Immunohistochemical demonstration of the nm23-H1 gene product in human malignant melanoma and Spitz nevi

Pathology

Volumn 28, Issue 3, 1996, Pages 220-224

  Lee, C S ^a,d   Pirdas, A ^b   Lee, M W K ^c  

^a UNIVERSITY OF MELBOURNE   (Australia)

^b ST VINCENT S HOSPITAL   (Australia)

^c HEIDELBERG REPATRIATION HOSPITAL   (Australia)

^d ST GEORGE HOSPITAL   (Australia)

Author keywords

Immunohistochemistry; Melanoma; nm23; Tumor suppressor gene

Indexed keywords

GENE PRODUCT;

ADOLESCENT; ADULT; ARTICLE; CLINICAL ARTICLE; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; JUVENILE MELANOMA; MALE; MELANOMA; METASTASIS POTENTIAL;

EID: 0030432708     PISSN: 00313025     EISSN: None     Source Type: Journal    
DOI: 10.1080/00313029600169014     Document Type: Article

References (15)

1. Ross DW. Molecular markers of cancer. Arch Pathol Lab Med 1991; 115: 402.
2. Steeg PS, Bevilacqua G, Kopper L et al. Evidence for a novel gene associated with low tumor metastatic potential. J Natl Cancer Inst 1988; 80(3): 200-4.
3. Leone A, McBride OW, Weston A et al. Somatic allelic deletion of nm23 in human cancer. Cancer Res 1991; 51: 2490-3.
4. Bevilacqua G, Sobel ME, Liotta LA, Steeg PS. Association of low nm23 RNA levels in human primary infiltrating ductal breast carcinomas with lymph node involvement and other histopathological indicators of high metastatic potential. Cancer Res 1989; 49: 5185-90.
5. Hennessy C, Henry JA, May FEB et al. Expression of the anti-metastatic gene nm 23 in human breast cancer; association with good prognosis. J Natl Cancer Inst 1991; 83: 281-85.
6. Cohn KH, Wang F, Desoto-La Paix F et al. Association of nm23-H1 allelic deletions with distant metastases in colorectal carcinoma. Lancet 1991; 338: 722-4.
7. Barnes R, Masood S, Barker E et al. Low nm 23 protein expression in infiltrating ductal breast carcinomas correlates with reduced patient survival. Am J Pathol 1991; 139: 245-50.
8. Flørenes VA, Aamdal S, Myklebost O et al. Levels of nm23 messenger RNA in metastatic malignant melanomas: inverse correlation to disease progression. Cancer Res 1992; 52: 6088-91.
9. Sawan A, Lascu I, Veron M et al. NDP-K/nm23 expression in human breast cancer in relation to relapse, survival, and other prognostic factors: an immunohistochemical study. J Pathol 1994; 172: 27-34.
10. Lee CS, Pirdas-Zivcic A. nm23-H1 protein immunoreactivity in cancers of the gallbladder, extrahepatic bile ducts and ampulla of Vater. Pathol 1994 (in press).
11. Kernen JA, Ackerman LV. Spindle cell nevi and epithelioid cell nevi (so-called juvenile melanomas) in children and adults. A clinicopathologic study of 27 cases. Cancer 1960; 13: 612-25.
12. Spitz S. Melanomas of childhood. Am J Pathol 1948; 24: 591-609.
13. Price NM, Rywlin AM, Ackerman AB. Histologic criteria for the diagnosis of superficial spreading melanoma: formulated on the basis of proven metastatic lesions. Cancer 1976; 38: 2434-41.
14. Maize JC, Ackerman AB. Pigmented lesions of the skin. Clinicopathologic correlations. Philadelphia: Lea & Febinger, 1987.
15. Lever WF, Schaumberg-Lever G. Histopathology of the skin. Philadelphia: J.B. Lippincott, 1990; 780.