Ketotifen inhibits allergen-specific T lymphocytes' responses by suppressing antigen presentation with concomitant decrease of HLA-DQ antigen on macrophages

Asian Pacific Journal of Allergy and Immunology

Volumn 14, Issue 2, 1996, Pages 69-79

  Kawano, Yutaka ^a,b   Yoshizawa, Izumi ^a   Baba, Minoru ^c   Noma, Takeshi ^a,b  

^a SAITAMA MEDICAL UNIVERSITY   (Japan)

^b KITASATO UNIVERSITY   (Japan)

^c Doai Memorial Hospital   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIALLERGIC AGENT; HLA DQ ANTIGEN; INTERLEUKIN 2; KETOTIFEN; RECOMBINANT GAMMA INTERFERON;

ADOLESCENT; ADULT; ANTIGEN PRESENTATION; ARTICLE; CHILD; CLINICAL ARTICLE; DERMATOPHAGOIDES FARINAE; HUMAN; HUMAN CELL; MACROPHAGE; PRESCHOOL CHILD; SCHOOL CHILD; T LYMPHOCYTE;

ADOLESCENT; ADULT; ANTI-ALLERGIC AGENTS; ANTIGEN PRESENTATION; ASTHMA; CELL ADHESION; CELLS, CULTURED; CHILD; CHILD, PRESCHOOL; DOSE-RESPONSE RELATIONSHIP, DRUG; FLOW CYTOMETRY; HLA-DQ ANTIGENS; HUMANS; INTERFERON TYPE II; INTERLEUKIN-2; INTERLEUKIN-4; KETOTIFEN; MACROPHAGES; T-LYMPHOCYTES;

EID: 0030429370     PISSN: 0125877X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (35)

1. Mastsui T, Baba M. Death from asthma in children. Acta Paediatr Jpn 1990;32:205-8.
2. Girard JP, Rose NR, Kunz ML, Kobayashi S, Arbesman CE. In virto lymphocyte tranformation in atopic patients by antigens. J Allergy 1967;39 :65-81.
3. Romagnani S, Biliotti G, Passaleva A, Ricci M. Mites and house dust allergy. III. In vitro lymphocyte transformation and precipitating antibody to house dust and mite. Clin Allergy 1973;:3:51-6.
4. Gatien JG, Merler E, Colten HR . Allergy to ragweed antigen E: Effect of specific immunotherapy on the reactivity of human T-lymphocytes in vitro. Clin Immunol Immunopathol 1975;4:32-47.
5. Buckley RH, Seymour F, Sanal SO, Ownby DR, Becker WG. Lymphocyte responses to purified ragweed antigens in vitro. I. Proliferative responses in normal and atopic subjects. J Allergy Clin Immunol 1977;59:70-8.
6. Black PL, Marsh DG. Correlation between lymphocyte response and immediate hypersitivity to purified allergen. J Allergy Clin Immunol 1980;66:394-401.
7. Hiratani M, Muto K, Oshida Y, Itoh S, Kasei M. Lymhocyte responsiveness to Dermatophagoides farinae extract in mite sensitive patiens:effect of immunotherapy on cellular proliferative response and specific immunotherapy on cellular proliferative response and specific immunoglobulin E antibody (RAST score). J Allergy Clin Immunol 1981;68:205-11.
8. Rawle FC, Mitchell EB, Platts-Mills TEA. T cell responses to the major allergen from the house dust mite Dermatophagoides pteronyssinus, antigen P1:comparison of patients with asthma, atopic dermatitis, and perennial rhinitis. J Immunol 1984; 133:195-201.
9. Noma T. Toshizawa I, Kawano Y, Itoh M, Baba M, Yata J. Allergen-induced IL2 responsiveness in lymphocytes from patients with atopic dermatitis and/or bronchial asthma. Jpn J Allergology 1987;36:1075-85.
10. Yoshizawa I, Noma T. Kawano Y, Yata J. Allergen specific induction of IL2 responsiveness in lymphocytes from asthmatic children. I. Antigen specificity and initial events of the induction. J Allergy Clin Immunol 1989;84:246-55.
11. Norma T, Yoshizawa I, Maeda K, Ichikawa K, Baba M, Yata J. Allergen specific induction of IL2 responsiveness in lymphocytes from asthmatic children. II. regulation of IL2 responsiveness by supernatants of normal lymphocytes. J Allergy Clin Immunol 1989;84:255-62.
12. Noma T, Yoshizawa I, Kou K, et al. Pattern of cytokine production by T cells from adolescents with asthma in remission, after stimulation with Dermatophagoides farinae antigen. Pediatr Res 1995; 38:187-93.
13. Wierenga EA, Snoek M, de Groot C, et al. Evidence for compartmentalization of functional subsets of CD4+ T lymphocytes in atopic patients. J Immunol 1990; 144:4651-6.
14. Wierenga EA, Snoek M, Jansen HM, Bos JD, van Lier RA, Kapsenberg ML. Human atopen-specific types 1 and 2 T helper cell clones. J Immunol 1991;147: 2942-9.
15. Yssel H, Johnson KE, Schneider PV, et al. T cell activation-inducing epitopes of the house dust mite allergen Der p1. Proliferation and lymphokine production patterns by Der p 1-specific CD4+ T cell clones. J Immunol 1992; 148: 738-45.
16. Kennedy CR. Metabolism and phramac okinetices of Ketotifen in children. Res Clin Formus 1982; 4: 17-20.
17. Craps L. Ketotifen in the prophylaxis of brachial asthma. Clin Ther 1982; 5: 129-35.
18. Noma T, Yoshizawa I, Baba M, Yata J, Akasaka T, Maeda K. Effect of Ketotifen on antigen-induced interleukin 2 (IL-2) responsiveness in lymphocytes from patients with atopic dermatitis and for bronchial asthma. Int J Pharmac 1990; 12: 269-77.
19. Ichikawa K, Baba M, Kawano Y, Norma T. Effect of interferon-γ on HLA class 2 expressi on by antigen-presenting cells inducing Dermatophagoides farinae-specific interleukin-2 responsiveness of lymphocytes in asthmatic children. Pediatr Allergy Immunol 1994;5:53-8.
20. te Velde AA, Klomp JPG, Yard BA, de Vries JE, Figdor CG. Modulation of phenotypic and functional properties of human peripheral blood monocytes by IL-4 J Immunol 1988;140: 1548-54.
21. Miyamoto T, Johansson SGO, Itoh K, Horiuchi Y. Atopic allergy in Japanese subjects: studies primarily with radioallergosorbent test. J Allergy Clin Immunol 1974; 53:9-19.
22. Boyum A. Isolation of mononuclear cells and granulocytes from human blood. Scand J Clin Lab Invest 1968; 21 : 77-90.
23. Minami M, Shereffler DC, Cowing C. Characterization of the stimulator cells in the murine primary mixed leukocyte response. J Immunol 1980; 124: 1314-21.
24. Indiveri F, Pellegrino MA, Molinaro GA, Quaranta V, Ferron S. Resetting of human T lymphocytes with goat red blood cells : effect of treatment with 2-aminoethylisothiouronium bromide (AET) and comparison with AET treated sheep red blood cells J Immunol Meth 1979;30: 317-28.
25. Becker S. Interferon-γ accelerates immune proliferation via its effect on monocyte HLA-DR expression. Cell Immunol 1985; 91: 301-7.
26. Beller DI. Functional significance of the regulation of macrophage Ia expression. Eur J Immunol 1984; 14: 138-43.
27. Gerrard TL, Dyer DR, Mostowski HS. IL-4 and granulocyte-macrophage colony-stimulating factor selectively increase HLA-DR and HLA-DP antigens but not HLA-DQ antigens on human monocytes. J Immunol 1990; 144: 4670-4.
28. Uanae ER. The regulation of lymphocyte functions by the macrophages. Immunol Rev 1978; 40: 227-55.
29. Gajewski TP, Pinnas M, Wong T, Fitch FW. Murine Th1 and Th2 clones proliferate optimally in response to distinct antigen-presenting cell populations. J Immunol 1991;146: 1750-8.
30. Secrist H, DeKruyff RH, Umetsu DT. Interleukin 4 production by CD4+ T cells from allergic individuals is modulated by antigen concentration and antigen-presenting cell type. J Exp Med 1995; 181:1081-9
31. Kawano Y, Itoh M, Noma T, Yata J. Interferon-γ modulates the ability of autologous non-T cells to produce and respond to interleukin 2. Cell Immunol 1988; 112: 166-73.
32. Gonwa TA, Frost JP, Karr RW. All human monocytes have the capability of expressing HLA-DQ and -DP molecules upon stimulation with interferon-γ. J Immunol 1986;137: 519-24.
33. Azuma M, Cayabyab M, Buck D, Phillips JH, Lanier LL. CD28 Interaction with B7 costimulates primary allogeneic proliferative responses and cytotoxicity mediated by small, resting T lymphocytes J Exp Med 1992; 175: 353-60.
34. Chan AC, Desai DM, Weiss A. The role of protein tyosine kinases and protein tyrosine phosphatases in T cell antigen receptor signal transduction. Ann Rev Immunol 1994; 12:555-92.
35. Weiss A, Littman Dr. Signal transduction by lymphocyte antigen receptors. Cell 1994;76: 263-74.