, K.; Kusumi, A.; Ohmori, T.; Watanabe, H.; Kumagai, K. Age-dependent increase of extrathymic T cells in the liver and their appearance in the periphery of older mice. J. Immunol. 149:1562-1570; 1992.
15. 15. Nussenzweig, M. C.; Steinman, R. M. Contribution of dendritic cells to stimulation of the murine syngeneic mixed leukocyte reaction. J. Exp. Med. 151:1196-1212; 1980.
16. 16. Inaba, K.; Steinman, R. M. Resting and sensitizing T lymphocytes exhibit distinct stimulatory (antigen-presenting cell) requirements for growth and lymphokine release. J. Exp. Med. 160:1717-1735; 1984.
17. 17. Steinman, R. M. The dendritic cell system and its role in immunogenicity. Annu. Rev. Immunol. 9:271-296; 1991.
18. 18. Pierce, S. K.; Morris, J. R; Grusby, M. J.; Kaumaya, P.; Buskirk, A. V.; Srinivasan, M.; Wiley, D. C.; Smolenski, L. Antigen-presenting function of B lymphocytes. Immunol. Rev. 106:149-178; 1988.
19. 19. Tsudo, M.; Goldman, C. K.; Bongiovanni, K. F.; Chan W. C.; Yagita, M.; Grimm, E. A.; Waldmann, T. A. The p75 peptide is the receptor for interleukin 2 expressed on large granular lymphocytes and is responsible for the interleukin 2 activation of these cells. Proc. Natl. Acad. Sci. USA 84:5394-5399; 1987.
20. 20. Inaba, K.; Young, J. W.; Steinman, R. M. Direct activation of CD8+ cytotoxic T lymphocytes by dendritic cells. J. Exp. Med. 166:182-194; 1987.
21. 21. Pure, E.; Inaba, K.; Metlay, J. Lymphokine production by murine T cells in the mixed leukocyte reaction. J. Exp. Med. 168:795-800; 1988.
22. 22. Minato, N.; Reid, L.; Cantor, H.; Lengyel, P.; Bloom, B. R. Mode of regulation of natural killer cell activity by interferon. J. Exp. Med. 152:124-138; 1980.
23. 23. Chan, S. H.; Perussia, B.; Gupta, J. W.; Kobayashi, M.; Rospisil, M.; Young, H. A.; Wolf, S. F.; Young, D.; Clark, S. C.; Trinchieri, G. Induction of interferon-γ production by natural killer cell stimulatory factor: characterization of the responder cells and synergy with other inducers. J. Exp. Med. 173:869-879; 1991.
24. 24. Motoki, K.; Maeda, K.; Ueno, H.; Kobayashi, E.; Uchida, T.; Fukushima, H.; Koezuka, Y. Antitumor activities of combined treatment with a novel immuno-modulator KRN7000 and radiotherapy in tumor-bearing mice. Oncol. Res. 8:155-162; 1996.
25. 25. Larsen, C. P.; Ritchie, S. C.; Hendrix, R.; Linsley, P. S.; Hathcock, K. S.; Hodes, R. J.; Lowry, R. P.; Pearson, T. C. Regulation of immunostimulatory function and costimulatory molecule (B7-1 and B7-2) expression on murine dendritic cells. J. Immunol. 152:5208-5219; 1994.
26. 26. Chang, C.; Furuse, M.; Tamaki, K. Selective regulation of ICAM-1 and major histocompatibility complex class I and II molecule expression on epidermal Langerhans cells by some of the cytokines released by keratinocytes and T cells. Eur. J. Immunol. 24:2889-2895; 1994.
27. 27. Enk, A. H.; Katz, S. I. Heat-stable antigen is an important costimulatory molecule on epidermal Langerhans' cells. J. Immunol. 152:3264-3270; 1994.
28. + T cells to enhance priming for interferon-γ production and diminishes interleukin 4 inhibition of such priming. Proc. Natl. Acad. Sci. USA 90:10188-10192; 1993.
29. 29. Okamura, H.; Tsutsui, H.; Komatsu, T.; Yutsudo, M.; Hakura, A.; Tanimoto, T.; Torigoe, K.; Okura, T.; Nukada, Y.; Hattori, K.; Akita, K.; Namba, M.; Tanabe, F.; Konishi, K.; Fukuda, S.; Kurimoto, M. Cloning of a new cytokine that induces IFN-γ production by B cells. Nature 378:88-91; 1995.
30. 30. Brunda, M. J.; Luistro, L.; Warrier, R. R.; Wright, R. B.; Hubbard, B. R.; Murphy, M.; Wolf, S. F.; Gately, M. K. Antitumor and antimetastatic activity of interleukin 12 against murine tumors. J. Exp. Med. 178:1223-1230; 1993.
31. 31. Wigginton, J. W.; Komschlies, K. L.; Back, T. C.; Franco, J. L.; Brunda, M. J.; Wiltrout, R. H. Administration of interleukin 12 with pulse interleukin 2 and the rapid and complete eradication of murine renal carcinoma. J. Natl. Cancer Inst. 88:38-43; 1996.
32. + T cells. J. Immunol. 154:5071-5079; 1995.
33. 33. Knight, S. C.; Hunt, R.; Dore, C; Medawar, T. B. Influence of dendritic cells on tumor growth. Proc. Natl. Acad. Sci. USA 82:4495-4497; 1985.
34. 34. Grabbe, S.; Beissert, S.; Schwartz, T.; Granstein, R. D. Dendritic cells as initiators of tumor immune responses: a possible strategy for tumor immunotherapy? Immunol. Today 16:117-121; 1995.
35. 35. Paglia, P.; Chiodoni, C.; Rodolfo, M.; Colombo, M. P. Murine dendritic cells loaded in vitro with soluble protein prime toxic T lymphocytes against tumor antigen in vivo. J. Exp. Med. 183:317-322; 1996.
36. 36. Celluzzi, C. M.; Mayordomo, J. I.; Storkus, W. J.; Lotze, M. T.; Falo, L. D., Jr. Peptide-pulsed dendritic cells induce antigen-specific, CTL-mediated protective tumor immunity. J. Exp. Med. 183:283-287; 1996.
37. 37. Hsu, F. J.; Benike, C.; Fangoni, F.; Liles, T. M.; Czerwinski, D.; Taidi, B.; Engelman, E. G.; Levy, R. Vaccination of patients with B-cell lymphoma using autologous antigen-pulsed dendritic cells. Nature Med. 2:52-58; 1996.