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Volumn 277, Issue 3, 1996, Pages 1292-1304

Effects of 3-[1-(phenylmethyl)-4-piperidinyl]-1-(2,3,4,5-tetrahydro-1H-1-benzazepin-8-yl)- 1-propanone fumarate (TAK-147), a novel acetylcholinesterase inhibitor, on impaired learning and memory in animal models

Author keywords

[No Author keywords available]

Indexed keywords

CHOLINESTERASE INHIBITOR; DIAZEPAM; ETHYLCHOLINE MUSTARD AZIRIDINIUM; METHYLSCOPOLAMINE; SCOPOLAMINE; TACRINE; ZANEPEZIL;

EID: 0030426815     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (26)

References (78)
  • 1
    • 0023248545 scopus 로고
    • Effects of scopolamine and physostigmine on recognition memory in monkeys with ibotenic-acid lesions of the nucleus basalis of Meynert
    • AIGNER, T., MITCHELL, S. J., AGCLETON, J. P., DELONG, M. R., STRUBLE, R. G., PRICE, D. L., WENK, G. L. AND MISHKIN, M.: Effects of scopolamine and physostigmine on recognition memory in monkeys with ibotenic-acid lesions of the nucleus basalis of Meynert. Psychopharmacology 92: 292-300, 1987.
    • (1987) Psychopharmacology , vol.92 , pp. 292-300
    • Aigner, T.1    Mitchell, S.J.2    Agcleton, J.P.3    Delong, M.R.4    Struble, R.G.5    Price, D.L.6    Wenk, G.L.7    Mishkin, M.8
  • 2
    • 0027969107 scopus 로고
    • Effects of disrupting the cholinergic system on short-term spatial memory in rata
    • ANDREWS, J. S., JANSEN, J. H. M., LINDERS, S. AND PRINCEN, A.: Effects of disrupting the cholinergic system on short-term spatial memory in rata. Psychopharmacology 115: 485-494, 1994.
    • (1994) Psychopharmacology , vol.115 , pp. 485-494
    • Andrews, J.S.1    Jansen, J.H.M.2    Linders, S.3    Princen, A.4
  • 3
    • 0028143666 scopus 로고
    • Opposite effects of cholinergic agents and benzodiazepine receptor ligands in a passive avoidance task in rats
    • ANGLADE, F., BIZOT, J.-C., DODD, R. H., BAUDOIN, C. AND CHAPOUTHIER, G.: Opposite effects of cholinergic agents and benzodiazepine receptor ligands in a passive avoidance task in rats. Neurosci. Lett. 182: 247-250, 1994.
    • (1994) Neurosci. Lett. , vol.182 , pp. 247-250
    • Anglade, F.1    Bizot, J.-C.2    Dodd, R.H.3    Baudoin, C.4    Chapouthier, G.5
  • 4
    • 0001496973 scopus 로고
    • A simple screening procedure for imipramine-like antidepressant agents
    • ASKEW, B. M.: A simple screening procedure for imipramine-like antidepressant agents. Life Sci. 10: 725-730, 1963.
    • (1963) Life Sci. , vol.10 , pp. 725-730
    • Askew, B.M.1
  • 5
    • 0019255833 scopus 로고
    • Memory deficits in aged cebus monkeys and facilitation with central cholinomimetics
    • BARTUS, R. T., DEAN, R. L. AND BEER, B.: Memory deficits in aged cebus monkeys and facilitation with central cholinomimetics. Neurobiol. Aging 1: 145-152, 1980.
    • (1980) Neurobiol. Aging , vol.1 , pp. 145-152
    • Bartus, R.T.1    Dean, R.L.2    Beer, B.3
  • 6
    • 0019972810 scopus 로고
    • The cholinergic hypothesis of geriatric memory dysfunction
    • Wash. DC
    • BARTUS, R. T., DEAN, R. L., BEER, B. AND LIPPA, A. S.: The cholinergic hypothesis of geriatric memory dysfunction. Science (Wash. DC) 217: 408-417, 1982.
    • (1982) Science , vol.217 , pp. 408-417
    • Bartus, R.T.1    Dean, R.L.2    Beer, B.3    Lippa, A.S.4
  • 7
    • 0024390654 scopus 로고
    • Effects of corticotropin releasing factor, desipramine and haloperidol on a DRL schedule of reinforcement
    • BRITTON, K. T. AND KOOB, G. F.: Effects of corticotropin releasing factor, desipramine and haloperidol on a DRL schedule of reinforcement. Pharmacol. Biochem. Behav. 32: 967-970, 1989.
    • (1989) Pharmacol. Biochem. Behav. , vol.32 , pp. 967-970
    • Britton, K.T.1    Koob, G.F.2
  • 8
    • 0019363538 scopus 로고
    • Physostigmine and arecoline: Effects of intravenous infusions in Alzheimer presenile dementia
    • CHRISTIE, J. E., SHERING, A., FERGUSON, J. AND GLEN, A. I. M.: Physostigmine and arecoline: Effects of intravenous infusions in Alzheimer presenile dementia. Br. J. Psychiatry 138: 46-50, 1981.
    • (1981) Br. J. Psychiatry , vol.138 , pp. 46-50
    • Christie, J.E.1    Shering, A.2    Ferguson, J.3    Glen, A.I.M.4
  • 10
    • 0022493338 scopus 로고
    • Effects of benzodiazepines on acquisition and performance: A critical assessment
    • COLE, S. O.: Effects of benzodiazepines on acquisition and performance: A critical assessment. Neurosci. Biobehav. Rev. 10: 265-272, 1986.
    • (1986) Neurosci. Biobehav. Rev. , vol.10 , pp. 265-272
    • Cole, S.O.1
  • 11
    • 0016136569 scopus 로고
    • Effect of diazepam on mouse whole brain and brain area acetylcholine and choline levels
    • CONSOLO, S., LADINSKY, H., PERI, G. AND GARATTINI, S.: Effect of diazepam on mouse whole brain and brain area acetylcholine and choline levels. Eur. J. Pharmacol. 27: 266-268, 1974.
    • (1974) Eur. J. Pharmacol. , vol.27 , pp. 266-268
    • Consolo, S.1    Ladinsky, H.2    Peri, G.3    Garattini, S.4
  • 12
    • 0020686674 scopus 로고
    • Alzheimer's disease: A disorder of cortical cholinergic innervation
    • Wash. DC
    • COYLE, J. T., PRICE, D. L. AND DELONG, M. R.: Alzheimer's disease: A disorder of cortical cholinergic innervation. Science (Wash. DC) 219: 1184-1190, 1983.
    • (1983) Science , vol.219 , pp. 1184-1190
    • Coyle, J.T.1    Price, D.L.2    Delong, M.R.3
  • 13
    • 0019949485 scopus 로고
    • Enhancement of memory processes in Alzheimer's disease with multiple-dose intravenous physostigmine
    • DAVIS, K. L. AND MOHS, R. C.: Enhancement of memory processes in Alzheimer's disease with multiple-dose intravenous physostigmine. Am. J. Psychiatry 139: 1421-1424, 1982.
    • (1982) Am. J. Psychiatry , vol.139 , pp. 1421-1424
    • Davis, K.L.1    Mohs, R.C.2
  • 15
    • 0011162190 scopus 로고
    • Selective loss of central cholinergic neurons in Alzheimer's disease
    • DAVIS, P. AND MALONEY, A. J. F.: Selective loss of central cholinergic neurons in Alzheimer's disease. Lancet ii: 1403, 1977.
    • (1977) Lancet , vol.2 , pp. 1403
    • Davis, P.1    Maloney, A.J.F.2
  • 16
    • 0027743382 scopus 로고
    • The effects of novel cholinesterase inhibitors and selective muscarinic receptor agonists in tests of reference and working memory
    • DAWSON, G. R. AND IVERSEN, S. D.: The effects of novel cholinesterase inhibitors and selective muscarinic receptor agonists in tests of reference and working memory. Behav. Brain Res. 57: 143-153, 1993.
    • (1993) Behav. Brain Res. , vol.57 , pp. 143-153
    • Dawson, G.R.1    Iversen, S.D.2
  • 17
    • 0017652462 scopus 로고
    • Memory and cognitive function in man: Does the cholinergic system have a specific role?
    • DRACHMAN, D. A.: Memory and cognitive function in man: Does the cholinergic system have a specific role? Neurology 27: 783-790, 1977.
    • (1977) Neurology , vol.27 , pp. 783-790
    • Drachman, D.A.1
  • 18
    • 0022384940 scopus 로고
    • Comparative effects of cholinergic drugs and lesions of nucleus basalis or fimbria-fornix on delayed matching in rats
    • DUNNETT, S. B.: Comparative effects of cholinergic drugs and lesions of nucleus basalis or fimbria-fornix on delayed matching in rats. Psychopharmacology 87: 357-363, 1985.
    • (1985) Psychopharmacology , vol.87 , pp. 357-363
    • Dunnett, S.B.1
  • 19
    • 0023810627 scopus 로고
    • Delay-dependent short-term memory deficits in aged rats
    • DUNNETT, S. B., EVENDEN, J. L. AND IVERSEN, S. D.: Delay-dependent short-term memory deficits in aged rats. Psychopharmacology 96: 174-180, 1988.
    • (1988) Psychopharmacology , vol.96 , pp. 174-180
    • Dunnett, S.B.1    Evenden, J.L.2    Iversen, S.D.3
  • 21
    • 0004116672 scopus 로고
    • Cambridge University, London
    • FINNEY, D. J.: Probit Analysis, Cambridge University, London, 1952.
    • (1952) Probit Analysis
    • Finney, D.J.1
  • 22
    • 0016468979 scopus 로고
    • A rapid radiochemical method for the determination of choline acetyltransferase
    • FONNUM, F.: A rapid radiochemical method for the determination of choline acetyltransferase, J. Neurochem. 24: 407-409, 1975.
    • (1975) J. Neurochem. , vol.24 , pp. 407-409
    • Fonnum, F.1
  • 24
    • 0025307713 scopus 로고
    • Benzodiazepines and human memory: A review
    • GHONEIM, M. M. AND MEWALDT, S. P.: Benzodiazepines and human memory: A review. Anesthesiology 72: 926-938, 1990.
    • (1990) Anesthesiology , vol.72 , pp. 926-938
    • Ghoneim, M.M.1    Mewaldt, S.P.2
  • 25
    • 0021800219 scopus 로고
    • Alzheimer's disease and senile dementia: Biochemical characteristics and aspects of treatment
    • GOTTFRIES, C. G.: Alzheimer's disease and senile dementia: Biochemical characteristics and aspects of treatment. Psychopharmacology 86: 245, 1985.
    • (1985) Psychopharmacology , vol.86 , pp. 245
    • Gottfries, C.G.1
  • 26
    • 0024551069 scopus 로고
    • Divided attention, as measured by dichotic speech performance in dementia of the Alzheimer type
    • GRADY, C. L., GRIMES, A. M., PATRONAS, N., SUNDERLAND, T., FOSTER, N. L. AND RAPOPORT, S. I.: Divided attention, as measured by dichotic speech performance in dementia of the Alzheimer type. Arch. Neurol. 46: 317-320, 1989.
    • (1989) Arch. Neurol. , vol.46 , pp. 317-320
    • Grady, C.L.1    Grimes, A.M.2    Patronas, N.3    Sunderland, T.4    Foster, N.L.5    Rapoport, S.I.6
  • 27
    • 0022809720 scopus 로고
    • Differential effects of nerve-growth factor and glioma conditioned medium on neurons cultured from various regions of fetal rat central nervous system
    • HATANAKA, H. AND TSUKUI, H.: Differential effects of nerve-growth factor and glioma conditioned medium on neurons cultured from various regions of fetal rat central nervous system. Dev. Brain Res. 30: 47-56, 1986.
    • (1986) Dev. Brain Res. , vol.30 , pp. 47-56
    • Hatanaka, H.1    Tsukui, H.2
  • 28
    • 0019793609 scopus 로고
    • Differential effects of several dopamine uptake inhibitors and releasing agents on locomotor activity in normal and in reserpinized mice
    • HEIKKILA, R. E.: Differential effects of several dopamine uptake inhibitors and releasing agents on locomotor activity in normal and in reserpinized mice. Life Sci. 28: 1867-1873, 1981.
    • (1981) Life Sci. , vol.28 , pp. 1867-1873
    • Heikkila, R.E.1
  • 29
    • 0000472463 scopus 로고
    • Characteristics of neuropharmacological effects of TAK-147, a novel acetylcholinesterase inhibitor, in vitro
    • HIRAI, K., NAKAYAMA, T., MURAKOSHI, H., ISHIHARA, Y., GOTO, G. AND MIYAMOTO, M.: Characteristics of neuropharmacological effects of TAK-147, a novel acetylcholinesterase inhibitor, in vitro (Abstract). Soc. Neurosci. 19: 1812, 1993.
    • (1993) Soc. Neurosci. , vol.19 , pp. 1812
    • Hirai, K.1    Nakayama, T.2    Murakoshi, H.3    Ishihara, Y.4    Goto, G.5    Miyamoto, M.6
  • 30
    • 0022614259 scopus 로고
    • Effects of chlordiazepoxide on cued radial maze performance in rats
    • HODGES, H. AND GREEN, S.: Effects of chlordiazepoxide on cued radial maze performance in rats. Psychopharmacology 88: 460-466, 1986.
    • (1986) Psychopharmacology , vol.88 , pp. 460-466
    • Hodges, H.1    Green, S.2
  • 31
    • 0028104107 scopus 로고
    • Central cholinergic agents. 6. Synthesis and evaluation of 3[1-(phenylmethyl)-4-piperidinyl-1-(2,3,4,5-tetrahydro-1H-1-benzazepin-8-yl)-1- propanones and their analogs as central selective acetylcholinesterase inhibitors
    • ISHIHARA, Y., HIRAI, K., MIYAMOTO, M. AND GOTO, G.: Central cholinergic agents. 6. Synthesis and evaluation of 3[1-(phenylmethyl)-4-piperidinyl)-1-(2,3,4,5-tetrahydro-1H-1-benzazepin-8-yl)-1- propanones and their analogs as central selective acetylcholinesterase inhibitors. J. Med. Chem. 37: 2292-2299, 1994.
    • (1994) J. Med. Chem. , vol.37 , pp. 2292-2299
    • Ishihara, Y.1    Hirai, K.2    Miyamoto, M.3    Goto, G.4
  • 32
    • 0021207372 scopus 로고
    • Behavioral and neurochemical effects of intraventricular AF64A administration in rats
    • JERRARD, L. E., KANT, G. J., MEYERHOFF, J. L. AND LEVY, A.: Behavioral and neurochemical effects of intraventricular AF64A administration in rats. Pharmacol. Biochem. Behav. 21: 272-280, 1984
    • (1984) Pharmacol. Biochem. Behav. , vol.21 , pp. 272-280
    • Jerrard, L.E.1    Kant, G.J.2    Meyerhoff, J.L.3    Levy, A.4
  • 33
    • 0016654358 scopus 로고
    • A rapid simple radiometric assay for cholinesterase, suitable for multiple determinations
    • JOHNSON, C. D. AND RUSSELL, R. L.: A rapid simple radiometric assay for cholinesterase, suitable for multiple determinations. Anal. Biochem. 64: 229-238, 1975.
    • (1975) Anal. Biochem. , vol.64 , pp. 229-238
    • Johnson, C.D.1    Russell, R.L.2
  • 34
    • 0022616654 scopus 로고
    • Alzheimer's disease
    • KATZMAN, R.: Alzheimer's disease. N. Engl. J. Med. 315: 964-973, 1986.
    • (1986) N. Engl. J. Med. , vol.315 , pp. 964-973
    • Katzman, R.1
  • 35
    • 0022115985 scopus 로고
    • Early phenobarbital-induced alterations in hippocampal acetylcholinesterase activity and behavior
    • KLEINBERGER, N. AND YANAI, J.: Early phenobarbital-induced alterations in hippocampal acetylcholinesterase activity and behavior. Dev. Brain Res. 22: 113-123, 1985.
    • (1985) Dev. Brain Res. , vol.22 , pp. 113-123
    • Kleinberger, N.1    Yanai, J.2
  • 36
    • 0028270519 scopus 로고
    • A 30-week randomized controlled trial of high-dose tacrine in patients with Alzheimer's disease
    • KNAPP, M. J., KNOPMAN, D. S., SOLOMON, P. R., PENDLEBURY, W. W., DAVIS, C. S. AND GRACON, S. L: A 30-week randomized controlled trial of high-dose tacrine in patients with Alzheimer's disease. JAMA 271: 985-991, 1994.
    • (1994) JAMA , vol.271 , pp. 985-991
    • Knapp, M.J.1    Knopman, D.S.2    Solomon, P.R.3    Pendlebury, W.W.4    Davis, C.S.5    Gracon, S.L.6
  • 37
    • 0028359006 scopus 로고
    • Behavioral evidence for a modulating role of σ ligands in memory processes. I. Attenuation of dizocilpine (MK-801)-induced amnesia
    • MAURICE, T., HIRAMATSU, M., ITOH, J., KAMEYAMA, T., HASEGAWA, T. AND NABESHIMA, T; Behavioral evidence for a modulating role of σ ligands in memory processes. I. Attenuation of dizocilpine (MK-801)-induced amnesia. Brain Res. 647: 44-56, 1994.
    • (1994) Brain Res. , vol.647 , pp. 44-56
    • Maurice, T.1    Hiramatsu, M.2    Itoh, J.3    Kameyama, T.4    Hasegawa, T.5    Nabeshima, T.6
  • 38
    • 0018825716 scopus 로고
    • The effects of tricyclic antidepressants on performance under a differential-reinforcement-of-low-rates schedule in rats
    • MCGUIRE, P. S. AND SEIDEN, L. S.: The effects of tricyclic antidepressants on performance under a differential-reinforcement-of-low-rates schedule in rats. J. Pharmacol. Exp. Ther. 214: 635-641, 1980a.
    • (1980) J. Pharmacol. Exp. Ther. , vol.214 , pp. 635-641
    • Mcguire, P.S.1    Seiden, L.S.2
  • 39
    • 0019178746 scopus 로고
    • Differential effects of imipramine in rats as a function of DRL schedule value
    • MCGUIRE, P. S. AND SEIDEN, L. S.: Differential effects of imipramine in rats as a function of DRL schedule value. Pharmacol. Biochem. Behav. 13: 691-694, 1980b.
    • (1980) Pharmacol. Biochem. Behav. , vol.13 , pp. 691-694
    • Mcguire, P.S.1    Seiden, L.S.2
  • 40
    • 0027194392 scopus 로고
    • Effects of sustained release formulation of thyrotropin-releasing hormone on learning impairments caused by scopolamine and AF64A in rodents
    • MIYAMOTO, M., HIRAI, K., TAKAHASHI, H., KATO, K., NISHIYAMA, M., OKADA, H. AND NAGAOKA, A.: Effects of sustained release formulation of thyrotropin-releasing hormone on learning impairments caused by scopolamine and AF64A in rodents. Eur. J. Pharmacol. 238: 181-189, 1993.
    • (1993) Eur. J. Pharmacol. , vol.238 , pp. 181-189
    • Miyamoto, M.1    Hirai, K.2    Takahashi, H.3    Kato, K.4    Nishiyama, M.5    Okada, H.6    Nagaoka, A.7
  • 41
    • 0023627394 scopus 로고
    • Characteristics of memory impairment following lesioning of the basal forebrain and medial septal nucleus in rats
    • MIYAMOTO, M., KATO, J., NARUMI, S. AND NAGAOKA, A.: Characteristics of memory impairment following lesioning of the basal forebrain and medial septal nucleus in rats. Brain Res. 419: 19-31, 1987.
    • (1987) Brain Res. , vol.419 , pp. 19-31
    • Miyamoto, M.1    Kato, J.2    Narumi, S.3    Nagaoka, A.4
  • 42
    • 0024605033 scopus 로고
    • Effects of continuous infusion of cholinergic drugs on memory impairment in rats with basal forebrain lesions
    • MIYAMOTO, M., NARUMI, S. NAGAOKA, A. AND COYLE, J. T.: Effects of continuous infusion of cholinergic drugs on memory impairment in rats with basal forebrain lesions. J. Pharmacol. Exp. Ther. 248: 825-835, 1989.
    • (1989) J. Pharmacol. Exp. Ther. , vol.248 , pp. 825-835
    • Miyamoto, M.1    Narumi, S.2    Nagaoka, A.3    Coyle, J.T.4
  • 44
    • 0028316603 scopus 로고
    • AMPA-induced excitotoxic lesions of the basal forebrain: A significant role for the cortical cholinergic system in attentional function
    • MUIR, J. L., EVERITT, B. J. AND ROBBINS, T. W.: AMPA-induced excitotoxic lesions of the basal forebrain: A significant role for the cortical cholinergic system in attentional function. J. Neurosci. 14: 2313-2326, 1994.
    • (1994) J. Neurosci. , vol.14 , pp. 2313-2326
    • Muir, J.L.1    Everitt, B.J.2    Robbins, T.W.3
  • 45
    • 0025244916 scopus 로고
    • Effects of benzodiazepines on passive avoidance response and latent learning in mice: Relationship to benzodiazepine receptors and the cholinergic neuronal system
    • NABESHIMA, T., TOHYAMA, K., ICHIHARA, K. AND KAMEYAMA, T.: Effects of benzodiazepines on passive avoidance response and latent learning in mice: Relationship to benzodiazepine receptors and the cholinergic neuronal system. J. Pharmacol. Exp. Ther. 255: 789-794, 1990.
    • (1990) J. Pharmacol. Exp. Ther. , vol.255 , pp. 789-794
    • Nabeshima, T.1    Tohyama, K.2    Ichihara, K.3    Kameyama, T.4
  • 46
    • 0001946349 scopus 로고
    • Beneficial effects of TAK-147, a novel acetylcholinesterase inhibitor, on cerebral energy metabolism and learning impairments in aged rats
    • NAKAYAMA, T., TAKAHASHI, H., MIYAMOTO, M., GOTO, G. AND NAGAI, Y.: Beneficial effects of TAK-147, a novel acetylcholinesterase inhibitor, on cerebral energy metabolism and learning impairments in aged rats. Jpn. J. Pharmacol. 64: 156P, 1994.
    • (1994) Jpn. J. Pharmacol. , vol.64
    • Nakayama, T.1    Takahashi, H.2    Miyamoto, M.3    Goto, G.4    Nagai, Y.5
  • 47
    • 0020664669 scopus 로고
    • Differential-reinforcement-of-low-rate 72-sec schedule: Selective effects of antidepressant drugs
    • O'DONNELL, J. M. AND SEIDEN, L. S.: Differential-reinforcement-of-low-rate 72-sec schedule: Selective effects of antidepressant drugs. J. Pharmacol. Exp. Ther. 224: 80-88, 1983.
    • (1983) J. Pharmacol. Exp. Ther. , vol.224 , pp. 80-88
    • O'Donnell, J.M.1    Seiden, L.S.2
  • 48
    • 0028353485 scopus 로고
    • Cognition in Alzheimer's disease: Disorders of attention and semantic knowledge
    • PARASURAMAN, R. AND MARTIN, A.: Cognition in Alzheimer's disease: Disorders of attention and semantic knowledge. Curr. Opin. Neurobiol. 4, 237-244, 1994.
    • (1994) Curr. Opin. Neurobiol. , vol.4 , pp. 237-244
    • Parasuraman, R.1    Martin, A.2
  • 51
    • 0018078940 scopus 로고
    • Correlation of cholinergic abnormalities with senile plaques and mental test scores
    • PERRY, E. K., TOMLINSON, B. E., BLESSED, G., BERGMANN, K., GIBSON, P. H. AND PERRY, R. H.: Correlation of cholinergic abnormalities with senile plaques and mental test scores. Br. Med. J. 2: 1457-1159, 1978.
    • (1978) Br. Med. J. , vol.2 , pp. 1457-11159
    • Perry, E.K.1    Tomlinson, B.E.2    Blessed, G.3    Bergmann, K.4    Gibson, P.H.5    Perry, R.H.6
  • 52
    • 0018319269 scopus 로고
    • Effects of physostigmine and lecithin on memory in Alzheimer's disease
    • PETERS, B. H. AND LEVIN, H. S.: Effects of physostigmine and lecithin on memory in Alzheimer's disease. Ann. Neurol. 6: 219-221, 1979.
    • (1979) Ann. Neurol. , vol.6 , pp. 219-221
    • Peters, B.H.1    Levin, H.S.2
  • 53
    • 0017651126 scopus 로고
    • Behavioral despair in mice: A primary screening test for antidepressants
    • PORSOLT, R. D., BERTIN, A. AND JALFRE, M.: Behavioral despair in mice: A primary screening test for antidepressants. Arch. Int. Pharamacodyn. Ther. 229: 327-336, 1977.
    • (1977) Arch. Int. Pharamacodyn. Ther. , vol.229 , pp. 327-336
    • Porsolt, R.D.1    Bertin, A.2    Jalfre, M.3
  • 54
    • 0027248501 scopus 로고
    • Alzheimer disease and the prion disorders amyloid β-protein and prion protein amyloidoses
    • PRICE, D. L., BORCHELT, D. R. AND SISODIA, S. S.: Alzheimer disease and the prion disorders amyloid β-protein and prion protein amyloidoses. Proc. Natl. Acad. Sci. U.S.A. 90: 6381-6384, 1993.
    • (1993) Proc. Natl. Acad. Sci. U.S.A. , vol.90 , pp. 6381-6384
    • Price, D.L.1    Borchelt, D.R.2    Sisodia, S.S.3
  • 56
    • 0027526076 scopus 로고
    • Further analysis of the cognitive effects of tetrahydroaminoacridine (THA) in Alzheimer's disease: Assessment of attentional and mnemonic function using CANTAB
    • SAHAKIAN, B. J., OWEN, A. M., MORANT, N. J., EAGER, S. A., BODDINGTON, S., CRAYTON, L., CROCKFORD, H. A., CROOKS, M., HILL, K. AND LEVY, R.: Further analysis of the cognitive effects of tetrahydroaminoacridine (THA) in Alzheimer's disease: Assessment of attentional and mnemonic function using CANTAB. Psychopharmacology 110: 395-401, 1993.
    • (1993) Psychopharmacology , vol.110 , pp. 395-401
    • Sahakian, B.J.1    Owen, A.M.2    Morant, N.J.3    Eager, S.A.4    Boddington, S.5    Crayton, L.6    Crockford, H.A.7    Crooks, M.8    Hill, K.9    Levy, R.10
  • 57
    • 0023555122 scopus 로고
    • Contrasting effects of vasopressin, desglycinamide-vasopressin and amphetamine on a delayed matching to position task in rats
    • SAHGAL, A.: Contrasting effects of vasopressin, desglycinamide-vasopressin and amphetamine on a delayed matching to position task in rats. Psychopharmacology 93: 243-249, 1987.
    • (1987) Psychopharmacology , vol.93 , pp. 243-249
    • Sahgal, A.1
  • 58
    • 0028214258 scopus 로고
    • Impairment of spatially directed attention in patients with probable Alzheimer's disease as measured by eye movement
    • SCINTO, L. F. M., DAFFNER, K. R., CASTRO, L., WEINTRAUB, S., VAVRIK, M. AND MESULAM, M. M.: Impairment of spatially directed attention in patients with probable Alzheimer's disease as measured by eye movement. Arch. Neurol. 51: 682-688, 1994.
    • (1994) Arch. Neurol. , vol.51 , pp. 682-688
    • Scinto, L.F.M.1    Daffner, K.R.2    Castro, L.3    Weintraub, S.4    Vavrik, M.5    Mesulam, M.M.6
  • 59
    • 0028267440 scopus 로고
    • Normal and abnormal biology of the beta-amyloid precursor protein
    • SELKOE, D. J.: Normal and abnormal biology of the beta-amyloid precursor protein. Ann. Rev. Neurosci. 17: 489-517, 1994.
    • (1994) Ann. Rev. Neurosci. , vol.17 , pp. 489-517
    • Selkoe, D.J.1
  • 60
    • 0018188259 scopus 로고
    • Human serial learning: Enhancement with arecoline and impairment with scopolamine
    • Wash. DC
    • SITARAM, N., WEINGARTNER, H. AND GILLIN, J. C.: Human serial learning: Enhancement with arecoline and impairment with scopolamine. Science (Wash. DC) 201: 274-276, 1978.
    • (1978) Science , vol.201 , pp. 274-276
    • Sitaram, N.1    Weingartner, H.2    Gillin, J.C.3
  • 61
    • 0027416260 scopus 로고
    • The prevalence of psychotic, depressive and anxiety syndromes in demented and non-demented 85-year-olds
    • SKOOG, I.: The prevalence of psychotic, depressive and anxiety syndromes in demented and non-demented 85-year-olds. Int. J. Geriatr. Psychiatry 8: 247-253, 1993.
    • (1993) Int. J. Geriatr. Psychiatry , vol.8 , pp. 247-253
    • Skoog, I.1
  • 62
    • 0026584397 scopus 로고
    • Cholinergic blockade and response timing in rats
    • SOFFIE, M. AND LEJEUNE: Cholinergic blockade and response timing in rats. Psychopharmacology 106: 215-220, 1992.
    • (1992) Psychopharmacology , vol.106 , pp. 215-220
    • Soffie, M.1    Lejeune2
  • 63
    • 4043171664 scopus 로고
    • On the mechanism of antidepressant action of imipramine-like drugs
    • SULSER, F., WATTS, J. AND BRODIE, B. B.: On the mechanism of antidepressant action of imipramine-like drugs. Ann. N. Y. Acad. Sci. 98: 279-288, 1962.
    • (1962) Ann. N. Y. Acad. Sci. , vol.98 , pp. 279-288
    • Sulser, F.1    Watts, J.2    Brodie, B.B.3
  • 64
    • 0022899577 scopus 로고
    • Oral tetrahydroaminoacridine in long-term treatment of senile dementia, Alzheimer type
    • SUMMERS, W. K., MAJOVSKI, L. V., MARSH, G. M., TACHIKI, K. AND KLING, A.: Oral tetrahydroaminoacridine in long-term treatment of senile dementia, Alzheimer type. N. Engl. J. Med. 315: 1241-1245, 1986.
    • (1986) N. Engl. J. Med. , vol.315 , pp. 1241-1245
    • Summers, W.K.1    Majovski, L.V.2    Marsh, G.M.3    Tachiki, K.4    Kling, A.5
  • 65
    • 0025193144 scopus 로고
    • Chlordiazepoxide reduces discriminability but not rate of forgetting in delayed conditional discrimination
    • TAN, S., KIRK, R. C., ABRAHAM, W. C., MCNAUGHTON, N.: Chlordiazepoxide reduces discriminability but not rate of forgetting in delayed conditional discrimination. Psychopharmacology 101: 550-554, 1990.
    • (1990) Psychopharmacology , vol.101 , pp. 550-554
    • Tan, S.1    Kirk, R.C.2    Abraham, W.C.3    Mcnaughton, N.4
  • 66
    • 0021944233 scopus 로고
    • Some evidence for amnesic-like effects of benzodiazepines in animals
    • THIEBOT, M. H.: Some evidence for amnesic-like effects of benzodiazepines in animals. Neurosci. Biobehav. Rev. 9: 95-100, 1985.
    • (1985) Neurosci. Biobehav. Rev. , vol.9 , pp. 95-100
    • Thiebot, M.H.1
  • 67
    • 0028885380 scopus 로고
    • How to manage depression and psychosis in Alzheimer's disease
    • TUETH, M. J.: How to manage depression and psychosis in Alzheimer's disease. Geriatrics 50: 43-49, 1995.
    • (1995) Geriatrics , vol.50 , pp. 43-49
    • Tueth, M.J.1
  • 68
    • 0024362380 scopus 로고
    • The effects of scopolamine and methylscopolamine on visual and auditory discriminations in male and female Wistar rats
    • VAN HAAREN, F. AND VAN HEST, A.: The effects of scopolamine and methylscopolamine on visual and auditory discriminations in male and female Wistar rats. Pharmacol. Biochem. Behav. 32: 707-710, 1989.
    • (1989) Pharmacol. Biochem. Behav. , vol.32 , pp. 707-710
    • Van Haaren, F.1    Van Hest, A.2
  • 69
    • 0022485519 scopus 로고
    • d-Amphetamine differentially affects low, but not high response rates of male and female Wistar rats
    • VAN HAAREN, F., HEINSBROEK, R. P. W., LOUWERSE, A. AND VAN DE POLL, N. E.: d-Amphetamine differentially affects low, but not high response rates of male and female Wistar rats. Psychopharmacology 89: 73-76, 1986.
    • (1986) Psychopharmacology , vol.89 , pp. 73-76
    • Van Haaren, F.1    Heinsbroek, R.P.W.2    Louwerse, A.3    Van De Poll, N.E.4
  • 70
    • 0025268065 scopus 로고
    • Scopolamine differentially disrupts the behaviour of male and female Wistar rats in a delayed nonmatching to position procedure
    • VAN HEST, A., STROET, J., VAN HAAREN, F. AND FEENSTRA, M.: Scopolamine differentially disrupts the behaviour of male and female Wistar rats in a delayed nonmatching to position procedure. Pharmacol. Biochem. Behav. 35: 903-909, 1990.
    • (1990) Pharmacol. Biochem. Behav. , vol.35 , pp. 903-909
    • Van Hest, A.1    Stroet, J.2    Van Haaren, F.3    Feenstra, M.4
  • 71
    • 0026528217 scopus 로고
    • Flesinoxan shows antidepressant activity in a DRL 72-s screen
    • VAN HEST, A., VAN DRIMMELEN, M. AND OLIVIER, B.: Flesinoxan shows antidepressant activity in a DRL 72-s screen. Psychopharmacology 107: 474-479, 1992.
    • (1992) Psychopharmacology , vol.107 , pp. 474-479
    • Van Hest, A.1    Van Drimmelen, M.2    Olivier, B.3
  • 72
    • 0027994752 scopus 로고
    • Prevalence of depression in Alzheimer's disease and validity of research diagnostic criteria
    • VIDA, S., DES. ROSIERS, P., CARRIER, L. AND GAUTHIER, S.: Prevalence of depression in Alzheimer's disease and validity of research diagnostic criteria. J. Geriatr. Psychiatry Neurol. 7: 238-244, 1994.
    • (1994) J. Geriatr. Psychiatry Neurol. , vol.7 , pp. 238-244
    • Vida, S.1    Des Rosiers, P.2    Carrier, L.3    Gauthier, S.4
  • 74
    • 0025214116 scopus 로고
    • Behavioral effects of cocaine and its interaction with d-amphetamine and morphine in rats
    • WENGER, G. R. AND WRIGHT, D. W.: Behavioral effects of cocaine and its interaction with d-amphetamine and morphine in rats. Pharmacol. Biochem. Behav. 36: 595-600, 1990.
    • (1990) Pharmacol. Biochem. Behav. , vol.36 , pp. 595-600
    • Wenger, G.R.1    Wright, D.W.2
  • 75
    • 0025973463 scopus 로고
    • Tetrahydroamino-acridine and lecithin in the treatment of Alzheimer's disease. Effect on cognition, functioning in daily life, behavioral disturbances and burden experienced by carers
    • WEINSTEIN, H. C., TEUNISSE, S. AND VAN GOOL, W. A.: Tetrahydroamino-acridine and lecithin in the treatment of Alzheimer's disease. Effect on cognition, functioning in daily life, behavioral disturbances and burden experienced by carers. J. Neurol. 238: 34-38, 1991.
    • (1991) J. Neurol. , vol.238 , pp. 34-38
    • Weinstein, H.C.1    Teunisse, S.2    Van Gool, W.A.3
  • 76
    • 0020072221 scopus 로고
    • Alzheimer's disease and senile dementia: Loss of neurons in the basal forebrain
    • Wash. DC
    • WHITEHOUSE, P. J., PRICE, D. L., STRUBLE, R. G., CLERK, A. W., COYLE, J. T. AND DELONG, M. R.: Alzheimer's disease and senile dementia: Loss of neurons in the basal forebrain. Science (Wash. DC) 216: 1237-1239, 1982.
    • (1982) Science , vol.216 , pp. 1237-1239
    • Whitehouse, P.J.1    Price, D.L.2    Struble, R.G.3    Clerk, A.W.4    Coyle, J.T.5    Delong, M.R.6
  • 77
    • 0028985085 scopus 로고
    • FR121196, a potential antidementia drug, ameliorates the impaired memory of rat in the Morris water maze
    • YAMAZAKI, M., MATSUOKA, N., MAEDA, N., KURATANI, K., OHKUBO, Y. AND YAMAGUCHI, I.: FR121196, a potential antidementia drug, ameliorates the impaired memory of rat in the Morris water maze. J. Pharmacol. Exp Ther. 272: 256-263, 1995.
    • (1995) J. Pharmacol. Exp Ther. , vol.272 , pp. 256-263
    • Yamazaki, M.1    Matsuoka, N.2    Maeda, N.3    Kuratani, K.4    Ohkubo, Y.5    Yamaguchi, I.6
  • 78
    • 0025978708 scopus 로고
    • Cholinergic drugs reverse AF64A-induced impairment of passive avoidance learning in rats
    • YAMAZAKI, N., KATO, K., KURIHARA, E. AND NAGAOKA, A.: Cholinergic drugs reverse AF64A-induced impairment of passive avoidance learning in rats. Psychopharmacology 103: 215-222, 1991.
    • (1991) Psychopharmacology , vol.103 , pp. 215-222
    • Yamazaki, N.1    Kato, K.2    Kurihara, E.3    Nagaoka, A.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.