Effects of caffeine and theophylline on acetaminophen pharmacokinetics: P450 inhibition and activation

Journal of Pharmacology and Experimental Therapeutics

Volumn 277, Issue 1, 1996, Pages 287-291

  Lee, Caroline A ^a   Lillibridge, James H ^a   Nelson, Sidney D ^a   Slattery, John T ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CAFFEINE; CYTOCHROME P450; DRUG METABOLITE; METHYLXANTHINE DERIVATIVE; N ACETYL 1,4 BENZOQUINONE IMINE; PARACETAMOL; PHENOBARBITAL; THEOPHYLLINE;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG CLEARANCE; DRUG MIXTURE; DRUG POTENTIATION; INTRAPERITONEAL DRUG ADMINISTRATION; INTRAVENOUS DRUG ADMINISTRATION; LIVER MICROSOME; LIVER TOXICITY; MALE; NONHUMAN; PRIORITY JOURNAL; RAT;

ACETAMINOPHEN; ANALGESICS, NON-NARCOTIC; ANIMALS; BENZOQUINONES; CAFFEINE; CYTOCHROME P-450 ENZYME SYSTEM; DRUG INTERACTIONS; ENZYME ACTIVATION; GLUTATHIONE; IMINES; MALE; METABOLIC CLEARANCE RATE; RATS; RATS, SPRAGUE-DAWLEY; THEOPHYLLINE;

EID: 0030431445     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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