Protein: Protein interactions in Alzheimer's disease and the CAG triplet repeat diseases

Cold Spring Harbor Symposia on Quantitative Biology

Volumn 61, Issue 1, 1996, Pages 597-605

  Strittmatter, W J ^a   Burke, J R ^a   DeSerrano, V S ^a   Huang, D Y ^a   Matthew, W ^a   Saunders, A M ^a   Scott, B L ^a   Vance, J M ^a   Weisgraber, K H ^b   Roses, A D ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

^b GLADSTONE INSTITUTE OF CARDIOVASCULAR DISEASE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN; APOLIPOPROTEIN E; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; MICROTUBULE ASSOCIATED PROTEIN 2; MICROTUBULE BINDING PROTEIN TAU; MICROTUBULE PROTEIN; POLYGLUTAMINE; POLYGLUTAMINE DOMAIN PROTEIN; UNCLASSIFIED DRUG;

ALLELE; ALZHEIMER DISEASE; ARTICLE; CAG REPEAT; CENTRAL NERVOUS SYSTEM; CHOLESTEROL TRANSPORT; CYTOSKELETON; DEGENERATIVE DISEASE; DNA REPAIR; HUMAN; LIPID PEROXIDATION; MOLECULAR PATHOLOGY; NERVE CELL DEGENERATION; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN CROSS LINKING; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; RECEPTOR BINDING; CONFERENCE PAPER; NERVE DEGENERATION;

ALZHEIMER DISEASE; ANIMALS; APOLIPOPROTEIN E4; APOLIPOPROTEINS E; HUMANS; NERVE TISSUE PROTEINS; TRINUCLEOTIDE REPEATS;

EID: 0030432832     PISSN: 00917451     EISSN: 19434456     Source Type: Book Series    
DOI: 10.1101/SQB.1996.061.01.060     Document Type: Article

References (75)

1. Arriagada, P.V., J.H. Growdon, T. Hedley-White, and B.T. Hyman. 1992. Neurofibrillary tangles but not senile plaques parallel duration and severity of Alzheimer's disease. Neurology 42:631.
2. Andrew, S.E., Y.P. Goldberg, B. Kremer, H. Telenius, J. Theilmann, S. Adam, E. Starr, F. Squitieri, B. Lin, M.A. Kalchman, U.K. Graham, and M.R. Hayden. 1993. The relationship between trinucleotide (CAG) repeat length and clinical features of Huntington's disease. Nat. Genet. 4: 398.
3. Beal, M.F. 1992. Does impairment of energy metabolism result in excitotoxic neuronal death in neurodegenerative illnesses? Ann. Neurol. 31:119.
4. Biernat, J., N. Gustke, G. Drewes, E.-M. Mandelkow, and E. Mandelkow. 1993. Phosphorylation of Ser-262 strongly reduces binding of tau to microtubules: Distinction between PHF-like immunoreactivity and microtubule binding. Neuron 11:153.
5. Bradley, W.A., E.B. Gilliam, A.M. Gotto, Jr., and S.H. Gianturco. 1982. Apolipoprotein E degradation in human very low density lipoporoteins by plasma protease(s): Chemical and biological consequences. Biochem. Biophys. Res. Commun. 109:1360.
6. Burke, J.R., J. Enghild, M.E. Martin, Y.-S. Jou, R.M. Myers, A.D. Roses, J.M. Vance, and W.J. Strittmatter. 1996. Huntingtin and DRPLA proteins selectively interact with the enzyme GAPDH. Nat. Med. 2:347.
7. Burright, E.N., H.B. Clark, A Servadio, T. Matilla, R.M. Fed-derson, W.S. Yunis, L.A. Duvick, H.Y. Zoghbi, and H.T. Orr. 1995. SCA1 transgenic mice: A model for neurodegeneration caused by CAG trinucleotide expansion. Am. J. Hum. Genet, (suppl.) 57:8.
8. Corder, E.H., A.M. Saunders, W.J. Strittmatter, D. Schmechel, P. Gaskell, G.W. Small, A.D.Roses, J.L. Haines, and M.A. Pericak-Vance. 1993. Apolipoprotein E gene dose affects the risk of Alzheimer's diease. Science 261:921.
9. Crowther, R.A. 1993. Tau protein and paired helical filaments of Alzheimer's disease. Curr. Opin. Struct. Biol. 3:202.
10. Crowther, R.A., O.F. Olesen, M.J. Smith, R. Jakes, and M. Goedert. 1994. Assembly of Alzheimer-like filaments from full-length tau protein. FEBS Lett. 337:135.
11. DiFiglia, M., E. Sapp, K. Chase, C. Schwarz, A. Meloni, C. Young, E. Martin, J-P. Vonsattel, R. Carraway, S.A. Reeves, F.M. Boyce, and N. Aronin. 1995. Huntingtin is a cytoplasmic protein associated with vesicles in human and rat brain neurons. Neuron 14:1075.
12. Duyao, M.P., A.B. Auerbach, A. Ryan, F. Persichetti, G.T. Barnes, S.M. McNeil, P. Ge, J-P. Vonsattel, J.F. Gusella, A.L. Joyner, and M.E. MacDonald. 1995. Inactivation of the mouse Huntington's disease gene homolog Hdh. Science 269:407.
13. Ferrante, R.J., N.W. Kowall, and E.P. Richardson, Jr. 1991. Proliferative and degenerative changes in striatal spiny neurons in Huntington's disease: A combined study using the section-Golgi method and calbindin D28k im-munocytochemistry. J. Neurosci. 11:3877.
14. Fleming, L., K.H. Weisgraber, W.J. Strittmatter, J.C. Tron-coso, and G.V.W. Johnson. 1996. Differential binding of apoE isoforms to tau and other cytoskeletal proteins. Exp. Neurol. 138:252.
15. Goedert, M., R.A. Crowther, and C.C. Garner. 1991. Molecular characterization of microtubule-associated proteins tau and MAP 2. Trends Neurosci. 14:193.
16. Goedert, M., M.G. Spillantini, N.J. Cairns, and R.A. Crowther. 1992. Tau proteins of Alzheimer paired helical filaments: Abnormal phosphorylation of all six brain isoforms. Neuron 8:159.
17. Grafton, S.T., J.C. Mazziotta, J.J. Pahl, P. St. George-Hyslop, J.L. Haines, J.M. Hoffman, L.R. Baxter, and M.E. Phelps. 1992. Serial changes of cerebral glucose metabolism and caudate size in persons at risk for Huntington's disease. Arch. Neurol. 49:1161.
18. Graveland, G.A., R.S. Williams, and M. DiFiglia. 1985. Evidence for degenerative and regenerative changes in neostriatal spiny neurons in Huntington's disease. Science 227:770.
19. Gregg, R.E., G. Ghiselli, and H.B. Brewer, Jr. 1983. Apolipoprotein EBethesda: A new variant of apolipoprotein E associated with type III hyperlipidemia. J. Clin. Endocrinol. Metab. 57:969.
20. Han, S.-H., G. Einstein, K.H. Weisgraber, W.J. Strittmatter, A. Saunders, M. Pericak-Vance, A.D. Roses, and D.E. Schmechel. 1994a. Apolipoprotein E is localized to the cytoplasm of human cortical neurons: A light and electron microscopic study. J. Neuropathoi Exp. Neurol. 53:535.
21. Han, S.-H., C. Hulette, A.M. Saunders, G. Einstein, V.M. Pericak, W.J. Strittmatter, A.D. Roses, and D.E. Schmechel. 1994b. Apolipoprotein E is present in hip-pocampal neurons without neurofibrillary tangles in Alzheimer's diease and in age-matched controls. Exp. Neurol. 128:13.
22. Huang, D.Y., K.H. Weisgraber, W.J. Strittmatter, and W. Matthew. 1995a. apoE interacts with laminin, increases neuron attachment and alters morphology. Exp. Neurol. 136:251.
23. Huang, D.Y., K.H. Weisgraber, M. Goedert, A.M. Saunders, A.D. Roses, and W.J. Strittmatter. 1995b. apoE3 binding to tau tandem repeat I is abolished by tau serine 262 phosphorylation. Neurosci. Lett. 192:209.
24. Huang, D.Y., M. Goedert, R. Jakes, K.H. Weisgraber, C. Garner, A.M. Saunders, M. Pericak-Vance, D. Schmechel, A.D. Roses, and W.J. Strittmatter. 1994. Isoform-specific interactions of apolipoprotein E with the microtubule-associated protein MAP 2c: Implications for Alzheimer's disease. Neurosci. Lett. 182:55.
25. Jenkins, B.G., W.J. Koroshetz, M.F. Beal, and B.R. Rosen. 1993. Evidence for impairment of energy metabolism in vivo in Huntington's disease using localized 1H NMR spectroscopy. Neurology 43:2689.
26. Jou, Y.S. and R.M. Myers. 1995. Evidence from antibody studies that the CAG repeat in the Huntington disease gene is expressed in the protein. Hum. Mol. Genet. 4:465.
27. Kosik, K.S. 1992. Tau protein and neurodegeneration. Mol. Neurobiol. 4:171.
28. Lachaal, M., C.J. Berenski, J. Kim, and C.Y. Jung. 1990. An ATP-modulated specific association of glyceraldehyde-3-phosphate dehydrogenase with human erythrocyte glucose transporter. J. Biol. Chem. 265:15449.
29. LaDu, M.J., T.M. Pederson, D.E. Frail, C.A. Reardon, G.S. Getz, and M.T. Falduto. 1995. Purification of apolipoprotein E attenuates isoform-specific binding to 0-amyloid. J. Biol. Chem. 270:9039.
30. LaSpada, A.R., D.B. Roling, A.E. Harding, C.L. Warner, R. Spiegel, W.C. Yee, and K.H. Fischbeck. 1992. Meiotic stability and genotype-phenotype correlation of the trinucleotide repeat in X-linked spinal and bulbar muscular atrophy. Nat. Genet. 2:301.
31. Li, S-H, G. Schilling, W.S. Young, X-J. Li, R.L. Margolis, O.C. Stine, M.V. Wagster, M.H. Abbott, M.L. Franz, N.G. Ranen, S.E. Folstein, J.C. Hedreen, and C.A. Ross. 1993. Huntington's disease gene (IT15) is widely expressed in human and rat tissues. Neuron 11:985.
32. Lindahl, T. and B. Nyberg. 1974. Heat-induced deamination of cytosine residues in deoxyribonucleic acid. Biochemistry 13:3405.
33. Liu, W-K., H. Ksiezak-Reding, and S-H. Yen. 1991. Abnormal tau proteins from Alzheimer's disease brains. Purification and amino acid analysis. J Biol. Chem. 266: 21723.
34. Martin, W.R., C. Clark, W. Ammann, A.J. Stoessl, W. Shtybel, and M.R. Hayden. 1992. Cortical glucose metabolism in Huntington's disease. Neurology 42:223.
35. Mazziotta, J.C, M.E. Phelps, J.J. Pahl, S.C. Huang, L.R. Baxter, W.H. Riege, J.M. Hoffman, D.E. Kuhl, A.B. Lanto, J.A. Wapenski, and C.H. Markham. 1987. Reduced cerebral glucose metabolism in asymptomatic subjects at risk for Huntington's disease. N. Engl. J. Med. 316:357.
36. Mejean, C, F. Pons, Y. Benyamin, and C. Roustan. 1989. Antigenic probes locate binding sites for the glycolytic enzymes gIyceraldehyde-3-phosphate dehydrogenase, aldolase and phosphofructokinase on the actin monomer in microfilaments. Biochem. J. 264:671.
37. Meyer-Siegler, K., D.J. Mauro, G. Seal, J. Wurzer, J.K. deRiel, and M.A. Sirover. 1991. A human nuclear uracil DNA glycosylase is the 37-kDa subunit of glyceraldehyde-3-phosphate dehydrogenase. Proc. Natl. Acad. Sci. 88: 8460.
38. Montine, T.J., V. Amarnath, M.E. Martin, W.J. Strittmatter, and D.G. Graham. 1996a. E-4-hydroxy-2-nonenal, is cytotoxic and covalently crosslinks cytoskeletal proteins in P19 neuroglial cells. Am. J. Pathol. 148:89.
39. Montine, T.J., D.Y. Huang, W.M. Valentine, V. Amarnath, A.M. Saunders, K.H. Weisgraber, D.G. Graham, and W.J. Strittmatter. 1996b. Crosslinking of apolipoprotein E by products of lipid peroxidation. J. Neuropathoi. Exp. Neurol. 55:202.
40. Morgenegg, G., G.C. Winkler, U. Hubscher, C.W. Heizmann, J. Mous, and C.C. Kuenzle. 1986. Glyceraldehyde-3-phosphate dehydrogenase is a nonhistone protein and a possible activator of transcription in neurons. J Neurochem. 47:54.
41. Muronetz, V.I., Z.X. Wang, T.J. Keith, H.R. Knull, and D.K. Srivastava. 1994. Binding constants and stoichiometries of glyceraldehyde 3-phosphate dehydrogenase-tubulin complexes. Arch. Biochem. Biophys. 313:253.
42. Nagy, E. and W.F. Rigby. 1995. Glyceraldehyde-3-phosphate dehydrogenase selectively binds AU-rich RNA in the NAD(+)-binding region (Rossmann fold). J. Biol. Chem. 270:2755.
43. Nakai, A., M. Satoh, K. Hirayoshi, and K. Nagata. 1991. Identification of the ATP-binding heat-inducible protein of MR = 37,000 as glyceraldehyde-3-phosphate dehydrogenase. Biochem. Biophys. Res. Commun. 176:59.
44. Namba, Y., M. Tomonaga, H. Kawasaki, E. Otomo, and K. Ikeda. 1991. Apolipoprotein E immunoreactivity in cerebral amyloid deposits and neurofibrillary tangles in Alzheimer's disease and kuru plaque amyloid in Creutzfeldt-Jakob disease. Brain Res. 541:163.
45. Nixon, R.A. 1993. The regulation of neurofilament protein dynamics by phosphorylation: Clues to neurofibrillary pathobiology. Brain Pathol. 3:29.
46. Onodera, O., M. Oyake, H. Takano, T. Ikeuchi, S. Igarashi, and S. Tsuji. 1995. Molecular cloning of a full-length cDNA for dentatorubral-pallido luysian atrophy and regional expression of the expanded alleles in the CNS. Am. J. Hum. Genet. 57:1050.
47. Orr, H.T., M.Y. Chung, S. Banfi, T.J. Kwiatkowski, Jr., A. Servadio, A.L. Beaudet, LA. Duvick, L.P. Ranum, and H.Y. Zoghbi. 1993. Expansion of an unstable trinucleotide CAG repeat in spinocerebellar ataxia type 1. Nat. Genet. 4:221.
48. Perutz, M.F., T. Johnson, M. Suzuki, and J.T. Finch. 1994. Glutamine repeats as polar zippers: Their possible role in inherited neurodegenerative diseases. Proc. Natl. Acad. Sci. 91:5355.
49. Piechaczyk, M., J.M. Blanchard, S. Riaad-El Sabouty, C. Dani, L. Marty, and P. Jeanteur. 1984. Unusual abundance of vertebrate 3-phosphate dehydrogenase pseudogenes. Nature 312:469.
50. Quigley, C.A. and F.S. French. 1994. Androgen insensitivity syndromes. Curr. Ther. Endocrinol. Metab. 5:342.
51. Rao, K.S. 1993. Genomic damage and its repair in young and aging brain. (Review). Mol. Neurobiol. 7:23.
52. Rebeck, G.W., J.S. Reiter, D.K. Strickland, and B.T. Hyman. 1993. Apolipoprotein E in sporadic Alzheimer's disease: Allelic variation and receptor interactions. Neuron 11:575.
53. Ronai, Z. 1993. Glycolytic enzymes as DNA binding proteins. (Review). Int. J. Biochem. 25:1073.
54. Roses, A.D., W.J. Strittmatter, M.A. Pericak-Vance, E.H. Corder, A.M. Saunders, and D.E. Schmechel. 1994. Clinical application of apolipoprotein E genotyping to Alzheimer's disease. Lancet 343:1564.
55. Sanan, D., K.H. Weisgraber, R.W. Mahley, D.Y. Huang, S.J. Russell, A. Saunders, D. Schmechel, T. Wisniewski, B. Frangione, A.D. Roses, and W.J. Strittmatter. 1994. Apolipoprotein E associates with Ap amyloid peptide to form novel monofibrils in vitro: Isoform apoE4 associates more efficiently than apoE3. J. Clin. Invest. 94:860.
56. Saunders, A.M., C. Hulette, K.A. Welsh, D.E. Schmechel, B. Crain, J.R. Burke, M.J. Alberts, W.J. Strittmatter, J.C. Breitner, C. Rosenberg, S.V. Scott, P.C. Gaskell, Jr., M.A. Pericak-Vance, and A.D. Roses. 1996. Specificity, sensitivity, and predictive value of apolipoprotein E genotyping in a consecutive autopsy series of sporadic Alzheimer's disease patients. Lancet 348:90.
57. Saunders, A.M., W.J. Strittmatter, D. Schmechel, P.H. St. George-Hyslop, M.A. Pericak-Vance, S.H. Joo, B.L. Rosi, J.F. Gusella, D.R. Crapper-MacLachlan, J. Growden, M.J. Alberts, C. Hulette, B. Crain, D.Goldgaber, and A.D. Roses. 1993. Association of apolipoprotein E allele c4 with late-onset familial and sporadic Alzheimer's disease. Neurology 43:1467.
58. Schmechel, D.E., A.M. Saunders, W. J. Strittmatter, S.H. Joo, C. Hulette, B. Crain, D. Goldgaber, and A.D. Roses. 1993. Increased vascular and plaque AB4 amyloid deposits in sporadic Alzheimer's disease patients with apolipoprotein E-e4 allele. Proc. Natl. Acad. Sci. 90:9649.
59. Schulze, H., A. Schuler, D. Stuber, H. Dobeli, H. Langen, and G. Huber. 1993. Rat brain glyceraldehyde-3-phosphate dehydrogenase interacts with the recombinant cytoplasmic domain of Alzheimer's beta-amyloid precursor protein. J. Neurochem. 60:1915.
60. Servadio, A., B. Koshy, D. Armstrong, B. Antalffy, H.T. Orr, and H.Y. Zoghbi. 1995. Expression analysis of the ataxin-1 protein in tissues from normal and spinocerebellar ataxia type 1 individuals. Nat. Genet. 10:94.
61. Singh, R. and M.R. Green. 1993. Sequence-specific binding of transfer RNA by glyceraldehyde-3-phosphate dehydrogenase. Science 259:365.
62. Somers, M., Y. Engelborghs, and J. Baert. 1990. Analysis of the binding of glyceraldehyde-3-phosphate dehydrogenase to microtubules, the mechanism of bundle formation and the linkage effect. Eur. J. Biochem. 193:437.
63. Stott, D., J.M. Blackburn, P.J.G. Butler, and M. Perutz. 1995. Incorporation of glutamine repeats makes protein oligomerize: Implications for neurodegenerative diseases. Proc. Natl. Acad. Sci. 92:6509.
64. Strittmatter, W.J., A.M. Saunders, M. Pericak-Vance, G.S. Salvesen, J. Enghild, and A.D. Roses. 1993a. Apolipoprotein E: High avidity binding to Ap amyloid and increased frequency of type 4 isoform in familial Alzheimer's disease. Proc. Natl. Acad. Sci. 90:1977.
65. Strittmatter, W.J., A.M. Saunders, M. Goedert, K. Weisgraber, L.-M. Dong, R. Jakes, D.Y. Huang, M. Pericak-Vance, D. Schmechel, and A.D. Roses. 1994a. Isoform-specific interactions of apolipoprotein E with microtubule-associated protein tau: Implications for Alzheimer's disease. Proc. Natl. Acad. Sci. 91:11183.
66. Strittmatter, W.J., K.H.Weisgraber, D. Huang, L.-M. Dong, G.S. Salvesen, M. Pericak-Vance, D. Schmechel, A.M. Saunders, D.M. Goldgaber, and A.D. Roses. 1993b. Binding of human apolipoprotein E to Ap4 peptide: Isoform-specific effects and implications for late-onset Alzheimer's disease. Proc. Natl. Acad. Sci. 90:8098.
67. Strittmatter, W.J., K.H. Weisgraber, M. Goedert, A.M. Saunders, D. Huang, E.H. Corder, L.-M. Dong, R. Jakes, M.J. Alberts, J.R. Gilbert, D.E. Schmechel, M.A. Pericak-Vance, and A.D. Roses. 1994b. Hypothesis: Microtubule instability and paired helical filament formation in the Alzheimer's disease brain as a function of apolipoprotein E genotype. Exp. Neurol. 125:163.
68. Tso, J.Y., X.H. Sun, T.H.Kao, K.S. Reece, and R. Wu. 1985. Isolation and characterization of rat and human glyceraldehyde-3-phosphate dehydrogenase cDNAs: Genomic complexity and molecular evolution of the gene. Nucleic Acids Res. 13:2485.
69. Weisgraber, K.H. 1990. Apolipoprotein E distribution among human plasma lipoproteins: Role of the cysteine-arginine interchange at residue 112. J. Lipid Res. 31:1503.
70. Weisgraber, K.H. 1994. Apolipoprotein E: Structure-function relationships. Adv. Protein Chem. 45:249.
71. Weisgraber, K.H. and R.W. Mahley. 1978. Apoprotein (E-A-II) complex of human plasma lipoproteins. I. Characterization of this mixed disulfide and its identification in a high density lipoprotein subfraction. J. Biol. Chem. 253: 6281.
72. Weisgraber, K.H. and L.H. Shinto. 1991. Identification of the disulfide-linked homodimer of apolipoprotein E3 in plasma. J. Biol. Chem. 266:12029.
73. Willems, P.J. 1994. Dynamic mutations hit double figures. Nat. Genet. 8: 213.
74. Yazawa, I., N. Nukina, H. Hashida, J. Goto, M. Yamada, and I. Kanazawa. 1995. Abnormal gene product identified in hereditary dentatorubral-pallidoluysian atrophy (DRPLA) brain. Nat. Genet. 10:99.
75. Zeng, F.Y., V. Gerke, and H.J. Gabius. 1993. Identification of annexin II, annexin VI and glyceraldehyde-3-phosphate dehydrogenase as calcyclin-binding proteins in bovine heart. Int. J. Biochem. 25:1019.