Characterization of mouse leukemia L1210 cells resistant to the ribonucleotide reductase inhibitor 4-methyl-5-amino-1-formylisoquinoline thiosemicarbazone

Oncology Research

Volumn 8, Issue 10-11, 1996, Pages 449-456

  Cory, Ann H ^b   Sato, Atsushi ^a,b   Thompson, David P ^a,b   Cory, Joseph G ^a,b  

^a Osaka Womens Univ   (Japan)

^b EAST CAROLINA UNIVERSITY   (United States)

Author keywords

4 methyl 5 amino 1 formylisoquinoline thiosemicarbazone; drug resistance; nonheme iron subunit; ribonucleotide reductase

Indexed keywords

5 AMINO 4 METHYLISOQUINOLINE 1 CARBOXALDEHYDE THIOSEMICARBAZONE; CISPLATIN; DAUNORUBICIN; ETOPOSIDE; OXIDOREDUCTASE INHIBITOR; RIBONUCLEOTIDE REDUCTASE; VINBLASTINE;

ANIMAL CELL; ARTICLE; CELL FREE SYSTEM; DRUG EFFECT; ENZYME ACTIVITY; ENZYME ASSAY; LEUKEMIA CELL; LEUKEMIA L 1210; MOUSE; NONHUMAN; PRIORITY JOURNAL;

EID: 0030426531     PISSN: 09650407     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (36)

1. 1. Cory, J. G. Role of ribonucleotide reductase in cell division. In: Cory, J. G.; Cory, A. H., eds. Inhibitors of nucleoside disphosphate reductase. New York: Pergamon Press; 1989:pp. 1-16.
2. 2. Moore, E. C.; Sartorelli, A. C. The inhibition of ribonucleotide reductase by α-(N)-heterocyclic carboxaldehyde thiosemicarbazones. In: Cory, J. G; Cory, A. H., eds. Inhibitors of nucleoside diphosphate reductase. New York: Pergamon Press; 1989: pp. 204-215.
3. 3. Cory, J. G.; Cory, A. H.; Rappa, G.; Lorico, A.; Liu, M.-C.; Lin, T.-S.; Sartorelli, A. C. Inhibitors of ribonucleotide reductase: comparative effects of amino- and hydroxy-substituted pyridine-2-carboxaldehyde thiosemicarbazones. Biochem. Pharmacol. 48:335-344; 1994.
4. 4. Moore, E. C.; Hurlbert, R. B. The inhibition of ribonucleoside diphosphate reductase by hydroxyurea, guanazole and pyrazoloimidazole (IMPY). In: Cory, J. G.; Cory, A. H., eds. Inhibitors of nucleoside diphosphate reductase. New York: Pergamon Press; 1989:pp. 165-201.
5. 5. Chang, C.-H.; Cheng, Y.-C. Effects of nucleoside triphosphates on human ribonucleotide reductase from Molt-4F cells. Cancer Res. 39:5087-5092; 1979.
6. 6. Moore, E. C. Components and control of the ribonucleotide reductase system of the rat. Adv. Enz. Regul. 15:101-114; 1977.
7. 7. Cory, J. G.; Fleischer, A. E.; Munro, J. Reconstitution of ribonucleotide reductase from Ehrlich tumor cells. J. Biol. Chem. 253:2898-2901; 1978.
8. 1 and M2. J. Biol. Chem. 255:7426-7432; 1980.
9. 1 cDNA reveals amino acid sequence homology with Escherichia coli and herpes virus ribonucleotide reductase. J. Biol. Chem. 260:7015-7022; 1985.
10. 1 and M2 subunits of mouse ribonucleotide reductase. Mol. Cell. Biol. 6:3433-3442; 1986.
11. 11. Cory, J. G.; Fleischer, A. E. Specific inhibitors directed at the individual components of ribonucleotide reductase as an approach to combination chemotherapy. Cancer Res. 39:4600-4604; 1979.
12. 12. Sato, A.; Carter, G. L.; Bacon, P. E.; Cory, J. G. Effects of combinations of drugs having different modes of action at the ribonucleotide reductase site on the growth of L1210 cells in culture. Cancer Res. 42:4353-4357; 1982.
13. 13. Graslund, A.; Ehrenberg, A.; Thelander, L. Characterization of the free radical of mammalian ribonucleotide reductase. J. Biol. Chem. 257:5711-5715; 1982.
14. 14. Thelander, M.; Graslund, A.; Thelander, L. Subunit M2 of mammalian ribonucleotide reductase. Characterization of a homogeneous protein isolated from M2-overproducing mouse cells. J. Biol. Chem. 260:2737-2741; 1985.
15. 15. Cory, J. G.; Fleischer, A. E. Mode of inhibition of tumor cell ribonucleotide reductase by 2,3-dihydro-1H-pyrazolo[2,3-A] imidazole (NSC 51143). Cancer Res. 40: 3891-3894; 1980.
16. 16. Thelander, L.; Graslund, A. Mechanism of inhibition of mammalian ribonucleotide reductase by the iron chelate of 1-formylisoquinoline thiosemicarbazone. J. Biol. Chem. 258:4063-4066; 1983.
17. 17. Eriksson, S.; Thelander, L.; Akerman, M. Allosteric regulation of calf thymus ribonucleoside diphosphate reductase. Biochemistry 14:2948-2952; 1979.
18. 18. Tseng, W.-C.; Derse, D.; Cheng, Y.-C.; Brockman, R.W.; Bennett, L. L., Jr. In vitro biological activity of 9-β-D-arabinosyl-2-fluoroadenine and the biological actions of its triphosphate on DNA polymerases and ribonucleotide reductase from HeLa cells. Mol. Pharmacol. 21: 474-477; 1982.
19. 19. Wright, J. Altered mammalian ribonucleoside diphosphate reductase from mutant cell lines. In: Cory, J. G.; Cory, A. H., eds. Inhibitors of nucleoside diphosphate reductase. New York: Pergamon Press; 1989:pp. 89-111.
20. 20. Carter, G. L.; Cory, J. G. Cross-resistance patterns in hydroxyurea-resistant leukemia L1210 cells. Cancer Res. 48:5796-5799; 1988.
21. 21. Eriksson, S.; Gudas, L. J.; Ullman, B.; Clift, S. M.; Martin, D. W., Jr. Deoxy ATP-resistant ribonucleotide reductase of mutant mouse lymphoma cells. J. Biol. Chem. 256:10184-10188; 1981.
22. 22. Cory, J. G.; Carter, G. L. Leukemia L1210 cell lines resistant to ribonucleotide reductase inhibitors. Cancer Res. 48:839-843; 1988.
23. 23. Carter, G. L.; Cory, J. G. Selective resistance of L1210 cell lines to inhibitors directed at the subunits of ribonucleotide reductase. Adv. Enz. Regul. 29:123-139; 1989.
24. 24. Carter, G. L.; Thompson, D. P.; Cory, J. G. Mechanisms of drug resistance to inhibitors directed at the individual subunits of ribonucleotide reductase. Cancer Commun. 1:13-20; 1989.
25. 1 is sufficient to increase resistance to hydroxyurea in transfected cells. Cancer Res. 55:1328-1333; 1995.
26. 26. Rittberg, D. A. H.; Wright, J. A. Relationships between sensitivity to hydroxyurea and 4-methyl-5-amino-1-formylisoquinoline thiosemicarbazones (MAIQ) and ribonucleotide reductase RNR2 messenger RNA levels in strains of Saccharomyces cerevisiae. Biochem. Cell Biol. 67:352-357; 1989.
27. 27. Cory, J. G.; Downes, D. L.; Cory, A. H.; Schaper, K.-J.; Seydel, J. K. Substituted 2-acylpyridine-α-(N)-hetaryl-hydrazones as inhibitors of ribonucleotide reductase activity and L1210 cell growth. Anticancer Res. 14: 875-879; 1994.
28. 28. Cory, J. G.; Carter, G. L.; Bacon, P. E.; Tang, A.; Lien, E. J. Inhibition of ribonucleotide reductase and L1210 cell growth by N-hydroxy-N′-aminoguanidine derivatives. Biochem. Pharmacol. 34:2645-2650; 1985.
29. 29. Cory, A. H.; Owen, T. C.; Barltrop, J. A.; Cory, J. G. Use of an aqueous soluble tetrazolium/formazan assay for cell growth assays in culture. Cancer Commun. 3: 207-212; 1991.
30. 30. Cory, J. G.; Mansell, M. M.; George, C. B.; Wilkinson, D. S. Inhibition of nucleic acid synthesis in Ehrlich tumor cells by periodate-oxidized adenosine and adenylic acid. Arch. Biochem. Biophys. 160:495-503; 1974.
31. 31. Steeper, J. R.; Steuart, C. E. A rapid assay for CDP reductase activity in mammalian cell extracts. Anal. Biochem. 34: 123-130; 1970.
32. 32. Chomczynski, P.; Sacchi, N. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem. 162:156-159; 1987.
33. 33. Fourney, R. M.; Miryakoski, J.; Day, R. S., III; Paterson, M. C. Northern blotting: efficient RNA staining and transfer. Focus 10:5-6; 1988.
34. 34. Sambrook, J.; Fritsch, E. F.; Maniatis, T. Appendix. In: Molecular cloning: a laboratory manual. 2nd edition. Cold Spring Harbor: Cold Spring Harbor Laboratory Press; 1989:p. B.13.
35. 35. Yansura, D. G. Expression as trp E fusion. Meth. Enzymol. 185:161-166; 1990.
36. 36. Lowry, O. H.; Rosebrough, N. J.; Farr, A. L.; Randall, R. J. Protein measurement with the Folin phenol reagent. J. Biol. Chem. 193:265-275; 1951.